Ceramide–palmitic acid complex based Curcumin solid lipid nanoparticles for transdermal delivery: pharmacokinetic and pharmacodynamic study

Journal of Experimental Nanoscience

Volumn 11, Issue 1, 2016, Pages 38-53

  Gaur, Praveen Kumar ^a   Mishra, Shikha ^b   Verma, Anurag ^c   Verma, Navneet ^c  

^a DR A P J ABDUL KALAM TECHNICAL UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

^c IFTM UNIVERSITY   (India)

Author keywords

anti inflammatory; ceramide 2; Curcumin; permeation; pharmacokinetics

Indexed keywords

BIOCHEMISTRY; CERAMIDES; DRUG DELIVERY; DRUG PRODUCTS; EMULSIFICATION; NANOPARTICLES; PALMITIC ACID; PERMEATION; SKIN;

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY ACTIVITY; CERAMIDE 2; CURCUMIN; EMULSION SOLVENT EVAPORATION; PHARMACOKINETIC PARAMETERS; SOLID LIPID NANOPARTICLE (SLN); SOLID LIPID NANOPARTICLES;

PHARMACOKINETICS;

EID: 84949530513     PISSN: 17458080     EISSN: 17458099     Source Type: Journal    
DOI: 10.1080/17458080.2015.1025301     Document Type: Article

References (38)

1. R.C.Srimal, B.N.Dhawan. Pharmacology of diferuloyl methane (Curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol. 1973;25:447–452.
2. M.N.A.Sreejayan, Rao. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol. 1994;46:1013–1016.
3. R.J.Anto, G.Kuttan, K.V.D.Babu, K.N.Rajasekharan, R.Kuttan. Anti inflammatory activity of natural and synthetic curcuminoids. Pharm Pharmacol Commun. 1998;4:103–106.
4. M.T.Huang, R.C.Smart, C.Q.Wong, A.H.Conney. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1988;48:5941–5946.
5. D.S.Rao, N.C.Sekhara. M.N.Satyanarayana, M.Srinivasan, Effect of curcumin on serum and liver cholesterol levels in the rat. J Nutr. 1970;100:1307–1315.
6. R.S.Mulik, J.Mönkkönen, R.O.Juvonen, K.R.Mahadik, A.R.Paradkar. Transferrin mediated solid lipid nanoparticles containing curcumin:enhanced in vitro anticancer activity by induction of apoptosis. Int J Pharm. 2010;398:190–203.
7. Y.J.Wang, M.H.Pan, A.L.Cheng, L.I.Lin, Y.S.Ho, C.Y.Hsieh. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal. 1997;15:1867–1876.
8. H.H.Tønnesen, J.Karlsen, G.HenegouwenGBv. Studies on curcumin and curcuminoids. VIII. Photochemical stability of curcumin. Z Lebensm Unters Forsch. 1986;183:116–122.
9. V.Ravindranath, N.Chandrasekhara. Absorption and tissue distribution of curcumin in rats. Toxicology. 1980;16:259–265.
10. A.Asai, T.Miyazawa. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. Life Sci. 2000;67:2785–2793.
11. A.Preetha, A.B.Kunnumakkara, R.A.Newman, B.B.Aggarwal. Bioavailability of Curcumin: problems and promises. Mol Pharm. 2007;4(6):807–818.
12. I.Castangia, A.Nácher, C.Caddeo, D.Valenti, A.M.Fadda, O.Díez-Sales, A.Ruiz-Saurí, M.Manconi. Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice. Acta Biomater. 2014;10:1292–1300.
13. H.Chaudhary, K.Kohli, V.Kumar. Nano-transfersomes as a novel carrier for transdermal delivery. Int J Pharm. 2013;454:367–380.
14. W.Tiyaboonchai, W.Tungpradit, P.Plianbangchang. Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. Int J Pharm. 2007;337:299–306.
15. K.Vidyalakshmi, K.N.Rashmi, T.M.Pramod Kumar, Siddaramaiah. Studies on formulation and in vitro evaluation of PVA/Chitosan blend films for drug delivery. J Macromol Sci Pure Appl Chem. 2004;41:1115–1122.
16. V.Kumar, S.A.Lewis, S.Mutalik, D.B.Shenoy, M.Venkatesh, N.Udupa. Biodegradable microspheres of curcumin for treatment of inflammation. Indian J Physiol Pharmacol. 2002;46:209–217.
17. X.Wang, Y.Jiang, Y.-W.Wang, M.-T.Huang, C.-T.Ho, Q.Huang. Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chem. 2008;108:419–424.
18. P.Batheja, R.Thakur, B.Michniak. Transdermal iontophoresis. Expert Opin Drug Deliv. 2006;3:127–138.
19. A.-R.Denet, R.Vanbever, V.Préat. Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev. 2004;56:659–674.
20. A.H.El-Kamel, I.M.Al-Fagih, I.A.Alsarra. Effect of sonophoresis and chemical enhancers on testosterone transdermal delivery from solid lipid microparticles: an in vitro study. Curr Drug Deliv. 2008;5:20–26.
21. J.W.Lee, P.Gadiraju, J.-H.Park, M.G.Allen, M.R.Prausnitz. Microsecond thermal ablation of skin for transdermal drug delivery. J Control Release. 2011;154:58–68.
22. R.J.Babu, M.Singh, N.Kanikkannan. Fatty alcohols and fatty acids. In: E.W.Smith, H.I.Maibach, editors. Percutaneous penetration enhancers. Boca Raton, FL: CRC Press; Taylor & Francis Group; 2005. p. 137–158.
23. C.-H.Liu, F.-Y.Chang, D.-K.Hung. Terpene microemulsions for transdermal curcumin delivery: effects of terpenes and cosurfactants. Colloids Surf B Biointerfaces. 2011;82:63–70.
24. C.A.Phillips, B.B.Michniak. Transdermal delivery of drugs with differing lipophilicities using azone analogs as dermal penetration enhancers. J Pharm Sci. 1995;84:1427–1433.
25. A.W.Jasper, N.E.Schultz, D.G.Truhlar. Analytic potential energy functions for simulating aluminum nanoparticles. J Phys Chem B. 2005;109:3915–3920
26. H.Reithmeier, J.Hermann, A.Göpferich. Development and characterization of lipid microparticles as a drug carrier for somatostatin. Int J Pharm. 2001;218:133–143.
27. S.Morel, E.Ugazio, R.Cavalli, M.R.Gasco. Thymopentin in solid lipid nanoparticles. Int J Pharm. 1996;132:259–261.
28. C.Schwarz, W.Mehnert, J.S.Lucks, R.H.Müller. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J Control Rel. 1994;30:83–96.
29. A.Nemmar, J.A.Holme, I.Rosas, P.E.Schwarze, E.Alfaro-Moreno. Recent advances in particulate matter and nanoparticle toxicology: a review of the in vivo and in vitro studies. Biomed Res Int. 2013;2013:22.
30. J.Varshosaz, S.Ghaffari, S.F.Mirshojaei, A.Jafarian, F.Atyabi, F.Kobarfard, S.Azarmi. Biodistribution of Amikacin solid lipid nanoparticles after pulmonary delivery. Biomed Res Int. 2013;2013:8.
31. M.S.Falzarano, C.Passarelli, E.Bassi, M.Fabris, D.Perrone, P.Sabatelli, N.M.Maraldi, S.Donà, R.Selvatici, P.Bonaldo, K.Sparnacci, M.Laus, P.Braghetta, P.Rimessi, A.Ferlini. Biodistribution and molecular studies on orally administered nanoparticle-AON complexes encapsulated with alginate aiming at inducing dystrophin rescue in MDX mice. Biomed Res Int. 2013;2013:13.
32. P.K.Gaur, S.Mishra, S.Purohit. Development of aceclofenac nanovesicular system using biomaterial for transdermal delivery: physical characterization, ex vivo, in vivo, and anti-inflammatory studies. J Biomater Sci Polym Ed. 2013;24:2126–2141.
33. F.M.Goñi, A.Alonso. Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids. Biochim Biophys Acta. 2006;1758:1902–1921.
34. S.Wartewig, R.H.H.Neubert. Properties of ceramides and their impact on the stratum corneum structure: a review. Skin Pharmacol Physiol. 2007;20:220–229.
35. P.K.Gaur, S.Mishra. Diclofenac loaded nanoparticles fabricated with biomaterial (ceramide 2) for transdermal delivery. Sci Adv Mater. 2014;6:736–745.
36. P.K.Gaur, S.Purohit, S.Mishra. Solid lipid nanoparticles of Guggul lipid as drug carrier for transdermal drug delivery. Biomed Res Int. 2013;2013:10.
37. M.Manconi, C.Caddeo, C.Sinico, D.Valenti, M.C.Mostallino, G.Biggio, A.M.Fadda. Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle-skin interaction. Eur J Pharm Biopharm, 2011;78:27–35.
38. P.K.Gaur, S.Purohit, Y.Kumar, S.Mishra, A.Bhandari. Ceramide-2 nanovesicles for effective transdermal delivery: development: characterization and pharmacokinetic evaluation. Drug Dev Ind Pharm. 2014;40:568–576.