Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: Effects of process variables

Colloids and Surfaces B: Biointerfaces

Volumn 88, Issue 1, 2011, Pages 483-489

  Das, Surajit ^a   Ng, Wai Kiong ^a   Kanaujia, Parijat ^a   Kim, Sanggu ^a   Tan, Reginald B H ^a,b  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Drug release; Encapsulation; Hydrophobic drug; Solid lipid nanoparticle; Tretinoin

Indexed keywords

AQUEOUS PHASE; CROSS-POLARIZED; CRYSTALLINITIES; DRUG CARRIER; DRUG CONCENTRATION; DRUG CRYSTALS; DRUG ENCAPSULATION; DRUG ENCAPSULATION EFFICIENCY; DRUG LOADING; DRUG RELEASE; DRUG RELEASE STUDY; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; FORMULATION DESIGN; HYDROPHOBIC DRUG; MATRIX; ORAL ABSORPTION; PHYSICO-CHEMICAL CHARACTERIZATION; POLYDISPERSITY INDICES; POWDER X-RAY DIFFRACTION (PXRD); PROCESS VARIABLES; SMOOTH SURFACE; SOLID LIPID NANOPARTICLES; SPHERICAL PARTICLE; STABILITY STUDY; TRETINOIN; ZETA POTENTIAL (ZP);

DIFFERENTIAL SCANNING CALORIMETRY; DRUG PRODUCTS; EMULSIFICATION; ENCAPSULATION; FIELD EMISSION MICROSCOPES; HYDROPHOBICITY; LIGHT POLARIZATION; POLYDISPERSITY; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION; ZETA POTENTIAL;

NANOPARTICLES;

GLYCEROL BEHENATE; GLYCEROL PALMITOSTEARATE; RETINOIC ACID; SOLID LIPID NANOPARTICLE;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG STABILITY; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; HYDROPHOBICITY; NANOANALYSIS; NANOENCAPSULATION; NANOFABRICATION; NANOPHARMACEUTICS; PHYSICAL CHEMISTRY; POLARIZATION MICROSCOPY; PRIORITY JOURNAL; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION; ZETA POTENTIAL;

CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; NANOPARTICLES; TRETINOIN; X-RAY DIFFRACTION;

EID: 80052099308     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2011.07.036     Document Type: Article

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