메뉴 건너뛰기




Volumn 2, Issue 4, 2001, Pages 255-265

Mitochondrial uncoupling as a target for drug development for the treatment of obesity

Author keywords

Mitochondria; Obesity; Standard Metabolic Rate; Uncoupling

Indexed keywords

ANTIOBESITY AGENT; CARRIER PROTEIN; ION CHANNEL; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

EID: 0035502402     PISSN: 14677881     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1467-789X.2001.00043.x     Document Type: Article
Times cited : (209)

References (123)
  • 1
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 2
    • 0027482070 scopus 로고
    • Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials
    • Wadden TA. Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials. Ann Intern Med 1993; 119: 688-693.
    • (1993) Ann Intern Med , vol.119 , pp. 688-693
    • Wadden, T.A.1
  • 4
    • 0034516930 scopus 로고    scopus 로고
    • Effect of sibutramine on weight maintenance after weight loss: A randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance
    • James WP, Astrup A, Finer N, Hilsted J, Kopelman P, Rossner S, Saris WH, Van Gaal LF. Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet 2000; 356: 2119-2125.
    • (2000) Lancet , vol.356 , pp. 2119-2125
    • James, W.P.1    Astrup, A.2    Finer, N.3    Hilsted, J.4    Kopelman, P.5    Rossner, S.6    Saris, W.H.7    Van Gaal, L.F.8
  • 5
    • 0033763243 scopus 로고    scopus 로고
    • Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity
    • Ryan DH. Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity. Endocrine 2000; 13: 193-199.
    • (2000) Endocrine , vol.13 , pp. 193-199
    • Ryan, D.H.1
  • 6
    • 0032543870 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group
    • Sjostrom L, Rissanen A, Andersen T, Boldrin M, Golay A, Koppeschaar HP, Krempf M. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group. Lancet 1998; 352: 167-172.
    • (1998) Lancet , vol.352 , pp. 167-172
    • Sjostrom, L.1    Rissanen, A.2    Andersen, T.3    Boldrin, M.4    Golay, A.5    Koppeschaar, H.P.6    Krempf, M.7
  • 7
    • 0032752435 scopus 로고    scopus 로고
    • Orlistat: A review of its use in the management of obesity
    • Hvizdos KM, Markham A. Orlistat: a review of its use in the management of obesity. Drugs 1999; 58: 743-760.
    • (1999) Drugs , vol.58 , pp. 743-760
    • Hvizdos, K.M.1    Markham, A.2
  • 9
    • 0032883447 scopus 로고    scopus 로고
    • Sibutramine and thermogenesis in humans
    • Danforth E Jr. Sibutramine and thermogenesis in humans. Int J Obes Relat Metab Disord 1999; 23: 1007-1008.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 1007-1008
    • Danforth Jr., E.1
  • 11
    • 0024420814 scopus 로고
    • A review: Exercise and its influence on resting energy metabolism in man
    • Poehlman ET. A review: exercise and its influence on resting energy metabolism in man. Med Sci Sports Exerc 1989; 21: 515-525.
    • (1989) Med Sci Sports Exerc , vol.21 , pp. 515-525
    • Poehlman, E.T.1
  • 12
    • 0016271265 scopus 로고
    • Dinitrophenol and bioenergetics: A historical perspective
    • Parascandola J, Dinitrophenol and bioenergetics: a historical perspective. Mol Cell Biochem 1974; 5: 69-77.
    • (1974) Mol Cell Biochem , vol.5 , pp. 69-77
    • Parascandola, J.1
  • 13
    • 0032923340 scopus 로고    scopus 로고
    • 3-adrenoceptor agonists for the treatment of obesity and diabetes-an update
    • 3-adrenoceptor agonists for the treatment of obesity and diabetes-an update. Diabetes Metab 1999; 25: 11-21.
    • (1999) Diabetes Metab , vol.25 , pp. 11-21
    • Weyer, C.1    Gautier, J.F.2    Danforth Jr., E.3
  • 15
    • 0029976895 scopus 로고    scopus 로고
    • Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate
    • Rolfe DFS, Brand MD. Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate. Am J Physiol 1996; 271: C1380-C1389.
    • (1996) Am J Physiol , vol.271
    • Rolfe, D.F.S.1    Brand, M.D.2
  • 16
    • 0032953969 scopus 로고    scopus 로고
    • Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR
    • Rolfe DFS, Newman JM, Buckingham JA, Clark MG, Brand MD. Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR. Am J Physiol 1999; 276: C692-C699.
    • (1999) Am J Physiol , vol.276
    • Rolfe, D.F.S.1    Newman, J.M.2    Buckingham, J.A.3    Clark, M.G.4    Brand, M.D.5
  • 18
    • 0033787068 scopus 로고    scopus 로고
    • Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    • Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO, Semenkovich CF. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 2000; 6: 1115-1120.
    • (2000) Nat Med , vol.6 , pp. 1115-1120
    • Li, B.1    Nolte, L.A.2    Ju, J.S.3    Han, D.H.4    Coleman, T.5    Holloszy, J.O.6    Semenkovich, C.F.7
  • 19
    • 0025166707 scopus 로고
    • The contribution of the leak of protons across the mitochondrial inner membrane to standard metabolic rate
    • Brand MD. The contribution of the leak of protons across the mitochondrial inner membrane to standard metabolic rate. J Theor Biol 1990; 145: 267-286.
    • (1990) J Theor Biol , vol.145 , pp. 267-286
    • Brand, M.D.1
  • 20
    • 0033854607 scopus 로고    scopus 로고
    • Mechanisms underlying the cost of living in animals
    • Hulbert AJ, Else PL. Mechanisms underlying the cost of living in animals. Annu Rev Physiol 2000; 62: 207-235.
    • (2000) Annu Rev Physiol , vol.62 , pp. 207-235
    • Hulbert, A.J.1    Else, P.L.2
  • 21
    • 0002224317 scopus 로고
    • Energy metabolism as related to body size and respiratory surfaces and its evolution
    • Hemmingsen AM. Energy metabolism as related to body size and respiratory surfaces and its evolution. Rep Steno Mem Hosp Nord Insulinab 1960; 9: 1-110.
    • (1960) Rep Steno Mem Hosp Nord Insulinab , vol.9 , pp. 1-110
    • Hemmingsen, A.M.1
  • 22
    • 0000664818 scopus 로고
    • Body size and metabolism
    • Kleiber M. Body size and metabolism. Hilgardia 1932; 6: 315-353.
    • (1932) Hilgardia , vol.6 , pp. 315-353
    • Kleiber, M.1
  • 23
    • 0002433342 scopus 로고
    • Relation between basal metabolism and mature body weight in different species of mammals and birds
    • Brody S, Procter RC. Relation between basal metabolism and mature body weight in different species of mammals and birds. Univ Miss Agric Exp Sta Res Bull 1932; 166: 89-101.
    • (1932) Univ Miss Agric Exp Sta Res Bull , vol.166 , pp. 89-101
    • Brody, S.1    Procter, R.C.2
  • 24
    • 0023496122 scopus 로고
    • Field metabolic rate and food requirement scaling in mammals and birds
    • Nagy KA. Field metabolic rate and food requirement scaling in mammals and birds. Ecol Mono 1987; 57: 111-128.
    • (1987) Ecol Mono , vol.57 , pp. 111-128
    • Nagy, K.A.1
  • 25
    • 84971047345 scopus 로고
    • Field bioenergetics of mammals: What determines field metabolic rates
    • Nagy KA. Field bioenergetics of mammals: what determines field metabolic rates. Aust J Zool 1994; 42: 43-53.
    • (1994) Aust J Zool , vol.42 , pp. 43-53
    • Nagy, K.A.1
  • 26
    • 0028556635 scopus 로고
    • Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat
    • Rolfe DFS, Hulbert AJ, Brand MD. Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat. Biochim Biophys Acta 1994; 1188: 405-416.
    • (1994) Biochim Biophys Acta , vol.1188 , pp. 405-416
    • Dfs, R.1    Hulbert, A.J.2    Brand, M.D.3
  • 30
    • 0027480085 scopus 로고
    • + leak in mitochondria and its relevance to metabolic rate
    • + leak in mitochondria and its relevance to metabolic rate. Nature 1993; 362: 628-630.
    • (1993) Nature , vol.362 , pp. 628-630
    • Porter, R.K.1    Brand, M.D.2
  • 31
    • 0025801060 scopus 로고
    • Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile
    • Brand MD, Couture P, Else PL, Withers KW, Hulbert AJ. Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile. Biochem J 1991; 275: 81-86.
    • (1991) Biochem J , vol.275 , pp. 81-86
    • Brand, M.D.1    Couture, P.2    Else, P.L.3    Withers, K.W.4    Hulbert, A.J.5
  • 32
    • 0028884511 scopus 로고
    • Causes of differences in respiration rate of hepatocytes from mammals of different body mass
    • Porter RK, Brand MD. Causes of differences in respiration rate of hepatocytes from mammals of different body mass. Am J Physiol 1995; 269: R1213-R1224.
    • (1995) Am J Physiol , vol.269
    • Porter, R.K.1    Brand, M.D.2
  • 33
    • 0030444861 scopus 로고    scopus 로고
    • Allometry of mitochondrial proton leak: Influence of membrane surface area and fatty acid composition
    • Porter RK, Hulbert AJ, Brand MD. Allometry of mitochondrial proton leak: influence of membrane surface area and fatty acid composition. Am J Physiol 1996; 271: R1550-R1560.
    • (1996) Am J Physiol , vol.271
    • Porter, R.K.1    Hulbert, A.J.2    Brand, M.D.3
  • 34
    • 0030782293 scopus 로고    scopus 로고
    • The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: No effect of fatty acid composition
    • Brookes PS, Hulbert AJ, Brand MD. The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: no effect of fatty acid composition. Biochim Biophys Acta 1997; 1330: 157-164.
    • (1997) Biochim Biophys Acta , vol.1330 , pp. 157-164
    • Brookes, P.S.1    Hulbert, A.J.2    Brand, M.D.3
  • 35
    • 0033533045 scopus 로고    scopus 로고
    • Membranes as possible pacemakers of metabolism
    • Hulbert AJ, Else PL. Membranes as possible pacemakers of metabolism. J Theor Biol 1999; 199: 257-274.
    • (1999) J Theor Biol , vol.199 , pp. 257-274
    • Hulbert, A.J.1    Else, P.L.2
  • 36
    • 0032940250 scopus 로고    scopus 로고
    • Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak
    • Pehowich DJ. Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak. Biochim Biophys Acta 1999; 1411: 192-200.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 192-200
    • Pehowich, D.J.1
  • 37
    • 0027215407 scopus 로고
    • Fish oil n-3 fatty acids selectively limit the hypertrophy of abdominal fat depots in growing rats fed high-fat diets
    • Belzung F, Raclot T, Groscolas R. Fish oil n-3 fatty acids selectively limit the hypertrophy of abdominal fat depots in growing rats fed high-fat diets. Am J Physiol 1993; 264: R1111-R1118.
    • (1993) Am J Physiol , vol.264
    • Belzung, F.1    Raclot, T.2    Groscolas, R.3
  • 38
    • 0033609292 scopus 로고    scopus 로고
    • Increased uncoupling protein 2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid
    • Hun CS, Hasegawa K, Kawabata T, Kato M, Shimokawa T, Kagawa Y. Increased uncoupling protein 2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid. Biochem Biophys Res Commun 1999; 259: 85-90.
    • (1999) Biochem Biophys Res Commun , vol.259 , pp. 85-90
    • Hun, C.S.1    Hasegawa, K.2    Kawabata, T.3    Kato, M.4    Shimokawa, T.5    Kagawa, Y.6
  • 40
    • 0345379057 scopus 로고
    • Use of dinitrophenol in nutritional disorders: A critical survey of clinical results
    • Tainter ML, Cutting WC, Stockton AB. Use of dinitrophenol in nutritional disorders: a critical survey of clinical results. Am J Public Health 1934; 24: 1045-1053.
    • (1934) Am J Public Health , vol.24 , pp. 1045-1053
    • Tainter, M.L.1    Cutting, W.C.2    Stockton, A.B.3
  • 44
    • 27944438812 scopus 로고
    • Dinitrophenol in the treatment of obesity: Final report
    • Tainter ML, Stockton AB, Cutting WC. Dinitrophenol in the treatment of obesity: Final report. J Am Med Assoc 1935; 101: 322-336.
    • (1935) J Am Med Assoc , vol.101 , pp. 322-336
    • Tainter, M.L.1    Stockton, A.B.2    Cutting, W.C.3
  • 45
    • 84944363995 scopus 로고
    • Actions and uses of dinitrophenol: Promising metabolic applications
    • Cutting WC, Mehrtens HG, Tainter ML. Actions and uses of dinitrophenol: Promising metabolic applications. J Am Med Assoc 1933; 101: 193-195.
    • (1933) J Am Med Assoc , vol.101 , pp. 193-195
    • Cutting, W.C.1    Mehrtens, H.G.2    Tainter, M.L.3
  • 46
    • 50949115874 scopus 로고
    • Use of dinitrophenol in obesity and related conditions: A progress report
    • Tainter ML, Stockton AB, Cutting WC. Use of dinitrophenol in obesity and related conditions: a progress report. J Am Med Assoc 1933; 101: 1472-1475.
    • (1933) J Am Med Assoc , vol.101 , pp. 1472-1475
    • Tainter, M.L.1    Stockton, A.B.2    Cutting, W.C.3
  • 47
    • 0038036009 scopus 로고
    • Metabolic actions of dinitrophenol with the use of balanced and unbalanced diets
    • Cutting WC, Tainter ML. Metabolic actions of dinitrophenol with the use of balanced and unbalanced diets. J Am Med Assoc 1933; 101: 2099-2102.
    • (1933) J Am Med Assoc , vol.101 , pp. 2099-2102
    • Cutting, W.C.1    Tainter, M.L.2
  • 48
    • 84942483136 scopus 로고
    • Dinitrophenol and desiccated thyroid in the treatment of obesity: A comprehensive clinical and laboratory study
    • Simkins S. Dinitrophenol and desiccated thyroid in the treatment of obesity: a comprehensive clinical and laboratory study. J Am Med Assoc 1937; 108: 2110-2118.
    • (1937) J Am Med Assoc , vol.108 , pp. 2110-2118
    • Simkins, S.1
  • 49
    • 0005762612 scopus 로고
    • Rapidly developing cataract after dinitrophenol
    • Boardman WW. Rapidly developing cataract after dinitrophenol. J Am Med Assoc 1935; 105: 108.
    • (1935) J Am Med Assoc , vol.105 , pp. 108
    • Boardman, W.W.1
  • 50
    • 5444246421 scopus 로고
    • Cataracts following the use of dinitrophenol
    • Horner W, Jones R, Boardman WW. Cataracts following the use of dinitrophenol. J Am Med Assoc 1935; 105: 108-110.
    • (1935) J Am Med Assoc , vol.105 , pp. 108-110
    • Horner, W.1    Jones, R.2    Boardman, W.W.3
  • 52
    • 28244459920 scopus 로고
    • Nature of myxoedema
    • Byrom FB. Nature of myxoedema. Clin Sc 1933; 1: 273-285.
    • (1933) Clin Sc , vol.1 , pp. 273-285
    • Byrom, F.B.1
  • 53
    • 0030058269 scopus 로고    scopus 로고
    • Low resting metabolic rate in subjects predisposed to obesity: A role for thyroid status
    • Astrup A, Buemann B, Toubro S, Ranneries C, Raben A. Low resting metabolic rate in subjects predisposed to obesity: a role for thyroid status. Am J Clin Nutr 1996; 63: 879-883.
    • (1996) Am J Clin Nutr , vol.63 , pp. 879-883
    • Astrup, A.1    Buemann, B.2    Toubro, S.3    Ranneries, C.4    Raben, A.5
  • 54
    • 0027729260 scopus 로고
    • Thyroid hormones, procollagen III peptide, body composition and basal metabolic rate in euthyroid individuals
    • Stenlof K, Sjostrom L, Fagerberg B, Nystrom E, Lindstedt G. Thyroid hormones, procollagen III peptide, body composition and basal metabolic rate in euthyroid individuals. Scand J Clin Lab Invest 1993; 53: 793-803.
    • (1993) Scand J Clin Lab Invest , vol.53 , pp. 793-803
    • Stenlof, K.1    Sjostrom, L.2    Fagerberg, B.3    Nystrom, E.4    Lindstedt, G.5
  • 55
    • 0027227273 scopus 로고
    • The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid status
    • Harper ME, Brand MD. The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid status. J Biol Chem 1993; 268: 14850-14860.
    • (1993) J Biol Chem , vol.268 , pp. 14850-14860
    • Harper, M.E.1    Brand, M.D.2
  • 56
    • 0024240359 scopus 로고
    • Altered relationship between protonmotive force and respiration rate in non-phosphorylating liver mitochondria isolated from rats of different thyroid hormone status
    • Hafner RP, Nobes CD, McGown AD, Brand MD. Altered relationship between protonmotive force and respiration rate in non-phosphorylating liver mitochondria isolated from rats of different thyroid hormone status. Eur J Biochem 1988; 178: 511-518.
    • (1988) Eur J Biochem , vol.178 , pp. 511-518
    • Hafner, R.P.1    Nobes, C.D.2    McGown, A.D.3    Brand, M.D.4
  • 57
    • 0026693011 scopus 로고
    • The mechanism of the increase in mitochondrial proton permeability induced by thyroid hormones
    • Brand MD, Steverding D, Kadenbach B, Stevenson PM, Hafner RP. The mechanism of the increase in mitochondrial proton permeability induced by thyroid hormones. Eur J Biochem 1992; 206: 775-781.
    • (1992) Eur J Biochem , vol.206 , pp. 775-781
    • Brand, M.D.1    Steverding, D.2    Kadenbach, B.3    Stevenson, P.M.4    Hafner, R.P.5
  • 58
    • 8544219969 scopus 로고
    • Cytochrome c metabolism and liver regeneration. Influence of thyroid gland and thyroxine
    • Drabkin DL. Cytochrome c metabolism and liver regeneration. Influence of thyroid gland and thyroxine. J Biol Chem 1949; 182: 335-349.
    • (1949) J Biol Chem , vol.182 , pp. 335-349
    • Drabkin, D.L.1
  • 60
    • 0033678364 scopus 로고    scopus 로고
    • Thyroid hormones and their effects: A new perspective
    • Hulbert AJ. Thyroid hormones and their effects: a new perspective. Biol Rev Camb Philos Soc 2000; 75: 519-631.
    • (2000) Biol Rev Camb Philos Soc , vol.75 , pp. 519-631
    • Hulbert, A.J.1
  • 61
    • 0024222984 scopus 로고
    • Lipids and thyroid hormones
    • Hoch FL. Lipids and thyroid hormones. Prog Lipid Res 1988; 27: 199-270.
    • (1988) Prog Lipid Res , vol.27 , pp. 199-270
    • Hoch, F.L.1
  • 62
    • 0031898524 scopus 로고    scopus 로고
    • The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: Correlations with standard metabolic rate and phospholipid fatty acid composition
    • Brookes PS, Buckingham JA, Tenreiro AM, Hulbert AJ, Brand MD. The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition. Comp Biochem Physiol B Biochem Mol Biol 1998; 119: 325-334.
    • (1998) Comp Biochem Physiol B Biochem Mol Biol , vol.119 , pp. 325-334
    • Brookes, P.S.1    Buckingham, J.A.2    Tenreiro, A.M.3    Hulbert, A.J.4    Brand, M.D.5
  • 63
    • 0027979906 scopus 로고
    • Enhanced cytochrome oxidase activity and modification of lipids in heart mitochondria from hyperthyroid rats
    • Paradies G, Ruggiero FM, Petrosillo G, Quagliariello E. Enhanced cytochrome oxidase activity and modification of lipids in heart mitochondria from hyperthyroid rats. Biochim Biophys Acta 1994; 1225: 165-170.
    • (1994) Biochim Biophys Acta , vol.1225 , pp. 165-170
    • Paradies, G.1    Ruggiero, F.M.2    Petrosillo, G.3    Quagliariello, E.4
  • 64
    • 0027260708 scopus 로고
    • Thyroid hormone action on mitochondrial energy transfer
    • Soboll S. Thyroid hormone action on mitochondrial energy transfer. Biochim Biophys Acta 1993; 1144: 1-16.
    • (1993) Biochim Biophys Acta , vol.1144 , pp. 1-16
    • Soboll, S.1
  • 65
    • 0030712088 scopus 로고    scopus 로고
    • Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone
    • Masaki T, Yoshimatsu H, Kakuma T, Hidaka S, Kurokawa M, Sakata T. Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone. FEBS Lett 1997; 418: 323-326.
    • (1997) FEBS Lett , vol.418 , pp. 323-326
    • Masaki, T.1    Yoshimatsu, H.2    Kakuma, T.3    Hidaka, S.4    Kurokawa, M.5    Sakata, T.6
  • 66
    • 0033040742 scopus 로고    scopus 로고
    • Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle
    • Lanni A, Beneduce L, Lombardi A, Moreno M, Boss O, Muzzin P, Giacobino JP, Goglia F. Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle. FEBS Lett 1999; 444: 250-254.
    • (1999) FEBS Lett , vol.444 , pp. 250-254
    • Lanni, A.1    Beneduce, L.2    Lombardi, A.3    Moreno, M.4    Boss, O.5    Muzzin, P.6    Giacobino, J.P.7    Goglia, F.8
  • 68
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
    • Gong DW, He Y, Karas M, Reitman M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem 1997; 272: 24129-24132.
    • (1997) J Biol Chem , vol.272 , pp. 24129-24132
    • Gong, D.W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 70
    • 0021341617 scopus 로고
    • New perspectives on thyroid hormone, catecholamines, and the heart
    • Klein I, Levey GS. New perspectives on thyroid hormone, catecholamines, and the heart. Am J Med 1984; 76: 167-172.
    • (1984) Am J Med , vol.76 , pp. 167-172
    • Klein, I.1    Levey, G.S.2
  • 71
    • 0025689073 scopus 로고
    • T3 plus high doses of beta-blockers: Effects on energy intake, body composition, bat and heart in rats
    • Burgi U, Burgi-Saville ME, Burgherr J, Clement M, Lauber K. T3 plus high doses of beta-blockers: effects on energy intake, body composition, bat and heart in rats. Int J Obes 1990; 14: 1023-1038.
    • (1990) Int J Obes , vol.14 , pp. 1023-1038
    • Burgi, U.1    Burgi-Saville, M.E.2    Burgherr, J.3    Clement, M.4    Lauber, K.5
  • 72
    • 0021366031 scopus 로고
    • Severe thyroid atrophy due to prolonged ingestion of thyroid hormone for treatment of obesity
    • Mittleman RE, Goldberg RB, Nadji M. Severe thyroid atrophy due to prolonged ingestion of thyroid hormone for treatment of obesity. South Med J 1984; 77: 268-270.
    • (1984) South Med J , vol.77 , pp. 268-270
    • Mittleman, R.E.1    Goldberg, R.B.2    Nadji, M.3
  • 73
    • 0014008158 scopus 로고
    • Effect of thyroid hormone on body composition in myxedema and obesity
    • Kyle LH, Ball MF, Doolan PD. Effect of thyroid hormone on body composition in myxedema and obesity. N Engl J Med 1966; 275: 12-17.
    • (1966) N Engl J Med , vol.275 , pp. 12-17
    • Kyle, L.H.1    Ball, M.F.2    Doolan, P.D.3
  • 74
    • 0022398414 scopus 로고
    • The effects of triiodothyronine on energy expenditure, nitrogen balance and rates of weight and fat loss in obese patients during prolonged caloric restriction
    • Abraham RR, Densem JW, Davies P, Davie MW, Wynn V. The effects of triiodothyronine on energy expenditure, nitrogen balance and rates of weight and fat loss in obese patients during prolonged caloric restriction. Int J Obes 1985; 9: 433-442.
    • (1985) Int J Obes , vol.9 , pp. 433-442
    • Abraham, R.R.1    Densem, J.W.2    Davies, P.3    Davie, M.W.4    Wynn, V.5
  • 75
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 1984; 64: 1-64.
    • (1984) Physiol Rev , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 77
    • 0017638174 scopus 로고
    • The effective proton conductance of the inner membrane of mitochondria from brown adipose tissue. Dependency on proton electrochemical potential gradient
    • Nicholls DG. The effective proton conductance of the inner membrane of mitochondria from brown adipose tissue. Dependency on proton electrochemical potential gradient. Eur J Biochem 1977; 77: 349-356.
    • (1977) Eur J Biochem , vol.77 , pp. 349-356
    • Nicholls, D.G.1
  • 78
    • 0015899581 scopus 로고
    • Brown-adipose-tissue mitochondria. The influence of albumin and nucleotides on passive ion permeabilities
    • Nicholls DG, Lindberg O. Brown-adipose-tissue mitochondria. The influence of albumin and nucleotides on passive ion permeabilities. Eur J Biochem 1973; 37: 523-530.
    • (1973) Eur J Biochem , vol.37 , pp. 523-530
    • Nicholls, D.G.1    Lindberg, O.2
  • 79
    • 0017264191 scopus 로고
    • Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site
    • Nicholls DG. Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site. Eur J Biochem 1976; 62: 223-228.
    • (1976) Eur J Biochem , vol.62 , pp. 223-228
    • Nicholls, D.G.1
  • 80
    • 0017817970 scopus 로고
    • Brown-adipose-tissue mitochondria: Photoaffinity labelling of the regulatory site of energy dissipation
    • Heaton GM, Wagenvoord RJ, Kemp AJ, Nicholls DG. Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur J Biochem 1978; 82: 515-521.
    • (1978) Eur J Biochem , vol.82 , pp. 515-521
    • Heaton, G.M.1    Wagenvoord, R.J.2    Kemp, A.J.3    Nicholls, D.G.4
  • 81
    • 0019154366 scopus 로고
    • The uncoupling protein from brown adipose tissue mitochondria is a dimer. A hydrodynamic study
    • Lin CS, Hackenberg H, Klingenberg EM. The uncoupling protein from brown adipose tissue mitochondria is a dimer. A hydrodynamic study. FEBS Lett 1980; 113: 304-306.
    • (1980) FEBS Lett , vol.113 , pp. 304-306
    • Lin, C.S.1    Hackenberg, H.2    Klingenberg, E.M.3
  • 82
    • 0020477476 scopus 로고
    • Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria
    • Lin CS, Klingenberg M. Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria. Biochemistry 1982; 21: 2950-2956.
    • (1982) Biochemistry , vol.21 , pp. 2950-2956
    • Lin, C.S.1    Klingenberg, M.2
  • 83
    • 0026564645 scopus 로고
    • Functional expression of the rat brown adipose tissue uncoupling protein in Saccharomyces cerevisiae
    • Bathgate B, Freebairn EM, Greenland AJ, Reid GA. Functional expression of the rat brown adipose tissue uncoupling protein in Saccharomyces cerevisiae. Mol Microbiol 1992; 6: 363-370.
    • (1992) Mol Microbiol , vol.6 , pp. 363-370
    • Bathgate, B.1    Freebairn, E.M.2    Greenland, A.J.3    Reid, G.A.4
  • 84
    • 0025093093 scopus 로고
    • Reconstitution of the uncoupling protein of brown adipose tissue mitochondria. Demonstration of GDP-sensitive halide anion uniport
    • Jezek P, Orosz DE, Garlid KD. Reconstitution of the uncoupling protein of brown adipose tissue mitochondria. Demonstration of GDP-sensitive halide anion uniport. J Biol Chem 1990; 265: 19296-19302.
    • (1990) J Biol Chem , vol.265 , pp. 19296-19302
    • Jezek, P.1    Orosz, D.E.2    Garlid, K.D.3
  • 85
    • 0024598249 scopus 로고
    • Reconstitution of purified brown adipose tissue mitochondria uncoupling protein: Demonstration of separate identity of nucleotide binding and proton translocation sites by chemical probes
    • Katiyar SS, Shrago E. Reconstitution of purified brown adipose tissue mitochondria uncoupling protein: demonstration of separate identity of nucleotide binding and proton translocation sites by chemical probes. Proc Natl Acad Sci USA 1989; 86: 2559-2562.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2559-2562
    • Katiyar, S.S.1    Shrago, E.2
  • 87
    • 0022404018 scopus 로고
    • Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein
    • Strieleman PJ, Schalinske KL, Shrago E. Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein. J Biol Chem 1985; 260: 13402-13405.
    • (1985) J Biol Chem , vol.260 , pp. 13402-13405
    • Strieleman, P.J.1    Schalinske, K.L.2    Shrago, E.3
  • 88
    • 0035282775 scopus 로고    scopus 로고
    • Mitochondrial efficiency: Lessons learned from transgenic mice
    • Harper ME, Himms-Hagen J. Mitochondrial efficiency: lessons learned from transgenic mice. Biochim Biophys Acta 2001; 1504: 159-172.
    • (2001) Biochim Biophys Acta , vol.1504 , pp. 159-172
    • Harper, M.E.1    Himms-Hagen, J.2
  • 90
    • 0030908827 scopus 로고    scopus 로고
    • Raising at thermoneutrality prevents obesity and hyperphagia in BAT- Ablated transgenic mice
    • Melnyk A, Harper ME, Himms-Hagen J. Raising at thermoneutrality prevents obesity and hyperphagia in BAT- ablated transgenic mice. Am J Physiol 1997; 272: R1088-R1093.
    • (1997) Am J Physiol , vol.272
    • Melnyk, A.1    Harper, M.E.2    Himms-Hagen, J.3
  • 91
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995; 96: 2914-2923.
    • (1995) J Clin Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 92
  • 93
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • Ricquier D, Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J 2000; 345: 161-179.
    • (2000) Biochem J , vol.345 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 94
    • 0033391964 scopus 로고    scopus 로고
    • A history of the first uncoupling protein, UCP1
    • Nicholls DG, Rial E. A history of the first uncoupling protein, UCP1. J Bioenerg Biomembr 1999; 31: 399-406.
    • (1999) J Bioenerg Biomembr , vol.31 , pp. 399-406
    • Nicholls, D.G.1    Rial, E.2
  • 95
    • 0029865228 scopus 로고    scopus 로고
    • Prospects for β3-adrenoceptor agonists in the treatment of obesity and diabetes
    • Arch JR, Wilson S. Prospects for β3-adrenoceptor agonists in the treatment of obesity and diabetes. Int J Obes Relat Metab Disord 1996; 20: 191-199.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 191-199
    • Arch, J.R.1    Wilson, S.2
  • 96
    • 0023126791 scopus 로고
    • Immunochemical detection and quantitation of brown adipose tissue uncoupling protein
    • Henningfield MF, Swick RW. Immunochemical detection and quantitation of brown adipose tissue uncoupling protein. Biochem Cell Biol 1987; 65: 245-251.
    • (1987) Biochem Cell Biol , vol.65 , pp. 245-251
    • Henningfield, M.F.1    Swick, R.W.2
  • 97
    • 0020597306 scopus 로고
    • Measurement of rat brown-adipose-tissue mitochondrial uncoupling protein by radioimmunoassay: Increased concentration after cold acclimation
    • Lean ME, Branch WJ, James WP, Jennings G, Ashwell M. Measurement of rat brown-adipose-tissue mitochondrial uncoupling protein by radioimmunoassay: increased concentration after cold acclimation. Biosci Rep 1983; 3: 61-71.
    • (1983) Biosci Rep , vol.3 , pp. 61-71
    • Lean, M.E.1    Branch, W.J.2    James, W.P.3    Jennings, G.4    Ashwell, M.5
  • 98
    • 0020628596 scopus 로고
    • An immunological study of the uncoupling protein of brown adipose tissue mitochondria
    • Ricquier D, Barlet JP, Garel JM, Combes-George M, Dubois MP. An immunological study of the uncoupling protein of brown adipose tissue mitochondria. Biochem J 1983; 210: 859-866.
    • (1983) Biochem J , vol.210 , pp. 859-866
    • Ricquier, D.1    Barlet, J.P.2    Garel, J.M.3    Combes-George, M.4    Dubois, M.P.5
  • 100
    • 0032980686 scopus 로고    scopus 로고
    • Fasting and leptin modulate adipose and muscle uncoupling protein: Divergent effects between messenger ribonucleic acid and protein expression
    • Sivitz WI, Fink BD, Donohoue PA. Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression. Endocrinology 1999; 140: 1511-1519.
    • (1999) Endocrinology , vol.140 , pp. 1511-1519
    • Sivitz, W.I.1    Fink, B.D.2    Donohoue, P.A.3
  • 103
    • 0033039965 scopus 로고    scopus 로고
    • Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells
    • Hinz W, Faller B, Gruninger S, Gazzotti P, Chiesi M. Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells. FEBS Lett 1999; 448: 57-61.
    • (1999) FEBS Lett , vol.448 , pp. 57-61
    • Hinz, W.1    Faller, B.2    Gruninger, S.3    Gazzotti, P.4    Chiesi, M.5
  • 104
    • 28244488587 scopus 로고    scopus 로고
    • Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria
    • Stuart JA, Harper JA, Brindle KM, Jekabsons MB, Brand MD. Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J Biol Chem 2001; 22: 22.
    • (2001) J Biol Chem , vol.22 , pp. 22
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Jekabsons, M.B.4    Brand, M.D.5
  • 106
    • 0035875366 scopus 로고    scopus 로고
    • A mitochondrial uncoupling artefact can be caused by expression of uncoupling protein 1 in yeast
    • Stuart JA, Harper JA, Jekabsons MB, Brindle KM, Brand MD. A mitochondrial uncoupling artefact can be caused by expression of uncoupling protein 1 in yeast. Biochem J 2001; 356: 779-789.
    • (2001) Biochem J , vol.356 , pp. 779-789
    • Stuart, J.A.1    Harper, J.A.2    Jekabsons, M.B.3    Brindle, K.M.4    Brand, M.D.5
  • 109
    • 0034724170 scopus 로고    scopus 로고
    • Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions
    • Echtay KS, Winkler E, Bienengraeber M, Klingenberg M. Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions. Biochemistry 2000; 39: 3311-3317.
    • (2000) Biochemistry , vol.39 , pp. 3311-3317
    • Echtay, K.S.1    Winkler, E.2    Bienengraeber, M.3    Klingenberg, M.4
  • 110
    • 0035282920 scopus 로고    scopus 로고
    • Uncoupling proteins: The issues from a biochemist point of view
    • Klingenberg M, Echtay KS. Uncoupling proteins: the issues from a biochemist point of view. Biochim Biophys Acta 2001; 1504: 128-143.
    • (2001) Biochim Biophys Acta , vol.1504 , pp. 128-143
    • Klingenberg, M.1    Echtay, K.S.2
  • 111
    • 0034735799 scopus 로고    scopus 로고
    • Coenzyme Q is an obligatory cofactor for uncoupling protein function
    • Echtay KS, Winkler E, Klingenberg M. Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 2000; 408: 609-613.
    • (2000) Nature , vol.408 , pp. 609-613
    • Echtay, K.S.1    Winkler, E.2    Klingenberg, M.3
  • 113
    • 0033214039 scopus 로고    scopus 로고
    • The bioenergetics of brown fat mitochondria from UCP1-ablated mice. UCP1 is not involved in fatty acid-induced de-energization ('uncoupling')
    • Matthias A, Jacobsson A, Cannon B, Nedergaard J. The bioenergetics of brown fat mitochondria from UCP1-ablated mice. UCP1 is not involved in fatty acid-induced de-energization ('uncoupling'). J Biol Chem 1999; 274: 28150-28160.
    • (1999) J Biol Chem , vol.274 , pp. 28150-28160
    • Matthias, A.1    Jacobsson, A.2    Cannon, B.3    Nedergaard, J.4
  • 114
    • 0032996040 scopus 로고    scopus 로고
    • Mitochondrial proton leak in brown adipose tissue mitochondria of Ucp1- Deficient mice is GDP insensitive
    • Monemdjou S, Kozak LP, Harper ME. Mitochondrial proton leak in brown adipose tissue mitochondria of Ucp1- deficient mice is GDP insensitive. Am J Physiol 1999; 276: E1073-E1082.
    • (1999) Am J Physiol , vol.276
    • Monemdjou, S.1    Kozak, L.P.2    Harper, M.E.3
  • 117
    • 0031832185 scopus 로고    scopus 로고
    • Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?
    • Samec S, Seydoux J, Dulloo AG. Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J 1998; 12: 715-724.
    • (1998) FASEB J , vol.12 , pp. 715-724
    • Samec, S.1    Seydoux, J.2    Dulloo, A.G.3
  • 118
    • 0022993093 scopus 로고
    • Starvation-induced changes in metabolic rate, blood flow, and regional energy expenditure in rats
    • Ma SW, Foster DO. Starvation-induced changes in metabolic rate, blood flow, and regional energy expenditure in rats. Can J Physiol Pharmacol 1986; 64: 1252-1258.
    • (1986) Can J Physiol Pharmacol , vol.64 , pp. 1252-1258
    • Ma, S.W.1    Foster, D.O.2
  • 119
    • 0032742372 scopus 로고    scopus 로고
    • UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
    • Cadenas S, Buckingham JA, Samec S, Seydoux J, Din N, Dulloo AG, Brand MD. UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett 1999; 462: 257-260.
    • (1999) FEBS Lett , vol.462 , pp. 257-260
    • Cadenas, S.1    Buckingham, J.A.2    Samec, S.3    Seydoux, J.4    Din, N.5    Dulloo, A.G.6    Brand, M.D.7
  • 121
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics
    • Skulachev VP. Uncoupling: new approaches to an old problem of bioenergetics. Biochim Biophys Acta 1998; 1363: 100-124.
    • (1998) Biochim Biophys Acta , vol.1363 , pp. 100-124
    • Skulachev, V.P.1
  • 123
    • 0025186853 scopus 로고
    • Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria
    • Hafner RP, Brown GC, Brand MD. Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria. Biochem J 1990; 265: 731-734.
    • (1990) Biochem J , vol.265 , pp. 731-734
    • Hafner, R.P.1    Brown, G.C.2    Brand, M.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.