In vivo sustained release of siRNA from solid lipid nanoparticles

ACS Nano

Volumn 5, Issue 12, 2011, Pages 9977-9983

  Lobovkina, Tatsiana ^a   Jacobson, Gunilla B ^a   Gonzalez Gonzalez, Emilio ^a,b   Hickerson, Robyn P ^c   Leake, Devin ^d   Kaspar, Roger L ^b,c   Contag, Christopher H ^a,b   Zare, Richard N ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TransDerm Inc   (United States)

^d Thermo Fisher Scientific   (United States)

Author keywords

drug delivery; siRNA; solid lipid nanoparticles; sustained release

Indexed keywords

ALTERNATIVE APPROACH; CATIONIC LIPIDS; CONTROLLED RELEASE; DRUG DELIVERY SYSTEM; IN-VITRO; IN-VIVO; INTRADERMAL INJECTION; ION PAIRING; LOADING RATIO; NANOCARRIERS; NANOPRECIPITATION; POLYMERIC NANOPARTICLES; POTENT DRUGS; SIRNA; SMALL INTERFERING RNA (SIRNA); SOLID LIPID NANOPARTICLES; SUSTAINED RELEASE; TRISTEARIN;

CONTROLLED DRUG DELIVERY; DRUG DELIVERY; DRUG THERAPY; NANOPARTICLES; RNA;

GENE THERAPY;

NANOCAPSULE; SMALL INTERFERING RNA; TRIACYLGLYCEROL; TRISTEARIN;

ANIMAL; ARTICLE; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; GENE SILENCING; MATERIALS TESTING; MOUSE;

ANIMALS; DELAYED-ACTION PREPARATIONS; DIFFUSION; GENE SILENCING; MATERIALS TESTING; MICE; NANOCAPSULES; RNA, SMALL INTERFERING; TRIGLYCERIDES;

EID: 84555223589     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn203745n     Document Type: Article

References (41)

1. Juliano, R.; Bauman, J.; Kang, H.; Ming, X. Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides Mol. Pharmaceutics 2009, 6, 686-695
2. Gonzalez-Gonzalez, E.; Speaker, T. J.; Hickerson, R. P.; Spitler, R.; Flores, M. A.; Leake, D.; Contag, C. H.; Kaspar, R. L. Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD) Mol. Ther. 2010, 18, 1667-1674
3. Li, C. X.; Parker, A.; Menocal, E.; Xiang, S. L.; Borodyansky, L.; Fruehauf, J. H. Delivery of RNA Interference Cell Cycle 2006, 5, 2103-2109 (Pubitemid 44553744)
4. Tokatlian, T.; Segura, T. siRNA Applications in Nanomedicine Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. 2010, 2, 305-315
5. Hickerson, R. P.; Vlassov, A. V.; Wang, Q.; Leake, D.; Ilves, H.; Gonzalez-Gonzalez, E.; Contag, C. H.; Johnston, B. H.; Kaspar, R. L. Stability Study of Unmodified siRNA and Relevance to Clinical Use Oligonucleotides 2008, 18, 345-354 (Pubitemid 352791342)
6. Dykxhoorn, D. M.; Lieberman, J. Knocking Down Disease with siRNAs Cell 2006, 126, 231-235 (Pubitemid 44092975)
7. Li, W. J.; Szoka, F. C. Lipid-Based Nanoparticles for Nucleic Acid Delivery Pharm. Res. 2007, 24, 438-449
8. Whitehead, K. A.; Langer, R.; Anderson, D. G. Knocking Down Barriers: Advances in siRNA Delivery Nat. Rev. Drug Discovery 2009, 9, 412-412
9. Kornek, M.; Lukacs-Kornek, V.; Limmer, A.; Raskopf, E.; Becker, U.; Kloeckner, M.; Sauerbruch, T.; Schmitz, V. 1,2-Dioleoyl-3-trimethylammonium- propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor a Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Mol. Med. 2008, 14, 365-373
10. Urban-Klein, B.; Werth, S.; Abuharbeid, S.; Czubayko, F.; Aigner, A. RNAi-Mediated Gene-Targeting through Systemic Application of Polyethylenimine (PEI)-Complexed siRNA in Vivo Gene Ther. 2005, 12, 461-466 (Pubitemid 40394299)
11. Davis, M. E.; Zuckerman, J. E.; Choi, C. H. J.; Seligson, D.; Tolcher, A.; Alabi, C. A.; Yen, Y.; Heidel, J. D.; Ribas, A. Evidence of RNAi in Humans from Systemically Administered siRNA via Targeted Nanoparticles Nature 2010, 464, 1067-1070
12. Guo, P. X.; Coban, O.; Snead, N. M.; Trebley, J.; Hoeprich, S.; Guo, S. C.; Shu, Y. Engineering RNA for Targeted siRNA Delivery and Medical Application Adv. Drug Delivery Rev. 2010, 62, 650-666
13. Tsutsumi, T.; Hirayama, F.; Uekama, K.; Arima, H. Potential Use of Polyamidoamine Dendrimer/α-Cyclodextrin Conjugate (Generation 3, G3) as a Novel Carrier for Short Hairpin RNA-Expressing Plasmid DNA J. Pharm. Sci. 2008, 97, 3022-3034
14. Han, H. D.; Mangala, L. S.; Lee, J. W.; Shahzad, M. M. K.; Kim, H. S.; Shen, D. Y.; Nam, E. J.; Mora, E. M.; Stone, R. L.; Lu, C. H. et al. Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles Clin. Cancer Res. 2010, 16, 3910-3922
15. Woodrow, K. A.; Cu, Y.; Booth, C. J.; Saucier-Sawyer, J. K.; Wood, M. J.; Saltzman, W. M. Intravaginal Gene Silencing Using Biodegradable Polymer Nanoparticles Densely Loaded with Small-Interfering RNA Nat. Mater. 2009, 8, 526-533
16. Siegwart, D. J.; Whitehead, K. A.; Nuhn, L.; Sahay, G.; Cheng, H.; Jiang, S.; Ma, M. L.; Lytton-Jean, A.; Vegas, A.; Fenton, P. et al. Combinatorial Synthesis of Chemically Diverse Core-Shell Nanoparticles for Intracellular Delivery Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 12996-13001
17. Gonzalez-Gonzalez, E.; Ra, H.; Hickerson, R. P.; Wang, Q.; Piyawattanametha, W.; Mandella, M. J.; Kino, G. S.; Leake, D.; Avilion, A. A.; Solgaard, O.; Doyle, T. C. et al. siRNA Silencing of Keratinocyte-Specific GFP Expression in a Transgenic Mouse Skin Model Gene Ther. 2009, 16, 963-972
18. Judge, A.; Maclachlan, I. Overcoming the Innate Immune Response to Small Interfering RNA Hum. Gene Ther. 2008, 19, 111-124 (Pubitemid 351271512)
19. Lee, S.; Yang, S. C.; Kao, C.-Y.; Pierce, R. H.; Murthy, N. Solid Polymeric Microparticles Enhance the Delivery of siRNA to Macrophages in Vivo Nucleic Acids Res. 2009, 37, e145
20. Jacobson, G. B.; Gonzalez-Gonzalez, E.; Spitler, R.; Shinde, R.; Leake, D.; Kaspar, R. L.; Contag, C. H.; Zare, R. N. Biodegradable Nanoparticles with Sustained Release of Functional siRNA in Skin J. Pharm. Sci. 2010, 99, 4261-4266
21. Krebs, M. D.; Jeon, O.; Alsberg, E. Localized and Sustained Delivery of Silencing RNA from Macroscopic Biopolymer Hydrogels J. Am. Chem. Soc. 2009, 131, 9204-9206
22. Patil, Y.; Panyam, J. Polymeric Nanoparticles for siRNA Delivery and Gene Silencing Int. J. Pharm. 2009, 367, 195-203
23. Shi, J.; Xiao, Z.; Votruba, A. R.; Vilos, C.; Farokhzad, O. C. Differentially Charged Hollow Core/Shell Lipid-Polymer-wqLipid Hybrid Nanoparticles for Small Interfering RNA Delivery Angew. Chem., Int. Ed. 2011, 50, 7027-31
24. Mehnert, W.; Mader, K. Solid Lipid Nanoparticles: Production, Characterization and Applications Adv. Drug Delivery Rev. 2001, 47, 165-196 (Pubitemid 32324113)
25. Jain, A.; Agarwal, A.; Majumder, S.; Lariya, N.; Khaya, A.; Agrawal, H.; Majumdar, S.; Agrawal, G. P. Mannosylated Solid Lipid Nanoparticles as Vectors for Site-Specific Delivery of an Anti-Cancer Drug J. Controlled Release 2010, 148, 359-367
26. Xue, H. Y.; Wong, H. L. Tailoring Nanostructured Solid-Lipid Carriers for Time-Controlled Intracellular siRNA Kinetics To Sustain RNAi-Mediated Chemosensitizationd Biomaterials 2011, 32, 2662-2672
27. Wissing, S. A.; Kayser, O.; Muller, R. H. Solid Lipid Nanoparticles for Parenteral Drug Delivery Adv. Drug Delivery Rev. 2004, 56, 1257-1272 (Pubitemid 38510473)
28. Almelda, A. J.; Souto, E. Solid Lipid Nanoparticles as a Drug Delivery System for Peptides and Proteins Adv. Drug Delivery Rev. 2007, 59, 478-490 (Pubitemid 47260710)
29. Gallarate, M.; Battaglia, L.; Peira, E.; Trotta, M. Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique Int. J. Chem. Eng. 2011, 2011, 1-6
30. Andreozzi, E.; Seo, J. W.; Ferrara, K.; Louie, A. Novel Method To Label Solid Lipid Nanoparticles with Cu-64 for Positron Emission Tomography Imaging Bioconjugate Chem. 2011, 22, 808-818
31. Kim, H. R.; Kim, I. K.; Bae, K. H.; Lee, S. H.; Lee, Y.; Park, T. G. Cationic Solid Lipid Nanoparticles Reconstituted from Low Density Lipoprotein Components for Delivery of siRNA Mol. Pharmaceutics 2008, 5, 622-631
32. Pedersen, N.; Hansen, S.; Heydenreich, A. V.; Kristensen, H. G.; Poulsen, H. S. Solid Lipid Nanoparticles Can Effectively Bind DNA, Streptavidin and Biotinylated Ligands Eur. J. Pharm. Biopharm. 2006, 62, 155-162 (Pubitemid 43143267)
33. Yu, W.; Liu, C.; Liu, Y.; Zhang, N.; Xu, W. Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages Pharm. Res. 2010, 27, 1584-1596
34. Yu, W.; Liu, C.; Ye, J.; Zou, W.; Zhang, N.; Xu, W. Novel Cationic SLN Containing a Synthesized Single-Tailed Lipid as a Modifier for Gene Delivery Nanotechnology 2009, 20, 215102
35. Patel, M. M.; Zeles, M. G.; Manning, M. C.; Randolph, T. W.; Anchordoquy, T. J. Degradation Kinetics of High Molecular Weight Poly(l -lactide) Microspheres and Release Mechanism of Lipid: DNA Complexes J. Pharm. Sci. 2004, 93, 2573-2584 (Pubitemid 39319441)
36. Bligh, E. G.; Dyer, W. J.; Rapid, A Method of Total Lipid Extraction and Purification Can. J. Biochem. Physiol. 1959, 37, 911-917
37. Chan, J. M.; Zhang, L. F.; Yuet, K. P.; Liao, G.; Rhee, J. W.; Langer, R.; Farokhzad, O. C. PLGA-Lecithin-PEG Core-Shell Nanoparticles for Controlled Drug Delivery Biomaterials 2009, 30, 1627-1634
38. Zhang, S.; Yun, J.; Shen, S.; Chen, Z.; Yao, K.; Chen, J.; Chen, B. Formation of Solid Lipid Nanoparticles in a Microchannel System with a Cross-Shaped Junction Chem. Eng. Sci. 2008, 63, 5600-5605
39. Alexis, F.; Pridgen, E.; Molnar, L. K.; Farokhzad, O. C. Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles Mol. Pharmaceutics 2008, 5, 505-515
40. Hickerson, R. P.; Smith, F. J. D.; Reeves, R. E.; Contag, C. H.; Leake, D.; Leachman, S. A.; Milstone, L. M.; McLean, W. H. I.; Kaspar, R. L. Single-Nucleotide-Specific siRNA Targeting in a Dominant-Negative Skin Model J. Invest. Dermatol. 2008, 128, 594-605 (Pubitemid 351252662)
41. Ge, J.; Jacobson, G. B.; Lobovkina, T.; Holmberg, K.; Zare, R. N. Sustained Release of Nucleic Acids from Polymeric Nanoparticles Using Microemulsion Precipitation in Supercritical Carbon Dioxide Chem. Commun. 2010, 46, 9034-9036