Inhalable microparticles as carriers for pulmonary delivery of thymopentin-loaded solid lipid nanoparticles

Pharmaceutical Research

Volumn 27, Issue 9, 2010, Pages 1977-1986

  Li, Yan Zhen ^a   Sun, Xun ^a   Gong, Tao ^a   Liu, Jie ^a   Zuo, Jiao ^a   Zhang, Zhi Rong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

microparticles; pulmonary delivery; solid lipid nanoparticles; spray drying; thymopentin

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; SOLID LIPID NANOPARTICLE; SUPEROXIDE DISMUTASE; THYMOPENTIN;

ARTICLE; BIOEQUIVALENCE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; ENZYME ACTIVITY; LUNG; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SPRAY DRYING; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INHALATION; ANIMALS; CD4-CD8 RATIO; DRUG CARRIERS; DRUG STABILITY; IMMUNOLOGIC DEFICIENCY SYNDROMES; LIPIDS; LUNG; LYMPHOCYTE SUBSETS; MICROSCOPY, CONFOCAL; NANOPARTICLES; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; SURFACE PROPERTIES; THYMOPENTIN;

EID: 77955472829     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0201-z     Document Type: Article

References (33)

1. G Goldstein M Scheid E Boyse D Schlesinger JV Wauwe 1979 A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin Science 204 1309 1310 10.1126/science.451537 1:CAS:528: DyaE1MXks1yqtrY%3D 451537
2. N Clumeck S Cran P Van de Perre FM Lemone J Duchateau K Bolla 1985 Thymopentin treatment in AIDS and pre-AIDS patients Immunol Res 4 58 62
3. VK Singh S Biswas KB Mathur W Haq SK Garg SS Agarwal 1998 Thymopentin and splenopentin as immunomodulators Immunol Res 17 345 368 10.1007/BF02786456 1:CAS:528:DyaK1cXktVSju7k%3D 9638477
4. JP Tischio JE Patrick HS Weintraub M Chasin G Goldstein 1979 Short in vitro half-life of thymopoietin32-36 pentapeptide in human plasma Int J Pept Protein Res 14 479 484 1:CAS:528:DyaL3cXhvFGhtw%3D%3D 395119
5. M Jalalipour K Gilani H Tajerzadeh AR Najafabadi M Barghi 2008 Characterization and aerodynamic evaluation of spray dried recombinant human growth hormone using protein stabilizing agents Int J Pharm 352 209 216 1:CAS:528:DC%2BD1cXitlWhtr8%3D 18164150
6. F Ungaro GD Rosa A Miro F Quaglia MIL Rotonda 2006 Cyclodextrins in the production of large porous particles: development of dry powders for the sustained release of insulin to the lungs Eur J Pharm Sci 28 423 432 10.1016/j.ejps.2006.05.005 1:CAS:528:DC%2BD28XntFWrtbw%3D 16806857 (Pubitemid 44038350)
7. RO Salama D Traini H-K Chan A Sung AJ Ammit PM Young 2009 Preparation and evaluation of controlled release microparticles for respiratory protein therapy J Pharm Sci 98 2709 2717 10.1002/jps.21653 1:CAS:528:DC%2BD1MXns1eqt7Y%3D 19130607
8. EXUBERA official site. http://www.exubera.com/content/con-index.jsp? setShowOn=../content/con-indx.jsp&setShowHighlightOn=../content/con-index. jsp.ed.
9. Y Yang N Bajaj P Xu K Ohn MD Tsifansky Y Yeo 2009 Development of highly porous large PLGA microparticles for pulmonary drug delivery Biomaterials 30 1947 1953 10.1016/j.biomaterials.2008.12.044 1:CAS:528:DC%2BD1MXhvFahsbw%3D 19135245
10. PC Seville TP Learoyd H-Y Li IJ Williamson JC Birchall 2007 Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery Powder Technol 178 40 50 10.1016/j.powtec.2007.03.046 1:CAS:528:DC%2BD2sXpt1yksro%3D (Pubitemid 47247802)
11. N Sivadasa D O'Rourkea A Tobina V Buckley Z Ramtoolaa JG Kellya AJ Hickey S-A Cryana 2008 A comparative study of a range of polymeric microspheres as potential carriers for the inhalation of proteins Int J Pharm 358 159 167 10.1016/j.ijpharm.2008.03.024
12. N Tsapis D Bennett B Jackson DA Weitz DA Edwards 2002 Trojan particles: large porous carriers of nanoparticles for drug delivery Proc Natl Acad Sci 99 12001 12005 10.1073/pnas.182233999 1:CAS:528:DC%2BD38XntlCltb4%3D 12200546
13. K Hadinoto P Phanapavudhikul Z Kewu RBH Tan 2006 Novel formulation of large hollow nanoparticles aggregates as potential carriers in inhaled delivery of nanoparticulate drugs Ind Eng Chem Res 45 3697 3706 10.1021/ie0513191 1:CAS:528:DC%2BD28XjtlSitLo%3D (Pubitemid 43812807)
14. K Hadinoto K Zhu RBH Tan 2007 Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery Int J Pharm 341 195 206 10.1016/j.ijpharm.2007.03.035 1:CAS:528:DC%2BD2sXot1CmurY%3D 17467934 (Pubitemid 47088103)
15. JO-H Shama Y Zhang WH Finlay WH Roaa R Löbenberg 2004 Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung Int J Pharm 269 457 467 10.1016/j.ijpharm.2003.09.041 (Pubitemid 38045308)
16. K Makino N Yamamoto K Higuchi N Harada H Ohshima H Terada 2003 Phagocytic uptake of polystyrene microspheres by alveolar macrophages: effects of the size and surface properties of the microspheres Colloids Surf B Biointerfaces 27 33 39 10.1016/S0927-7765(02)00042-5 1:CAS:528:DC%2BD38XoslGht7w%3D (Pubitemid 35346319)
17. M García-Fuentes D Torres MJ Alonso 2002 Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules Colloids Surf B Biointerfaces 27 159 168 10.1016/S0927-7765(02)00053-X
18. K Kho K Hadinoto 2010 Aqueous re-dispersibility characterization of spray-dried hollow spherical silica nano-aggregates Powder Technol 198 354 363 10.1016/j.powtec.2009.11.031 1:CAS:528:DC%2BC3cXhtlSjs70%3D
19. C Freitas RH Müller 1998 Spray-drying of solid lipid nanoparticles (SLN™) Eur J Pharm Biopharm 46 145 151 10.1016/S0939-6411(97)00172-0 1:CAS:528:DyaK1cXnsFKhtLY%3D 9795036 (Pubitemid 28414472)
20. A Grenha B Seijo C Serra C Remuñán-López 2007 Chitosan nanoparticle-loaded mannitol microspheres: structure and surface characterization Biomacromolecules 8 2072 2079 10.1021/bm061131g 1:CAS:528:DC%2BD2sXmslyrsrk%3D 17585804 (Pubitemid 47104289)
21. A Grenha C Remuñán-López ELS Carvalho B Seijo 2008 Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins Eur J Pharm Biopharm 69 83 93 10.1016/j.ejpb.2007.10.017 1:CAS:528:DC%2BD1cXktlGlu70%3D 18166446
22. C Gómez-Gaete E Fattal L Silva M Besnard N Tsapis 2008 Dexamethasone acetate encapsulation into Trojan particles J Control Release 128 41 49 10.1016/j.jconrel.2008.02.008 18374442
23. J Liu T Gong CG Wang ZR Zhong ZR Zhang 2007 Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization Int J Pharm 340 153 162 10.1016/j.ijpharm.2007. 03.009 1:CAS:528:DC%2BD2sXns1Kgs7o%3D 17428627 (Pubitemid 47044961)
24. C Bosquillon V Préat R Vanbever 2004 Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats J Control Release 96 233 244 10.1016/j.jconrel.2004.01.027 1:CAS:528:DC%2BD2cXivFGmsbg%3D 15081215 (Pubitemid 38481506)
25. J Wang WL Lu GW Liang KC Wu C-G Zhang X Zhang J-C Wang H Zhang X-Q Wang Q Zhang 2006 Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in sprague-dawley rats following intranasal delivery of thymopentin with or without enhancers Peptides 27 826 835 10.1016/j.peptides.2005.09.008 1:CAS:528:DC%2BD28XjtFWqs7w%3D 16242213
26. A Treitinger C Spada JC Verdi AFB Miranda OV Oliveira MVS Silveira P Moriel DSP Abdalla 2001 Decreased antioxidant defence in individuals infected by the human immunodeficiency virus Eur J Clin Investig 30 454 459 10.1046/j.1365-2362.2000.00642.x
27. YS Yin DW Chen MX Qiao Z Lu HY Hu 2006 Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin J Control Release 116 337 345 10.1016/j.jconrel.2006.09.015 1:CAS:528:DC%2BD28Xht1KitL%2FL 17097180 (Pubitemid 44827411)
28. DL French DA Edwards RW Niven 1996 The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation J Aerosol Sci 27 769 783 10.1016/0021-8502(96)00021-3 1:CAS:528:DyaK28Xks1entbc%3D (Pubitemid 26234318)
29. M Maury K Murphy S Kumar A Mauerer G Lee 2005 Spray-drying of proteins: effects of sorbitol and trehalose on aggregation and FT-IR amide I spectrum of an immunoglobulin G Eur J Pharm Biopharm 59 251 261 10.1016/j.ejpb.2004.07.010 1:CAS:528:DC%2BD2MXmtlCqtw%3D%3D 15661497 (Pubitemid 40127582)
30. C Bosquillon C Lombry V Préat R Vanbever 2001 Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance J Control Release 70 329 339 10.1016/S0168-3659(00)00362-X 1:CAS:528:DC%2BD3MXhtV2mtbY%3D 11182203 (Pubitemid 32155456)
31. Kibbe AH. Handbook of pharmaceutical excipients, London; 2000.
32. PO Souilliac CR Middaugh JH Rytting 2002 Investigation of protein/carbohydrate interactions in the dried state. 2. Diffuse reflectance FTIR studies Int J Pharm 235 207 218 10.1016/S0378-5173(01)00987-5 (Pubitemid 34185451)
33. ST Tzannis SJ Prestrelski 1999 Activity-stability consideration of trypsinogen during spray drying: effect of sucrose J Pharm Sci 88 351 359 10.1021/js980011e 1:CAS:528:DyaK1MXot1aguw%3D%3D 10052995 (Pubitemid 29116105)