Cysteine-Functionalized Nanostructured Lipid Carriers for Oral Delivery of Docetaxel: A Permeability and Pharmacokinetic Study

Molecular Pharmaceutics

Volumn 12, Issue 7, 2015, Pages 2384-2395

  Fang, Guihua ^a   Tang, Bo ^a   Chao, Yanhui ^a   Xu, Helin ^a   Gou, Jingxin ^a   Zhang, Yu ^a   Xu, Hui ^a   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

cysteine; docetaxel; intestinal absorption; mucoadhesion; nanostructured lipid carriers

Indexed keywords

CYSTEINE DERIVATIVE; DOCETAXEL; GLYCOPROTEIN; LIPID; MACROGOL 2000; MUCIN; NANOCARRIER; NANOMATERIAL; PACLITAXEL; STEARIC ACID; THIOL GROUP; CYSTEINE; DRUG CARRIER; TAXOID;

ABSORPTION RATE CONSTANT; ANIMAL EXPERIMENT; ANIMAL TISSUE; APPARENT PERMEABILITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; DRUG TRANSPORT; HIGH TEMPERATURE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE PERFUSION; MALE; MOLECULAR WEIGHT; MUCOADHESION; NANOENCAPSULATION; NANOMEDICINE; NONHUMAN; OXIDATION; PARTICLE SIZE; PASSIVE TRANSPORT; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; RATE CONSTANT; SURFACE PROPERTY; SYNTHESIS; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG EFFECTS; ORAL DRUG ADMINISTRATION; PERMEABILITY; PROCEDURES; SPRAGUE DAWLEY RAT; X RAY PHOTOELECTRON SPECTROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CYSTEINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; INTESTINAL ABSORPTION; LIPIDS; MALE; NANOSTRUCTURES; PARTICLE SIZE; PERMEABILITY; PHOTOELECTRON SPECTROSCOPY; RATS; RATS, SPRAGUE-DAWLEY; TAXOIDS;

EID: 84936792249     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00081     Document Type: Article

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