In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment

International Journal of Pharmaceutics

Volumn 463, Issue 1, 2014, Pages 31-37

  Souza, Ana Luiza Ribeiro De ^a,b   Andreani, Tatiana ^b,c   De Oliveira, Rosimeire Nunes ^d   Kiill, Charlene Priscila ^a   Santos, Fernanda Kolenyak Dos ^a   Allegretti, Silmara Marques ^d   Chaud, Marco Vinícius ^e   Souto, Eliana B ^b,f   Silva, Amélia M ^b,c   Gremião, Maria Palmira Daflon ^a,g  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^c UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^d UNIVERSITY OF CAMPINAS   (Brazil)

^e UNIVERSITY OF SOROCABA   (Brazil)

^f UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^g School of Pharmaceutical Sciences   (Brazil)

Author keywords

Cytotoxicity; HepG2 cells; Praziquantel; Schistosoma mansoni; Schistosomiasis; Solid lipid nanoparticles

Indexed keywords

PRAZIQUANTEL; SOLID LIPID NANOPARTICLE;

ARTICLE; CELL STRAIN HEPG2; CYTOTOXICITY; DRUG ABSORPTION; DRUG EFFICACY; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENCAPSULATION; EVALUATION STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INTESTINE ABSORPTION; PARASITE CULTIVATION; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

CYTOTOXICITY; HEPG2 CELLS; PRAZIQUANTEL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SOLID LIPID NANOPARTICLES;

ANIMALS; ANTHELMINTICS; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; FEMALE; HEP G2 CELLS; HUMANS; INTESTINAL ABSORPTION; INTESTINES; LIPIDS; NANOPARTICLES; PRAZIQUANTEL; RATS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

EID: 84892910774     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.12.022     Document Type: Article

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