The cell biology of fat expansion

Journal of Cell Biology

Volumn 208, Issue 5, 2015, Pages 501-512

  Rutkowski, Joseph M ^a   Stern, Jennifer H ^a   Scherer, Philipp E ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; FAT; FAT DROPLET; GLUCOSE TRANSPORTER 4; INSULIN;

ADIPOCYTE; ADIPOSE TISSUE; CELL EXPANSION; CYTOLOGY; ENERGY TRANSFER; FAT EXPANSION; FIBROSIS; GLUCOSE TRANSPORT; HOMEOSTASIS; HUMAN; HYPOXIA; LIPID STORAGE; LIPOLYSIS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; TISSUE EXPANSION; ANIMAL; ENERGY METABOLISM; METABOLISM; PATHOLOGY;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; ENERGY METABOLISM; HUMANS; OBESITY;

EID: 84924904421     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201409063     Document Type: Review

References (162)

1. Abel, E.D., O. Peroni, J.K. Kim, Y.B. Kim, O. Boss, E. Hadro, T. Minnemann, G.I. Shulman, and B.B. Kahn. 2001. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 409:729-733. http://dx.doi.org/10.1038/35055575.
2. Agarwal, A.K., and A. Garg. 2003. Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways. Trends Endocrinol. Metab. 14:214-221. http://dx.doi.org/10.1016/S1043-2760(03)00078-X.
3. 2-/- gene lipodystrophic mice. J. Biol. Chem. 286:37676-37691. http://dx.doi.org/10.1074/jbc.M111.250449.
4. Ahmed, K., S. Tunaru, C. Tang, M. Müller, A. Gille, A. Sassmann, J. Hanson, and S. Offermanns. 2010. An autocrine lactate loop mediates insulindependent inhibition of lipolysis through GPR81. Cell Metab. 11:311-319. http://dx.doi.org/10.1016/j.cmet.2010.02.012.
5. Alligier, M., E. Meugnier, C. Debard, S. Lambert-Porcheron, E. Chanseaume, M. Sothier, E. Loizon, A.A. Hssain, J. Brozek, J.Y. Scoazec, et al. 2012. Subcutaneous adipose tissue remodeling during the initial phase of weight gain induced by overfeeding in humans. J. Clin. Endocrinol. Metab. 97:E183-E192. http://dx.doi.org/10.1210/jc.2011-2314.
6. Amole, B.O., M. Wittner, D. Hewlett, and H.B. Tanowitz. 1985. Trypanosoma brucei: infection in murine diabetes. Exp. Parasitol. 60:342-347. http://dx.doi.org/10.1016/0014-4894(85)90040-2.
7. Apostolova, N., A. Blas-García, and J.V. Esplugues. 2011. Mitochondrial toxicity in HAART: an overview of in vitro evidence. Curr. Pharm. Des. 17:2130-2144. http://dx.doi.org/10.2174/138161211796904731.
8. Ariotti, N., S. Murphy, N.A. Hamilton, L. Wu, K. Green, N.L. Schieber, P. Li, S. Martin, and R.G. Parton. 2012. Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes. Mol. Biol. Cell. 23:1826-1837. http://dx.doi.org/10.1091/mbc.E11-10-0847.
9. Asterholm, I.W., D.I. Mundy, J. Weng, R.G. Anderson, and P.E. Scherer. 2012. Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Cell Metab. 15:171-185. http://dx.doi.org/10.1016/j.cmet.2012.01.004.
10. Asterholm, I.W., J.M. Rutkowski, T. Fujikawa, Y.R. Cho, M. Fukuda, C. Tao, Z.V. Wang, R.K. Gupta, J.K. Elmquist, and P.E. Scherer. 2014. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 57:1209-1218. http://dx.doi.org/10.1007/s00125-014-3210-3
11. Barbarroja, N., S. Rodriguez-Cuenca, H. Nygren, A. Camargo, A. Pirraco, J. Relat, I. Cuadrado, V. Pellegrinelli, G. Medina-Gomez, C. Lopez-Pedrera, et al. 2014. Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Diabetes. http://dx.doi.org/10.2337/db14-0359.
12. Bikman, B.T., Y. Guan, G. Shui, M.M. Siddique, W.L. Holland, J.Y. Kim, G. Fabriàs, M.R. Wenk, and S.A. Summers. 2012. Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J. Biol. Chem. 287:17426-17437. http://dx.doi.org/10.1074/jbc.M112.359950.
13. Blachnio-Zabielska, A.U., C. Koutsari, T. Tchkonia, and M.D. Jensen. 2012. Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance. Obesity (Silver Spring). 20:2341-2347. http://dx.doi.org/10.1038/oby.2012.126.
14. Blachnio-Zabielska, A.U., M. Pulka, M. Baranowski, A. Nikolajuk, P. Zabielski, M. Górska, and J. Górski. 2012. Ceramide metabolism is affected by obesity and diabetes in human adipose tissue. J. Cell. Physiol. 227:550-557. http://dx.doi.org/10.1002/jcp.22745.
15. Blüher, M. 2014. Adipokines-removing road blocks to obesity and diabetes therapy. Mol. Metab. 3:230-240. http://dx.doi.org/10.1016/j.molmet.2014.01.005.
16. Blüher, M., M.D. Michael, O.D. Peroni, K. Ueki, N. Carter, B.B. Kahn, and C.R. Kahn. 2002. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell. 3:25-38. http://dx.doi.org/10.1016/S1534-5807(02)00199-5.
17. Bolten, C.W., P.M. Blanner, W.G. McDonald, N.R. Staten, R.A. Mazzarella, G.B. Arhancet, M.F. Meier, D.J. Weiss, P.M. Sullivan, A.E. Hromockyj, et al. 2007. Insulin sensitizing pharmacology of thiazolidinediones correlates with mitochondrial gene expression rather than activation of PPAR gamma. Gene Regul. Syst. Bio. 1:73-82.
18. Brasaemle, D.L., G. Dolios, L. Shapiro, and R. Wang. 2004. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem. 279:46835-46842. http://dx.doi.org/10.1074/jbc.M409340200.
19. Cao, H. 2014. Adipocytokines in obesity and metabolic disease. J. Endocrinol. 220:T47-T59. http://dx.doi.org/10.1530/JOE-13-0339.
20. Caspar-Bauguil, S., B. Cousin, S. Bour, L. Casteilla, L. Penicaud, and C. Carpéné. 2009. Adipose tissue lymphocytes: types and roles. J. Physiol. Biochem. 65:423-436. (published erratum appears in J. Physiol. Biochem. 2011. 67:497) http://dx.doi.org/10.1007/BF03185938.
21. Cho, Y.M., D.H. Kim, S.N. Kwak, S.W. Jeong, and O.J. Kwon. 2013. X-box binding protein 1 enhances adipogenic differentiation of 3T3-L1 cells through the downregulation of Wnt10b expression. FEBS Lett. 587:1644-1649. http://dx.doi.org/10.1016/j.febslet.2013.04.005.
22. Choi, S.M., D.F. Tucker, D.N. Gross, R.M. Easton, L.M. DiPilato, A.S. Dean, B.R. Monks, and M.J. Birnbaum. 2010. Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Mol. Cell. Biol. 30:5009-5020. http://dx.doi.org/10.1128/MCB.00797-10.
23. Choi, K.M., Y.S. Lee, M.H. Choi, D.M. Sin, S. Lee, S.Y. Ji, M.K. Lee, Y.M. Lee, Y.P. Yun, J.T. Hong, and H.S. Yoo. 2011. Inverse relationship between adipocyte differentiation and ceramide level in 3T3-L1 cells. Biol. Pharm. Bull. 34:912-916. http://dx.doi.org/10.1248/bpb.34.912.
24. Choo, H.J., J.H. Kim, O.B. Kwon, C.S. Lee, J.Y. Mun, S.S. Han, Y.S. Yoon, G. Yoon, K.M. Choi, and Y.G. Ko. 2006. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia. 49:784-791. http://dx.doi.org/10.1007/s00125-006-0170-2.
25. Chun, T.H., M. Inoue, H. Morisaki, I. Yamanaka, Y. Miyamoto, T. Okamura, K. Sato-Kusubata, and S.J. Weiss. 2010. Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. Diabetes. 59:2484-2494. http://dx.doi.org/10.2337/db10-0073.
26. Coburn, C.T., F.F. Knapp Jr., M. Febbraio, A.L. Beets, R.L. Silverstein, and N.A. Abumrad. 2000. Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J. Biol. Chem. 275:32523-32529. http://dx.doi.org/10.1074/jbc.M003826200.
27. Cohen, A.W., B. Razani, X.B. Wang, T.P. Combs, T.M. Williams, P.E. Scherer, and M.P. Lisanti. 2003. Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am. J. Physiol. Cell Physiol. 285:C222-C235. http://dx.doi.org/10.1152/ajpcell.00006.2003.
28. Cohen, A.W., B. Razani, W. Schubert, T.M. Williams, X.B. Wang, P. Iyengar, D.L. Brasaemle, P.E. Scherer, and M.P. Lisanti. 2004. Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes. 53:1261-1270. http://dx.doi.org/10.2337/diabetes.53.5.1261.
29. Combs, T.P., S. Nagajyothi, S. Mukherjee, C.J. de Almeida, L.A. Jelicks, W. Schubert, Y. Lin, D.S. Jayabalan, D. Zhao, V.L. Braunstein, et al. 2005. The adipocyte as an important target cell for Trypanosoma cruzi infection. J. Biol. Chem. 280:24085-24094. http://dx.doi.org/10.1074/jbc.M412802200.
30. Dalen, K.T., K. Schoonjans, S.M. Ulven, M.S. Weedon-Fekjaer, T.G. Bentzen, H. Koutnikova, J. Auwerx, and H.I. Nebb. 2004. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes. 53:1243-1252. http://dx.doi.org/10.2337/diabetes.53.5.1243.
31. Davis, K.E., M. D Neinast, K. Sun, W. M Skiles, J. D Bills, J. A Zehr, D. Zeve, L. D Hahner, D. W Cox, L. M Gent, et al. 2013. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Mol Metab. 2:227-242. http://dx.doi.org/10.1016/j.molmet.2013.05.006.
32. Deng, Y., and P.E. Scherer. 2010. Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann. NY Acad. Sci. 1212:E1-E19. http://dx.doi.org/10.1111/j.1749-6632.2010.05875.x.
33. Deng, J., S. Liu, L. Zou, C. Xu, B. Geng, and G. Xu. 2012. Lipolysis response to endoplasmic reticulum stress in adipose cells. J. Biol. Chem. 287:6240-6249. http://dx.doi.org/10.1074/jbc.M111.299115.
34. Digel, M., R. Ehehalt, and J. Füllekrug. 2010. Lipid droplets lighting up: insights from live microscopy. FEBS Lett. 584:2168-2175. http://dx.doi.org/10.1016/j.febslet.2010.03.035.
35. Ding, S.Y., M.J. Lee, R. Summer, L. Liu, S.K. Fried, and P.F. Pilch. 2014. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J. Biol. Chem. 289:8473-8483. http://dx.doi.org/10.1074/jbc.M113.546242.
36. Feldmann, H.M., V. Golozoubova, B. Cannon, and J. Nedergaard. 2009. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9:203-209. http://dx.doi.org/10.1016/j.cmet.2008.12.014.
37. Ferreira, A.V., M. Segatto, Z. Menezes, A.M. Macedo, C. Gelape, L. de Oliveira Andrade, F. Nagajyothi, P.E. Scherer, M.M. Teixeira, and H.B. Tanowitz. 2011. Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease. Microbes Infect. 13:1002-1005. http://dx.doi.org/10.1016/j.micinf.2011.06.002.
38. Festuccia, W.T., P.G. Blanchard, V. Turcotte, M. Laplante, M. Sariahmetoglu, D.N. Brindley, D. Richard, and Y. Deshaies. 2009. The PPARγ agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296:R1327-R1335. http://dx.doi.org/10.1152/ajpregu.91012.2008.
39. Forest, C., J. Tordjman, M. Glorian, E. Duplus, G. Chauvet, J. Quette, E.G. Beale, and B. Antoine. 2003. Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase. Biochem. Soc. Trans. 31:1125-1129. http://dx.doi.org/10.1042/BST0311125.
40. Franckhauser, S., S. Muñoz, A. Pujol, A. Casellas, E. Riu, P. Otaegui, B. Su, and F. Bosch. 2002. Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance. Diabetes. 51:624-630. http://dx.doi.org/10.2337/diabetes.51.3.624.
41. Frayn, K.N., and S.M. Humphreys. 2012. Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast. Am. J. Physiol. Endocrinol. Metab. 302:E468-E475. http://dx.doi.org/10.1152/ajpendo.00527.2011.
42. Furukawa, S., T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada, Y. Nakajima, O. Nakayama, M. Makishima, M. Matsuda, and I. Shimomura. 2004. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114:1752-1761. http://dx.doi.org/10.1172/JCI21625.
43. Gao, C.L., C. Zhu, Y.P. Zhao, X.H. Chen, C.B. Ji, C.M. Zhang, J.G. Zhu, Z.K. Xia, M.L. Tong, and X.R. Guo. 2010. Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes. Mol. Cell. Endocrinol. 320:25-33. http://dx.doi.org/10.1016/j.mce.2010.01.039.
44. Garg, A. 2011. Clinical review#: Lipodystrophies: genetic and acquired body fat disorders. J. Clin. Endocrinol. Metab. 96:3313-3325. http://dx.doi.org/10.1210/jc.2011-1159.
45. Gburcik, V., W.P. Cawthorn, J. Nedergaard, J.A. Timmons, and B. Cannon. 2012. An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes. Am. J. Physiol. Endocrinol. Metab. 303:E1053-E1060. http://dx.doi.org/10.1152/ajpendo.00104.2012.
46. Gregor, M.F., E.S. Misch, L. Yang, S. Hummasti, K.E. Inouye, A.H. Lee, B. Bierie, and G.S. Hotamisligil. 2013. The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Reports. 3:1430-1439. http://dx.doi.org/10.1016/j.celrep.2013.03.042.
47. Grujic, D., V.S. Susulic, M.E. Harper, J. Himms-Hagen, B.A. Cunningham, B.E. Corkey, and B.B. Lowell. 1997. β3-adrenergic receptors on white and brown adipocytes mediate β3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J. Biol. Chem. 272:17686-17693. http://dx.doi.org/10.1074/jbc.272.28.17686.
48. Guan, H.P., Y. Li, M.V. Jensen, C.B. Newgard, C.M. Steppan, and M.A. Lazar. 2002. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat. Med. 8:1122-1128. http://dx.doi.org/10.1038/nm780.
49. Gupta, R.K., R.J. Mepani, S. Kleiner, J.C. Lo, M.J. Khandekar, P. Cohen, A. Frontini, D.C. Bhowmick, L. Ye, S. Cinti, and B.M. Spiegelman. 2012. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 15:230-239. http://dx.doi.org/10.1016/j.cmet.2012.01.010.
50. Hage Hassan, R., O. Bourron, and E. Hajduch. 2014. Defect of insulin signal in peripheral tissues: Important role of ceramide. World J Diabetes. 5:244-257. http://dx.doi.org/10.4239/wjd.v5.i3.244.
51. Halberg, N., T. Khan, M.E. Trujillo, I. Wernstedt-Asterholm, A.D. Attie, S. Sherwani, Z.V. Wang, S. Landskroner-Eiger, S. Dineen, U.J. Magalang, et al. 2009. Hypoxia-inducible factor 1α induces fibrosis and insulin resistance in white adipose tissue. Mol. Cell. Biol. 29:4467-4483. http://dx.doi.org/10.1128/MCB.00192-09.
52. Han, J., R. Murthy, B. Wood, B. Song, S. Wang, B. Sun, H. Malhi, and R.J. Kaufman. 2013. ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice. Diabetologia. 56:911-924. http://dx.doi.org/10.1007/s00125-012-2809-5.
53. Hao, Q., J.B. Hansen, R.K. Petersen, P. Hallenborg, C. Jørgensen, S. Cinti, P.J. Larsen, K.R. Steffensen, H. Wang, S. Collins, et al. 2010. ADD1/SREBP1c activates the PGC1-α promoter in brown adipocytes. Biochim. Biophys. Acta. 1801:421-429. http://dx.doi.org/10.1016/j.bbalip.2009.11.008.
54. Hapala, I., E. Marza, and T. Ferreira. 2011. Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation. Biol. Cell. 103:271-285. http://dx.doi.org/10.1042/BC20100144.
55. Henegar, C., J. Tordjman, V. Achard, D. Lacasa, I. Cremer, M. Guerre-Millo, C. Poitou, A. Basdevant, V. Stich, N. Viguerie, et al. 2008. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 9:R14. http://dx.doi.org/10.1186/gb-2008-9-1-r14.
56. Herman, M.A., O.D. Peroni, J. Villoria, M.R. Schön, N.A. Abumrad, M. Blüher, S. Klein, and B.B. Kahn. 2012. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 484:333-338. http://dx.doi.org/10.1038/nature10986.
57. Holland, W.L., and P.E. Scherer. 2013. Cell Biology. Ronning after the adiponectin receptors. Science. 342:1460-1461. http://dx.doi.org/10.1126/science.1249077.
58. Holland, W.L., and S.A. Summers. 2008. Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr. Rev. 29:381-402. http://dx.doi.org/10.1210/er.2007-0025.
59. Holland, W.L., J.T. Brozinick, L.P. Wang, E.D. Hawkins, K.M. Sargent, Y. Liu, K. Narra, K.L. Hoehn, T.A. Knotts, A. Siesky, et al. 2007. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5:167-179. http://dx.doi.org/10.1016/j.cmet.2007.01.002.
60. Holland, W.L., B.T. Bikman, L.P. Wang, G. Yuguang, K.M. Sargent, S. Bulchand, T.A. Knotts, G. Shui, D.J. Clegg, M.R. Wenk, et al. 2011a. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Invest. 121:1858-1870. http://dx.doi.org/10.1172/JCI43378.
61. Holland, W.L., R.A. Miller, Z.V. Wang, K. Sun, B.M. Barth, H.H. Bui, K.E. Davis, B.T. Bikman, N. Halberg, J.M. Rutkowski, et al. 2011b. Receptormediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat. Med. 17:55-63. http://dx.doi.org/10.1038/nm.2277.
62. Holland, W.L., A.C. Adams, J.T. Brozinick, H.H. Bui, Y. Miyauchi, C.M. Kusminski, S.M. Bauer, M. Wade, E. Singhal, C.C. Cheng, et al. 2013. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab. 17:790-797. http://dx.doi.org/10.1016/j.cmet.2013.03.019.
63. Huh, J.Y., E.Y. Seo, H.B. Lee, and H. Ha. 2012. Glucose-based peritoneal dialysis solution suppresses adiponectin synthesis through oxidative stress in an experimental model of peritoneal dialysis. Perit. Dial. Int. 32:20-28. http://dx.doi.org/10.3747/pdi.2009.00228.
64. Jaworski, D.M., O. Sideleva, H.M. Stradecki, G.D. Langlois, A. Habibovic, B. Satish, W.G. Tharp, J. Lausier, K. Larock, T.L. Jetton, et al. 2011. Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice. Endocrinology. 152:1300-1313. http://dx.doi.org/10.1210/en.2010-1029.
65. Kahn, B.B., and S.W. Cushman. 1985. Subcellular translocation of glucose transporters: role in insulin action and its perturbation in altered metabolic states. Diabetes Metab. Rev. 1:203-227. http://dx.doi.org/10.1002/dmr.5610010301.
66. Keller, M.P., and A.D. Attie. 2010. Physiological insights gained from gene expression analysis in obesity and diabetes. Annu. Rev. Nutr. 30:341-364. http://dx.doi.org/10.1146/annurev.nutr.012809.104747.
67. Khan, T., E.S. Muise, P. Iyengar, Z.V. Wang, M. Chandalia, N. Abate, B.B. Zhang, P. Bonaldo, S. Chua, and P.E. Scherer. 2009. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol. Cell. Biol. 29:1575-1591. http://dx.doi.org/10.1128/MCB.01300-08.
68. Kim, M., M.D. Neinast, A.P. Frank, K. Sun, J. Park, J.A. Zehr, L. Vishvanath, E. Morselli, M. Amelotte, B.F. Palmer, et al. 2014. ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue. Mol Metab. 3:642-651. http://dx.doi.org/10.1016/j.molmet.2014.05.007.
69. Kleiner, S., R.J. Mepani, D. Laznik, L. Ye, M.J. Jurczak, F.R. Jornayvaz, J.L. Estall, D. Chatterjee Bhowmick, G.I. Shulman, and B.M. Spiegelman. 2012. Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proc. Natl. Acad. Sci. USA. 109:9635-9640. http://dx.doi.org/10.1073/pnas.1207287109.
70. Konige, M., H. Wang, and C. Sztalryd. 2014. Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis. Biochim. Biophys. Acta. 1842:393-401. http://dx.doi.org/10.1016/j.bbadis.2013.05.007.
71. Koves, T.R., J.R. Ussher, R.C. Noland, D. Slentz, M. Mosedale, O. Ilkayeva, J. Bain, R. Stevens, J.R. Dyck, C.B. Newgard, et al. 2008. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7:45-56. http://dx.doi.org/10.1016/j.cmet.2007.10.013.
72. Kusminski, C.M., and P.E. Scherer. 2012. Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol. Metab. 23:435-443. http://dx.doi.org/10.1016/j.tem.2012.06.004.
73. Kusminski, C.M., W.L. Holland, K. Sun, J. Park, S.B. Spurgin, Y. Lin, G.R. Askew, J.A. Simcox, D.A. McClain, C. Li, and P.E. Scherer. 2012. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat. Med. 18:1539-1549. http://dx.doi.org/10.1038/nm.2899.
74. Lackey, D.E., D.H. Burk, M.R. Ali, R. Mostaedi, W.H. Smith, J. Park, P.E. Scherer, S.A. Seay, C.S. McCoin, P. Bonaldo, and S.H. Adams. 2014. Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am. J. Physiol. Endocrinol. Metab. 306:E233-E246. http://dx.doi.org/10.1152/ajpendo.00476.2013.
75. Lahiri, S., H. Park, E.L. Laviad, X. Lu, R. Bittman, and A.H. Futerman. 2009. Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. J. Biol. Chem. 284:16090-16098. http://dx.doi.org/10.1074/jbc.M807438200.
76. Lass, A., R. Zimmermann, M. Oberer, and R. Zechner. 2011. Lipolysis-a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog. Lipid Res. 50:14-27. http://dx.doi.org/10.1016/j.plipres.2010.10.004.
77. Le Lay, S., C.M. Blouin, E. Hajduch, and I. Dugail. 2009. Filling up adipocytes with lipids. Lessons from caveolin-1 deficiency. Biochim. Biophys. Acta. 1791:514-518. http://dx.doi.org/10.1016/j.bbalip.2008.10.008.
78. Lee, Y.H., A.P. Petkova, E.P. Mottillo, and J.G. Granneman. 2012. In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding. Cell Metab. 15:480-491. http://dx.doi.org/10.1016/j.cmet.2012.03.009.
79. Lee, Y.S., J.W. Kim, O. Osborne, Y. Oh, R. Sasik, S. Schenk, A. Chen, H. Chung, A. Murphy, S.M. Watkins, et al. 2014. Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell. 157:1339-1352. http://dx.doi.org/10.1016/j.cell.2014.05.012.
80. Levy, A., S. Enzer, N. Shoham, U. Zaretsky, and A. Gefen. 2012. Large, but not small sustained tensile strains stimulate adipogenesis in culture. Ann. Biomed. Eng. 40:1052-1060. http://dx.doi.org/10.1007/s10439-011-0496-x.
81. Lim, J.H., H.J. Lee, M. Ho Jung, and J. Song. 2009. Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. Cell. Signal. 21:169-177. http://dx.doi.org/10.1016/j.cellsig.2008.10.004.
82. Liu, L., D. Brown, M. McKee, N.K. Lebrasseur, D. Yang, K.H. Albrecht, K. Ravid, and P.F. Pilch. 2008. Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab. 8:310-317. http://dx.doi.org/10.1016/j.cmet.2008.07.008.
83. Lobo, S., B.M. Wiczer, A.J. Smith, A.M. Hall, and D.A. Bernlohr. 2007. Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4. J. Lipid Res. 48:609-620. http://dx.doi.org/10.1194/jlr.M600441-JLR200.
84. Long, J.Z., K.J. Svensson, L. Tsai, X. Zeng, H.C. Roh, X. Kong, R.R. Rao, J. Lou, I. Lokurkar, W. Baur, et al. 2014. A smooth muscle-like origin for beige adipocytes. Cell Metab. 19:810-820. http://dx.doi.org/10.1016/j.cmet.2014.03.025.
85. Lowe, C.E., R.J. Dennis, U. Obi, S. O'Rahilly, and J.J. Rochford. 2012. Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis. Int. J. Obes. (Lond). 36:1248-1251. http://dx.doi.org/10.1038/ijo.2011.233.
86. Lu, R.H., H. Ji, Z.G. Chang, S.S. Su, and G.S. Yang. 2010. Mitochondrial development and the influence of its dysfunction during rat adipocyte differentiation. Mol. Biol. Rep. 37:2173-2182. http://dx.doi.org/10.1007/s11033-009-9695-z.
87. MacLaren, R., W. Cui, and K. Cianflone. 2008. Adipokines and the immune system: an adipocentric view. Adv. Exp. Med. Biol. 632:1-21. http://dx.doi.org/10.1007/978-0-387-78952-1_1.
88. Meshulam, T., M.R. Breen, L. Liu, R.G. Parton, and P.F. Pilch. 2011. Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. J. Lipid Res. 52:1526-1532. http://dx.doi.org/10.1194/jlr.M015628.
89. Millward, C.A., D. Desantis, C.W. Hsieh, J.D. Heaney, S. Pisano, Y. Olswang, L. Reshef, M. Beidelschies, M. Puchowicz, and C.M. Croniger. 2010. Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice. J. Lipid Res. 51:1452-1463. http://dx.doi.org/10.1194/jlr.M005363.
90. Mitsutake, S., T. Date, H. Yokota, M. Sugiura, T. Kohama, and Y. Igarashi. 2012. Ceramide kinase deficiency improves diet-induced obesity and insulin resistance. FEBS Lett. 586:1300-1305. http://dx.doi.org/10.1016/j.febslet.2012.03.032.
91. Nagajyothi, F., M.S. Desruisseaux, N. Thiruvur, L.M. Weiss, V.L. Braunstein, C. Albanese, M.M. Teixeira, C.J. de Almeida, M.P. Lisanti, P.E. Scherer, and H.B. Tanowitz. 2008. Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype. Obesity (Silver Spring). 16:1992-1997. http://dx.doi.org/10.1038/oby.2008.331.
92. Nagajyothi, F., D. Zhao, F.S. Machado, L.M. Weiss, G.J. Schwartz, M.S. Desruisseaux, Y. Zhao, S.M. Factor, H. Huang, C. Albanese, et al. 2010. Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection. J. Infect. Dis. 202:1104-1113. http://dx.doi.org/10.1086/656189.
93. Nagajyothi, F., L.M. Weiss, D.L. Silver, M.S. Desruisseaux, P.E. Scherer, J. Herz, and H.B. Tanowitz. 2011. Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion. PLoS Negl. Trop. Dis. 5:e953. http://dx.doi.org/10.1371/journal.pntd.0000953.
94. Nagajyothi, F., F.S. Machado, B.A. Burleigh, L.A. Jelicks, P.E. Scherer, S. Mukherjee, M.P. Lisanti, L.M. Weiss, N.J. Garg, and H.B. Tanowitz. 2012. Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Cell. Microbiol. 14:634-643. http://dx.doi.org/10.1111/j.1462-5822.2012.01764.x.
95. Nagajyothi, F., R. Kuliawat, C.M. Kusminski, F.S. Machado, M.S. Desruisseaux, D. Zhao, G.J. Schwartz, H. Huang, C. Albanese, M.P. Lisanti, et al. 2013. Alterations in glucose homeostasis in a murine model of Chagas disease. Am. J. Pathol. 182:886-894. http://dx.doi.org/10.1016/j.ajpath.2012.11.027.
96. Nallamshetty, S., S.Y. Chan, and J. Loscalzo. 2013. Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic. Biol. Med. 64:20-30. http://dx.doi.org/10.1016/j.freeradbiomed.2013.05.022.
97. Nedergaard, J., and B. Cannon. 2013. UCP1 mRNA does not produce heat. Biochim. Biophys. Acta. 1831:943-949. http://dx.doi.org/10.1016/j.bbalip.2013.01.009.
98. Nedergaard, J., and B. Cannon. 2014. The browning of white adipose tissue: some burning issues. Cell Metab. 20:396-407. http://dx.doi.org/10.1016/j.cmet.2014.07.005.
99. Nobusue, H., N. Onishi, T. Shimizu, E. Sugihara, Y. Oki, Y. Sumikawa, T. Chiyoda, K. Akashi, H. Saya, and K. Kano. 2014. Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat. Commun. 5:3368. http://dx.doi.org/10.1038/ncomms4368.
100. Okada-Iwabu, M., T. Yamauchi, M. Iwabu, T. Honma, K. Hamagami, K. Matsuda, M. Yamaguchi, H. Tanabe, T. Kimura-Someya, M. Shirouzu, et al. 2013. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 503:493-499. http://dx.doi.org/10.1038/nature12656.
101. Orlicky, D.J., J. Monks, A.L. Stefanski, and J.L. McManaman. 2013. Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion. PLoS ONE. 8:e66837. http://dx.doi.org/10.1371/journal.pone.0066837.
102. Pasarica, M., O.R. Sereda, L.M. Redman, D.C. Albarado, D.T. Hymel, L.E. Roan, J.C. Rood, D.H. Burk, and S.R. Smith. 2009. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes. 58:718-725. http://dx.doi.org/10.2337/db08-1098.
103. Pellegrinelli, V., J. Heuvingh, O. du Roure, C. Rouault, A. Devulder, C. Klein, M. Lacasa, E. Clément, D. Lacasa, and K. Clément. 2014. Human adipocyte function is impacted by mechanical cues. J. Pathol. 233:183-195. http://dx.doi.org/10.1002/path.4347.
104. Pérez-Matute, P., L. Pérez-Martínez, J.R. Blanco, and J.A. Oteo. 2013. Role of mitochondria in HIV infection and associated metabolic disorders: focus on nonalcoholic fatty liver disease and lipodystrophy syndrome. Oxid. Med. Cell. Longev. 2013:493413.
105. Pilch, P.F., and L. Liu. 2011. Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes. Trends Endocrinol. Metab. 22:318-324. http://dx.doi.org/10.1016/j.tem.2011.04.001.
106. Puri, V., S. Konda, S. Ranjit, M. Aouadi, A. Chawla, M. Chouinard, A. Chakladar, and M.P. Czech. 2007. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J. Biol. Chem. 282:34213-34218. http://dx.doi.org/10.1074/jbc.M707404200.
107. Razani, B., T.P. Combs, X.B. Wang, P.G. Frank, D.S. Park, R.G. Russell, M. Li, B. Tang, L.A. Jelicks, P.E. Scherer, and M.P. Lisanti. 2002. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J. Biol. Chem. 277:8635-8647. http://dx.doi.org/10.1074/jbc.M110970200.
108. Regazzetti, C., F. Bost, Y. Le Marchand-Brustel, J.F. Tanti, and S. Giorgetti-Peraldi. 2010. Insulin induces REDD1 expression through hypoxiainducible factor 1 activation in adipocytes. J. Biol. Chem. 285:5157-5164. http://dx.doi.org/10.1074/jbc.M109.047688.
109. Reue, K., and J.R. Dwyer. 2009. Lipin proteins and metabolic homeostasis. J. Lipid Res. 50:S109-S114. http://dx.doi.org/10.1194/jlr.R800052-JLR200.
110. Ring, A., S. Le Lay, J. Pohl, P. Verkade, and W. Stremmel. 2006. Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts. Biochim. Biophys. Acta. 1761:416-423. http://dx.doi.org/10.1016/j.bbalip.2006.03.016.
111. Rodeheffer, M.S., K. Birsoy, and J.M. Friedman. 2008. Identification of white adipocyte progenitor cells in vivo. Cell. 135:240-249. http://dx.doi.org/10.1016/j.cell.2008.09.036.
112. Roh, C., R. Roduit, B. Thorens, S. Fried, and K.V. Kandror. 2001. Lipoprotein lipase and leptin are accumulated in different secretory compartments in rat adipocytes. J. Biol. Chem. 276:35990-35994. http://dx.doi.org/10.1074/jbc.M102791200.
113. Samuel, V.T., Z.X. Liu, X. Qu, B.D. Elder, S. Bilz, D. Befroy, A.J. Romanelli, and G.I. Shulman. 2004. Mechanism of hepatic insulin resistance in nonalcoholic fatty liver disease. J. Biol. Chem. 279:32345-32353. http://dx.doi.org/10.1074/jbc.M313478200.
114. Scherer, P.E., M.P. Lisanti, G. Baldini, M. Sargiacomo, C.C. Mastick, and H.F. Lodish. 1994. Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J. Cell Biol. 127:1233-1243. http://dx.doi.org/10.1083/jcb.127.5.1233.
115. Seale, P., B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A. Scimè, S. Devarakonda, H.M. Conroe, H. Erdjument-Bromage, et al. 2008. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 454:961-967. http://dx.doi.org/10.1038/nature07182.
116. Sha, H., Y. He, H. Chen, C. Wang, A. Zenno, H. Shi, X. Yang, X. Zhang, and L. Qi. 2009. The IRE1α-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab. 9:556-564. http://dx.doi.org/10.1016/j.cmet.2009.04.009.
117. Sha, H., L. Yang, M. Liu, S. Xia, Y. Liu, F. Liu, S. Kersten, and L. Qi. 2014. Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis. Diabetes. 63:867-879. http://dx.doi.org/10.2337/db13-1067.
118. Shan, D., J.L. Li, L. Wu, D. Li, J. Hurov, J.F. Tobin, R.E. Gimeno, and J. Cao. 2010. GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. J. Lipid Res. 51:1971-1981. http://dx.doi.org/10.1194/jlr.M006304.
119. Shepherd, P.R., L. Gnudi, E. Tozzo, H. Yang, F. Leach, and B.B. Kahn. 1993. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J. Biol. Chem. 268:22243-22246.
120. Shigematsu, S., R.T. Watson, A.H. Khan, and J.E. Pessin. 2003. The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4. J. Biol. Chem. 278:10683-10690. http://dx.doi.org/10.1074/jbc.M208563200.
121. Shoham, N., R. Gottlieb, O. Sharabani-Yosef, U. Zaretsky, D. Benayahu, and A. Gefen. 2012. Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway. Am. J. Physiol. Cell Physiol. 302:C429-C441. http://dx.doi.org/10.1152/ajpcell.00167.2011.
122. Shoham, N., P. Girshovitz, R. Katzengold, N.T. Shaked, D. Benayahu, and A. Gefen. 2014. Adipocyte stiffness increases with accumulation of lipid droplets. Biophys. J. 106:1421-1431. http://dx.doi.org/10.1016/j.bpj.2014.01.045.
123. Spalding, K.L., E. Arner, P.O. Westermark, S. Bernard, B.A. Buchholz, O. Bergmann, L. Blomqvist, J. Hoffstedt, E. Näslund, T. Britton, et al. 2008. Dynamics of fat cell turnover in humans. Nature. 453:783-787. http://dx.doi.org/10.1038/nature06902.
124. Stark, R., F. Guebre-Egziabher, X. Zhao, C. Feriod, J. Dong, T.C. Alves, S. Ioja, R.L. Pongratz, S. Bhanot, M. Roden, et al. 2014. A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis. J. Biol. Chem. 289:7257-7263. http://dx.doi.org/10.1074/jbc.C113.544759.
125. Stöckli, J., D.J. Fazakerley, and D.E. James. 2011. GLUT4 exocytosis. J. Cell Sci. 124:4147-4159. http://dx.doi.org/10.1242/jcs.097063.
126. Sturley, S.L., and M.M. Hussain. 2012. Lipid droplet formation on opposing sides of the endoplasmic reticulum. J. Lipid Res. 53:1800-1810. http://dx.doi.org/10.1194/jlr.R028290.
127. Summers, S.A., L.A. Garza, H. Zhou, and M.J. Birnbaum. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18:5457-5464.
128. Sun, K., C.M. Kusminski, and P.E. Scherer. 2011. Adipose tissue remodeling and obesity. J. Clin. Invest. 121:2094-2101. http://dx.doi.org/10.1172/JCI45887.
129. Sun, K., I. Wernstedt Asterholm, C.M. Kusminski, A.C. Bueno, Z.V. Wang, J.W. Pollard, R.A. Brekken, and P.E. Scherer. 2012. Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc. Natl. Acad. Sci. USA. 109:5874-5879. http://dx.doi.org/10.1073/pnas.1200447109.
130. Sun, K., N. Halberg, M. Khan, U.J. Magalang, and P.E. Scherer. 2013a. Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction. Mol. Cell. Biol. 33:904-917. http://dx.doi.org/10.1128/MCB.00951-12.
131. Sun, K., J. Tordjman, K. Clément, and P.E. Scherer. 2013b. Fibrosis and adipose tissue dysfunction. Cell Metab. 18:470-477. http://dx.doi.org/10.1016/j.cmet.2013.06.016.
132. Takahashi, Y., A. Shinoda, N. Furuya, E. Harada, N. Arimura, I. Ichi, Y. Fujiwara, J. Inoue, and R. Sato. 2013. Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation. PLoS ONE. 8:e64605. http://dx.doi.org/10.1371/journal.pone.0064605.
133. Tan, G.D., C. Debard, C. Tiraby, S.M. Humphreys, K.N. Frayn, D. Langin, H. Vidal, and F. Karpe. 2003. A "futile cycle" induced by thiazolidinediones in human adipose tissue? Nat. Med. 9:811-812. http://dx.doi.org/10.1038/nm0703-811.
134. Tanaka, N., S. Takahashi, T. Matsubara, C. Jiang, W. Sakamoto, T. Chanturiya, R. Teng, O. Gavrilova, and F.J. Gonzalez. 2015. Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice. J. Biol. Chem. 290:3092-3105. http://dx.doi.org/10.1074/jbc.M114.605980.
135. Tang, W., D. Zeve, J.M. Suh, D. Bosnakovski, M. Kyba, R.E. Hammer, M.D. Tallquist, and J.M. Graff. 2008. White fat progenitor cells reside in the adipose vasculature. Science. 322:583-586. http://dx.doi.org/10.1126/science.1156232.
136. Tanowitz, H.B., B. Amole, D. Hewlett, and M. Wittner. 1988. Trypanosoma cruzi infection in diabetic mice. Trans. R. Soc. Trop. Med. Hyg. 82:90-93. http://dx.doi.org/10.1016/0035-9203(88)90272-6.
137. Tansey, J.T., C. Sztalryd, J. Gruia-Gray, D.L. Roush, J.V. Zee, O. Gavrilova, M.L. Reitman, C.X. Deng, C. Li, A.R. Kimmel, and C. Londos. 2001. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA. 98:6494-6499. http://dx.doi.org/10.1073/pnas.101042998.
138. Tordjman, J., G. Chauvet, J. Quette, E.G. Beale, C. Forest, and B. Antoine. 2003. Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells. J. Biol. Chem. 278:18785-18790. http://dx.doi.org/10.1074/jbc.M206999200.
139. Turpin, S.M., H.T. Nicholls, D.M. Willmes, A. Mourier, S. Brodesser, C.M. Wunderlich, J. Mauer, E. Xu, P. Hammerschmidt, H.S. Brönneke, et al. 2014. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 20:678-686. http://dx.doi.org/10.1016/j.cmet.2014.08.002.
140. Unger, R.H., and P.E. Scherer. 2010. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol. Metab. 21:345-352. http://dx.doi.org/10.1016/j.tem.2010.01.009.
141. Unger, R.H., P.E. Scherer, and W.L. Holland. 2013. Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine. Mol. Biol. Cell. 24:3011-3015. http://dx.doi.org/10.1091/mbc.E12-10-0774.
142. Van Hul, M., H. Piccard, and H.R. Lijnen. 2010. Gelatinase B (MMP-9) deficiency does not affect murine adipose tissue development. Thromb. Haemost. 104:165-171. http://dx.doi.org/10.1160/TH09-10-0739.
143. Vankoningsloo, S., A. De Pauw, A. Houbion, S. Tejerina, C. Demazy, F. de Longueville, V. Bertholet, P. Renard, J. Remacle, P. Holvoet, et al. 2006. CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes. J. Cell Sci. 119:1266-1282. http://dx.doi.org/10.1242/jcs.02848.
144. Vergnes, L., A.P. Beigneux, R. Davis, S.M. Watkins, S.G. Young, and K. Reue. 2006. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J. Lipid Res. 47:745-754. http://dx.doi.org/10.1194/jlr.M500553-JLR200.
145. Waldén, T.B., I.R. Hansen, J.A. Timmons, B. Cannon, and J. Nedergaard. 2012. Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues. Am. J. Physiol. Endocrinol. Metab. 302:E19-E31. http://dx.doi.org/10.1152/ajpendo.00249.2011.
146. Wang, Z.V., T.D. Schraw, J.Y. Kim, T. Khan, M.W. Rajala, A. Follenzi, and P.E. Scherer. 2007. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol. Cell. Biol. 27:3716-3731. http://dx.doi.org/10.1128/MCB.00931-06.
147. Wang, C.H., C.C. Wang, and Y.H. Wei. 2010. Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes. Ann. NY Acad. Sci. 1201:157-165. http://dx.doi.org/10.1111/j.1749-6632.2010.05625.x.
148. Wang, Q.A., C. Tao, R.K. Gupta, and P.E. Scherer. 2013. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19:1338-1344. http://dx.doi.org/10.1038/nm.3324.
149. Wang, Y., X. Wang, W.B. Lau, Y. Yuan, D. Booth, J.J. Li, R. Scalia, K. Preston, E. Gao, W. Koch, and X.L. Ma. 2014. Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. Circ. Res. 114:792-805. http://dx.doi.org/10.1161/CIRCRESAHA.114.302439.
150. Wernstedt Asterholm, I., C. Tao, T.S. Morley, Q.A. Wang, F. Delgado-Lopez, Z.V. Wang, and P.E. Scherer. 2014. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 20:103-118. http://dx.doi.org/10.1016/j.cmet.2014.05.005.
151. Wilson-Fritch, L., S. Nicoloro, M. Chouinard, M.A. Lazar, P.C. Chui, J. Leszyk, J. Straubhaar, M.P. Czech, and S. Corvera. 2004. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J. Clin. Invest. 114:1281-1289. http://dx.doi.org/10.1172/JCI200421752.
152. Wu, Z., Y. Xie, R.F. Morrison, N.L. Bucher, and S.R. Farmer. 1998. PPARγ induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPα during the conversion of 3T3 fibroblasts into adipocytes. J. Clin. Invest. 101:22-32. http://dx.doi.org/10.1172/JCI1244.
153. Wu, Q., A.M. Ortegon, B. Tsang, H. Doege, K.R. Feingold, and A. Stahl. 2006. FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol. Cell. Biol. 26:3455-3467. http://dx.doi.org/10.1128/MCB.26.9.3455-3467.2006.
154. Wu, J., P. Boström, L.M. Sparks, L. Ye, J.H. Choi, A.H. Giang, M. Khandekar, K.A. Virtanen, P. Nuutila, G. Schaart, et al. 2012. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 150:366-376. http://dx.doi.org/10.1016/j.cell.2012.05.016.
155. Xia, J.Y., T.S. Morley, and P.E. Scherer. 2014. The adipokine/ceramide axis: key aspects of insulin sensitization. Biochimie. 96:130-139. http://dx.doi.org/10.1016/j.biochi.2013.08.013.
156. Xu, L., G.A. Spinas, and M. Niessen. 2010. ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport. Horm. Metab. Res. 42:643-651. http://dx.doi.org/10.1055/s-0030-1255034.
157. Yamaguchi, S., H. Katahira, S. Ozawa, Y. Nakamichi, T. Tanaka, T. Shimoyama, K. Takahashi, K. Yoshimoto, M.O. Imaizumi, S. Nagamatsu, and H. Ishida. 2005. Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 289:E643-E649. http://dx.doi.org/10.1152/ajpendo.00456.2004.
158. Ye, J., Z. Gao, J. Yin, and Q. He. 2007. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metab. 293:E1118-E1128. http://dx.doi.org/10.1152/ajpendo.00435.2007.
159. Ye, R., W.L. Holland, R. Gordillo, M. Wang, Q.A. Wang, M. Shao, T.S. Morley, R.K. Gupta, A. Stahl, and P.E. Scherer. 2014. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. eLife. 3. http://dx.doi.org/10.7554/eLife.03851.
160. Yuan, T., S. Hong, Y. Yao, and K. Liao. 2007. Glut-4 is translocated to both caveolae and non-caveolar lipid rafts, but is partially internalized through caveolae in insulin-stimulated adipocytes. Cell Res. 17:772-782. http://dx.doi.org/10.1038/cr.2007.73.
161. Zechner, R., J.G. Strauss, G. Haemmerle, A. Lass, and R. Zimmermann. 2005. Lipolysis: pathway under construction. Curr. Opin. Lipidol. 16:333-340. http://dx.doi.org/10.1097/01.mol.0000169354.20395.1c.
162. Zeve, D., W. Tang, and J. Graff. 2009. Fighting fat with fat: the expanding field of adipose stem cells. Cell Stem Cell. 5:472-481. http://dx.doi.org/10.1016/j.stem.2009.10.014.