A novel therapeutic approach to treating obesity through modulation of TGFβ signaling

Endocrinology

Volumn 153, Issue 7, 2012, Pages 3133-3146

  Koncarevic, Alan ^a   Kajimura, Shingo ^c   Cornwall Brady, Milton ^a   Andreucci, Amy ^b   Pullen, Abigail ^a   Sako, Dianne ^b   Kumar, Ravindra ^b   Grinberg, Asya V ^b   Liharska, Katia ^b   Ucran, Jeffrey A ^b   Howard, Elizabeth ^b   Spiegelman, Bruce M ^d   Seehra, Jasbir ^a   Lachey, Jennifer ^a  

^a Acceleron Pharma Inc   (United States)

^b Bioanalytical Development and Cell Biology   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ACTIVIN RECEPTOR 2; ACTIVIN RECEPTOR TYPE IIB FC RECEPTOR FUSION PROTEIN; ANTIOBESITY AGENT; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; GROWTH DIFFERENTIATION FACTOR 3; GROWTH DIFFERENTIATION FACTOR 5; GROWTH DIFFERENTIATION FACTOR 6; MESSENGER RNA; MYOSTATIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; ENERGY EXPENDITURE; GENE EXPRESSION; MALE; METABOLIC DISORDER; MOUSE; MUSCLE MASS; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THERMOGENESIS; WHITE ADIPOSE TISSUE;

ACTIVIN RECEPTORS, TYPE II; ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; OBESITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; SURFACE PLASMON RESONANCE; THERMOGENESIS; TOMOGRAPHY, X-RAY COMPUTED; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84862740881     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1016     Document Type: Article

References (48)

1. National Institutes of Health 1998 Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults-the evidence report. Obes Res 6(Suppl 2):51S-209S
2. 2002 Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care 25:202-212
3. GoldsteinDJ1992 Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord 16:397-415
4. Wing RR, Koeske R, Epstein LH, Nowalk MP, Gooding W, Becker D 1987 Long-term effects of modest weight loss in type II diabetic patients. Arch Intern Med 147:1749-1753 (Pubitemid 17159673)
5. Frontini A, Cinti S 2010 Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 11:253-256
6. Kajimura S, Seale P, Spiegelman BM 2010 Transcriptional control of brown fat development. Cell Metab 11:257-262
7. Nedergaard J, Cannon B 2010 The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab 11: 268-272
8. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM 2008 PRDM16 controls a brown fat/skeletal muscle switch. Nature 454:961-967
9. Cypess AM, Kahn CR 2010 Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes 17:143-149
10. Attisano L, Wrana JL, Cheifetz S, Massagué J 1992 Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell 68:97-108
11. Mathews LS, Vale WW 1991 Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65:973-982
12. Sako D, Grinberg AV, Liu J, Davies MV, Castonguay R, Maniatis S, Andreucci AJ, Pobre EG, Tomkinson KN, Monnell TE, Ucran JA, Martinez-Hackert E, Pearsall RS, UnderwoodKW,Seehra J, Kumar R 2010 Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb. J Biol Chem 285: 21037-21048
13. Souza TA, Chen X, Guo Y, Sava P, Zhang J, Hill JJ, Yaworsky PJ, Qiu Y 2008 Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators. Mol Endocrinol 22:2689-2702
14. Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN, Wright JF, Barker C, Ehrmantraut G, Holmstrom J, Trowell B, Gertz B, Jiang MS, Sebald SM, Matzuk M, Li E, Liang LF, Quattlebaum E, Stotish RL, Wolfman NM 2005 Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci USA 102:18117-18122 (Pubitemid 41798511)
15. Lee SJ, Lee YS, Zimmers TA, Soleimani A, Matzuk MM, Tsuchida K, Cohn RD, Barton ER 2010 Regulation of muscle mass by follistatin and activins. Mol Endocrinol 24:1998-2008
16. McPherron AC, Lee SJ 2002 Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 109:595-601 (Pubitemid 34204838)
17. Allen DL, Cleary AS, Speaker KJ, Lindsay SF, Uyenishi J, Reed JM, Madden MC, Mehan RS 2008 Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. Am J Physiol Endocrinol Metab 294:E918-E927
18. Zhang C, McFarlane C, Lokireddy S, Masuda S, Ge X, Gluckman PD, Sharma M, Kambadur R 2012 Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. Diabetologia 55:183-193
19. Morrison BM, Lachey JL, Warsing LC, Ting BL, Pullen AE, Underwood KW, Kumar R, Sako D, Grinberg A, Wong V, Colantuoni E, Seehra JS, Wagner KR 2009 A soluble activin type IIB receptor improves function in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 217:258-268
20. Pistilli EE, Bogdanovich S, Mosqueira M, Lachey J, Seehra J, Khurana TS 2010 Pretreatment with a soluble activin type IIB receptor/Fc fusion protein improves hypoxia-induced muscle dysfunction. Am J Physiol Regul Integr Comp Physiol 298:R96-R103
21. Akpan I, Goncalves MD, Dhir R, Yin X, Pistilli EE, Bogdanovich S, Khurana TS, Ucran J, Lachey J, Ahima RS 2009 The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. Int J Obes (Lond) 33:1265-1273
22. Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC 2009 Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One 4:e4937
23. Hoggard N, Cruickshank M, Moar KM, Barrett P, Bashir S, Miller JD 2009 Inhibin βB expression in murine adipose tissue and its regulation by leptin, insulin and dexamethasone. J Mol Endocrinol 43:171-177
24. McPherron AC, Lee SJ 1993 GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. J Biol Chem 268:3444-3449 (Pubitemid 23070981)
25. Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, Dani C 2010 Activin A plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes 59:2513-2521
26. Wang W, Yang Y, Meng Y, Shi Y 2004 GDF-3 is an adipogenic cytokine under high fat dietary condition. Biochem Biophys Res Commun 321:1024-1031 (Pubitemid 39044412)
27. Shen JJ, Huang L, Li L, Jorgez C, Matzuk MM, Brown CW 2009 Deficiency of growth differentiation factor 3 protects against dietinduced obesity by selectively acting on white adipose. Mol Endocrinol 23:113-123
28. Koncarevic A, Cornwall-Brady M, Pullen A, Davies M, Sako D, Liu J, Kumar R, Tomkinson K, Baker T, Umiker B, Monnell T, Grinberg AV, Liharska K, Underwood KW, Ucran JA, Howard E, Barberio J, SpaitsM,Pearsall S, Seehra J, Lachey J 2010Asoluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone health. Endocrinology 151:4289-4300
29. Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos- Flier E 2007 A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab 292:E1724-E1739
30. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM 2009 Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex. Nature 460:1154-1158
31. Herberg L, Döppen W, Major E, Gries FA 1974 Dietary-induced hypertrophic-hyperplastic obesity in mice. J Lipid Res 15:580-585
32. Jo J, Gavrilova O, Pack S, Jou W, Mullen S, Sumner AE, Cushman SW, Periwal V 2009 Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput Biol 5:e1000324
33. Mercer SW, Trayhurn P 1987 Effect of high fat diets on energy balance and thermogenesis in brown adipose tissue of lean and genetically obese ob/ob mice. J Nutr 117:2147-2153 (Pubitemid 18030601)
34. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Meerasahib MF, Fareez MM, Gonzalez-Cadavid NF 2005 Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 146:3547-3557 (Pubitemid 41058126)
35. Li L, Shen JJ, Bournat JC, Huang L, Chattopadhyay A, Li Z, Shaw C, Graham BH, BrownCW2009 Activin signaling: effects on body composition and mitochondrial energy metabolism. Endocrinology 150:3521-3529
36. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM 2011 Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 121:96-105
37. Cadena SM, Tomkinson KN, Monnell TE, Spaits MS, Kumar R, Underwood KW, Pearsall RS, Lachey JL 2010 Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type. J Appl Physiol 109:635-642
38. Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP 2007 Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 48:41-51 (Pubitemid 46052896)
39. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L 1992 Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 103(Pt 4):931-942 (Pubitemid 23042237)
40. Lean ME, James WP, Jennings G, Trayhurn P 1986 Brown adipose tissue in patients with phaeochromocytoma. Int J Obes 10:219-227 (Pubitemid 16048557)
41. Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP 1998 Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 102:412-420 (Pubitemid 28335201)
42. Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM 2000 Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet 25:453-457 (Pubitemid 32983442)
43. Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG 2011 Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab 14:67-79
44. Gilchrist RB, Lane M, Thompson JG 2008 Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Hum Reprod Update 14:159-177 (Pubitemid 351321110)
45. Sjöholm K, Palming J, Lystig TC, Jennische E, Woodruff TK, Carlsson B, CarlssonLM2006 The expression of inhibin βB is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. Biochem Biophys ResCommun 344:1308-1314
46. Carlsson LM, Jacobson P, Walley A, Froguel P, Sjöstrom L, Svensson PA, Sjöholm K 2009 ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochem Biophys Res Commun 382:309-314
47. McPherron AC, Guo T, Wang Q, Portas J 2011 Soluble activin receptor type IIB treatment does not cause fat loss in mice with diet-induced obesity. Diabetes Obes Metab 14:279-282
48. Andersson O, Korach-Andre M, Reissmann E, Ibáñez CF, Bertolino P 2008 Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc Natl Acad Sci USA 105:7252-7256 (Pubitemid 351754464)