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Volumn 30, Issue , 2007, Pages 367-398

Neurobiology of feeding and energy expenditure

Author keywords

Arcuate nucleus; GABA; Ghrelin; Glutamate; Leptin; NPY; POMC

Indexed keywords

BEHAVIOR; ELECTROPHYSIOLOGY; ENERGY EXPENDITURE; ENERGY METABOLISM; FEEDING BEHAVIOR; HOMEOSTASIS; HUMAN; METABOLIC REGULATION; METABOLISM; MOLECULAR GENETICS; NEUROANATOMY; NEUROBIOLOGY; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 34547701951     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.30.051606.094324     Document Type: Review
Times cited : (298)

References (217)
  • 1
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, et al. 2006. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116:3229-39
    • (2006) J. Clin. Invest , vol.116 , pp. 3229-3239
    • Abizaid, A.1    Liu, Z.W.2    Andrews, Z.B.3    Shanabrough, M.4    Borok, E.5
  • 2
    • 0028606308 scopus 로고
    • Differential effects of melanocortin peptides on neural melanocortin receptors
    • Adan RA, Cone RD, Burbach JP, Gispen WH. 1994. Differential effects of melanocortin peptides on neural melanocortin receptors. Mol. Pharmacol. 46:1182-90
    • (1994) Mol. Pharmacol , vol.46 , pp. 1182-1190
    • Adan, R.A.1    Cone, R.D.2    Burbach, J.P.3    Gispen, W.H.4
  • 3
    • 32544433424 scopus 로고    scopus 로고
    • Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    • Alon T, Friedman JM. 2006. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. J. Neurosci. 26:389-97
    • (2006) J. Neurosci , vol.26 , pp. 389-397
    • Alon, T.1    Friedman, J.M.2
  • 4
    • 84964125510 scopus 로고
    • Localization of a feeding center in the hypothalamus of the rat
    • Anand BK, Brobeck JR. 1951. Localization of a feeding center in the hypothalamus of the rat. Proc. Soc. Exp. Biol. Med. 77:323-24
    • (1951) Proc. Soc. Exp. Biol. Med , vol.77 , pp. 323-324
    • Anand, B.K.1    Brobeck, J.R.2
  • 5
    • 1842582870 scopus 로고    scopus 로고
    • AMP-activated protein kinase plays a role in the control of food intake
    • Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, et al. 2004. AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. 279:12005-8
    • (2004) J. Biol. Chem , vol.279 , pp. 12005-12008
    • Andersson, U.1    Filipsson, K.2    Abbott, C.R.3    Woods, A.4    Smith, K.5
  • 6
    • 27644448810 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in the central nervous system: In support of function, survival
    • Andrews ZB, Diano S, Horvath TL. 2005. Mitochondrial uncoupling proteins in the central nervous system: in support of function, survival. Nat. Rev. Neurosci. 6(11):829-40
    • (2005) Nat. Rev. Neurosci , vol.6 , Issue.11 , pp. 829-840
    • Andrews, Z.B.1    Diano, S.2    Horvath, T.L.3
  • 7
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
    • Araki E, Lipes MA, Patti ME, Bruning JC, Haag B 3rd, et al. 1994. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-90
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3    Bruning, J.C.4    Haag 3rd, B.5
  • 8
    • 0036827697 scopus 로고    scopus 로고
    • Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy
    • Bagnasco M, Dube MG, Kalra PS, Kalra SP. 2002. Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology 143:4409-21
    • (2002) Endocrinology , vol.143 , pp. 4409-4421
    • Bagnasco, M.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 9
    • 0034060310 scopus 로고    scopus 로고
    • Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway
    • Bailey AR, Von Englehardt N, Leng G, Smith RG, Dickson SL. 2000. Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway. J. Neuroendocrinol. 12:191-97
    • (2000) J. Neuroendocrinol , vol.12 , pp. 191-197
    • Bailey, A.R.1    Von Englehardt, N.2    Leng, G.3    Smith, R.G.4    Dickson, S.L.5
  • 10
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    • Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, et al. 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42:983-91
    • (2004) Neuron , vol.42 , pp. 983-991
    • Balthasar, N.1    Coppari, R.2    McMinn, J.3    Liu, S.M.4    Lee, C.E.5
  • 11
    • 27544450765 scopus 로고    scopus 로고
    • Divergence of melanocortin pathways in the control of food intake and energy expenditure
    • Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, et al. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123:493-505
    • (2005) Cell , vol.123 , pp. 493-505
    • Balthasar, N.1    Dalgaard, L.T.2    Lee, C.E.3    Yu, J.4    Funahashi, H.5
  • 12
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks AS, Davis SM, Bates SH, Myers MG Jr. 2000. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275:14563-72
    • (2000) J. Biol. Chem , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers Jr., M.G.4
  • 13
    • 0032998652 scopus 로고    scopus 로고
    • Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus
    • Baskin DG, Breininger JF, Schwartz MW. 1999a. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 48:828-33
    • (1999) Diabetes , vol.48 , pp. 828-833
    • Baskin, D.G.1    Breininger, J.F.2    Schwartz, M.W.3
  • 14
    • 0034714047 scopus 로고    scopus 로고
    • SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats
    • Baskin DG, Breininger JF, Schwartz MW. 2000. SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats. Regul. Pept. 92:9-15
    • (2000) Regul. Pept , vol.92 , pp. 9-15
    • Baskin, D.G.1    Breininger, J.F.2    Schwartz, M.W.3
  • 16
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signaling is required for leptin regulation of energy balance but not reproduction
    • Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, et al. 2003. STAT3 signaling is required for leptin regulation of energy balance but not reproduction. Nature 421:856-59
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5
  • 17
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H, Morella KK, White DW, Dembski M, Bailon PS, et al. 1996. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. USA 93:8374-78
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3    Dembski, M.4    Bailon, P.S.5
  • 18
    • 0036069863 scopus 로고    scopus 로고
    • The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: Lessons learned from lesioning studies
    • Bellinger LL, Bernardis LL. 2002. The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies. Physiol. Behav. 76:431-42
    • (2002) Physiol. Behav , vol.76 , pp. 431-442
    • Bellinger, L.L.1    Bernardis, L.L.2
  • 19
    • 0033938492 scopus 로고    scopus 로고
    • CNS melanocortin system involvement in the regulation of food intake
    • Benoit S, Schwartz M, Baskin D, Woods SC, Seeley RJ. 2000. CNS melanocortin system involvement in the regulation of food intake. Horm. Behav. 37:299-305
    • (2000) Horm. Behav , vol.37 , pp. 299-305
    • Benoit, S.1    Schwartz, M.2    Baskin, D.3    Woods, S.C.4    Seeley, R.J.5
  • 20
    • 0029656135 scopus 로고    scopus 로고
    • Food reward: Brain substrates of wanting and liking
    • Berridge KC. 1996. Food reward: brain substrates of wanting and liking. Neurosci. Biobehav. Rev. 20:1-25
    • (1996) Neurosci. Biobehav. Rev , vol.20 , pp. 1-25
    • Berridge, K.C.1
  • 21
    • 0036627597 scopus 로고    scopus 로고
    • Multiple neural systems controlling food intake and body weight
    • Berthoud HR. 2002. Multiple neural systems controlling food intake and body weight. Neurosci. Biobehav. Rev. 26:393-428
    • (2002) Neurosci. Biobehav. Rev , vol.26 , pp. 393-428
    • Berthoud, H.R.1
  • 22
    • 3042683537 scopus 로고    scopus 로고
    • The caudal brainstem and the control of food intake and energy balance
    • ed. EM Stricker, SC Woods, pp, New York: Plenum
    • Berthoud HR. 2004. The caudal brainstem and the control of food intake and energy balance. In Handbook of Behavioral Neurobiology, ed. EM Stricker, SC Woods, pp. 195-240. New York: Plenum
    • (2004) Handbook of Behavioral Neurobiology , pp. 195-240
    • Berthoud, H.R.1
  • 25
    • 0030678119 scopus 로고    scopus 로고
    • Independent and additive effects of central POMC and leptin pathways on murine obesity
    • Boston BA, Blaydon KM, Varnerin J, Cone RD. 1997. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278:1641-44
    • (1997) Science , vol.278 , pp. 1641-1644
    • Boston, B.A.1    Blaydon, K.M.2    Varnerin, J.3    Cone, R.D.4
  • 26
    • 0029139783 scopus 로고
    • Effects of NPY and NPY2-36 on body temperature and food intake following administration into hypothalamic nuclei
    • Bouali SM, Fournier A, St-Pierre S, Jolicoeur FB. 1995. Effects of NPY and NPY2-36 on body temperature and food intake following administration into hypothalamic nuclei. Brain. Res. Bull. 36:131-35
    • (1995) Brain. Res. Bull , vol.36 , pp. 131-135
    • Bouali, S.M.1    Fournier, A.2    St-Pierre, S.3    Jolicoeur, F.B.4
  • 27
    • 0033811433 scopus 로고    scopus 로고
    • Afferent signals regulating food intake
    • Bray GA. 2000. Afferent signals regulating food intake. Proc. Nutr. Soc. 59:373-84
    • (2000) Proc. Nutr. Soc , vol.59 , pp. 373-384
    • Bray, G.A.1
  • 28
    • 0011850027 scopus 로고
    • Experimental hypothalamic hyperphagia in the albino rat
    • Brobeck JR, Tepperman J, Long CNH. 1943. Experimental hypothalamic hyperphagia in the albino rat. Yale J. Biol. Med. 15:831-53
    • (1943) Yale J. Biol. Med , vol.15 , pp. 831-853
    • Brobeck, J.R.1    Tepperman, J.2    Long, C.N.H.3
  • 29
    • 0032576536 scopus 로고    scopus 로고
    • Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
    • Broberger C, De Lecea L, Sutcliffe JG, Hokfelt T. 1998a. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol. 402:460-74
    • (1998) J. Comp. Neurol , vol.402 , pp. 460-474
    • Broberger, C.1    De Lecea, L.2    Sutcliffe, J.G.3    Hokfelt, T.4
  • 30
    • 0032443807 scopus 로고    scopus 로고
    • The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    • Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T. 1998b. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. USA 95:15043-48
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15043-15048
    • Broberger, C.1    Johansen, J.2    Johansson, C.3    Schalling, M.4    Hokfelt, T.5
  • 31
  • 32
    • 33644863678 scopus 로고    scopus 로고
    • Cell biology of the ghrelin receptor
    • Camina JP. 2006. Cell biology of the ghrelin receptor. J. Neuroendocrinol. 18:65-76
    • (2006) J. Neuroendocrinol , vol.18 , pp. 65-76
    • Camina, J.P.1
  • 33
  • 34
    • 0028133318 scopus 로고
    • Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris-leucoagglutinin study in the rat
    • Canteras NS, Simerly RB, Swanson LW. 1994. Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 348:41-79
    • (1994) J. Comp. Neurol , vol.348 , pp. 41-79
    • Canteras, N.S.1    Simerly, R.B.2    Swanson, L.W.3
  • 35
    • 14544271907 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Balancing the scales
    • Carling D. 2005. AMP-activated protein kinase: balancing the scales. Biochimie 87:87-91
    • (2005) Biochimie , vol.87 , pp. 87-91
    • Carling, D.1
  • 36
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
    • Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, et al. 1999. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-51
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1    Willie, J.T.2    Sinton, C.M.3    Elmquist, J.K.4    Scammell, T.5
  • 37
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, et al. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-95
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5
  • 39
    • 0344011437 scopus 로고    scopus 로고
    • Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    • Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. 2003. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J. Neurosci. 23:10691-702
    • (2003) J. Neurosci , vol.23 , pp. 10691-10702
    • Chou, T.C.1    Scammell, T.E.2    Gooley, J.J.3    Gaus, S.E.4    Saper, C.B.5    Lu, J.6
  • 40
    • 0021740308 scopus 로고
    • Coexistence of neuropeptide Y and somatostatin in rat and human cortical and rat hypothalamic neurons
    • Chronwall BM, Chase TN, O'Donohue TL. 1984. Coexistence of neuropeptide Y and somatostatin in rat and human cortical and rat hypothalamic neurons. Neurosci. Lett. 52:213-17
    • (1984) Neurosci. Lett , vol.52 , pp. 213-217
    • Chronwall, B.M.1    Chase, T.N.2    O'Donohue, T.L.3
  • 41
    • 0030685790 scopus 로고    scopus 로고
    • Fine structure of the murine leptin receptor gene: Splice site suppression is required to form two alternatively spliced transcripts
    • Chua SC Jr, Koutras IK, Han L, Liu SM, Kay J, et al. 1997. Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45:264-70
    • (1997) Genomics , vol.45 , pp. 264-270
    • Chua Jr, S.C.1    Koutras, I.K.2    Han, L.3    Liu, S.M.4    Kay, J.5
  • 42
    • 0021248888 scopus 로고
    • Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
    • Clark JT, Kalra PS, Crowley WR, Kalra SP. 1984. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115:427-29
    • (1984) Endocrinology , vol.115 , pp. 427-429
    • Clark, J.T.1    Kalra, P.S.2    Crowley, W.R.3    Kalra, S.P.4
  • 43
    • 0031832660 scopus 로고    scopus 로고
    • Little and often: Ingestive behavior patterns following hippocampal lesions in rats
    • Clifton PG, Vickers SP, Somerville EM. 1998. Little and often: ingestive behavior patterns following hippocampal lesions in rats. Behav. Neurosci. 112:502-11
    • (1998) Behav. Neurosci , vol.112 , pp. 502-511
    • Clifton, P.G.1    Vickers, S.P.2    Somerville, E.M.3
  • 44
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • Coleman DL. 1978. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14:141-48
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 45
    • 0014608866 scopus 로고
    • Effects of parabiosis of normal with genetically diabetic mice
    • Coleman DL, Hummel KP. 1969. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 217:1298-304
    • (1969) Am. J. Physiol , vol.217 , pp. 1298-1304
    • Coleman, D.L.1    Hummel, K.P.2
  • 46
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone RD. 2005. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8:571-78
    • (2005) Nat. Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 48
    • 33845582594 scopus 로고    scopus 로고
    • A central thermogenic-like mechanism in feeding regulation: An interplay between arcuate nucleus T3 and UCP2
    • Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, et al. 2007. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab. 5:21-33
    • (2007) Cell Metab , vol.5 , pp. 21-33
    • Coppola, A.1    Liu, Z.W.2    Andrews, Z.B.3    Paradis, E.4    Roy, M.C.5
  • 50
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD. 1999. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:155-63
    • (1999) Neuron , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 51
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, et al. 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-84
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5
  • 52
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, et al. 2003. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-61
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschöp, M.4    Pronchuk, N.5
  • 53
    • 3042793951 scopus 로고    scopus 로고
    • Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus
    • Davis AM, Seney ML, Stallings NR, Zhao L, Parker KL, Tobet SA. 2004. Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus. J. Neurobiol. 60:424-36
    • (2004) J. Neurobiol , vol.60 , pp. 424-436
    • Davis, A.M.1    Seney, M.L.2    Stallings, N.R.3    Zhao, L.4    Parker, K.L.5    Tobet, S.A.6
  • 54
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, et al. 2006. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49:191-203
    • (2006) Neuron , vol.49 , pp. 191-203
    • Dhillon, H.1    Zigman, J.M.2    Ye, C.3    Lee, C.E.4    McGovern, R.A.5
  • 55
    • 33344479006 scopus 로고    scopus 로고
    • Ghrelin controls hippocampal spine synapse density and memory performance
    • Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, et al. 2006. Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9:381-88
    • (2006) Nat. Neurosci , vol.9 , pp. 381-388
    • Diano, S.1    Farr, S.A.2    Benoit, S.C.3    McNay, E.C.4    da Silva, I.5
  • 56
    • 0041920735 scopus 로고    scopus 로고
    • Fasting activates the nonhuman primate hypocretin (orcxin) system and its postsynaptic targets
    • Diano S, Horvath B, Urbanski HF, Sotonyi P, Horvath TL. 2003. Fasting activates the nonhuman primate hypocretin (orcxin) system and its postsynaptic targets. Endocrinology 144:3774-78
    • (2003) Endocrinology , vol.144 , pp. 3774-3778
    • Diano, S.1    Horvath, B.2    Urbanski, H.F.3    Sotonyi, P.4    Horvath, T.L.5
  • 57
    • 0031663067 scopus 로고    scopus 로고
    • Monosynaptic pathway between the arcuate nucleus expressing glial type II iodothyronine 5′-deiodinase mRNA and the median eminence-projective TRH cells of the rat paraventricular nucleus
    • Diano S, Naftolin F, Goglia F, Csernus V, Horvath TL. 1998a. Monosynaptic pathway between the arcuate nucleus expressing glial type II iodothyronine 5′-deiodinase mRNA and the median eminence-projective TRH cells of the rat paraventricular nucleus. J. Neuroendocrinol. 10:731-42
    • (1998) J. Neuroendocrinol , vol.10 , pp. 731-742
    • Diano, S.1    Naftolin, F.2    Goglia, F.3    Csernus, V.4    Horvath, T.L.5
  • 58
    • 0032566817 scopus 로고    scopus 로고
    • Segregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone
    • Diano S, Naftolin F, Goglia F, Horvath TL. 1998b. Segregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone. Regul. Pept. 75/76:117-26
    • (1998) Regul. Pept , vol.75-76 , pp. 117-126
    • Diano, S.1    Naftolin, F.2    Goglia, F.3    Horvath, T.L.4
  • 59
    • 0018568299 scopus 로고
    • The forebrain is not essential for sympathoadrenal hyperglycemic response to glucoprivation
    • DiRocco RJ, Grill HJ. 1979. The forebrain is not essential for sympathoadrenal hyperglycemic response to glucoprivation. Science 204:1112-14
    • (1979) Science , vol.204 , pp. 1112-1114
    • DiRocco, R.J.1    Grill, H.J.2
  • 60
    • 0032863991 scopus 로고    scopus 로고
    • Food intake elicited by central administration of orexins/hypocretins: Identification of hypothalamic sites of action
    • Dube MG, Kalra SP, Kalra PS. 1999. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res. 842:473-77
    • (1999) Brain Res , vol.842 , pp. 473-477
    • Dube, M.G.1    Kalra, S.P.2    Kalra, P.S.3
  • 61
    • 15444366416 scopus 로고    scopus 로고
    • Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
    • Dunn SL, Bjornholm M, Bates SH, Chen Z, Seifert M, Myers MG Jr. 2004. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol. Endocrinol. 19:925-38
    • (2004) Mol. Endocrinol , vol.19 , pp. 925-938
    • Dunn, S.L.1    Bjornholm, M.2    Bates, S.H.3    Chen, Z.4    Seifert, M.5    Myers Jr., M.G.6
  • 62
    • 0032436307 scopus 로고    scopus 로고
    • Leptin activates hypothalamic CART neurons projecting to the spinal cord
    • Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, et al. 1998a. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-85
    • (1998) Neuron , vol.21 , pp. 1375-1385
    • Elias, C.F.1    Lee, C.2    Kelly, J.3    Aschkenasi, C.4    Ahima, R.S.5
  • 63
    • 0032576592 scopus 로고    scopus 로고
    • Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
    • Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, et al. 1998b. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J. Comp. Neurol. 402:442-59
    • (1998) J. Comp. Neurol , vol.402 , pp. 442-459
    • Elias, C.F.1    Saper, C.B.2    Maratos-Flier, E.3    Tritos, N.A.4    Lee, C.5
  • 64
    • 2342427535 scopus 로고    scopus 로고
    • The central melanocortin system and the integration of short-and long-term regulators of energy homeostasis
    • Ellacott KL, Cone RD. 2004. The central melanocortin system and the integration of short-and long-term regulators of energy homeostasis. Recent Prog. Horm. Res. 59:395-408
    • (2004) Recent Prog. Horm. Res , vol.59 , pp. 395-408
    • Ellacott, K.L.1    Cone, R.D.2
  • 65
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson JC, Clegg KE, Palmiter RD. 1996. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-21
    • (1996) Nature , vol.381 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 66
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. 1997. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-68
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 68
    • 0037385790 scopus 로고    scopus 로고
    • Adiposity signals and food reward: Expanding the CNS roles of insulin and leptin
    • Figlewicz DP. 2003. Adiposity signals and food reward: expanding the CNS roles of insulin and leptin. Am. J. Physiol. Regal. Integr. Comp. Physiol. 284:R882-92
    • (2003) Am. J. Physiol. Regal. Integr. Comp. Physiol , vol.284
    • Figlewicz, D.P.1
  • 69
    • 0034614698 scopus 로고    scopus 로고
    • Modulation of brain reward circuitry by leptin
    • Fulton S, Woodside B, Shizgal P. 2000. Modulation of brain reward circuitry by leptin. Science 287:125-28
    • (2000) Science , vol.287 , pp. 125-128
    • Fulton, S.1    Woodside, B.2    Shizgal, P.3
  • 70
    • 12144262253 scopus 로고    scopus 로고
    • Dynamics of volume transmission in the brain. Focus on catecholamine and opioid peptide communication and the role of uncoupling protein 2
    • Fuxe K, Rivera A, Jacobsen KX, Hoistad M, Leo G, et al. 2005. Dynamics of volume transmission in the brain. Focus on catecholamine and opioid peptide communication and the role of uncoupling protein 2. J. Neural Transm. 112:65-76
    • (2005) J. Neural Transm , vol.112 , pp. 65-76
    • Fuxe, K.1    Rivera, A.2    Jacobsen, K.X.3    Hoistad, M.4    Leo, G.5
  • 71
    • 33846046623 scopus 로고    scopus 로고
    • Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
    • Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, et al. 2007. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat. Med. 13:89-94
    • (2007) Nat. Med , vol.13 , pp. 89-94
    • Gao, Q.1    Mezei, G.2    Nie, Y.3    Rao, Y.4    Choi, C.S.5
  • 72
    • 1842584949 scopus 로고    scopus 로고
    • Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
    • Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, et al. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. USA 101:4661-66
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4661-4666
    • Gao, Q.1    Wolfgang, M.J.2    Neschen, S.3    Morino, K.4    Horvath, T.L.5
  • 73
    • 0035867028 scopus 로고    scopus 로고
    • Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus
    • Gao XB, van den Pol AN. 2001. Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J. Physiol. 533:237-52
    • (2001) J. Physiol , vol.533 , pp. 237-252
    • Gao, X.B.1    van den Pol, A.N.2
  • 74
    • 0028104495 scopus 로고
    • Gonadal hormones as promoters of structural synaptic plasticity: Cellular mechanisms
    • Garcia-Segura LM, Chowen JA, Parducz A, Naftolin F. 1994. Gonadal hormones as promoters of structural synaptic plasticity: cellular mechanisms. Prog. Neurobiol. 44:279-307
    • (1994) Prog. Neurobiol , vol.44 , pp. 279-307
    • Garcia-Segura, L.M.1    Chowen, J.A.2    Parducz, A.3    Naftolin, F.4
  • 75
    • 33344469291 scopus 로고    scopus 로고
    • The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms
    • Gooley JJ, Schomer A, Saper CB. 2006. The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat. Neurosci. 9:398-407
    • (2006) Nat. Neurosci , vol.9 , pp. 398-407
    • Gooley, J.J.1    Schomer, A.2    Saper, C.B.3
  • 76
    • 0032400808 scopus 로고    scopus 로고
    • Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight
    • Grill HJ, Ginsberg AB, Seeley RJ, Kaplan JM. 1998. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J. Neurosci. 18:10128-35
    • (1998) J. Neurosci , vol.18 , pp. 10128-10135
    • Grill, H.J.1    Ginsberg, A.B.2    Seeley, R.J.3    Kaplan, J.M.4
  • 77
    • 0035710711 scopus 로고    scopus 로고
    • Interoceptive and integrative contributions of forebrain and brainstem to energy balance control
    • Grill HJ, Kaplan JM. 2001. Interoceptive and integrative contributions of forebrain and brainstem to energy balance control. Int. J. Obes. Relat. Metab. Disord. 25(Suppl. 5):S73-77
    • (2001) Int. J. Obes. Relat. Metab. Disord , vol.25 , Issue.SUPPL. 5
    • Grill, H.J.1    Kaplan, J.M.2
  • 78
    • 0036162117 scopus 로고    scopus 로고
    • The neuroanatomical axis for control of energy balance
    • Grill HJ, Kaplan JM. 2002. The neuroanatomical axis for control of energy balance. Front Neuroendocrinol. 23:2-40
    • (2002) Front Neuroendocrinol , vol.23 , pp. 2-40
    • Grill, H.J.1    Kaplan, J.M.2
  • 79
    • 0034625579 scopus 로고    scopus 로고
    • Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortin
    • Grill HJ, Markison S, Ginsberg A, Kaplan JM. 2000. Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortin. Brain Res. 867:19-28
    • (2000) Brain Res , vol.867 , pp. 19-28
    • Grill, H.J.1    Markison, S.2    Ginsberg, A.3    Kaplan, J.M.4
  • 80
    • 0018098925 scopus 로고
    • Chronically decerebrate rats demonstrate satiation but not bait shyness
    • Grill HJ, Norgren R. 1978. Chronically decerebrate rats demonstrate satiation but not bait shyness. Science 201:267-69
    • (1978) Science , vol.201 , pp. 267-269
    • Grill, H.J.1    Norgren, R.2
  • 82
    • 27344433932 scopus 로고    scopus 로고
    • Agouti-related peptide-expressing neurons are mandatory for feeding
    • Gropp E, Shanabrough M, Borok E, Xu AW, Janoshek R, et al. 2005. Agouti-related peptide-expressing neurons are mandatory for feeding. Nat. Neurosci. 8:1289-91
    • (2005) Nat. Neurosci , vol.8 , pp. 1289-1291
    • Gropp, E.1    Shanabrough, M.2    Borok, E.3    Xu, A.W.4    Janoshek, R.5
  • 83
    • 0036949711 scopus 로고    scopus 로고
    • Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: A novel circuit implicated in feeding regulation
    • Guan JL, Uehara K, Lu S, Wang QP, Funahashi H, et al. 2002. Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation. Int. J. Obes. Relat. Metab. Disord. 26:1523-32
    • (2002) Int. J. Obes. Relat. Metab. Disord , vol.26 , pp. 1523-1532
    • Guan, J.L.1    Uehara, K.2    Lu, S.3    Wang, Q.P.4    Funahashi, H.5
  • 84
    • 0030762351 scopus 로고    scopus 로고
    • Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
    • Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, et al. 1997. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res. Mol. Brain Res. 48:23-29
    • (1997) Brain Res. Mol. Brain Res , vol.48 , pp. 23-29
    • Guan, X.M.1    Yu, H.2    Palyha, O.C.3    McKee, K.K.4    Feighner, S.D.5
  • 85
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • Hahn TM, Breininger JF, Baskin DG, Schwartz MW. 1998. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1:271-72
    • (1998) Nat. Neurosci , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 86
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • Hakansson ML, Brown H, Ghilardi N, Skoda RC, Meister B. 1998. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18:559-72
    • (1998) J. Neurosci , vol.18 , pp. 559-572
    • Hakansson, M.L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 87
    • 0032968698 scopus 로고    scopus 로고
    • Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: Further evidence that activation of MC4-R is a physiological inhibitor of feeding
    • Harrold JA, Widdowson PS, Williams G. 1999. Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding. Diabetes 48:267-71
    • (1999) Diabetes , vol.48 , pp. 267-271
    • Harrold, J.A.1    Widdowson, P.S.2    Williams, G.3
  • 89
    • 70449255388 scopus 로고
    • The effects of lesions in the hypothalamus in parabiotic rats
    • Hervey GR. 1959. The effects of lesions in the hypothalamus in parabiotic rats. J. Physiol. 145:336-52
    • (1959) J. Physiol , vol.145 , pp. 336-352
    • Hervey, G.R.1
  • 90
    • 3542998657 scopus 로고
    • Non-production of hypothalamic obesity in the rat by lesions rostral or dorsal to the ventromedial hypothalamic nuclei
    • Hetherington AW. 1944. Non-production of hypothalamic obesity in the rat by lesions rostral or dorsal to the ventromedial hypothalamic nuclei. J. Comp. Neurol. 80:33
    • (1944) J. Comp. Neurol , vol.80 , pp. 33
    • Hetherington, A.W.1
  • 91
    • 85027474023 scopus 로고
    • Hypothalamic lesions and adipocity in the rat
    • Hetherington AW, Ranson SW. 1940. Hypothalamic lesions and adipocity in the rat. Anat. Record 78:149
    • (1940) Anat. Record , vol.78 , pp. 149
    • Hetherington, A.W.1    Ranson, S.W.2
  • 93
    • 0030990363 scopus 로고    scopus 로고
    • Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations
    • Horvath TL, Bechmann I, Kalra SP, Naftolin F, Leranth C. 1997. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res. 756:283-86
    • (1997) Brain Res , vol.756 , pp. 283-286
    • Horvath, T.L.1    Bechmann, I.2    Kalra, S.P.3    Naftolin, F.4    Leranth, C.5
  • 94
    • 0033081871 scopus 로고    scopus 로고
    • Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
    • Horvath TL, Diano S, van den Pol AN. 1999a. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J. Neurosci. 19:1072-87
    • (1999) J. Neurosci , vol.19 , pp. 1072-1087
    • Horvath, T.L.1    Diano, S.2    van den Pol, A.N.3
  • 95
    • 17844393711 scopus 로고    scopus 로고
    • Inpur organization and plasticity of hypocretin neurons: Possible clues for obesity's association with insomnia
    • Horvath TL, Gao XB. 2005. Inpur organization and plasticity of hypocretin neurons: possible clues for obesity's association with insomnia. Cell Metab. 1:279-86
    • (2005) Cell Metab , vol.1 , pp. 279-286
    • Horvath, T.L.1    Gao, X.B.2
  • 96
    • 0026463547 scopus 로고
    • Neuropeptide-Y innervation of β-endorphin-containing cells in the rat mediobasal hypothalamus: A light and electron microscopic double immunostaining analysis
    • Horvath TL, Naftolin F, Kalra SP, Leranth C. 1992. Neuropeptide-Y innervation of β-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 131:2461-67
    • (1992) Endocrinology , vol.131 , pp. 2461-2467
    • Horvath, T.L.1    Naftolin, F.2    Kalra, S.P.3    Leranth, C.4
  • 97
    • 0033552658 scopus 로고    scopus 로고
    • Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
    • Horvath TL, Peyron C, Diano S, Ivanov A, Aston-Jones G, et al. 1999b. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J. Comp. Neurol. 415:145-59
    • (1999) J. Comp. Neurol , vol.415 , pp. 145-159
    • Horvath, T.L.1    Peyron, C.2    Diano, S.3    Ivanov, A.4    Aston-Jones, G.5
  • 98
    • 0033492873 scopus 로고    scopus 로고
    • Brain uncoupling protein 2: Uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers
    • Horvath TL, Warden CH, Hajos M, Lombardi A, Goglia F, Diano S. 1999c. Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J. Neurosci. 19:10417-27
    • (1999) J. Neurosci , vol.19 , pp. 10417-10427
    • Horvath, T.L.1    Warden, C.H.2    Hajos, M.3    Lombardi, A.4    Goglia, F.5    Diano, S.6
  • 99
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, et al. 1996. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-77
    • (1996) Science , vol.273 , pp. 974-977
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3    Arena, J.P.4    Liberator, P.A.5
  • 101
    • 0031036144 scopus 로고    scopus 로고
    • The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus
    • Jacob RJ, Dziura J, Medwick MB, Leone P, Caprio S, et al. 1997. The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. Diabetes 46:150-52
    • (1997) Diabetes , vol.46 , pp. 150-152
    • Jacob, R.J.1    Dziura, J.2    Medwick, M.B.3    Leone, P.4    Caprio, S.5
  • 102
    • 0033969792 scopus 로고    scopus 로고
    • Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
    • Jain MR, Horvath TL, Kalra PS, Kalra SP. 1999. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul. Pept. 87:19-24
    • (1999) Regul. Pept , vol.87 , pp. 19-24
    • Jain, M.R.1    Horvath, T.L.2    Kalra, P.S.3    Kalra, S.P.4
  • 103
    • 0034991515 scopus 로고    scopus 로고
    • Melanin-concentrating hormone (MCH) suppresses thyroid stimulating hormone (TSH) release, in vivo and in vitro, via the hypothalamus and the pituitary
    • Kennedy AR, Todd JF, Stanley SA, Abbott CR, Small CJ, et al. 2001. Melanin-concentrating hormone (MCH) suppresses thyroid stimulating hormone (TSH) release, in vivo and in vitro, via the hypothalamus and the pituitary. Endocrinology 142:3265-68
    • (2001) Endocrinology , vol.142 , pp. 3265-3268
    • Kennedy, A.R.1    Todd, J.F.2    Stanley, S.A.3    Abbott, C.R.4    Small, C.J.5
  • 104
    • 84958689411 scopus 로고
    • The role of depot fat in the hypothalamic control of food intake in the rat
    • Kennedy GC. 1953. The role of depot fat in the hypothalamic control of food intake in the rat. Proc. R. Soc. London Ser. B 140:579-92
    • (1953) Proc. R. Soc. London Ser. B , vol.140 , pp. 579-592
    • Kennedy, G.C.1
  • 105
    • 2442631468 scopus 로고    scopus 로고
    • C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
    • Kim EK, Miller I, Aja S, Landree LE, Pinn M, et al. 2004. C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J. Biol. Chem. 279:19970-76
    • (2004) J. Biol. Chem , vol.279 , pp. 19970-19976
    • Kim, E.K.1    Miller, I.2    Aja, S.3    Landree, L.E.4    Pinn, M.5
  • 106
    • 3142677140 scopus 로고    scopus 로고
    • Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
    • Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, et al. 2004. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat. Med. 10:727-33
    • (2004) Nat. Med , vol.10 , pp. 727-733
    • Kim, M.S.1    Park, J.Y.2    Namkoong, C.3    Jang, P.G.4    Ryu, J.W.5
  • 107
    • 4544235733 scopus 로고    scopus 로고
    • The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes
    • Kim MS, Yoon CY, Jang PG, Park YJ, Shin CS, et al. 2004. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol. Endocrinol. 18:2291-301
    • (2004) Mol. Endocrinol , vol.18 , pp. 2291-2301
    • Kim, M.S.1    Yoon, C.Y.2    Jang, P.G.3    Park, Y.J.4    Shin, C.S.5
  • 108
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-60
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 109
    • 21644453934 scopus 로고    scopus 로고
    • Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
    • Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, et al. 2005. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J. Biol. Chem. 280:25196-201
    • (2005) J. Biol. Chem , vol.280 , pp. 25196-25201
    • Kola, B.1    Hubina, E.2    Tucci, S.A.3    Kirkham, T.C.4    Garcia, E.A.5
  • 110
    • 33646139871 scopus 로고    scopus 로고
    • Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus
    • Komori T, Morikawa Y, Nanjo K, Senba E. 2006. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neuroscience 139:1107-15
    • (2006) Neuroscience , vol.139 , pp. 1107-1115
    • Komori, T.1    Morikawa, Y.2    Nanjo, K.3    Senba, E.4
  • 111
    • 23244458439 scopus 로고    scopus 로고
    • Regulation of blood glucose by hypothalamic pyruvate metabolism
    • Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L. 2005a. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309:943-47
    • (2005) Science , vol.309 , pp. 943-947
    • Lam, T.K.1    Gutierrez-Juarez, R.2    Pocai, A.3    Rossetti, L.4
  • 113
    • 9144219529 scopus 로고    scopus 로고
    • C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism
    • Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, et al. 2004. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. J. Biol. Chem. 279:3817-27
    • (2004) J. Biol. Chem , vol.279 , pp. 3817-3827
    • Landree, L.E.1    Hanlon, A.L.2    Strong, D.W.3    Rumbaugh, G.4    Miller, I.M.5
  • 114
    • 0036144322 scopus 로고    scopus 로고
    • Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
    • Lawrence CB, Snape AC, Baudoin FM, Luckman SM. 2002. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 143:155-62
    • (2002) Endocrinology , vol.143 , pp. 155-162
    • Lawrence, C.B.1    Snape, A.C.2    Baudoin, F.M.3    Luckman, S.M.4
  • 115
    • 11144242445 scopus 로고    scopus 로고
    • Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior
    • Lee K, Li B, Xi X, Suh Y, Martin RJ. 2005. Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 146:3-10
    • (2005) Endocrinology , vol.146 , pp. 3-10
    • Lee, K.1    Li, B.2    Xi, X.3    Suh, Y.4    Martin, R.J.5
  • 116
    • 33645048441 scopus 로고    scopus 로고
    • A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance
    • Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, et al. 2006. A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab. 3:135-40
    • (2006) Cell Metab , vol.3 , pp. 135-140
    • Lee, Y.S.1    Challis, B.G.2    Thompson, D.A.3    Yeo, G.S.4    Keogh, J.M.5
  • 117
    • 0037137682 scopus 로고    scopus 로고
    • Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system
    • Li Y, Gao XB, Sakurai T, van den Pol AN. 2002. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36:1169-81
    • (2002) Neuron , vol.36 , pp. 1169-1181
    • Li, Y.1    Gao, X.B.2    Sakurai, T.3    van den Pol, A.N.4
  • 118
    • 3442899304 scopus 로고    scopus 로고
    • Food deprivation decreases responsiveness of ventromedial hypothalamic neurons to melanocortins
    • Li YZ, Davidowa H. 2004. Food deprivation decreases responsiveness of ventromedial hypothalamic neurons to melanocortins. J. Neurosci. Res. 77:596-602
    • (2004) J. Neurosci. Res , vol.77 , pp. 596-602
    • Li, Y.Z.1    Davidowa, H.2
  • 119
    • 0029833911 scopus 로고    scopus 로고
    • Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats
    • Lopez-Valpuesta FJ, Nyce JW, Griffin-Biggs TA, Ice JC, Myers RD. 1996. Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats. Proc. Biol. Sci. 263:881-86
    • (1996) Proc. Biol. Sci , vol.263 , pp. 881-886
    • Lopez-Valpuesta, F.J.1    Nyce, J.W.2    Griffin-Biggs, T.A.3    Ice, J.C.4    Myers, R.D.5
  • 120
    • 0031968521 scopus 로고    scopus 로고
    • Melanin-concentrating hormone: A functional melanocortin antagonist in the hypothalamus
    • Ludwig DS, Mountjoy KG, Tatro JB, Gillette JA, Frederich RC, et al. 1998. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am. J. Physiol. 274:627-33
    • (1998) Am. J. Physiol , vol.274 , pp. 627-633
    • Ludwig, D.S.1    Mountjoy, K.G.2    Tatro, J.B.3    Gillette, J.A.4    Frederich, R.C.5
  • 121
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet S, Perez FA, Hnasko TS, Palmiter RD. 2005. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310:683-85
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 122
    • 0036153668 scopus 로고    scopus 로고
    • Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity
    • Majdic G, Young M, Gomez-Sanchez E, Anderson P, Szczepaniak LS, et al. 2002. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 143:607-14
    • (2002) Endocrinology , vol.143 , pp. 607-614
    • Majdic, G.1    Young, M.2    Gomez-Sanchez, E.3    Anderson, P.4    Szczepaniak, L.S.5
  • 123
    • 5344241223 scopus 로고    scopus 로고
    • LTP and LTD: An embarrassment of riches
    • Malenka RC, Bear MF. 2004. LTP and LTD: an embarrassment of riches. Neuron 44:5-21
    • (2004) Neuron , vol.44 , pp. 5-21
    • Malenka, R.C.1    Bear, M.F.2
  • 124
    • 0014212914 scopus 로고
    • Regulation of food intake and obesity
    • Mayer J, Thomas DW. 1967. Regulation of food intake and obesity. Science 156:328-37
    • (1967) Science , vol.156 , pp. 328-337
    • Mayer, J.1    Thomas, D.W.2
  • 125
    • 4444289166 scopus 로고    scopus 로고
    • Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects
    • Mazzocchi G, Neri G, Rucinski M, Rebuffat P, Spinazzi R, et al. 2004. Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects. Peptides 25:1269-77
    • (2004) Peptides , vol.25 , pp. 1269-1277
    • Mazzocchi, G.1    Neri, G.2    Rucinski, M.3    Rebuffat, P.4    Spinazzi, R.5
  • 126
    • 3242811250 scopus 로고    scopus 로고
    • Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus
    • McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS. 2004. Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. Diabetes 53:1953-58
    • (2004) Diabetes , vol.53 , pp. 1953-1958
    • McCrimmon, R.J.1    Fan, X.2    Ding, Y.3    Zhu, W.4    Jacob, R.J.5    Sherwin, R.S.6
  • 127
    • 0031003664 scopus 로고    scopus 로고
    • Molecular analysis of rat pituitary and hypothalamic growth hormone secretogogue receptors
    • McKee KK, Palyha OC, Feighner SD, Hreniuk DL, Tan CP, et al. 1997. Molecular analysis of rat pituitary and hypothalamic growth hormone secretogogue receptors. Mol. Endocrinol. 11:415-23
    • (1997) Mol. Endocrinol , vol.11 , pp. 415-423
    • McKee, K.K.1    Palyha, O.C.2    Feighner, S.D.3    Hreniuk, D.L.4    Tan, C.P.5
  • 128
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. 1996. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:113-16
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 129
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, et al. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569-74
    • (2004) Nature , vol.428 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3    Kim, Y.B.4    Lee, A.5
  • 130
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, et al. 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415:339-43
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3    Fryer, L.G.4    Muller, C.5
  • 131
    • 0028237111 scopus 로고
    • Structural dynamics of neural plasticity in the supraoptic nucleus of the rat hypothalamus during dehydration and rehydration
    • Miyata S, Nakashima T, Kiyohara T. 1994. Structural dynamics of neural plasticity in the supraoptic nucleus of the rat hypothalamus during dehydration and rehydration. Brain Res. Bull. 34:169-75
    • (1994) Brain Res. Bull , vol.34 , pp. 169-175
    • Miyata, S.1    Nakashima, T.2    Kiyohara, T.3
  • 132
    • 11144310116 scopus 로고    scopus 로고
    • Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus
    • Mondal MS, Date Y, Yamaguchi H, Toshinai K, Tsuruta T, et al. 2005. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul. Pept. 126:55-59
    • (2005) Regul. Pept , vol.126 , pp. 55-59
    • Mondal, M.S.1    Date, Y.2    Yamaguchi, H.3    Toshinai, K.4    Tsuruta, T.5
  • 133
    • 3142723983 scopus 로고    scopus 로고
    • Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
    • Mori H, Hanada R, Hanada T, Aki D, Mashima R, et al. 2004. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat. Med. 10:739-43
    • (2004) Nat. Med , vol.10 , pp. 739-743
    • Mori, H.1    Hanada, R.2    Hanada, T.3    Aki, D.4    Mashima, R.5
  • 134
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. 1994. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 8:1298-308
    • (1994) Mol. Endocrinol , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 135
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H, Flier JS, Bjorbaek C. 2004. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880-89
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 138
    • 0344512367 scopus 로고    scopus 로고
    • Minireview: Nutrient sensing and the regulation of insulin action and energy balance
    • Obici S, Rossetti L. 2003. Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology 144:5172-78
    • (2003) Endocrinology , vol.144 , pp. 5172-5178
    • Obici, S.1    Rossetti, L.2
  • 139
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, et al. 1997. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-38
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5
  • 140
    • 0021249617 scopus 로고
    • Neural network of glucose monitoring system
    • Oomura Y, Yoshimatsu H. 1984. Neural network of glucose monitoring system. J. Auton. Nerv. Syst. 10:359-72
    • (1984) J. Auton. Nerv. Syst , vol.10 , pp. 359-372
    • Oomura, Y.1    Yoshimatsu, H.2
  • 141
    • 0037430755 scopus 로고    scopus 로고
    • Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats
    • Parducz A, Zsarnovszky A, Naftolin F, Horvath TL. 2003. Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats. Neuroscience 117:791-94
    • (2003) Neuroscience , vol.117 , pp. 791-794
    • Parducz, A.1    Zsarnovszky, A.2    Naftolin, F.3    Horvath, T.L.4
  • 142
  • 143
    • 0032402181 scopus 로고    scopus 로고
    • Neurons containing hypocretin (orexin) project to multiple neuronal systems
    • Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, et al. 1998. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18:9996-10015
    • (1998) J. Neurosci , vol.18 , pp. 9996-10015
    • Peyron, C.1    Tighe, D.K.2    van den Pol, A.N.3    de Lecea, L.4    Heller, H.C.5
  • 144
    • 1842529267 scopus 로고    scopus 로고
    • Rapid rewiring of arcuate nucleus feeding circuits by leptin
    • Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, et al. 2004. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304:110-15
    • (2004) Science , vol.304 , pp. 110-115
    • Pinto, S.1    Roseberry, A.G.2    Liu, H.3    Diano, S.4    Shanabrough, M.5
  • 145
    • 33745819212 scopus 로고    scopus 로고
    • Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
    • Plum L, Ma X, Hampel B, Balthasar N, Coppari R, et al. 2006. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J. Clin. Invest. 116:1886-901
    • (2006) J. Clin. Invest , vol.116 , pp. 1886-1901
    • Plum, L.1    Ma, X.2    Hampel, B.3    Balthasar, N.4    Coppari, R.5
  • 146
    • 33645531123 scopus 로고    scopus 로고
    • Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
    • Pocai A, Lam TK, Obici S, Gutierrez-Juarez R, Muse ED, et al. 2006. Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J. Clin. Invest. 116:1081-91
    • (2006) J. Clin. Invest , vol.116 , pp. 1081-1091
    • Pocai, A.1    Lam, T.K.2    Obici, S.3    Gutierrez-Juarez, R.4    Muse, E.D.5
  • 147
    • 0036288345 scopus 로고    scopus 로고
    • Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice
    • Qian S, Chen H, Weingarth D, Trumbauer ME, Novi DE, et al. 2002. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol. Cell Biol. 22:5027-35
    • (2002) Mol. Cell Biol , vol.22 , pp. 5027-5035
    • Qian, S.1    Chen, H.2    Weingarth, D.3    Trumbauer, M.E.4    Novi, D.E.5
  • 148
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behavior
    • Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, et al. 1996. A role for melanin-concentrating hormone in the central regulation of feeding behavior. Nature 380:243-47
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3    Piper, M.4    Pelleymounter, M.A.5
  • 149
    • 0037338694 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    • Rahmouni K, Haynes WG, Morgan DA, Mark AL. 2003. Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension 41:763-67
    • (2003) Hypertension , vol.41 , pp. 763-767
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 150
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    • Rios M, Fan G, Fekete C, Kelly J, Bates B, et al. 2001. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol. Endocrinol. 15:1748-57
    • (2001) Mol. Endocrinol , vol.15 , pp. 1748-1757
    • Rios, M.1    Fan, G.2    Fekete, C.3    Kelly, J.4    Bates, B.5
  • 151
    • 0019794835 scopus 로고
    • Glucoreceptors controlling feeding and blood glucose: Location in the hindbrain
    • Ritter RC, Slusser PG, Stone S. 1981. Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451-53
    • (1981) Science , vol.213 , pp. 451-453
    • Ritter, R.C.1    Slusser, P.G.2    Stone, S.3
  • 152
    • 0028037667 scopus 로고
    • The melanocortin (MC3) receptor from rat hypothalamus: Photoaffinity labeling and binding of alanine-substituted α-MSH analogues
    • Sahm UG, Qarawi MA, Olivier GW, Ahmed AR, Branch SK, et al. 1994. The melanocortin (MC3) receptor from rat hypothalamus: photoaffinity labeling and binding of alanine-substituted α-MSH analogues. FEBS Lett. 350:29-32
    • (1994) FEBS Lett , vol.350 , pp. 29-32
    • Sahm, U.G.1    Qarawi, M.A.2    Olivier, G.W.3    Ahmed, A.R.4    Branch, S.K.5
  • 153
    • 0037135167 scopus 로고    scopus 로고
    • Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats
    • Sahu A. 2002. Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats. Brain Res. 944:232-38
    • (2002) Brain Res , vol.944 , pp. 232-238
    • Sahu, A.1
  • 154
    • 0023867209 scopus 로고
    • Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus
    • Sahu A, Kalra PS, Kalra SP. 1988a. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9:83-86
    • (1988) Peptides , vol.9 , pp. 83-86
    • Sahu, A.1    Kalra, P.S.2    Kalra, S.P.3
  • 155
    • 0023759108 scopus 로고
    • Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: Implication in feeding behavior
    • Sahu A, Kalra SP, Crowley WR, Kalra PS. 1988b. Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Res. 457:376-78
    • (1988) Brain Res , vol.457 , pp. 376-378
    • Sahu, A.1    Kalra, S.P.2    Crowley, W.R.3    Kalra, P.S.4
  • 156
    • 0035908285 scopus 로고    scopus 로고
    • Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain
    • Saito Y, Cheng M, Leslie FM, Civelli O. 2001. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J. Comp. Neurol. 435:26-40
    • (2001) J. Comp. Neurol , vol.435 , pp. 26-40
    • Saito, Y.1    Cheng, M.2    Leslie, F.M.3    Civelli, O.4
  • 157
    • 0032489093 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-85
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5
  • 158
    • 20244374121 scopus 로고    scopus 로고
    • Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice
    • Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, et al. 2005. Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46:297-308
    • (2005) Neuron , vol.46 , pp. 297-308
    • Sakurai, T.1    Nagata, R.2    Yamanaka, A.3    Kawamura, H.4    Tsujino, N.5
  • 159
    • 0017138271 scopus 로고
    • The efferent connections of the ventromedial nucleus of the hypothalamus of the rat
    • Saper CB, Swanson LW, Cowan WM. 1976. The efferent connections of the ventromedial nucleus of the hypothalamus of the rat. J. Comp. Neurol. 169:409-42
    • (1976) J. Comp. Neurol , vol.169 , pp. 409-442
    • Saper, C.B.1    Swanson, L.W.2    Cowan, W.M.3
  • 160
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
    • Schindler C, Darnell JE Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621-51
    • (1995) Annu. Rev. Biochem , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell Jr., J.E.2
  • 161
    • 0028288666 scopus 로고
    • Neurological dissociation of gastrointestinal and metabolic contributions to meal size control
    • Seeley RJ, Grill HJ, Kaplan JM. 1994. Neurological dissociation of gastrointestinal and metabolic contributions to meal size control. Behav. Neurosci. 108:347-52
    • (1994) Behav. Neurosci , vol.108 , pp. 347-352
    • Seeley, R.J.1    Grill, H.J.2    Kaplan, J.M.3
  • 162
    • 22744441151 scopus 로고    scopus 로고
    • Fuel sensing and the central nervous system (CNS): Implications for the regulation of energy balance and the treatment for obesity
    • Seeley RJ, York DA. 2005. Fuel sensing and the central nervous system (CNS): implications for the regulation of energy balance and the treatment for obesity. Obes. Rev. 6:259-65
    • (2005) Obes. Rev , vol.6 , pp. 259-265
    • Seeley, R.J.1    York, D.A.2
  • 163
    • 0242363255 scopus 로고    scopus 로고
    • Monitoring of stored and available fuel by the CNS: Implications for obesity
    • Seeley RJ, Woods SC. 2003. Monitoring of stored and available fuel by the CNS: implications for obesity. Nat. Rev. Neurosci. 4:901-9
    • (2003) Nat. Rev. Neurosci , vol.4 , pp. 901-909
    • Seeley, R.J.1    Woods, S.C.2
  • 165
    • 0024602756 scopus 로고
    • Evidence for a physiological role for CCK in the regulation of food intake in mice
    • Silver AJ, Flood JF, Song AM, Morley JE. 1989. Evidence for a physiological role for CCK in the regulation of food intake in mice. Am. J. Physiol. 256:646-52
    • (1989) Am. J. Physiol , vol.256 , pp. 646-652
    • Silver, A.J.1    Flood, J.F.2    Song, A.M.3    Morley, J.E.4
  • 166
    • 0041422625 scopus 로고    scopus 로고
    • Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
    • Small DM, Jones-Gotman M, Dagher A. 2003. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroim age 19:1709-15
    • (2003) Neuroim age , vol.19 , pp. 1709-1715
    • Small, D.M.1    Jones-Gotman, M.2    Dagher, A.3
  • 167
    • 0022149006 scopus 로고
    • Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats
    • Smith GP, Jerome C, Norgren R. 1985. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am. J. Physiol. 249:638-41
    • (1985) Am. J. Physiol , vol.249 , pp. 638-641
    • Smith, G.P.1    Jerome, C.2    Norgren, R.3
  • 168
    • 18844404431 scopus 로고    scopus 로고
    • Development of growth hormone secretogogues
    • Smith RG. 2005. Development of growth hormone secretogogues. Endocr. Rev. 26:346-60
    • (2005) Endocr. Rev , vol.26 , pp. 346-360
    • Smith, R.G.1
  • 170
    • 0032567353 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
    • Song MM, Shuai K. 1998. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273:35056-62
    • (1998) J. Biol. Chem , vol.273 , pp. 35056-35062
    • Song, M.M.1    Shuai, K.2
  • 171
    • 27744519516 scopus 로고    scopus 로고
    • Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding
    • Sotak BN, Hnasko TS, Robinson S, Kremer EJ, Palmiter RD. 2005. Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Brain Res. 1061:88-96
    • (2005) Brain Res , vol.1061 , pp. 88-96
    • Sotak, B.N.1    Hnasko, T.S.2    Robinson, S.3    Kremer, E.J.4    Palmiter, R.D.5
  • 172
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML. 1997. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390:521-25
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 174
    • 0021713735 scopus 로고
    • Neuropeptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus
    • Stanley BG, Leibowitz SF. 1984. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 35:2635-42
    • (1984) Life Sci , vol.35 , pp. 2635-2642
    • Stanley, B.G.1    Leibowitz, S.F.2
  • 175
    • 0002244632 scopus 로고
    • The physiology of motivation
    • Stellar E. 1954. The physiology of motivation. Psychol. Rev. 61:5-22
    • (1954) Psychol. Rev , vol.61 , pp. 5-22
    • Stellar, E.1
  • 176
    • 0031915248 scopus 로고    scopus 로고
    • Reorganization of the dendritic trees of oxytocin and vasopressin neurons of the rat supraoptic nucleus during lactation
    • Stern JE, Armstrong WE. 1998. Reorganization of the dendritic trees of oxytocin and vasopressin neurons of the rat supraoptic nucleus during lactation. J. Neurosci. 18:841-53
    • (1998) J. Neurosci , vol.18 , pp. 841-853
    • Stern, J.E.1    Armstrong, W.E.2
  • 177
    • 27744457512 scopus 로고    scopus 로고
    • Topographic mapping of VMH -> arcuate nucleus microcircuits and their reorganization by fasting
    • Sternson SM, Shepherd GM, Friedman JM. 2005. Topographic mapping of VMH -> arcuate nucleus microcircuits and their reorganization by fasting. Nat. Neurosci. 8:1356-63
    • (2005) Nat. Neurosci , vol.8 , pp. 1356-1363
    • Sternson, S.M.1    Shepherd, G.M.2    Friedman, J.M.3
  • 178
    • 0021958991 scopus 로고
    • The role of the ventromedial hypothalamic area in periprandial glucoregulation
    • Storlien LH. 1985. The role of the ventromedial hypothalamic area in periprandial glucoregulation. Life Sci. 36:505-14
    • (1985) Life Sci , vol.36 , pp. 505-514
    • Storlien, L.H.1
  • 179
    • 0034964279 scopus 로고    scopus 로고
    • Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice
    • Szczypka MS, Kwok K, Brot MD, Marck BT, Matsumoto AM, et al. 2001. Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 30:819-28
    • (2001) Neuron , vol.30 , pp. 819-828
    • Szczypka, M.S.1    Kwok, K.2    Brot, M.D.3    Marck, B.T.4    Matsumoto, A.M.5
  • 181
    • 0034063046 scopus 로고    scopus 로고
    • Dopamine is required for hyperphagia in Lep(ob/ob) mice
    • Szczypka MS, Rainey MA, Palmiter RD. 2000. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat. Genet. 25:102-4
    • (2000) Nat. Genet , vol.25 , pp. 102-104
    • Szczypka, M.S.1    Rainey, M.A.2    Palmiter, R.D.3
  • 182
    • 0031765095 scopus 로고    scopus 로고
    • Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus
    • Tannenbaum GS, Lapointe M, Beaudet A, Howard AD. 1998. Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus. Endocrinology 139:4420-23
    • (1998) Endocrinology , vol.139 , pp. 4420-4423
    • Tannenbaum, G.S.1    Lapointe, M.2    Beaudet, A.3    Howard, A.D.4
  • 183
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia LA. 1997. The leptin receptor. J. Biol. Chem. 272:6093-96
    • (1997) J. Biol. Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 184
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, et al. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-71
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3    Deng, N.4    Culpepper, J.5
  • 185
    • 0022847631 scopus 로고    scopus 로고
    • Tejwani GA, Richard CW 3rd. 1986. Effect of electrolytic and chemical ventromedial hypothalamic lesions on food intake, body weight, analgesia and the CNS opioid peptides in rats and mice. NIDA Res. Monogr. 75:497-500
    • Tejwani GA, Richard CW 3rd. 1986. Effect of electrolytic and chemical ventromedial hypothalamic lesions on food intake, body weight, analgesia and the CNS opioid peptides in rats and mice. NIDA Res. Monogr. 75:497-500
  • 186
    • 0022626432 scopus 로고
    • The projections of the dorsomedial hypothalamic nucleus in the rat
    • ter Horst GJ, Luiten PG. 1986. The projections of the dorsomedial hypothalamic nucleus in the rat. Brain Res. Bull. 16:231-48
    • (1986) Brain Res. Bull , vol.16 , pp. 231-248
    • ter Horst, G.J.1    Luiten, P.G.2
  • 187
    • 0025954614 scopus 로고
    • Retention of embryonic features by an adult neuronal system capable of plasticity: Polysialylated neural cell adhesion molecule in the hypothalamo-neurohypophysial system
    • Theodosis DT, Rougon G, Poulain DA. 1991. Retention of embryonic features by an adult neuronal system capable of plasticity: polysialylated neural cell adhesion molecule in the hypothalamo-neurohypophysial system. Proc. Natl. Acad. Sci. USA 88:5494-98
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5494-5498
    • Theodosis, D.T.1    Rougon, G.2    Poulain, D.A.3
  • 188
    • 0038094513 scopus 로고    scopus 로고
    • Colocalization of orexin and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats
    • Torrealba F, Yanagisawa M, Saper CB. 2003. Colocalization of orexin and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats. Neuroscience 119:1033-44
    • (2003) Neuroscience , vol.119 , pp. 1033-1044
    • Torrealba, F.1    Yanagisawa, M.2    Saper, C.B.3
  • 190
    • 0025806796 scopus 로고
    • Coding the sweet taste in the nucleus of the solitary tract: Differential roles for anterior tongue and nasoincisor duct gustatory receptors in the rat
    • Travers SP, Norgren R. 1991. Coding the sweet taste in the nucleus of the solitary tract: differential roles for anterior tongue and nasoincisor duct gustatory receptors in the rat. J. Neurophysiol. 65:1372-80
    • (1991) J. Neurophysiol , vol.65 , pp. 1372-1380
    • Travers, S.P.1    Norgren, R.2
  • 191
    • 0035937540 scopus 로고    scopus 로고
    • Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus
    • Tritos NA, Mastaitis JW, Kokkotou E, Maratos-Flier E. 2001. Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res. 895:160-66
    • (2001) Brain Res , vol.895 , pp. 160-166
    • Tritos, N.A.1    Mastaitis, J.W.2    Kokkotou, E.3    Maratos-Flier, E.4
  • 192
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML. 2000. Ghrelin induces adiposity in rodents. Nature 407:908-13
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 194
    • 0347993676 scopus 로고    scopus 로고
    • Weighing the role of hypothalamic feeding neurotransmitters
    • van den Pol AN. 2003. Weighing the role of hypothalamic feeding neurotransmitters. Neuron 40:1059-61
    • (2003) Neuron , vol.40 , pp. 1059-1061
    • van den Pol, A.N.1
  • 195
    • 2442538044 scopus 로고    scopus 로고
    • Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    • van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK. 2004. Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 42:635-52
    • (2004) Neuron , vol.42 , pp. 635-652
    • van den Pol, A.N.1    Acuna-Goycolea, C.2    Clark, K.R.3    Ghosh, P.K.4
  • 196
    • 2142758640 scopus 로고    scopus 로고
    • Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D. 2004. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci. 7:493-94
    • (2004) Nat. Neurosci , vol.7 , pp. 493-494
    • van den Top, M.1    Lee, K.2    Whyment, A.D.3    Blanks, A.M.4    Spanswick, D.5
  • 197
    • 17844398708 scopus 로고    scopus 로고
    • How can drug addiction help us understand obesity?
    • Volkow ND, Wise RA. 2005. How can drug addiction help us understand obesity? Nat. Neurosci. 8:555-60
    • (2005) Nat. Neurosci , vol.8 , pp. 555-560
    • Volkow, N.D.1    Wise, R.A.2
  • 198
    • 0031040793 scopus 로고    scopus 로고
    • Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
    • White DW, Kuropatwinski KK, Devos R, Baumann H, Tartaglia LA. 1997. Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J. Biol. Chem. 272:4065-71
    • (1997) J. Biol. Chem , vol.272 , pp. 4065-4071
    • White, D.W.1    Kuropatwinski, K.K.2    Devos, R.3    Baumann, H.4    Tartaglia, L.A.5
  • 199
    • 0027319108 scopus 로고
    • Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse
    • Wilding JP, Gilbey SG, Bailey CJ, Batt RA, Williams G, et al. 1993. Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology 132:1939-44
    • (1993) Endocrinology , vol.132 , pp. 1939-1944
    • Wilding, J.P.1    Gilbey, S.G.2    Bailey, C.J.3    Batt, R.A.4    Williams, G.5
  • 200
    • 0032744366 scopus 로고    scopus 로고
    • Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
    • Willesen MG, Kristensen P, Romer J. 1999. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70:306-16
    • (1999) Neuroendocrinology , vol.70 , pp. 306-316
    • Willesen, M.G.1    Kristensen, P.2    Romer, J.3
  • 201
    • 0034456725 scopus 로고    scopus 로고
    • The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation
    • Williams DL, Kaplan JM, Grill HJ. 2000. The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141:1332-37
    • (2000) Endocrinology , vol.141 , pp. 1332-1337
    • Williams, D.L.1    Kaplan, J.M.2    Grill, H.J.3
  • 203
    • 0037057816 scopus 로고    scopus 로고
    • Brain reward circuitry: Insights from unsensed incentives
    • Wise RA. 2002. Brain reward circuitry: insights from unsensed incentives. Neuron 36:229-40
    • (2002) Neuron , vol.36 , pp. 229-240
    • Wise, R.A.1
  • 204
    • 0034020605 scopus 로고    scopus 로고
    • Adrenalectomy reduces neuropeptide Y-induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus
    • Wisialowski T, Parker R, Preston E, Sainsbury A, Kraegen E, et al. 2000. Adrenalectomy reduces neuropeptide Y-induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus. J. Clin. Invest. 105:1253-59
    • (2000) J. Clin. Invest , vol.105 , pp. 1253-1259
    • Wisialowski, T.1    Parker, R.2    Preston, E.3    Sainsbury, A.4    Kraegen, E.5
  • 206
    • 23944436338 scopus 로고    scopus 로고
    • Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors
    • Wollmann G, Acuna-Goycolea C, van den Pol AN. 2005. Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors. J. Neurophysiol. 94:2195-206
    • (2005) J. Neurophysiol , vol.94 , pp. 2195-2206
    • Wollmann, G.1    Acuna-Goycolea, C.2    van den Pol, A.N.3
  • 207
    • 0032577376 scopus 로고    scopus 로고
    • Signals that regulate food intake and energy homeostasis
    • Woods SC, Seeley RJ, Porte D Jr, Schwartz MW. 1998. Signals that regulate food intake and energy homeostasis. Science 280:1378-83
    • (1998) Science , vol.280 , pp. 1378-1383
    • Woods, S.C.1    Seeley, R.J.2    Porte Jr, D.3    Schwartz, M.W.4
  • 208
    • 0031046169 scopus 로고    scopus 로고
    • Evidence for seasonal plasticity in the gonadotropin-releasing hormone (GnRH) system of the ewe: Changes in synaptic inputs onto GnRH neurons
    • Xiong JJ, Karsch FJ, Lehman MN. 1997. Evidence for seasonal plasticity in the gonadotropin-releasing hormone (GnRH) system of the ewe: changes in synaptic inputs onto GnRH neurons. Endocrinology 138:1240-50
    • (1997) Endocrinology , vol.138 , pp. 1240-1250
    • Xiong, J.J.1    Karsch, F.J.2    Lehman, M.N.3
  • 209
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, et al. 2003. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 6:736-42
    • (2003) Nat. Neurosci , vol.6 , pp. 736-742
    • Xu, B.1    Goulding, E.H.2    Zang, K.3    Cepoi, D.4    Cone, R.D.5
  • 210
    • 0034708393 scopus 로고    scopus 로고
    • Orexin-induced food intake involves neuropeptide Y pathway
    • Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, et al. 2000. Orexin-induced food intake involves neuropeptide Y pathway. Brain Res. 859:404-9
    • (2000) Brain Res , vol.859 , pp. 404-409
    • Yamanaka, A.1    Kunii, K.2    Nambu, T.3    Tsujino, N.4    Sakai, A.5
  • 211
    • 0018295802 scopus 로고
    • Intrahypothalamic connections: An electron microscopic study in the rat
    • Zaborszky L, Makara GB. 1979. Intrahypothalamic connections: an electron microscopic study in the rat. Exp. Brain Res. 34:201-15
    • (1979) Exp. Brain Res , vol.34 , pp. 201-215
    • Zaborszky, L.1    Makara, G.B.2
  • 212
    • 8644268830 scopus 로고    scopus 로고
    • Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
    • Zhang EE, Chapeau E, Hagihara K, Feng GS. 2004. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. USA 101:16064-69
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16064-16069
    • Zhang, E.E.1    Chapeau, E.2    Hagihara, K.3    Feng, G.S.4
  • 214
    • 0036321620 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
    • Zhao AZ, Huan JN, Gupta S, Pal R, Sahu A. 2002. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat. Neurosci. 5(8):727-28
    • (2002) Nat. Neurosci , vol.5 , Issue.8 , pp. 727-728
    • Zhao, A.Z.1    Huan, J.N.2    Gupta, S.3    Pal, R.4    Sahu, A.5
  • 215
    • 24944511205 scopus 로고    scopus 로고
    • Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance
    • Zheng H, Patterson LM, Morrison C, Banfield BW, Randall JA, et al. 2005. Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance. Neuroscience 135(2):611-25
    • (2005) Neuroscience , vol.135 , Issue.2 , pp. 611-625
    • Zheng, H.1    Patterson, L.M.2    Morrison, C.3    Banfield, B.W.4    Randall, J.A.5
  • 217
    • 0035172417 scopus 로고    scopus 로고
    • Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback
    • Zsarnovszky A, Horvath TL, Garcia-Segura LM, Horvath B, Naftolin F. 2001. Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback. J. Neuroendocrinol. 13:22-28
    • (2001) J. Neuroendocrinol , vol.13 , pp. 22-28
    • Zsarnovszky, A.1    Horvath, T.L.2    Garcia-Segura, L.M.3    Horvath, B.4    Naftolin, F.5


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