Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Nature Medicine

Volumn 21, Issue 2, 2015, Pages 159-165

  Fang, Sungsoon ^a   Suh, Jae Myoung ^a   Reilly, Shannon M ^b   Yu, Elizabeth ^a   Osborn, Olivia ^c   Lackey, Denise ^c   Yoshihara, Eiji ^a   Perino, Alessia ^d   Jacinto, Sandra ^a   Lukasheva, Yelizaveta ^a   Atkins, Annette R ^a   Khvat, Alexander ^e   Schnabl, Bernd ^c   Yu, Ruth T ^a   Brenner, David A ^c   Coulter, Sally ^f   Liddle, Christopher ^f   Schoonjans, Kristina ^d   Olefsky, Jerrold M ^c   Saltiel, Alan R ^b   Downes, Michael ^a   Evans, Ronald M ^a,g   more..

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d EPFL   (Switzerland)

^e CHEMDIV INC   (United States)

^f UNIVERSITY OF SYDNEY   (Australia)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; GLUCOSE; HORMONE RECEPTOR STIMULATING AGENT; INSULIN; RNA; UNCLASSIFIED DRUG; BENZENE DERIVATIVE; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; FEXARAMINE; FIBROBLAST GROWTH FACTOR 15, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE ACID SYNTHESIS; CONTROLLED STUDY; GENE ACTIVATION; GENE TARGETING; GLUCONEOGENESIS; IN VIVO STUDY; INSULIN RESISTANCE; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SYSTEMIC THERAPY; THERMOGENESIS; WEIGHT GAIN; WHITE ADIPOSE TISSUE; WILD TYPE; AGONISTS; ANIMAL; BROWN ADIPOSE TISSUE; DRUG EFFECTS; GLUCOSE CLAMP TECHNIQUE; INTESTINE; METABOLISM;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; BENZENE DERIVATIVES; BILE ACIDS AND SALTS; FIBROBLAST GROWTH FACTORS; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; INTESTINES; MICE; OBESITY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; WEIGHT GAIN;

EID: 84925507991     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3760     Document Type: Article

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