-
1
-
-
80052245888
-
Health and economic burden of the projected obesity trends in the USA and the UK
-
Y. C. Wang, K. McPherson, T. Marsh, S. L. Gortmaker, M. Brown, Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378, 815-825 (2011).
-
(2011)
Lancet
, vol.378
, pp. 815-825
-
-
Wang, Y.C.1
McPherson, K.2
Marsh, T.3
Gortmaker, S.L.4
Brown, M.5
-
2
-
-
80052236883
-
The global obesity pandemic: Shaped by global drivers and local environments
-
B. A. Swinburn, G. Sacks, K. D. Hall, K. McPherson, D. T. Finegood, M. L. Moodie, S. L. Gortmaker, The global obesity pandemic: Shaped by global drivers and local environments. Lancet 378, 804-814 (2011).
-
(2011)
Lancet
, vol.378
, pp. 804-814
-
-
Swinburn, B.A.1
Sacks, G.2
Hall, K.D.3
McPherson, K.4
Finegood, D.T.5
Moodie, M.L.6
Gortmaker, S.L.7
-
3
-
-
79951558318
-
Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index), National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants
-
M. M. Finucane, G. A. Stevens, M. J. Cowan, G. Danaei, J. K. Lin, C. J. Paciorek, G. M. Singh, H. R. Gutierrez, Y. Lu, A. N. Bahalim, F. Farzadfar, L. M. Riley, M. Ezzati, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index), National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 377, 557-567 (2011).
-
(2011)
Lancet
, vol.377
, pp. 557-567
-
-
Finucane, M.M.1
Stevens, G.A.2
Cowan, M.J.3
Danaei, G.4
Lin, J.K.5
Paciorek, C.J.6
Singh, G.M.7
Gutierrez, H.R.8
Lu, Y.9
Bahalim, A.N.10
Farzadfar, F.11
Riley, L.M.12
Ezzati, M.13
-
5
-
-
0034611675
-
Obesity in the new millennium
-
J. M. Friedman, Obesity in the new millennium. Nature 404, 632-634 (2000).
-
(2000)
Nature
, vol.404
, pp. 632-634
-
-
Friedman, J.M.1
-
6
-
-
0021965878
-
Paleolithic nutrition-A consideration of its nature and current implications
-
S. B. Eaton, M. Konner, Paleolithic nutrition-A consideration of its nature and current implications. N. Engl. J. Med. 312, 283-289 (1985).
-
(1985)
N. Engl. J. Med
, vol.312
, pp. 283-289
-
-
Eaton, S.B.1
Konner, M.2
-
7
-
-
34547701951
-
Neurobiology of feeding and energy expenditure
-
Q. Gao, T. L. Horvath, Neurobiology of feeding and energy expenditure. Annu. Rev. Neurosci. 30, 367-398 (2007).
-
(2007)
Annu. Rev. Neurosci
, vol.30
, pp. 367-398
-
-
Gao, Q.1
Horvath, T.L.2
-
8
-
-
33845582594
-
A central thermogenic-like mechanism in feeding regulation: An interplay between arcuate nucleus T3 and UCP2
-
A. Coppola, Z.-W. Liu, Z. B. Andrews, E. Paradis, M.-C. Roy, J. M. Friedman, D. Ricquier, D. Richard, T. L. Horvath, X.-B. Gao, S. Diano, A central thermogenic-like mechanism in feeding regulation: An interplay between arcuate nucleus T3 and UCP2. Cell Metab. 5, 21-33 (2007).
-
(2007)
Cell Metab
, vol.5
, pp. 21-33
-
-
Coppola, A.1
Liu, Z.-W.2
Andrews, Z.B.3
Paradis, E.4
Roy, M.-C.5
Friedman, J.M.6
Ricquier, D.7
Richard, D.8
Horvath, T.L.9
Gao, X.-B.10
Diano, S.11
-
9
-
-
56549094962
-
Evolutionary origins of the obesity epidemic: Natural selection of thrifty genes or genetic drift following predation release? Int
-
A. M. Prentice, B. J. Hennig, A. J. Fulford, Evolutionary origins of the obesity epidemic: Natural selection of thrifty genes or genetic drift following predation release? Int. J. Obes. 32, 1607-1610 (2008).
-
(2008)
J. Obes
, vol.32
, pp. 1607-1610
-
-
Prentice, A.M.1
Hennig, B.J.2
Fulford, A.J.3
-
10
-
-
34547654219
-
The global epidemic of obesity: An overview
-
B. Caballero, The global epidemic of obesity: An overview. Epidemiol. Rev. 29, 1-5 (2007).
-
(2007)
Epidemiol. Rev
, vol.29
, pp. 1-5
-
-
Caballero, B.1
-
11
-
-
84880669127
-
Evolutionary perspectives on the obesity epidemic: Adaptive, maladaptive, and neutral viewpoints
-
J. R. Speakman, Evolutionary perspectives on the obesity epidemic: Adaptive, maladaptive, and neutral viewpoints. Annu. Rev. Nutr. 33, 289-317 (2013).
-
(2013)
Annu. Rev. Nutr
, vol.33
, pp. 289-317
-
-
Speakman, J.R.1
-
12
-
-
84866108680
-
Limitations in anti-obesity drug development: The critical role of hunger-promoting neurons
-
M. O. Dietrich, T. L. Horvath, Limitations in anti-obesity drug development: The critical role of hunger-promoting neurons. Nat. Rev. Drug Discov. 11, 675-691 (2012).
-
(2012)
Nat. Rev. Drug Discov
, vol.11
, pp. 675-691
-
-
Dietrich, M.O.1
Horvath, T.L.2
-
13
-
-
0242363255
-
Monitoring of stored and available fuel by the CNS: Implications for obesity
-
R. J. Seeley, S. C. Woods, Monitoring of stored and available fuel by the CNS: Implications for obesity. Nat. Rev. Neurosci. 4, 901-909 (2003).
-
(2003)
Nat. Rev. Neurosci
, vol.4
, pp. 901-909
-
-
Seeley, R.J.1
Woods, S.C.2
-
14
-
-
33845572889
-
Studies on the physiological functions of the melanocortin system
-
R. D. Cone, Studies on the physiological functions of the melanocortin system. Endocr. Rev. 27, 736-749 (2006).
-
(2006)
Endocr. Rev
, vol.27
, pp. 736-749
-
-
Cone, R.D.1
-
15
-
-
84944733460
-
Sympathetic neuro-adipose connections mediate leptin-driven lipolysis
-
W. Zeng, R. M. Pirzgalska, M. M. A. Pereira, N. Kubasova, A. Barateiro, E. Seixas, Y.-H. Lu, A. Kozlova, H. Voss, G. G. Martins, J. M. Friedman, A. I. Domingos, Sympathetic neuro-adipose connections mediate leptin-driven lipolysis. Cell 163, 84-94 (2015).
-
(2015)
Cell
, vol.163
, pp. 84-94
-
-
Zeng, W.1
Pirzgalska, R.M.2
Pereira, M.M.A.3
Kubasova, N.4
Barateiro, A.5
Seixas, E.6
Lu, Y.-H.7
Kozlova, A.8
Voss, H.9
Martins, G.G.10
Friedman, J.M.11
Domingos, A.I.12
-
16
-
-
0037008157
-
BAR signaling required for diet-induced thermogenesis and obesity resistance
-
E. S. Bachman, H. Dhillon, C.-Y. Zhang, S. Cinti, A. C. Bianco, B. K. Kobilka, B. B. Lowell, bAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297, 843-845 (2002).
-
(2002)
Science
, vol.297
, pp. 843-845
-
-
Bachman, E.S.1
Dhillon, H.2
Zhang, C.-Y.3
Cinti, S.4
Bianco, A.C.5
Kobilka, B.K.6
Lowell, B.B.7
-
17
-
-
84920972410
-
Leptin and insulin act on POMC neurons to promote the browning of white fat
-
G. T. Dodd, S. Decherf, K. Loh, S. E. Simonds, F. Wiede, E. Balland, T. L. Merry, H. Münzberg, Z.-Y. Zhang, B. B. Kahn, B. G. Neel, K. K. Bence, Z. B. Andrews, M. A. Cowley, T. Tiganis, Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell 160, 88-104 (2015).
-
(2015)
Cell
, vol.160
, pp. 88-104
-
-
Dodd, G.T.1
Decherf, S.2
Loh, K.3
Simonds, S.E.4
Wiede, F.5
Balland, E.6
Merry, T.L.7
Münzberg, H.8
Zhang, Z.-Y.9
Kahn, B.B.10
Neel, B.G.11
Bence, K.K.12
Andrews, Z.B.13
Cowley, M.A.14
Tiganis, T.15
-
18
-
-
26444530145
-
Leptin, leptin receptors, and the control of body weight
-
J. M. Friedman, Leptin, leptin receptors, and the control of body weight. Nutr. Rev. 56, s38-s46 (1998).
-
(1998)
Nutr. Rev
, vol.56
, pp. s38-s46
-
-
Friedman, J.M.1
-
19
-
-
0028959193
-
Changes in energy expenditure resulting from altered body weight
-
R. L. Leibel, M. Rosenbaum, J. Hirsch, Changes in energy expenditure resulting from altered body weight. N. Engl. J. Med. 332, 621-628 (1995).
-
(1995)
N. Engl. J. Med
, vol.332
, pp. 621-628
-
-
Leibel, R.L.1
Rosenbaum, M.2
Hirsch, J.3
-
20
-
-
84924969384
-
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
-
J. R. Brestoff, B. S. Kim, S. A. Saenz, R. R. Stine, L. A. Monticelli, G. F. Sonnenberg, J. J. Thome, D. L. Farber, K. Lutfy, P. Seale, D. Artis, Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519, 242-246 (2015).
-
(2015)
Nature
, vol.519
, pp. 242-246
-
-
Brestoff, J.R.1
Kim, B.S.2
Saenz, S.A.3
Stine, R.R.4
Monticelli, L.A.5
Sonnenberg, G.F.6
Thome, J.J.7
Farber, D.L.8
Lutfy, K.9
Seale, P.10
Artis, D.11
-
21
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
C. M. Taniguchi, B. Emanuelli, C. R. Kahn, Critical nodes in signalling pathways: Insights into insulin action. Nat. Rev. Mol. Cell Biol. 7, 85-96 (2006).
-
(2006)
Nat. Rev. Mol. Cell Biol
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
22
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
A. R. Saltiel, C. R. Kahn, Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806 (2001).
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
23
-
-
33645982255
-
From mice to men: Insights into the insulin resistance syndromes
-
S. B. Biddinger, C. R. Kahn, From mice to men: Insights into the insulin resistance syndromes. Annu. Rev. Physiol. 68, 123-158 (2006).
-
(2006)
Annu. Rev. Physiol
, vol.68
, pp. 123-158
-
-
Biddinger, S.B.1
Kahn, C.R.2
-
24
-
-
50049086521
-
The emerging genetic architecture of type 2 diabetes
-
A. Doria, M.-E. Patti, C. R. Kahn, The emerging genetic architecture of type 2 diabetes. Cell Metab. 8, 186-200 (2008).
-
(2008)
Cell Metab
, vol.8
, pp. 186-200
-
-
Doria, A.1
Patti, M.-E.2
Kahn, C.R.3
-
25
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
J. M. Olefsky, C. K. Glass, Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219-246 (2010).
-
(2010)
Annu. Rev. Physiol
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
26
-
-
0035936763
-
New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
-
A. R. Saltiel, New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104, 517-529 (2001).
-
(2001)
Cell
, vol.104
, pp. 517-529
-
-
Saltiel, A.R.1
-
27
-
-
22844449583
-
The insulin resistance syndrome: Definition and dietary approaches to treatment
-
G. M. Reaven, The insulin resistance syndrome: Definition and dietary approaches to treatment. Annu. Rev. Nutr. 25, 391-406 (2005).
-
(2005)
Annu. Rev. Nutr
, vol.25
, pp. 391-406
-
-
Reaven, G.M.1
-
28
-
-
22144496594
-
Why syndrome X? from Harold Himsworth to the insulin resistance syndrome
-
G. M. Reaven, Why syndrome X? From Harold Himsworth to the insulin resistance syndrome. Cell Metab. 1, 9-14 (2005).
-
(2005)
Cell Metab
, vol.1
, pp. 9-14
-
-
Reaven, G.M.1
-
29
-
-
17044386953
-
Type 2 diabetes: Principles of pathogenesis and therapy
-
M. Stumvoll, B. J. Goldstein, T. W. van Haeften, Type 2 diabetes: Principles of pathogenesis and therapy. Lancet 365, 1333-1346 (2005).
-
(2005)
Lancet
, vol.365
, pp. 1333-1346
-
-
Stumvoll, M.1
Goldstein, B.J.2
Van Haeften, T.W.3
-
30
-
-
84860441011
-
Inflammation and lipid signaling in the etiology of insulin resistance
-
C. K. Glass, J. M. Olefsky, Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 15, 635-645 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 635-645
-
-
Glass, C.K.1
Olefsky, J.M.2
-
31
-
-
77952083245
-
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice
-
P. Li, M. Lu, M. T. A. Nguyen, E. J. Bae, J. Chapman, D. Feng, M. Hawkins, J. E. Pessin, D. D. Sears, A.-K. Nguyen, A. Amidi, S. M. Watkins, U. Nguyen, J. M. Olefsky, Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J. Biol. Chem. 285, 15333-15345 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 15333-15345
-
-
Li, P.1
Lu, M.2
Nguyen, M.T.A.3
Bae, E.J.4
Chapman, J.5
Feng, D.6
Hawkins, M.7
Pessin, J.E.8
Sears, D.D.9
Nguyen, A.-K.10
Amidi, A.11
Watkins, S.M.12
Nguyen, U.13
Olefsky, J.M.14
-
32
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
C. N. Lumeng, A. R. Saltiel, Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121, 2111-2117 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
33
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
C. N. Lumeng, J. L. Bodzin, A. R. Saltiel, Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
34
-
-
51349156218
-
Insulin sensitivity: Modulation by nutrients and inflammation
-
S. Schenk, M. Saberi, J. M. Olefsky, Insulin sensitivity: Modulation by nutrients and inflammation. J. Clin. Invest. 118, 2992-3002 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 2992-3002
-
-
Schenk, S.1
Saberi, M.2
Olefsky, J.M.3
-
35
-
-
79751496064
-
Alternative macrophage activation and metabolism
-
J. I. Odegaard, A. Chawla, Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6, 275-297 (2011).
-
(2011)
Annu. Rev. Pathol
, vol.6
, pp. 275-297
-
-
Odegaard, J.I.1
Chawla, A.2
-
36
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
S. Nishimura, I. Manabe, M. Nagasaki, K. Eto, H. Yamashita, M. Ohsugi, M. Otsu, K. Hara, K. Ueki, S. Sugiura, K. Yoshimura, T. Kadowaki, R. Nagai, CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15, 914-920 (2009).
-
(2009)
Nat. Med
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
Yamashita, H.5
Ohsugi, M.6
Otsu, M.7
Hara, K.8
Ueki, K.9
Sugiura, S.10
Yoshimura, K.11
Kadowaki, T.12
Nagai, R.13
-
37
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
S. Winer, Y. Chan, G. Paltser, D. Truong, H. Tsui, J. Bahrami, R. Dorfman, Y. Wang, J. Zielenski, F. Mastronardi, Y. Maezawa, D. J. Drucker, E. Engleman, D. Winer, H.-M. Dosch, Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15, 921-929 (2009).
-
(2009)
Nat. Med
, vol.15
, pp. 921-929
-
-
Winer, S.1
Chan, Y.2
Paltser, G.3
Truong, D.4
Tsui, H.5
Bahrami, J.6
Dorfman, R.7
Wang, Y.8
Zielenski, J.9
Mastronardi, F.10
Maezawa, Y.11
Drucker, D.J.12
Engleman, E.13
Winer, D.14
Dosch, H.-M.15
-
38
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
M. Feuerer, L. Herrero, D. Cipolletta, A. Naaz, J. Wong, A. Nayer, J. Lee, A. B. Goldfine, C. Benoist, S. Shoelson, D. Mathis, Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009).
-
(2009)
Nat. Med
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
Nayer, A.6
Lee, J.7
Goldfine, A.B.8
Benoist, C.9
Shoelson, S.10
Mathis, D.11
-
39
-
-
85027938385
-
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
-
D. A. Winer, S. Winer, L. Shen, P. P. Wadia, J. Yantha, G. Paltser, H. Tsui, P. Wu, M. G. Davidson, M. N. Alonso, H. X. Leong, A. Glassford, M. Caimol, J. A. Kenkel, T. F. Tedder, T. McLaughlin, D. B. Miklos, H.-M. Dosch, E. G. Engleman, B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med. 17, 610-617 (2011).
-
(2011)
Nat. Med
, vol.17
, pp. 610-617
-
-
Winer, D.A.1
Winer, S.2
Shen, L.3
Wadia, P.P.4
Yantha, J.5
Paltser, G.6
Tsui, H.7
Wu, P.8
Davidson, M.G.9
Alonso, M.N.10
Leong, H.X.11
Glassford, A.12
Caimol, M.13
Kenkel, J.A.14
Tedder, T.F.15
McLaughlin, T.16
Miklos, D.B.17
Dosch, H.-M.18
Engleman, E.G.19
-
40
-
-
20044387026
-
IKK-b links inflammation to obesity-induced insulin resistance
-
M. C. Arkan, A. L. Hevener, F. R. Greten, S. Maeda, Z.-W. Li, J. M. Long, A. Wynshaw-Boris, G. Poli, J. Olefsky, M. Karin, IKK-b links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198 (2005).
-
(2005)
Nat. Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.-W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
41
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
J. Hirosumi, G. Tuncman, L. Chang, C. Z. Görgün, K. T. Uysal, K. Maeda, M. Karin, G. S. Hotamisligil, A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (2002).
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
42
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
T. Nakamura, M. Furuhashi, P. Li, H. Cao, G. Tuncman, N. Sonenberg, C. Z. Gorgun, G. S. Hotamisligil, Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 140, 338-348 (2010).
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Li, P.3
Cao, H.4
Tuncman, G.5
Sonenberg, N.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
43
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
G. S. Hotamisligil, Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140, 900-917 (2010).
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
44
-
-
77957348390
-
Sphingolipids and insulin resistance: The five Ws
-
S. A. Summers, Sphingolipids and insulin resistance: The five Ws. Curr. Opin. Lipidol. 21, 128-135 (2010).
-
(2010)
Curr. Opin. Lipidol
, vol.21
, pp. 128-135
-
-
Summers, S.A.1
-
45
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
B. Vandanmagsar Y.-H. Youm, A. Ravussin, J. E. Galgani, K. Stadler, R. L. Mynatt, E. Ravussin, J. M. Stephens, V. D. Dixit, The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
Youm, Y.-H.2
Ravussin, A.3
Galgani, J.E.4
Stadler, K.5
Mynatt, R.L.6
Ravussin, E.7
Stephens, J.M.8
Dixit, V.D.9
-
46
-
-
70350389389
-
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
-
M. Saberi, M. Saberi, N.-B. Woods, C. de Luca, S. Schenk, J. C. Lu, G. Bandyopadhyay, I. M. Verma, J. M. Olefsky, Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 10, 419-429 (2009).
-
(2009)
Cell Metab
, vol.10
, pp. 419-429
-
-
Saberi, M.1
Saberi, M.2
Woods, N.-B.3
De Luca, C.4
Schenk, S.5
Lu, J.C.6
Bandyopadhyay, G.7
Verma, I.M.8
Olefsky, J.M.9
-
47
-
-
34247511496
-
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis
-
K. E. Wellen, R. Fucho, M. F. Gregor, M. Furuhashi, C. Morgan, T. Lindstad, E. Vaillancourt, C. Z. Gorgun, F. Saatcioglu, G. S. Hotamisligil, Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 129, 537-548 (2007).
-
(2007)
Cell
, vol.129
, pp. 537-548
-
-
Wellen, K.E.1
Fucho, R.2
Gregor, M.F.3
Furuhashi, M.4
Morgan, C.5
Lindstad, T.6
Vaillancourt, E.7
Gorgun, C.Z.8
Saatcioglu, F.9
Hotamisligil, G.S.10
-
48
-
-
34147122535
-
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance
-
L. A. Lesniewski, S. E. Hosch, J. G. Neels, C. de Luca, M. Pashmforoush, C. N. Lumeng, S.-H. Chiang, M. Scadeng, A. R. Saltiel, J. M. Olefsky, Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat. Med. 13, 455-462 (2007).
-
(2007)
Nat. Med
, vol.13
, pp. 455-462
-
-
Lesniewski, L.A.1
Hosch, S.E.2
Neels, J.G.3
De Luca, C.4
Pashmforoush, M.5
Lumeng, C.N.6
Chiang, S.-H.7
Scadeng, M.8
Saltiel, A.R.9
Olefsky, J.M.10
-
49
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
W. L. Holland, J. T. Brozinick, L.-P. Wang, E. D. Hawkins, K. M. Sargent, Y. Liu, K. Narra, K. L. Hoehn, T. A. Knotts, A. Siesky, D. H. Nelson, S. K. Karathanasis, G. K. Fontenot, M. J. Birnbaum, S. A. Summers, Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5, 167-179 (2007).
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.-P.3
Hawkins, E.D.4
Sargent, K.M.5
Liu, Y.6
Narra, K.7
Hoehn, K.L.8
Knotts, T.A.9
Siesky, A.10
Nelson, D.H.11
Karathanasis, S.K.12
Fontenot, G.K.13
Birnbaum, M.J.14
Summers, S.A.15
-
50
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
H. Shi, M. V. Kokoeva, K. Inouye, I. Tzameli, H. Yin, J. S. Flier, TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116, 3015-3025 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
51
-
-
84862001089
-
Insulin resistance in the defense against obesity
-
A. R. Saltiel, Insulin resistance in the defense against obesity. Cell Metab. 15, 798-804 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 798-804
-
-
Saltiel, A.R.1
-
52
-
-
84961371956
-
Adipose tissue biology in 2014: Advances in our understanding of adipose tissue homeostasis
-
J. H. Stern, P. E. Scherer, Adipose tissue biology in 2014: Advances in our understanding of adipose tissue homeostasis. Nat. Rev. Endocrinol. 11, 71-72 (2015).
-
(2015)
Nat. Rev. Endocrinol
, vol.11
, pp. 71-72
-
-
Stern, J.H.1
Scherer, P.E.2
-
54
-
-
84904044334
-
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
-
I. Wernstedt Asterholm, C. Tao, T. S. Morley, Q. A. Wang, F. Delgado-Lopez, Z. V. Wang, P. E. Scherer, Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 20, 103-118 (2014).
-
(2014)
Cell Metab
, vol.20
, pp. 103-118
-
-
Wernstedt Asterholm, I.1
Tao, C.2
Morley, T.S.3
Wang, Q.A.4
Delgado-Lopez, F.5
Wang, Z.V.6
Scherer, P.E.7
-
55
-
-
0022385114
-
A macrophage factor inhibits adipocyte gene expression: An in vitro model of cachexia
-
F. M. Torti, B. Dieckmann, B. Beutler, A. Cerami, G. M. Ringold, A macrophage factor inhibits adipocyte gene expression: An in vitro model of cachexia. Science 229, 867-869 (1985).
-
(1985)
Science
, vol.229
, pp. 867-869
-
-
Torti, F.M.1
Dieckmann, B.2
Beutler, B.3
Cerami, A.4
Ringold, G.M.5
-
56
-
-
0041568670
-
TNF - A induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes
-
S. C. Souza, H. J. Palmer, Y.-H. Kang, M. T. Yamamoto, K. V. Muliro, K. E. Paulson, A. S. Greenberg, TNF-a induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. J. Cell. Biochem. 89, 1077-1086 (2003).
-
(2003)
J. Cell. Biochem
, vol.89
, pp. 1077-1086
-
-
Souza, S.C.1
Palmer, H.J.2
Kang, Y.-H.3
Yamamoto, M.T.4
Muliro, K.V.5
Paulson, K.E.6
Greenberg, A.S.7
-
57
-
-
0037465251
-
The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
-
A. Dunne, L. A. J. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense. Sci. STKE 2003, re3 (2003).
-
(2003)
Sci. STKE 2003 Re
, vol.3
-
-
Dunne, A.1
O'Neill, L.A.J.2
-
58
-
-
0022035225
-
Relationship between degree of obesity and in vivo insulin action in man
-
C. Bogardus, S. Lillioja, D. M. Mott, C. Hollenbeck, G. Reaven, Relationship between degree of obesity and in vivo insulin action in man. Am. J. Physiol. 248, E286-E291 (1985).
-
(1985)
Am. J. Physiol
, vol.248
, pp. E286-E291
-
-
Bogardus, C.1
Lillioja, S.2
Mott, D.M.3
Hollenbeck, C.4
Reaven, G.5
-
59
-
-
71449120759
-
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment
-
D. Patsouris, J. G. Neels, W. Fan, P.-P. Li, M. T. A. Nguyen, J. M. Olefsky, Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J. Biol. Chem. 284, 31223-31235 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 31223-31235
-
-
Patsouris, D.1
Neels, J.G.2
Fan, W.3
Li, P.-P.4
Nguyen, M.T.A.5
Olefsky, J.M.6
-
60
-
-
81055144760
-
Adipocyte NCoR knockout decreases PPARg phosphorylation and enhances PPARg activity and insulin sensitivity
-
P. Li, W. Fan, J. Xu, M. Lu, H. Yamamoto, J. Auwerx, D. D. Sears, S. Talukdar, D. Oh, A. Chen, G. Bandyopadhyay, M. Scadeng, J. M. Ofrecio, S. Nalbandian, J. M. Olefsky, Adipocyte NCoR knockout decreases PPARg phosphorylation and enhances PPARg activity and insulin sensitivity. Cell 147, 815-826 (2011).
-
(2011)
Cell
, vol.147
, pp. 815-826
-
-
Li, P.1
Fan, W.2
Xu, J.3
Lu, M.4
Yamamoto, H.5
Auwerx, J.6
Sears, D.D.7
Talukdar, S.8
Oh, D.9
Chen, A.10
Bandyopadhyay, G.11
Scadeng, M.12
Ofrecio, J.M.13
Nalbandian, S.14
Olefsky, J.M.15
-
61
-
-
79955694276
-
Brain PPAR-g promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones
-
M. Lu, D. A. Sarruf, S. Talukdar, S. Sharma, P. Li, G. Bandyopadhyay, S. Nalbandian, W. Fan, J. R. Gayen, S. K. Mahata, N. J. Webster, M. W. Schwartz, J. M. Olefsky, Brain PPAR-g promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat. Med. 17, 618-622 (2011).
-
(2011)
Nat. Med
, vol.17
, pp. 618-622
-
-
Lu, M.1
Sarruf, D.A.2
Talukdar, S.3
Sharma, S.4
Li, P.5
Bandyopadhyay, G.6
Nalbandian, S.7
Fan, W.8
Gayen, J.R.9
Mahata, S.K.10
Webster, N.J.11
Schwartz, M.W.12
Olefsky, J.M.13
-
64
-
-
0032504983
-
A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation
-
H. Jick, C. Vasilakis, L. A. Weinrauch, C. R. Meier, S. S. Jick, L. E. Derby, A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation. N. Engl. J. Med. 339, 719-724 (1998).
-
(1998)
N. Engl. J. Med
, vol.339
, pp. 719-724
-
-
Jick, H.1
Vasilakis, C.2
Weinrauch, L.A.3
Meier, C.R.4
Jick, S.S.5
Derby, L.E.6
-
65
-
-
0032504954
-
Appetite suppressants and valvular heart disease
-
R. B. Devereux, Appetite suppressants and valvular heart disease. N. Engl. J. Med. 339, 765-766 (1998).
-
(1998)
N. Engl. J. Med
, vol.339
, pp. 765-766
-
-
Devereux, R.B.1
-
66
-
-
9444287592
-
Appetite-suppressant drugs and the risk of primary pulmonary hypertension
-
International Primary Pulmonary Hypertension Study Group
-
L. Abenhaim, Y. Moride, F. Brenot, S. Rich, J. Benichou, X. Kurz, T. Higenbottam, C. Oakley, E. Wouters, M. Aubier, G. Simonneau, B. Bégaud, International Primary Pulmonary Hypertension Study Group, Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N. Engl. J. Med. 335, 609-616 (1996).
-
(1996)
N. Engl. J. Med
, vol.335
, pp. 609-616
-
-
Abenhaim, L.1
Moride, Y.2
Brenot, F.3
Rich, S.4
Benichou, J.5
Kurz, X.6
Higenbottam, T.7
Oakley, C.8
Wouters, E.9
Aubier, M.10
Simonneau, G.11
Bégaud, B.12
-
67
-
-
0036845652
-
The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: A randomized, placebo-controlled trial
-
M. Hanefeld, G. Sachse, The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: A randomized, placebo-controlled trial. Diabetes Obes. Metab. 4, 415-423 (2002).
-
(2002)
Diabetes Obes. Metab
, vol.4
, pp. 415-423
-
-
Hanefeld, M.1
Sachse, G.2
-
68
-
-
33750510903
-
The obesity pipeline: Current strategies in the development of antiobesity drugs
-
D. Cooke, S. Bloom, The obesity pipeline: Current strategies in the development of antiobesity drugs. Nat. Rev. Drug Discov. 5, 919-931 (2006).
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 919-931
-
-
Cooke, D.1
Bloom, S.2
-
69
-
-
84964125510
-
Localization of a "feeding center" in the hypothalamus of the rat
-
B. K. Anand, J. R. Brobeck, Localization of a "feeding center" in the hypothalamus of the rat. Proc. Soc. Exp. Biol. Med. 77, 323-324 (1951).
-
(1951)
Proc. Soc. Exp. Biol. Med
, vol.77
, pp. 323-324
-
-
Anand, B.K.1
Brobeck, J.R.2
-
70
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
J. M. Friedman, J. L. Halaas, Leptin and the regulation of body weight in mammals. Nature 395, 763-770 (1998).
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
71
-
-
84944510848
-
Drug targeting of leptin resistance
-
A. Santoro, G. Mattace Raso, R. Meli, Drug targeting of leptin resistance. Life Sci. 140, 64-74 (2015).
-
(2015)
Life Sci
, vol.140
, pp. 64-74
-
-
Santoro, A.1
Mattace Raso, G.2
Meli, R.3
-
72
-
-
0034118219
-
Leptin, nutrition, and the thyroid: The why, the wherefore, and the wiring
-
J. S. Flier, M. Harris, A. N. Hollenberg, Leptin, nutrition, and the thyroid: The why, the wherefore, and the wiring. J. Clin. Invest. 105, 859-861 (2000).
-
(2000)
J. Clin. Invest
, vol.105
, pp. 859-861
-
-
Flier, J.S.1
Harris, M.2
Hollenberg, A.N.3
-
73
-
-
80053258367
-
Leptin in human physiology and pathophysiology
-
C. S. Mantzoros, F. Magkos, M. Brinkoetter, E. Sienkiewicz, T. A. Dardeno, S.-Y. Kim, O.-P. R. Hamnvik, A. Koniaris, Leptin in human physiology and pathophysiology. Am. J. Physiol. Endocrinol. Metab. 301, E567-E584 (2011).
-
(2011)
Am. J. Physiol. Endocrinol. Metab
, vol.301
, pp. E567-E584
-
-
Mantzoros, C.S.1
Magkos, F.2
Brinkoetter, M.3
Sienkiewicz, E.4
Dardeno, T.A.5
Kim, S.-Y.6
Hamnvik, O.-P.R.7
Koniaris, A.8
-
74
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
C. T. Montague, I. S. Farooqi, J. P. Whitehead, M. A. Soos, H. Rau, N. J. Wareham, C. P. Sewter, J. E. Digby, S. N. Mohammed, J. A. Hurst, C. H. Cheetham, A. R. Earley, A. H. Barnett, J. B. Prins, S. O'Rahilly, Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908 (1997).
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
Sewter, C.P.7
Digby, J.E.8
Mohammed, S.N.9
Hurst, J.A.10
Cheetham, C.H.11
Earley, A.R.12
Barnett, A.H.13
Prins, J.B.14
O'Rahilly, S.15
-
75
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
R. V. Considine, M. K. Sinha, M. L. Heiman, A. Kriauciunas, T. W. Stephens, M. R. Nyce, J. P. Ohannesian, C. C. Marco, L. J. McKee, T. L. Bauer, J. F. Caro, Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295 (1996).
-
(1996)
N. Engl. J. Med
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.4
Stephens, T.W.5
Nyce, M.R.6
Ohannesian, J.P.7
Marco, C.C.8
McKee, L.J.9
Bauer, T.L.10
Caro, J.F.11
-
76
-
-
84866076374
-
Leptin revisited: Its mechanism of action and potential for treating diabetes
-
R. Coppari, C. Bjørbaek, Leptin revisited: Its mechanism of action and potential for treating diabetes. Nat. Rev. Drug Discov. 11, 692-708 (2012).
-
(2012)
Nat. Rev. Drug Discov
, vol.11
, pp. 692-708
-
-
Coppari, R.1
Bjørbaek, C.2
-
77
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
M. A. Cowley, J. L. Smart, M. Rubinstein, M. G. Cerdán, S. Diano, T. L. Horvath, R. D. Cone, M. J. Low, Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480-484 (2001).
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdán, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
78
-
-
77955326815
-
Hyperleptinemia is required for the development of leptin resistance
-
Z. A. Knight, K. S. Hannan, M. L. Greenberg, J. M. Friedman, Hyperleptinemia is required for the development of leptin resistance. PLOS One 5, e11376 (2010).
-
(2010)
PLOS One
, vol.5
, pp. e11376
-
-
Knight, Z.A.1
Hannan, K.S.2
Greenberg, M.L.3
Friedman, J.M.4
-
79
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
J. F. Caro, J. W. Kolaczynski, M. R. Nyce, J. P. Ohannesian, I. Opentanova, W. H. Goldman, R. B. Lynn, P.-L. Zhang, M. K. Sinha, R. V. Considine, Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance. Lancet 348, 159-161 (1996).
-
(1996)
Lancet
, vol.348
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
Ohannesian, J.P.4
Opentanova, I.5
Goldman, W.H.6
Lynn, R.B.7
Zhang, P.-L.8
Sinha, M.K.9
Considine, R.V.10
-
80
-
-
0031821377
-
Leptin receptor immunoreactivity is associatedwith the Golgi apparatus of hypothalamic neurons and glial cells
-
S. Diano, S. P. Kalra, T. L. Horvath, Leptin receptor immunoreactivity is associatedwith the Golgi apparatus of hypothalamic neurons and glial cells. J. Neuroendocrinol. 10, 647-650 (1998).
-
(1998)
J. Neuroendocrinol
, vol.10
, pp. 647-650
-
-
Diano, S.1
Kalra, S.P.2
Horvath, T.L.3
-
81
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
L. Ozcan, A. S. Ergin, A. Lu, J. Chung, S. Sarkar, D. Nie, M. G. Myers Jr., U. Ozcan, Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 9, 35-51 (2009).
-
(2009)
Cell Metab
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
Myers, M.G.7
Ozcan, U.8
-
82
-
-
52949096557
-
Hypothalamic IKKb/NF-kB and ER stress link overnutrition to energy imbalance and obesity
-
X. Zhang, G. Zhang, H. Zhang, M. Karin, H. Bai, D. Cai, Hypothalamic IKKb/NF-kB and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61-73 (2008).
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
-
83
-
-
77949693065
-
Transport across the blood-brain barrier of pluronic leptin
-
T. O. Price, S. A. Farr, X. Yi, S. Vinogradov, E. Batrakova, W. A. Banks, A. V. Kabanov, Transport across the blood-brain barrier of pluronic leptin. J. Pharmacol. Exp. Ther. 333, 253-263 (2010).
-
(2010)
J. Pharmacol. Exp. Ther
, vol.333
, pp. 253-263
-
-
Price, T.O.1
Farr, S.A.2
Yi, X.3
Vinogradov, S.4
Batrakova, E.5
Banks, W.A.6
Kabanov, A.V.7
-
84
-
-
80455122701
-
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance
-
K. Loh, A. Fukushima, X. Zhang, S. Galic, D. Briggs, P. J. Enriori, S. Simonds, F. Wiede, A. Reichenbach, C. Hauser, N. A. Sims, K. K. Bence, S. Zhang, Z.-Y. Zhang, B. B. Kahn, B. G. Neel, Z. B. Andrews, M. A. Cowley, T. Tiganis, Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab. 14, 684-699 (2011).
-
(2011)
Cell Metab
, vol.14
, pp. 684-699
-
-
Loh, K.1
Fukushima, A.2
Zhang, X.3
Galic, S.4
Briggs, D.5
Enriori, P.J.6
Simonds, S.7
Wiede, F.8
Reichenbach, A.9
Hauser, C.10
Sims, N.A.11
Bence, K.K.12
Zhang, S.13
Zhang, Z.-Y.14
Kahn, B.B.15
Neel, B.G.16
Andrews, Z.B.17
Cowley, M.A.18
Tiganis, T.19
-
85
-
-
0037317489
-
PTP1B inhibitors as potential therapeutics in the treatment of Type 2 diabetes and obesity
-
Z.-Y. Zhang, S.-Y. Lee, PTP1B inhibitors as potential therapeutics in the treatment of Type 2 diabetes and obesity. Expert Opin. Investig. Drugs 12, 223-233 (2003).
-
(2003)
Expert Opin. Investig. Drugs
, vol.12
, pp. 223-233
-
-
Zhang, Z.-Y.1
Lee, S.-Y.2
-
86
-
-
0036312394
-
Effects of acute and chronic administration of the melanocortin agonist MTII in mice with dietinduced obesity
-
D. D. Pierroz, M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, C. S. Mantzoros, Effects of acute and chronic administration of the melanocortin agonist MTII in mice with dietinduced obesity. Diabetes 51, 1337-1345 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 1337-1345
-
-
Pierroz, D.D.1
Ziotopoulou, M.2
Ungsunan, L.3
Moschos, S.4
Flier, J.S.5
Mantzoros, C.S.6
-
87
-
-
84859416906
-
Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response
-
W. Quan, H.-K. Kim, E.-Y. Moon, S. S. Kim, C. S. Choi, M. Komatsu, Y. T. Jeong, M.-K. Lee, K.-W. Kim, M.-S. Kim, M.-S. Lee, Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response. Endocrinology 153, 1817-1826 (2012).
-
(2012)
Endocrinology
, vol.153
, pp. 1817-1826
-
-
Quan, W.1
Kim, H.-K.2
Moon, E.-Y.3
Kim, S.S.4
Choi, C.S.5
Komatsu, M.6
Jeong, Y.T.7
Lee, M.-K.8
Kim, K.-W.9
Kim, M.-S.10
Lee, M.-S.11
-
88
-
-
84930199338
-
Treatment of obesity with celastrol
-
J. Liu, J. Lee, M. A. Salazar Hernandez, R. Mazitschek, U. Ozcan, Treatment of obesity with celastrol. Cell 161, 999-1011 (2015).
-
(2015)
Cell
, vol.161
, pp. 999-1011
-
-
Liu, J.1
Lee, J.2
Salazar Hernandez, M.A.3
Mazitschek, R.4
Ozcan, U.5
-
89
-
-
0037057802
-
The need to feed: Homeostatic and hedonic control of eating
-
C. B. Saper. T. C. Chou, J. K. Elmquist, The need to feed: Homeostatic and hedonic control of eating. Neuron 36, 199-211 (2002).
-
(2002)
Neuron
, vol.36
, pp. 199-211
-
-
Saper, C.B.1
Chou, T.C.2
Elmquist, J.K.3
-
90
-
-
0035798931
-
Brain dopamine and obesity
-
G.-J. Wang, N. D. Volkow, J. Logan, N. R. Pappas, C. T. Wong, W. Zhu, N. Netusil, J. S. Fowler, Brain dopamine and obesity. Lancet 357, 354-357 (2001).
-
(2001)
Lancet
, vol.357
, pp. 354-357
-
-
Wang, G.-J.1
Volkow, N.D.2
Logan, J.3
Pappas, N.R.4
Wong, C.T.5
Zhu, W.6
Netusil, N.7
Fowler, J.S.8
-
91
-
-
34548675339
-
Leptin regulates striatal regions and human eating behavior
-
I. S. Farooqi, E. Bullmore, J. Keogh, J. Gillard, S. O'Rahilly, P. C. Fletcher, Leptin regulates striatal regions and human eating behavior. Science 317, 1355 (2007).
-
(2007)
Science
, vol.317
, pp. 1355
-
-
Farooqi, I.S.1
Bullmore, E.2
Keogh, J.3
Gillard, J.4
O'Rahilly, S.5
Fletcher, P.C.6
-
92
-
-
77953169046
-
Cellular bioenergetics as a target for obesity therapy
-
Y.-H. Tseng, A. M. Cypess, C. R. Kahn, Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discov. 9, 465-482 (2010).
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 465-482
-
-
Tseng, Y.-H.1
Cypess, A.M.2
Kahn, C.R.3
-
93
-
-
0034611678
-
Towards a molecular understanding of adaptive thermogenesis
-
B. B. Lowell, B. M. Spiegelman, Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660 (2000).
-
(2000)
Nature
, vol.404
, pp. 652-660
-
-
Lowell, B.B.1
Spiegelman, B.M.2
-
94
-
-
50949125411
-
The efficiency of cellular energy transduction and its implications for obesity
-
M.-E. Harper, K. Green, M. D. Brand, The efficiency of cellular energy transduction and its implications for obesity. Annu. Rev. Nutr. 28, 13-33 (2008).
-
(2008)
Annu. Rev. Nutr
, vol.28
, pp. 13-33
-
-
Harper, M.-E.1
Green, K.2
Brand, M.D.3
-
95
-
-
0035502402
-
Mitochondrial uncoupling as a target for drug development for the treatment of obesity
-
J. A. Harper, K. Dickinson, M. D. Brand, Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes. Rev. 2, 255-265 (2001).
-
(2001)
Obes. Rev
, vol.2
, pp. 255-265
-
-
Harper, J.A.1
Dickinson, K.2
Brand, M.D.3
-
96
-
-
84887431711
-
Brown and beige fat: Development, function and therapeutic potential
-
M. Harms, P. Seale, Brown and beige fat: Development, function and therapeutic potential. Nat. Med. 19, 1252-1263 (2013).
-
(2013)
Nat. Med
, vol.19
, pp. 1252-1263
-
-
Harms, M.1
Seale, P.2
-
97
-
-
84859410604
-
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
-
A. Vitali, I. Murano, M. C. Zingaretti, A. Frontini, D. Ricquier, S. Cinti, The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J. Lipid Res. 53, 619-629 (2012).
-
(2012)
J. Lipid Res
, vol.53
, pp. 619-629
-
-
Vitali, A.1
Murano, I.2
Zingaretti, M.C.3
Frontini, A.4
Ricquier, D.5
Cinti, S.6
-
98
-
-
84864287504
-
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
-
J. Wu, P. Boström, L. M. Sparks, L. Ye, J. H. Choi, A.-H. Giang, M. Khandekar, K. A. Virtanen, P. Nuutila, G. Schaart, K. Huang, H. Tu, W. D. van Marken Lichtenbelt, J. Hoeks, S. Enerbäck, P. Schrauwen, B. M. Spiegelman, Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376 (2012).
-
(2012)
Cell
, vol.150
, pp. 366-376
-
-
Wu, J.1
Boström, P.2
Sparks, L.M.3
Ye, L.4
Choi, J.H.5
Giang, A.-H.6
Khandekar, M.7
Virtanen, K.A.8
Nuutila, P.9
Schaart, G.10
Huang, K.11
Tu, H.12
Van Lichtenbelt Marken, W.D.13
Hoeks, J.14
Enerbäck, S.15
Schrauwen, P.16
Spiegelman, B.M.17
-
99
-
-
84869233588
-
Human BAT possesses molecular signatures that resemble beige/brite cells
-
L. Z. Sharp, K. Shinoda, H. Ohno, D. W. Scheel, E. Tomoda, L. Ruiz, H. Hu, L. Wang, Z. Pavlova, V. Gilsanz, S. Kajimura, Human BAT possesses molecular signatures that resemble beige/brite cells. PLOS One 7, e49452 (2012).
-
(2012)
PLOS One
, vol.7
, pp. e49452
-
-
Sharp, L.Z.1
Shinoda, K.2
Ohno, H.3
Scheel, D.W.4
Tomoda, E.5
Ruiz, L.6
Hu, H.7
Wang, L.8
Pavlova, Z.9
Gilsanz, V.10
Kajimura, S.11
-
100
-
-
84943402947
-
Brown and beige fat: Physiological roles beyond heat generation
-
S. Kajimura, B. M. Spiegelman, P. Seale, Brown and beige fat: Physiological roles beyond heat generation. Cell Metab. 22, 546-559 (2015).
-
(2015)
Cell Metab
, vol.22
, pp. 546-559
-
-
Kajimura, S.1
Spiegelman, B.M.2
Seale, P.3
-
101
-
-
84961290714
-
Brown and beige fat in humans: Thermogenic adipocytes that control energy and glucose homeostasis
-
L. Sidossis, S. Kajimura, Brown and beige fat in humans: Thermogenic adipocytes that control energy and glucose homeostasis. J. Clin. Invest. 125, 478-486 (2015).
-
(2015)
J. Clin. Invest
, vol.125
, pp. 478-486
-
-
Sidossis, L.1
Kajimura, S.2
-
102
-
-
84863229962
-
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
-
M. Bordicchia, D. Liu, E.-Z. Amri, G. Ailhaud, P. Dessì-Fulgheri, C. Zhang, N. Takahashi, R. Sarzani, S. Collins, Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J. Clin. Invest. 122, 1022-1036 (2012).
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1022-1036
-
-
Bordicchia, M.1
Liu, D.2
Amri, E.-Z.3
Ailhaud, G.4
Dessì-Fulgheri, P.5
Zhang, C.6
Takahashi, N.7
Sarzani, R.8
Collins, S.9
-
103
-
-
20744441357
-
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38a MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes
-
J. Robidoux, W. Cao, H. Quan, K. W. Daniel, F. Moukdar, X. Bai, L. M. Floering, S. Collins, Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38a MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. Mol. Cell. Biol. 25, 5466-5479 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 5466-5479
-
-
Robidoux, J.1
Cao, W.2
Quan, H.3
Daniel, K.W.4
Moukdar, F.5
Bai, X.6
Floering, L.M.7
Collins, S.8
-
104
-
-
0347989317
-
Brown adipose tissue: Function and physiological significance
-
B. Cannon, J. Nedergaard, Brown adipose tissue: Function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
-
(2004)
Physiol. Rev
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
105
-
-
0030803534
-
CL-316, 243, a b3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats
-
C. J. de Souza, M. F. Hirshman, E. S. Horton, CL-316, 243, a b3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats. Diabetes 46, 1257-1263 (1997).
-
(1997)
Diabetes
, vol.46
, pp. 1257-1263
-
-
De Souza, C.J.1
Hirshman, M.F.2
Horton, E.S.3
-
106
-
-
0031011161
-
Appearance of brown adipocytes in white adipose tissue during CL 316, 243-induced reversal of obesity and diabetes in Zucker fa/fa rats
-
M. Ghorbani, J. Himms-Hagen, Appearance of brown adipocytes in white adipose tissue during CL 316, 243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int. J. Obes. Relat. Metab. Disord. 21, 465-475 (1997).
-
(1997)
Int. J. Obes. Relat. Metab. Disord
, vol.21
, pp. 465-475
-
-
Ghorbani, M.1
Himms-Hagen, J.2
-
107
-
-
84920627180
-
Activation of human brown adipose tissue by a b3-adrenergic receptor agonist
-
A. M. Cypess, L. S. Weiner, C. Roberts-Toler, E. Franquet Elía, S. H. Kessler, P. A. Kahn, J. English, K. Chatman, S. A. Trauger, A. Doria, G. M. Kolodny, Activation of human brown adipose tissue by a b3-adrenergic receptor agonist. Cell Metab. 21, 33-38 (2015).
-
(2015)
Cell Metab
, vol.21
, pp. 33-38
-
-
Cypess, A.M.1
Weiner, L.S.2
Roberts-Toler, C.3
Franquet Elía, E.4
Kessler, S.H.5
Kahn, P.A.6
English, J.7
Chatman, K.8
Trauger, S.A.9
Doria, A.10
Kolodny, G.M.11
-
108
-
-
84907433555
-
The odd sibling: Features of b3-adrenoceptor pharmacology
-
H. Cernecka, C. Sand, M. C. Michel, The odd sibling: Features of b3-adrenoceptor pharmacology. Mol. Pharmacol. 86, 479-484 (2014).
-
(2014)
Mol. Pharmacol
, vol.86
, pp. 479-484
-
-
Cernecka, H.1
Sand, C.2
Michel, M.C.3
-
109
-
-
84911933989
-
Adipose tissues and thyroid hormones
-
M.-J. Obregon, Adipose tissues and thyroid hormones. Front. Physiol. 5, 479 (2014).
-
(2014)
Front. Physiol
, vol.5
, pp. 479
-
-
Obregon, M.-J.1
-
110
-
-
0035185505
-
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
-
L. A. de Jesus, S. D. Carvalho, M. O. Ribeiro, M. Schneider, S.-W. Kim, J. W. Harney, P. R. Larsen, A. C. Bianco, The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J. Clin. Invest. 108, 1379-1385 (2001).
-
(2001)
J. Clin. Invest
, vol.108
, pp. 1379-1385
-
-
De Jesus, L.A.1
Carvalho, S.D.2
Ribeiro, M.O.3
Schneider, M.4
Kim, S.-W.5
Harney, J.W.6
Larsen, P.R.7
Bianco, A.C.8
-
111
-
-
0034932901
-
Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific
-
M. O. Ribeiro, S. D. Carvalho, J. J. Schultz, G. Chiellini, T. S. Scanlan, A. C. Bianco, G. A. Brent, Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. J. Clin. Invest. 108, 97-105 (2001).
-
(2001)
J. Clin. Invest
, vol.108
, pp. 97-105
-
-
Ribeiro, M.O.1
Carvalho, S.D.2
Schultz, J.J.3
Chiellini, G.4
Scanlan, T.S.5
Bianco, A.C.6
Brent, G.A.7
-
112
-
-
84891896777
-
Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production
-
M. Rossato, M. Granzotto, V. Macchi, A. Porzionato, L. Petrelli, A. Calcagno, J. Vencato, D. De Stefani, V. Silvestrin, R. Rizzuto, F. Bassetto, R. De Caro, R. Vettor, Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production. Mol. Cell. Endocrinol. 383, 137-146 (2014).
-
(2014)
Mol. Cell. Endocrinol
, vol.383
, pp. 137-146
-
-
Rossato, M.1
Granzotto, M.2
Macchi, V.3
Porzionato, A.4
Petrelli, L.5
Calcagno, A.6
Vencato, J.7
De Stefani, D.8
Silvestrin, V.9
Rizzuto, R.10
Bassetto, F.11
De Caro, R.12
Vettor, R.13
-
113
-
-
10544229796
-
Activation of the nuclear receptor peroxisome proliferator-activated receptor g promotes brown adipocyte differentiation
-
T. A. Tai, C. Jennermann, K. K. Brown, B. B. Oliver, M. A. MacGinnitie, W. O. Wilkison, H. R. Brown, J. M. Lehmann, S. A. Kliewer, D. C. Morris, R. A. Graves, Activation of the nuclear receptor peroxisome proliferator-activated receptor g promotes brown adipocyte differentiation. J. Biol. Chem. 271, 29909-29914 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 29909-29914
-
-
Tai, T.A.1
Jennermann, C.2
Brown, K.K.3
Oliver, B.B.4
MacGinnitie, M.A.5
Wilkison, W.O.6
Brown, H.R.7
Lehmann, J.M.8
Kliewer, S.A.9
Morris, D.C.10
Graves, R.A.11
-
114
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
A. Kharitonenkov, T. L. Shiyanova, A. Koester, A. M. Ford, R. Micanovic, E. J. Galbreath, G. E. Sandusky, L. J. Hammond, J. S. Moyers, R. A. Owens, J. Gromada, J. T. Brozinick, E. D. Hawkins, V. J. Wroblewski, D.-S. Li, F. Mehrbod, S. R. Jaskunas, A. B. Shanafelt, FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115, 1627-1635 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
Shiyanova, T.L.2
Koester, A.3
Ford, A.M.4
Micanovic, R.5
Galbreath, E.J.6
Sandusky, G.E.7
Hammond, L.J.8
Moyers, J.S.9
Owens, R.A.10
Gromada, J.11
Brozinick, J.T.12
Hawkins, E.D.13
Wroblewski, V.J.14
Li, D.-S.15
Mehrbod, F.16
Jaskunas, S.R.17
Shanafelt, A.B.18
-
115
-
-
84863012022
-
FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis
-
F. M. Fisher, S. Kleiner, N. Douris, E. C. Fox, R. J. Mepani, F. Verdeguer, J. Wu, A. Kharitonenkov, J. S. Flier, E. Maratos-Flier, B. M. Spiegelman, FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281 (2012).
-
(2012)
Genes Dev
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
Fox, E.C.4
Mepani, R.J.5
Verdeguer, F.6
Wu, J.7
Kharitonenkov, A.8
Flier, J.S.9
Maratos-Flier, E.10
Spiegelman, B.M.11
-
116
-
-
84883481988
-
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
-
G. Gaich, J. Y. Chien, H. Fu, L. C. Glass, M. A. Deeg, W. L. Holland, A. Kharitonenkov, T. Bumol, H. K. Schilske, D. E. Moller, The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab. 18, 333-340 (2013).
-
(2013)
Cell Metab
, vol.18
, pp. 333-340
-
-
Gaich, G.1
Chien, J.Y.2
Fu, H.3
Glass, L.C.4
Deeg, M.A.5
Holland, W.L.6
Kharitonenkov, A.7
Bumol, T.8
Schilske, H.K.9
Moller, D.E.10
-
117
-
-
84860850964
-
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
-
A. J. Whittle, S. Carobbio, L. Martins, M. Slawik, E. Hondares, M. J. Vázquez, D. Morgan, R. I. Csikasz, R. Gallego, S. Rodriguez-Cuenca, M. Dale, S. Virtue, F. Villarroya, B. Cannon, K. Rahmouni, M. López, A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149, 871-885 (2012).
-
(2012)
Cell
, vol.149
, pp. 871-885
-
-
Whittle, A.J.1
Carobbio, S.2
Martins, L.3
Slawik, M.4
Hondares, E.5
Vázquez, M.J.6
Morgan, D.7
Csikasz, R.I.8
Gallego, R.9
Rodriguez-Cuenca, S.10
Dale, M.11
Virtue, S.12
Villarroya, F.13
Cannon, B.14
Rahmouni, K.15
López, M.16
Vidal-Puig, A.17
-
118
-
-
84870265848
-
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals
-
N. C. Bal, S. K. Maurya, D. H. Sopariwala, S. K. Sahoo, S. C. Gupta, S. A. Shaikh, M. Pant, L. A. Rowland, E. Bombardier, S. A. Goonasekera, A. R. Tupling, J. D. Molkentin, M. Periasamy, Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nat. Med. 18, 1575-1579 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 1575-1579
-
-
Bal, N.C.1
Maurya, S.K.2
Sopariwala, D.H.3
Sahoo, S.K.4
Gupta, S.C.5
Shaikh, S.A.6
Pant, M.7
Rowland, L.A.8
Bombardier, E.9
Goonasekera, S.A.10
Tupling, A.R.11
Molkentin, J.D.12
Periasamy, M.13
-
119
-
-
84975757439
-
A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
-
L. Kazak, E. T. Chouchani, M. P. Jedrychowski, B. K. Erickson, K. Shinoda, P. Cohen, R. Vetrivelan, G. Z. Lu, D. Laznik-Bogoslavski, S. C. Hasenfuss, S. Kajimura, S. P. Gygi, B. M. Spiegelman, A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell 163, 643-655 (2015).
-
(2015)
Cell
, vol.163
, pp. 643-655
-
-
Kazak, L.1
Chouchani, E.T.2
Jedrychowski, M.P.3
Erickson, B.K.4
Shinoda, K.5
Cohen, P.6
Vetrivelan, R.7
Lu, G.Z.8
Laznik-Bogoslavski, D.9
Hasenfuss, S.C.10
Kajimura, S.11
Gygi, S.P.12
Spiegelman, B.M.13
-
120
-
-
84877585823
-
Beyond the sympathetic tone: The new brown fat activators
-
F. Villarroya, A. Vidal-Puig, Beyond the sympathetic tone: The new brown fat activators. Cell Metab. 17, 638-643 (2013).
-
(2013)
Cell Metab
, vol.17
, pp. 638-643
-
-
Villarroya, F.1
Vidal-Puig, A.2
-
121
-
-
84873518501
-
Adaptive thermogenesis in adipocytes: Is beige the new brown?
-
J. Wu, P. Cohen, B. M. Spiegelman, Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes Dev. 27, 234-250 (2013).
-
(2013)
Genes Dev
, vol.27
, pp. 234-250
-
-
Wu, J.1
Cohen, P.2
Spiegelman, B.M.3
-
122
-
-
0033825933
-
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
-
J. Himms-Hagen, A. Melnyk, M. C. Zingaretti, E. Ceresi, G. Barbatelli, S. Cinti, Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. Am. J. Physiol. Cell Physiol. 279, C670-C681 (2000).
-
(2000)
Am. J. Physiol. Cell Physiol
, vol.279
, pp. C670-C681
-
-
Himms-Hagen, J.1
Melnyk, A.2
Zingaretti, M.C.3
Ceresi, E.4
Barbatelli, G.5
Cinti, S.6
-
123
-
-
84887502374
-
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
-
Q. A. Wang, C. Tao, R. K. Gupta, P. E. Scherer, Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19, 1338-1344 (2013).
-
(2013)
Nat. Med
, vol.19
, pp. 1338-1344
-
-
Wang, Q.A.1
Tao, C.2
Gupta, R.K.3
Scherer, P.E.4
-
124
-
-
57849153917
-
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation
-
Y. Xue, N. Petrovic, R. Cao, O. Larsson, S. Lim, S. Chen, H. M. Feldmann, Z. Liang, Z. Zhu, J. Nedergaard, B. Cannon, Y. Cao, Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 9, 99-109 (2009).
-
(2009)
Cell Metab
, vol.9
, pp. 99-109
-
-
Xue, Y.1
Petrovic, N.2
Cao, R.3
Larsson, O.4
Lim, S.5
Chen, S.6
Feldmann, H.M.7
Liang, Z.8
Zhu, Z.9
Nedergaard, J.10
Cannon, B.11
Cao, Y.12
-
125
-
-
84862776702
-
A PGC1 - A-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
P. Boström, J. Wu, M. P. Jedrychowski, A. Korde, L. Ye, J. C. Lo, K. A. Rasbach, E. A. Boström, J. H. Choi, J. Z. Long, S. Kajimura, M. C. Zingaretti, B. F. Vind, H. Tu, S. Cinti, K. Højlund, S. P. Gygi, B. M. Spiegelman, A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468 (2012).
-
(2012)
Nature
, vol.481
, pp. 463-468
-
-
Boström, P.1
Wu, J.2
Jedrychowski, M.P.3
Korde, A.4
Ye, L.5
Lo, J.C.6
Rasbach, K.A.7
Boström, E.A.8
Choi, J.H.9
Long, J.Z.10
Kajimura, S.11
Zingaretti, M.C.12
Vind, B.F.13
Tu, H.14
Cinti, S.15
Højlund, K.16
Gygi, S.P.17
Spiegelman, B.M.18
-
126
-
-
79955755051
-
Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue
-
X. Xu, Z. Ying, M. Cai, Z. Xu, Y. Li, S. Y. Jiang, K. Tzan, A. Wang, S. Parthasarathy, G. He, S. Rajagopalan, Q. Sun, Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R1115-R1125 (2011).
-
(2011)
Am. J. Physiol. Regul. Integr. Comp. Physiol
, vol.300
, pp. R1115-R1125
-
-
Xu, X.1
Ying, Z.2
Cai, M.3
Xu, Z.4
Li, Y.5
Jiang, S.Y.6
Tzan, K.7
Wang, A.8
Parthasarathy, S.9
He, G.10
Rajagopalan, S.11
Sun, Q.12
-
127
-
-
8744267483
-
Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro
-
M. E. Trujillo, S. Sullivan, I. Harten, S. H. Schneider, A. S. Greenberg, S. K. Fried, Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro. J. Clin. Endocrinol. Metab. 89, 5577-5582 (2004).
-
(2004)
J. Clin. Endocrinol. Metab
, vol.89
, pp. 5577-5582
-
-
Trujillo, M.E.1
Sullivan, S.2
Harten, I.3
Schneider, S.H.4
Greenberg, A.S.5
Fried, S.K.6
-
128
-
-
84924390413
-
Irisin - A myth rather than an exerciseinducible myokine
-
E. Albrecht, F. Norheim, B. Thiede, T. Holen, T. Ohashi, L. Schering, S. Lee, J. Brenmoehl, S. Thomas, C. A. Drevon, H. P. Erickson, S. Maak, Irisin - a myth rather than an exerciseinducible myokine. Sci. Rep. 5, 8889 (2015).
-
(2015)
Sci. Rep
, vol.5
, pp. 8889
-
-
Albrecht, E.1
Norheim, F.2
Thiede, B.3
Holen, T.4
Ohashi, T.5
Schering, L.6
Lee, S.7
Brenmoehl, J.8
Thomas, S.9
Drevon, C.A.10
Erickson, H.P.11
Maak, S.12
-
129
-
-
84943451163
-
Detection and quantitation of circulating human Irisin by tandem mass spectrometry
-
M. P. Jedrychowski, C. D. Wrann, J. A. Paulo, K. K. Gerber, J. Szpyt, M. M. Robinson, K. S. Nair, S. P. Gygi, B. M. Spiegelman, Detection and quantitation of circulating human Irisin by tandem mass spectrometry. Cell Metab. 22, 734-740 (2015).
-
(2015)
Cell Metab
, vol.22
, pp. 734-740
-
-
Jedrychowski, M.P.1
Wrann, C.D.2
Paulo, J.A.3
Gerber, K.K.4
Szpyt, J.5
Robinson, M.M.6
Nair, K.S.7
Gygi, S.P.8
Spiegelman, B.M.9
-
130
-
-
84902097377
-
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
-
R. R. Rao, J. Z. Long, J. P.White, K. J. Svensson, J. Lou, I. Lokurkar, M. P. Jedrychowski, J. L. Ruas, C. D. Wrann, J. C. Lo, D. M. Camera, J. Lachey, S. Gygi, J. Seehra, J. A. Hawley, B. M. Spiegelman, Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157, 1279-1291 (2014).
-
(2014)
Cell
, vol.157
, pp. 1279-1291
-
-
Rao, R.R.1
Long, J.Z.2
White, J.P.3
Svensson, K.J.4
Lou, J.5
Lokurkar, I.6
Jedrychowski, M.P.7
Ruas, J.L.8
Wrann, C.D.9
Lo, J.C.10
Camera, D.M.11
Lachey, J.12
Gygi, S.13
Seehra, J.14
Hawley, J.A.15
Spiegelman, B.M.16
-
131
-
-
84874450879
-
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
-
S.-W. Qian, Y. Tang, X. Li, Y. Liu, Y.-Y. Zhang, H.-Y. Huang, R.-D. Xue, H.-Y. Yu, L. Guo, H.-D. Gao, Y. Liu, X. Sun, Y.-M. Li, W.-P. Jia, Q.-Q. Tang, BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc. Natl. Acad. Sci. U.S.A. 110, E798-E807 (2013).
-
(2013)
Proc. Natl. Acad. Sci. U.S.A
, vol.110
, pp. E798-E807
-
-
Qian, S.-W.1
Tang, Y.2
Li, X.3
Liu, Y.4
Zhang, Y.-Y.5
Huang, H.-Y.6
Xue, R.-D.7
Yu, H.-Y.8
Guo, L.9
Gao, H.-D.10
Liu, Y.11
Sun, X.12
Li, Y.-M.13
Jia, W.-P.14
Tang, Q.-Q.15
-
132
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
Y.-H. Tseng, E. Kokkotou, T. J. Schulz, T. L. Huang, J. N. Winnay, C. M. Taniguchi, T. T. Tran, R. Suzuki, D. O. Espinoza, Y. Yamamoto, M. J. Ahrens, A. T. Dudley, A. W. Norris, R. N. Kulkarni, C. R. Kahn, New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008).
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.-H.1
Kokkotou, E.2
Schulz, T.J.3
Huang, T.L.4
Winnay, J.N.5
Taniguchi, C.M.6
Tran, T.T.7
Suzuki, R.8
Espinoza, D.O.9
Yamamoto, Y.10
Ahrens, M.J.11
Dudley, A.T.12
Norris, A.W.13
Kulkarni, R.N.14
Kahn, C.R.15
-
133
-
-
84891783225
-
Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure
-
E. Hinoi, Y. Nakamura, S. Takada, H. Fujita, T. Iezaki, S. Hashizume, S. Takahashi, Y. Odaka, T. Watanabe, Y. Yoneda, Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure. Diabetes 63, 162-175 (2014).
-
(2014)
Diabetes
, vol.63
, pp. 162-175
-
-
Hinoi, E.1
Nakamura, Y.2
Takada, S.3
Fujita, H.4
Iezaki, T.5
Hashizume, S.6
Takahashi, S.7
Odaka, Y.8
Watanabe, T.9
Yoneda, Y.10
-
134
-
-
77952970098
-
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
-
A. Vegiopoulos, K. Müller-Decker, D. Strzoda, I. Schmitt, E. Chichelnitskiy, A. Ostertag, M. Berriel Diaz, J. Rozman, M. Hrabe de Angelis, R. M. Nüsing, C. W. Meyer, W. Wahli, M. Klingenspor, S. Herzig, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328, 1158-1161 (2010).
-
(2010)
Science
, vol.328
, pp. 1158-1161
-
-
Vegiopoulos, A.1
Müller-Decker, K.2
Strzoda, D.3
Schmitt, I.4
Chichelnitskiy, E.5
Ostertag, A.6
Berriel Diaz, M.7
Rozman, J.8
De Hrabe, A.M.9
Nüsing, R.M.10
Meyer, C.W.11
Wahli, W.12
Klingenspor, M.13
Herzig, S.14
-
135
-
-
84891840977
-
B-Aminoisobutyric acid induces browning of white fat and hepatic b-oxidation and is inversely correlated with cardiometabolic risk factors
-
L. D. Roberts, P. Boström, J. F. O'Sullivan, R. T. Schinzel, G. D. Lewis, A. Dejam, Y.-K. Lee, M. J. Palma, S. Calhoun, A. Georgiadi, M.-H. Chen, V. S. Ramachandran, M. G. Larson, C. Bouchard, T. Rankinen, A. L. Souza, C. B. Clish, T. J. Wang, J. L. Estall, A. A. Soukas, C. A. Cowan, B. M. Spiegelman, R. E. Gerszten, b-Aminoisobutyric acid induces browning of white fat and hepatic b-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 19, 96-108 (2014).
-
(2014)
Cell Metab
, vol.19
, pp. 96-108
-
-
Roberts, L.D.1
Boström, P.2
O'Sullivan, J.F.3
Schinzel, R.T.4
Lewis, G.D.5
Dejam, A.6
Lee, Y.-K.7
Palma, M.J.8
Calhoun, S.9
Georgiadi, A.10
Chen, M.-H.11
Ramachandran, V.S.12
Larson, M.G.13
Bouchard, C.14
Rankinen, T.15
Souza, A.L.16
Clish, C.B.17
Wang, T.J.18
Estall, J.L.19
Soukas, A.A.20
Cowan, C.A.21
Spiegelman, B.M.22
Gerszten, R.E.23
more..
-
136
-
-
79959933148
-
Protection from obesity and diabetes by blockade of TGF-b/Smad3 signaling
-
H. Yadav, C. Quijano, A. K. Kamaraju, O. Gavrilova, R. Malek, W. Chen, P. Zerfas, D. Zhigang, E. C. Wright, C. Stuelten, P. Sun, S. Lonning, M. Skarulis, A. E. Sumner, T. Finkel, S. G. Rane, Protection from obesity and diabetes by blockade of TGF-b/Smad3 signaling. Cell Metab. 14, 67-79 (2011).
-
(2011)
Cell Metab
, vol.14
, pp. 67-79
-
-
Yadav, H.1
Quijano, C.2
Kamaraju, A.K.3
Gavrilova, O.4
Malek, R.5
Chen, W.6
Zerfas, P.7
Zhigang, D.8
Wright, E.C.9
Stuelten, C.10
Sun, P.11
Lonning, S.12
Skarulis, M.13
Sumner, A.E.14
Finkel, T.15
Rane, S.G.16
-
137
-
-
84862740881
-
A novel therapeutic approach to treating obesity through modulation of TGFb signaling
-
A. Koncarevic, S. Kajimura, M. Cornwall-Brady, A. Andreucci, A. Pullen, D. Sako, R. Kumar, A. V. Grinberg, K. Liharska, J. A. Ucran, E. Howard, B. M. Spiegelman, J. Seehra, J. Lachey, A novel therapeutic approach to treating obesity through modulation of TGFb signaling. Endocrinology 153, 3133-3146 (2012).
-
(2012)
Endocrinology
, vol.153
, pp. 3133-3146
-
-
Koncarevic, A.1
Kajimura, S.2
Cornwall-Brady, M.3
Andreucci, A.4
Pullen, A.5
Sako, D.6
Kumar, R.7
Grinberg, A.V.8
Liharska, K.9
Ucran, J.A.10
Howard, E.11
Spiegelman, B.M.12
Seehra, J.13
Lachey, J.14
-
138
-
-
84905740317
-
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
-
P. Bi, T. Shan, W. Liu, F. Yue, X. Yang, X.-R. Liang, J. Wang, J. Li, N. Carlesso, X. Liu, S. Kuang, Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat. Med. 20, 911-918 (2014).
-
(2014)
Nat. Med
, vol.20
, pp. 911-918
-
-
Bi, P.1
Shan, T.2
Liu, W.3
Yue, F.4
Yang, X.5
Liang, X.-R.6
Wang, J.7
Li, J.8
Carlesso, N.9
Liu, X.10
Kuang, S.11
-
139
-
-
69449097633
-
The protein kinase IKKe regulates energy balance in obese mice
-
S.-H. Chiang, M. Bazuine, C. N. Lumeng, L. M. Geletka, J. Mowers, N. M.White, J.-T. Ma, J. Zhou, N. Qi, D. Westcott, J. B. Delproposto, T. S. Blackwell, F. E. Yull, A. R. Saltiel, The protein kinase IKKe regulates energy balance in obese mice. Cell 138, 961-975 (2009).
-
(2009)
Cell
, vol.138
, pp. 961-975
-
-
Chiang, S.-H.1
Bazuine, M.2
Lumeng, C.N.3
Geletka, L.M.4
Mowers, J.5
White, N.M.6
Ma, J.-T.7
Zhou, J.8
Qi, N.9
Westcott, D.10
Delproposto, J.B.11
Blackwell, T.S.12
Yull, F.E.13
Saltiel, A.R.14
-
140
-
-
84891534573
-
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKe and TBK1
-
J. Mowers, M. Uhm, S. M. Reilly, J. Simon, D. Leto, S.-H. Chiang, L. Chang, A. R. Saltiel, Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKe and TBK1. Elife 2, e01119 (2013).
-
(2013)
Elife
, vol.2
, pp. e01119
-
-
Mowers, J.1
Uhm, M.2
Reilly, S.M.3
Simon, J.4
Leto, D.5
Chiang, S.-H.6
Chang, L.7
Saltiel, A.R.8
-
141
-
-
84875179301
-
An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice
-
S. M. Reilly, S.-H. Chiang, S. J. Decker, L. Chang, M. Uhm, M. J. Larsen, J. R. Rubin, J. Mowers, N. M. White, I. Hochberg, M. Downes, R. T. Yu, C. Liddle, R. M. Evans, D. Oh, P. Li, J. M. Olefsky, A. R. Saltiel, An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nat. Med. 19, 313-321 (2013).
-
(2013)
Nat. Med
, vol.19
, pp. 313-321
-
-
Reilly, S.M.1
Chiang, S.-H.2
Decker, S.J.3
Chang, L.4
Uhm, M.5
Larsen, M.J.6
Rubin, J.R.7
Mowers, J.8
White, N.M.9
Hochberg, I.10
Downes, M.11
Yu, R.T.12
Liddle, C.13
Evans, R.M.14
Oh, D.15
Li, P.16
Olefsky, J.M.17
Saltiel, A.R.18
-
142
-
-
84896905991
-
Metabolic regulation of immune responses
-
K. Ganeshan, A. Chawla, Metabolic regulation of immune responses. Annu. Rev. Immunol. 32, 609-634 (2014).
-
(2014)
Annu. Rev. Immunol
, vol.32
, pp. 609-634
-
-
Ganeshan, K.1
Chawla, A.2
-
143
-
-
84920940721
-
Activated type 2 innate lymphoid cells regulate beige fat biogenesis
-
M.-W. Lee, J. I. Odegaard, L. Mukundan, Y. Qiu, A. B. Molofsky, J. C. Nussbaum, K. Yun, R. M. Locksley, A. Chawla, Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74-87 (2015).
-
(2015)
Cell
, vol.160
, pp. 74-87
-
-
Lee, M.-W.1
Odegaard, J.I.2
Mukundan, L.3
Qiu, Y.4
Molofsky, A.B.5
Nussbaum, J.C.6
Yun, K.7
Locksley, R.M.8
Chawla, A.9
-
144
-
-
84862986986
-
PPAR-g is a major driver of the accumulation and phenotype of adipose tissue Treg cells
-
D. Cipolletta, M. Feuerer, A. Li, N. Kamei, J. Lee, S. E. Shoelson, C. Benoist, D. Mathis, PPAR-g is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486, 549-553 (2012).
-
(2012)
Nature
, vol.486
, pp. 549-553
-
-
Cipolletta, D.1
Feuerer, M.2
Li, A.3
Kamei, N.4
Lee, J.5
Shoelson, S.E.6
Benoist, C.7
Mathis, D.8
-
145
-
-
80054913827
-
Targeting gut microbiota in obesity: Effects of prebiotics and probiotics
-
N. M. Delzenne, A. M. Neyrinck, F. Bäckhed, P. D. Cani, Targeting gut microbiota in obesity: Effects of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639-646 (2011).
-
(2011)
Nat. Rev. Endocrinol
, vol.7
, pp. 639-646
-
-
Delzenne, N.M.1
Neyrinck, A.M.2
Bäckhed, F.3
Cani, P.D.4
-
146
-
-
58749112734
-
A core gut microbiome in obese and lean twins
-
P. J. Turnbaugh, M. Hamady, T. Yatsunenko, B. L. Cantarel, A. Duncan, R. E. Ley, M. L. Sogin, W. J. Jones, B. A. Roe, J. P. Affourtit, M. Egholm, B. Henrissat, A. C. Heath, R. Knight, J. I. Gordon, A core gut microbiome in obese and lean twins. Nature 457, 480-484 (2009).
-
(2009)
Nature
, vol.457
, pp. 480-484
-
-
Turnbaugh, P.J.1
Hamady, M.2
Yatsunenko, T.3
Cantarel, B.L.4
Duncan, A.5
Ley, R.E.6
Sogin, M.L.7
Jones, W.J.8
Roe, B.A.9
Affourtit, J.P.10
Egholm, M.11
Henrissat, B.12
Heath, A.C.13
Knight, R.14
Gordon, J.I.15
-
147
-
-
33845901507
-
Microbial ecology: Human gut microbes associated with obesity
-
R. E. Ley, P. J. Turnbaugh, S. Klein, J. I. Gordon, Microbial ecology: Human gut microbes associated with obesity. Nature 444, 1022-1023 (2006).
-
(2006)
Nature
, vol.444
, pp. 1022-1023
-
-
Ley, R.E.1
Turnbaugh, P.J.2
Klein, S.3
Gordon, J.I.4
-
148
-
-
84924594572
-
The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes
-
R. J. Seeley, A. P. Chambers, D. A. Sandoval, The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab. 21, 369-378 (2015).
-
(2015)
Cell Metab.
, vol.21
, pp. 369-378
-
-
Seeley, R.J.1
Chambers, A.P.2
Sandoval, D.A.3
-
149
-
-
56449093424
-
Glucose sensing in L cells: A primary cell study
-
F. Reimann, A. M. Habib, G. Tolhurst, H. E. Parker, G. J. Rogers, F. M. Gribble, Glucose sensing in L cells: A primary cell study. Cell Metab. 8, 532-539 (2008).
-
(2008)
Cell Metab
, vol.8
, pp. 532-539
-
-
Reimann, F.1
Habib, A.M.2
Tolhurst, G.3
Parker, H.E.4
Rogers, G.J.5
Gribble, F.M.6
-
150
-
-
84962752390
-
The L-cell in nutritional sensing and the regulation of appetite
-
E. Spreckley, K. G. Murphy, The L-cell in nutritional sensing and the regulation of appetite. Front. Nutr. 2, 23 (2015).
-
(2015)
Front. Nutr
, vol.2
, pp. 23
-
-
Spreckley, E.1
Murphy, K.G.2
-
151
-
-
0030743452
-
Nutrient regulation of human intestinal sugar transporter (SGLT1) expression
-
J. Dyer, K. B. Hosie, S. P. Shirazi-Beechey, Nutrient regulation of human intestinal sugar transporter (SGLT1) expression. Gut 41, 56-59 (1997).
-
(1997)
Gut
, vol.41
, pp. 56-59
-
-
Dyer, J.1
Hosie, K.B.2
Shirazi-Beechey, S.P.3
-
152
-
-
14644415512
-
Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells
-
J. Dyer, K. S. H. Salmon, L. Zibrik, S. P. Shirazi-Beechey, Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem. Soc. Trans. 33, 302-305 (2005).
-
(2005)
Biochem. Soc. Trans
, vol.33
, pp. 302-305
-
-
Dyer, J.1
Salmon, K.S.H.2
Zibrik, L.3
Shirazi-Beechey, S.P.4
-
153
-
-
0031750108
-
Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene
-
M. Cordier-Bussat et al., Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene. Diabetes 47, 1038-1045 (1998).
-
(1998)
Diabetes
, vol.47
, pp. 1038-1045
-
-
Cordier-Bussat, M.1
-
154
-
-
84864283726
-
Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake
-
C. Duraffourd, F. De Vadder, D. Goncalves, F. Delaere, A. Penhoat, B. Brusset, F. Rajas, D. Chassard, A. Duchampt, A. Stefanutti, A. Gautier-Stein, G. Mithieux, Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake. Cell 150, 377-388 (2012).
-
(2012)
Cell
, vol.150
, pp. 377-388
-
-
Duraffourd, C.1
De Vadder, F.2
Goncalves, D.3
Delaere, F.4
Penhoat, A.5
Brusset, B.6
Rajas, F.7
Chassard, D.8
Duchampt, A.9
Stefanutti, A.10
Gautier-Stein, A.11
Mithieux, G.12
-
155
-
-
84874040640
-
The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagonlike peptide-1 secretion from GLUTag cells
-
M. Oya, T. Kitaguchi, R. Pais, F. Reimann, F. Gribble, T. Tsuboi, The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagonlike peptide-1 secretion from GLUTag cells. J. Biol. Chem. 288, 4513-4521 (2013).
-
(2013)
J. Biol. Chem
, vol.288
, pp. 4513-4521
-
-
Oya, M.1
Kitaguchi, T.2
Pais, R.3
Reimann, F.4
Gribble, F.5
Tsuboi, T.6
-
156
-
-
33644627958
-
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
-
H. A. Overton, A. J. Babbs, S. M. Doel, M. C. Fyfe, L. S. Gardner, G. Griffin, H. C. Jackson, M. J. Procter, C. M. Rasamison, M. Tang-Christensen, P. S. Widdowson, G. M. Williams, C. Reynet, Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3, 167-175 (2006).
-
(2006)
Cell Metab
, vol.3
, pp. 167-175
-
-
Overton, H.A.1
Babbs, A.J.2
Doel, S.M.3
Fyfe, M.C.4
Gardner, L.S.5
Griffin, G.6
Jackson, H.C.7
Procter, M.J.8
Rasamison, C.M.9
Tang-Christensen, M.10
Widdowson, P.S.11
Williams, G.M.12
Reynet, C.13
-
157
-
-
84896858573
-
AMPK in the small intestine in normal and pathophysiological conditions
-
E. Harmel, E. Grenier, A. Bendjoudi Ouadda, M. El Chebly, E. Ziv, J. F. Beaulieu, A. Sané, S. Spahis, M. Laville, E. Levy, AMPK in the small intestine in normal and pathophysiological conditions. Endocrinology 155, 873-888 (2014).
-
(2014)
Endocrinology
, vol.155
, pp. 873-888
-
-
Harmel, E.1
Grenier, E.2
Bendjoudi Ouadda, A.3
El Chebly, M.4
Ziv, E.5
Beaulieu, J.F.6
Sané, A.7
Spahis, S.8
Laville, M.9
Levy, E.10
-
158
-
-
84929177057
-
Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats
-
F. A. Duca, C. D. Côté, B. A. Rasmussen, M. Zadeh-Tahmasebi, G. A. Rutter, B. M. Filippi, T. K. T. Lam, Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat. Med. 21, 506-511 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 506-511
-
-
Duca, F.A.1
Côté, C.D.2
Rasmussen, B.A.3
Zadeh-Tahmasebi, M.4
Rutter, G.A.5
Filippi, B.M.6
Lam, T.K.T.7
-
159
-
-
84947610783
-
Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders
-
S. Fiorucci, E. Distrutti, Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders. Trends Mol. Med. 21, 702-714 (2015).
-
(2015)
Trends Mol. Med
, vol.21
, pp. 702-714
-
-
Fiorucci, S.1
Distrutti, E.2
-
160
-
-
84861978076
-
Host-gut microbiota metabolic interactions
-
J. K. Nicholson, E. Holmes, J. Kinross, R. Burcelin, G. Gibson, W. Jia, S. Pettersson, Host-gut microbiota metabolic interactions. Science 336, 1262-1267 (2012).
-
(2012)
Science
, vol.336
, pp. 1262-1267
-
-
Nicholson, J.K.1
Holmes, E.2
Kinross, J.3
Burcelin, R.4
Gibson, G.5
Jia, W.6
Pettersson, S.7
-
161
-
-
70349430938
-
Bile acids: Regulation of synthesis
-
J. Y. L. Chiang, Bile acids: Regulation of synthesis. J. Lipid Res. 50, 1955-1966 (2009).
-
(2009)
J. Lipid Res
, vol.50
, pp. 1955-1966
-
-
Chiang, J.Y.L.1
-
162
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
M. Makishima, A. Y. Okamoto, J. J. Repa, H. Tu, R. M. Learned, A. Luk, M. V. Hull, K. D. Lustig, D. J. Mangelsdorf, B. Shan, Identification of a nuclear receptor for bile acids. Science 284, 1362-1365 (1999).
-
(1999)
Science
, vol.284
, pp. 1362-1365
-
-
Makishima, M.1
Okamoto, A.Y.2
Repa, J.J.3
Tu, H.4
Learned, R.M.5
Luk, A.6
Hull, M.V.7
Lustig, K.D.8
Mangelsdorf, D.J.9
Shan, B.10
-
163
-
-
0003269455
-
A G protein-coupled receptor responsive to bile acids
-
Y. Kawamata, R. Fujii, M. Hosoya, M. Harada, H. Yoshida, M. Miwa, S. Fukusumi, Y. Habata, T. Itoh, Y. Shintani, S. Hinuma, Y. Fujisawa, M. Fujino, A G protein-coupled receptor responsive to bile acids. J. Biol. Chem. 278, 9435-9440 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 9435-9440
-
-
Kawamata, Y.1
Fujii, R.2
Hosoya, M.3
Harada, M.4
Yoshida, H.5
Miwa, M.6
Fukusumi, S.7
Habata, Y.8
Itoh, T.9
Shintani, Y.10
Hinuma, S.11
Fujisawa, Y.12
Fujino, M.13
-
164
-
-
33644867569
-
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
-
T. Inagaki, A. Moschetta, Y.-K. Lee, L. Peng, G. Zhao, M. Downes, R. T. Yu, J. M. Shelton, J. A. Richardson, J. J. Repa, D. J. Mangelsdorf, S. A. Kliewer, Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc. Natl. Acad. Sci. U.S.A. 103, 3920-3925 (2006).
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 3920-3925
-
-
Inagaki, T.1
Moschetta, A.2
Lee, Y.-K.3
Peng, L.4
Zhao, G.5
Downes, M.6
Yu, R.T.7
Shelton, J.M.8
Richardson, J.A.9
Repa, J.J.10
Mangelsdorf, D.J.11
Kliewer, S.A.12
-
165
-
-
84925507991
-
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
-
S. Fang, J. M. Suh, S. M. Reilly, E. Yu, O. Osborn, D. Lackey, E. Yoshihara, A. Perino, S. Jacinto, Y. Lukasheva, A. R. Atkins, A. Khvat, B. Schnabl, R. T. Yu, D. A. Brenner, S. Coulter, C. Liddle, K. Schoonjans, J. M. Olefsky, A. R. Saltiel, M. Downes, R. M. Evans, Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat. Med. 21, 159-165 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 159-165
-
-
Fang, S.1
Suh, J.M.2
Reilly, S.M.3
Yu, E.4
Osborn, O.5
Lackey, D.6
Yoshihara, E.7
Perino, A.8
Jacinto, S.9
Lukasheva, Y.10
Atkins, A.R.11
Khvat, A.12
Schnabl, B.13
Yu, R.T.14
Brenner, D.A.15
Coulter, S.16
Liddle, C.17
Schoonjans, K.18
Olefsky, J.M.19
Saltiel, A.R.20
Downes, M.21
Evans, R.M.22
more..
-
166
-
-
84946088116
-
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells
-
M.-S. Trabelsi, M. Daoudi, J. Prawitt, S. Ducastel, V. Touche, S. I. Sayin, A. Perino, C. A. Brighton, Y. Sebti, J. Kluza, O. Briand, H. Dehondt, E. Vallez, E. Dorchies, G. Baud, V. Spinelli, N. Hennuyer, S. Caron, K. Bantubungi, R. Caiazzo, F. Reimann, P. Marchetti, P. Lefebvre, F. Bäckhed, F. M. Gribble, K. Schoonjans, F. Pattou, A. Tailleux, B. Staels, S. Lestavel, Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells. Nat. Commun. 6, 7629 (2015).
-
(2015)
Nat. Commun
, vol.6
, pp. 7629
-
-
Trabelsi, M.-S.1
Daoudi, M.2
Prawitt, J.3
Ducastel, S.4
Touche, V.5
Sayin, S.I.6
Perino, A.7
Brighton, C.A.8
Sebti, Y.9
Kluza, J.10
Briand, O.11
Dehondt, H.12
Vallez, E.13
Dorchies, E.14
Baud, G.15
Spinelli, V.16
Hennuyer, N.17
Caron, S.18
Bantubungi, K.19
Caiazzo, R.20
Reimann, F.21
Marchetti, P.22
Lefebvre, P.23
Bäckhed, F.24
Gribble, F.M.25
Schoonjans, K.26
Pattou, F.27
Tailleux, A.28
Staels, B.29
Lestavel, S.30
more..
-
167
-
-
84898051705
-
FXR is a molecular target for the effects of vertical sleeve gastrectomy
-
K. K. Ryan, V. Tremaroli, C. Clemmensen, P. Kovatcheva-Datchary, A. Myronovych, R. Karns, H. E. Wilson-Pérez, D. A. Sandoval, R. Kohli, F. Bäckhed, R. J. Seeley, FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 509, 183-188 (2014).
-
(2014)
Nature
, vol.509
, pp. 183-188
-
-
Ryan, K.K.1
Tremaroli, V.2
Clemmensen, C.3
Kovatcheva-Datchary, P.4
Myronovych, A.5
Karns, R.6
Wilson-Pérez, H.E.7
Sandoval, D.A.8
Kohli, R.9
Bäckhed, F.10
Seeley, R.J.11
|