Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 94, Issue , 2015, Pages 64-72

  Din, Fakhar Ud ^a   Mustapha, Omer ^a   Kim, Dong Wuk ^a   Rashid, Rehmana ^a   Park, Jong Hyuck ^a   Choi, Ju Yeon ^b   Ku, Sae Kwang ^c   Yong, Chul Soon ^b   Kim, Jong Oh ^b   Choi, Han Gon ^a  

^a Hanyang University   (South Korea)

^b Yeungnam University   (South Korea)

^c Daegu Haany University   (South Korea)

Author keywords

Bioavailability; Burst effect; Dual reverse thermosensitive hydrogel; Flurbiprofen; Solid lipid nanoparticle

Indexed keywords

FLURBIPROFEN; LIPID; POLOXAMER; SOLID LIPID NANOPARTICLE; SURFACTANT; TRIETHANOLAMINE; DRUG CARRIER; ETHANOLAMINE DERIVATIVE; HYDROGEL; NANOPARTICLE; NONSTEROID ANTIINFLAMMATORY AGENT; TRIACYLGLYCEROL; TRICAPRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFECT; GEL; GELATION; HALF LIFE TIME; HEAT SENSITIVITY; HYDROGEL; MALE; MELTING POINT; NONHUMAN; PARTICLE SIZE; RAT; RECTUM MUCOSA; ROOM TEMPERATURE; STRENGTH; TEMPERATURE; VISCOSITY; ADHESION; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; FLOW KINETICS; HEAT; MEDICINAL CHEMISTRY; NANOMEDICINE; PHARMACEUTICS; PROCEDURES; RECTAL DRUG ADMINISTRATION; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADHESIVENESS; ADMINISTRATION, RECTAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; ETHANOLAMINES; FLURBIPROFEN; HOT TEMPERATURE; HYDROGELS; MALE; NANOMEDICINE; NANOPARTICLES; PARTICLE SIZE; POLOXAMER; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SOLUBILITY; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES; VISCOSITY;

EID: 84929996524     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.04.019     Document Type: Article

References (42)

1. H. Cui, X. Zhuang, C. He, Y. Wei, and X. Chen High performance and reversible ionic polypeptide hydrogel based on charge-driven assembly for biomedical applications Acta Biomater. 11 2015 183 190
2. J.J. Xuan, P. Balakrishnan, D.H. Oh, W.H. Yeo, S.M. Park, C.S. Yong, and H.G. Choi Rheological characterization and in vivo evaluation of thermosensitive poloxamer-based hydrogel for intramuscular injection of piroxicam Int. J. Pharm. 395 2010 317 323
3. D.W. Kim, T. Ramasamy, J.Y. Choi, J.H. Kim, C.S. Yong, J.O. Kim, and H.G. Choi The influence of bile salt on the chemotherapeutic response of docetaxel-loaded thermosensitive nanomicelles Int. J. Nanomedicine 9 2014 3815
4. Y.G. Seo, D.W. Kim, W.H. Yeo, T. Ramasamy, Y.K. Oh, Y.J. Park, J.A. Kim, D.H. Oh, S.K. Ku, and J.K. Kim Docetaxel-loaded thermosensitive and bioadhesive nanomicelles as a rectal drug delivery system for enhanced chemotherapeutic effect Pharm. Res. 30 2013 1860 1870
5. W.H. Yeo, T. Ramasamy, D.W. Kim, H.J. Cho, Y.I. Kim, K.H. Cho, C.S. Yong, J.O. Kim, and H.G. Choi Docetaxel-loaded thermosensitive liquid suppository: optimization of rheological properties Arch. Pharm. Res. 36 2013 1480 1486
6. K. Derakhshandeh, M. Fashi, and S. Seifoleslami Thermosensitive Pluronic® hydrogel: prolonged injectable formulation for drug abuse Drug Des. Devel. Ther. 4 2010 255
7. E. Ruel-Gariepy, and J.C. Leroux In situ-forming hydrogels - review of temperature-sensitive systems Eur. J. Pharm. Biopharm. 58 2004 409 426
8. H.G. Choi, Y.K. Oh, and C.K. Kim In situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability Int. J. Pharm. 165 1998 23 32
9. S. Miyazaki, F. Suisha, N. Kawasaki, M. Shirakawa, K. Yamatoya, and D. Attwood Thermally reversible xyloglucan gels as vehicles for rectal drug delivery J. Control. Release 56 1998 75 83
10. R.H. Mueller, K. Maeder, and S. Gohla Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art Eur. J. Pharm. Biopharm. 50 2000 161 177
11. L. Battaglia, and M. Gallarate Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery Expert. Opin. Drug Deliv. 9 2012 497 508
12. P. Ekambaram, A.A.H. Sathali, and K. Priyanka Solid lipid nanoparticles: a review Sci. Rev. Chem. Commun. 2 2012 80 102
13. 4 nanoparticles Pharm. Res. 2014 1 10
14. L. Veerappan, and S. Reddy Formulation development and evaluation of flurbiprofen lipospheres Int. J. Adv. Sci. Arts. 1 2010 90 95
15. P.R. Veerareddy, and S.K. Vemula Formulation, evaluation and pharmacokinetics of colon targeted pulsatile system of flurbiprofen J. Drug Target. 20 2012 703 714
16. K.N. Patel, and T.A. Mehta Formulation design and characterization of an elementary osmotic pump tablet of flurbiprofen PDA J. Pharm. Sci. Technol. 68 2014 333 346
17. E. Supuk, M.U. Ghori, K. Asare-Addo, P.R. Laity, P.M. Panchmatia, and B.R. Conway The influence of salt formation on electrostatic and compression properties of flurbiprofen salts Int. J. Pharm. 458 2013 118 127
18. B. Daravath, R.R. Tadikonda, and S.K. Vemula Formulation and pharmacokinetics of gelucire solid dispersions of flurbiprofen Drug Dev. Ind. Pharm. 2014 1 9
19. D.H. Oh, Y.J. Park, J.H. Kang, C.S. Yong, and H.G. Choi Physicochemical characterization and in vivo evaluation of flurbiprofen-loaded solid dispersion without crystalline change Drug Deliv. 18 2011 46 53
20. J. Kawadkar, A. Pathak, R. Kishore, and M.K. Chauhan Formulation, characterization and in vitro-in vivo evaluation of flurbiprofen-loaded nanostructured lipid carriers for transdermal delivery Drug Dev. Ind. Pharm. 39 2013 569 578
21. T. Uchino, Y. Matsumoto, A. Murata, T. Oka, Y. Miyazaki, and Y. Kagawa Transdermal delivery of flurbiprofen from surfactant-based vesicles: particle characterization and the effect of water on in vitro transport Int. J. Pharm. 464 2014 75 84
22. J. Kawadkar, R. Jain, R. Kishore, A. Pathak, and M.K. Chauhan Formulation and evaluation of flurbiprofen-loaded genipin cross-linked gelatin microspheres for intra-articular delivery J. Drug Target. 21 2013 200 210
23. K.M. Park, and C.K. Kim Preparation and evaluation of flurbiprofen-loaded microemulsion for parenteral delivery Int. J. Pharm. 181 1999 173 179
24. A. Kovacevic, S. Savic, G. Vuleta, R. Muller, and C. Keck Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure Int. J. Pharm. 406 2011 163 172
25. G. Abdelbary, and R.H. Fahmy Diazepam-loaded solid lipid nanoparticles: design and characterization AAPS PharmSciTech. 10 2009 211 219
26. Y. Agrawal, K.C. Petkar, and K.K. Sawant Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis Int. J. Pharm. 401 2010 93 102
27. D. Hou, C. Xie, K. Huang, and C. Zhu The production and characteristics of solid lipid nanoparticles (SLNs) Biomaterials 24 2003 1781 1785
28. C.S. Yong, Y.K. Oh, S.H. Jung, J.D. Rhee, H.D. Kim, C.K. Kim, and H.G. Choi Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol Eur. J. Pharm. Sci. 23 2004 347 353
29. H.G. Choi, D.D. Kim, H.W. Jun, B.K. Yoo, and C.S. Yong Improvement of dissolution and bioavailability of nitrendipine by inclusion in hydroxypropyl-β-cyclodextrin Drug Dev. Ind. Pharm. 29 2003 1085 1094
30. M. Gibaldi, and D. Perrier Non-compartmental analysis based on statistical moment theory Pharmacokinetics 2 1982 409 417
31. S. Park, S.C. Regmi, S.Y. Park, E.K. Lee, J.H. Chang, S.K. Ku, D.H. Kim, and J. Kim Protective effect of 7-O-succinyl macrolactin A against intestinal inflammation is mediated through PI3-kinase/Akt/mTOR and NF-κB signaling pathways Eur. J. Pharmacol. 735 2014 184 192
32. S.C. Regmi, S.Y. Park, S.K. Ku, and J. Kim Serotonin regulates innate immune responses of colon epithelial cells through Nox2-derived reactive oxygen species Free Radic. Biol. Med. 69 2014 377 389
33. M.A. Kalam, Y. Sultana, A. Ali, M. Aqil, A.K. Mishra, and K. Chuttani Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system J. Drug Target. 18 2010 191 204
34. M. Sznitowska, M. Gajewska, S. Janicki, A. Radwanska, and G. Lukowski Bioavailability of diazepam from aqueous-organic solution, submicron emulsion and solid lipid nanoparticles after rectal administration in rabbits Eur. J. Pharm. Biopharm. 52 2001 159 163
35. S.V. Mussi, R.C. Silva, M.C. Oliveira, C.M. Lucci, R.B. Azevedo, and L.A. Ferreira New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles Eur. J. Pharm. Sci. 48 2013 282 290
36. L.H. Reddy, and R. Murthy Etoposide-loaded nanoparticles made from glyceride lipids: formulation, characterization, in vitro drug release, and stability evaluation AAPS PharmSciTech. 6 2005 E158 E166
37. S.J. Lim, and C.K. Kim Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid Int. J. Pharm. 243 2002 135 146
38. H.G. Choi, M.K. Lee, M.H. Kim, and C.K. Kim Effect of additives on the physicochemical properties of liquid suppository bases Int. J. Pharm. 190 1999 13 19
39. L. Mayol, M. Biondi, F. Quaglia, S. Fusco, A. Borzacchiello, L. Ambrosio, and M.I. La Rotonda Injectable thermally responsive mucoadhesive gel for sustained protein delivery Biomacromolecules 12 2010 28 33
40. C.S. Yong, J.S. Choi, Q.Z. Quan, J.D. Rhee, C.K. Kim, S.J. Lim, K.M. Kim, P.S. Oh, and H.G. Choi Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium Int. J. Pharm. 226 2001 195 205
41. M.J. Chen, Y.M. Cheng, P.H. Lai, J.F. Wu, and Y.C. Hsu In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention Int. J. Colorectal Dis. 27 2012 869 878
42. N. Bhattarai, H.R. Ramay, J. Gunn, F.A. Matsen, and M. Zhang PEG-grafted Chitosan as an injectable thermosensitive hydrogel for sustained protein release J. Control. Release 103 2005 609 624