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Volumn 404, Issue 6778, 2000, Pages 652-660

Towards a molecular understanding of adaptive thermogenesis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ADRENALIN; ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; CARBON DIOXIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME C OXIDASE; DOPAMINE BETA MONOOXYGENASE; FAT; FATTY ACID; FIBRIC ACID DERIVATIVE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN; LEPTIN; NORADRENALIN; OXYGEN; PROTEIN; PROTIRELIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; THYROID HORMONE; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL LIPASE; UNINDEXED DRUG; WATER;

EID: 0034611678     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35007527     Document Type: Review
Times cited : (1377)

References (93)
  • 1
    • 0000622040 scopus 로고
    • Cold acclimation and the electromyogram of unanesthetized rats
    • Hart, J. S., Heroux, O. & Depocas, F. Cold acclimation and the electromyogram of unanesthetized rats. J. Appl. Physiol. 9, 404-408 (1956).
    • (1956) J. Appl. Physiol. , vol.9 , pp. 404-408
    • Hart, J.S.1    Heroux, O.2    Depocas, F.3
  • 2
    • 0005614677 scopus 로고
    • Regulation of shivering and nonshivering heat production during acclimation of rats
    • Davis, T. R. A., Johnston, D. R., Bell, F. C. & Cremer, B. I. Regulation of shivering and nonshivering heat production during acclimation of rats. Am. J. Physiol. 198, 471-475 (1960).
    • (1960) Am. J. Physiol. , vol.198 , pp. 471-475
    • Davis, T.R.A.1    Johnston, D.R.2    Bell, F.C.3    Cremer, B.I.4
  • 3
    • 0018348872 scopus 로고
    • Tissue distribution of cold-induced thermogenesis in conscious warm-or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis
    • Foster, D. O. & Frydman, M. L. Tissue distribution of cold-induced thermogenesis in conscious warm-or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. Can. J. Physiol. Pharmacol. 57, 257-270 (1979).
    • (1979) Can. J. Physiol. Pharmacol. , vol.57 , pp. 257-270
    • Foster, D.O.1    Frydman, M.L.2
  • 4
    • 0019405046 scopus 로고
    • Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis
    • Dauncey, M. J. Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis. Br. J. Nutr. 45, 257-267 (1981).
    • (1981) Br. J. Nutr. , vol.45 , pp. 257-267
    • Dauncey, M.J.1
  • 6
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel, R. L., Rosenbaum, M. & Hirsch, J. Changes in energy expenditure resulting from altered body weight. N. Engl. J. Med. 332, 621-628 (1995).
    • (1995) N. Engl. J. Med. , vol.332 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 7
    • 0023193393 scopus 로고
    • Expenditure and storage of energy in man
    • Sims, E. A. & Danforth, E. Jr Expenditure and storage of energy in man. J. Clin. Invest. 79, 1019-1025 (1987).
    • (1987) J. Clin. Invest. , vol.79 , pp. 1019-1025
    • Sims, E.A.1    Danforth E., Jr.2
  • 8
    • 0023626958 scopus 로고
    • Regulatory alterations of daily energy expenditure induced by fasting or overfeeding in unrestrained rats
    • Shibata, H. & Bukowiecki, I., J. Regulatory alterations of daily energy expenditure induced by fasting or overfeeding in unrestrained rats. J. Appl. Physiol. 63, 465-470 (1987).
    • (1987) J. Appl. Physiol. , vol.63 , pp. 465-470
    • Shibata, H.1    Bukowiecki, I.J.2
  • 9
    • 0033534524 scopus 로고    scopus 로고
    • Role of nonexercise activity thermogenesis in resistance to fat gain in humans
    • Levine, J. A., Eberhardt, N. L. & Jensen, M. D. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283, 212-214 (1999).
    • (1999) Science , vol.283 , pp. 212-214
    • Levine, J.A.1    Eberhardt, N.L.2    Jensen, M.D.3
  • 10
    • 0025292829 scopus 로고
    • The response to long-term overfeeding in identical twins
    • Bouchard, C., et al. The response to long-term overfeeding in identical twins. N. Engl. J. Med. 322, 1477-1482 (1990).
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1477-1482
    • Bouchard, C.1
  • 11
    • 0021353278 scopus 로고
    • Consumption of a low protein diet increase norepinephrine turnover in brown adipose tissue of adult rats
    • Kevonian, A. V., Vander Tuig, J. G. & Romsos, D. R. Consumption of a low protein diet increase norepinephrine turnover in brown adipose tissue of adult rats. J. Nutr. 114, 543-549 (1984).
    • (1984) J. Nutr. , vol.114 , pp. 543-549
    • Kevonian, A.V.1    Vander Tuig, J.G.2    Romsos, D.R.3
  • 12
    • 0023188024 scopus 로고
    • Effect of environmental temperature on energy balance and thermogenesis in rats fed normal or low protein diets
    • Rothwell, N. J. & Stock, M. J. Effect of environmental temperature on energy balance and thermogenesis in rats fed normal or low protein diets. J. Nutr. 117, 833-837 (1987).
    • (1987) J. Nutr. , vol.117 , pp. 833-837
    • Rothwell, N.J.1    Stock, M.J.2
  • 13
    • 0021470653 scopus 로고
    • Sympathoadrenal system and regulation of thermogenesis
    • Landsberg, L., Saville, M. E. & Young, J. B. Sympathoadrenal system and regulation of thermogenesis. Am. J. Physiol. 247, E181-E189 (1984).
    • (1984) Am. J. Physiol. , vol.247
    • Landsberg, L.1    Saville, M.E.2    Young, J.B.3
  • 14
    • 0030991928 scopus 로고    scopus 로고
    • Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline
    • Thomas, S. A. & Palmiter, R. D. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 387, 94-97 (1997).
    • (1997) Nature , vol.387 , pp. 94-97
    • Thomas, S.A.1    Palmiter, R.D.2
  • 15
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist, I. K., Elias, C. F. & Saper, C. B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22, 221-232 (1999).
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, I.K.1    Elias, C.F.2    Saper, C.B.3
  • 16
    • 0024831575 scopus 로고
    • Brown adipose tissue thermogenesis and obesity
    • Himms-Hagen, J. Brown adipose tissue thermogenesis and obesity. Prog. Lipid Res. 28, 67-115 (1989).
    • (1989) Prog. Lipid Res. , vol.28 , pp. 67-115
    • Himms-Hagen, J.1
  • 17
    • 0030905068 scopus 로고    scopus 로고
    • Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement
    • al-Adsani, H., Hoffer, L. J. & Silva, I. E. Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J. Clin. Endocrinol. Metab. 82, 1118-1125 (1997).
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1118-1125
    • Al-Adsani, H.1    Hoffer, L.J.2    Silva, I.E.3
  • 18
    • 0033031568 scopus 로고    scopus 로고
    • The significance and mechanism of mitochondrial proton conductance
    • Brand, M. D. et al. The significance and mechanism of mitochondrial proton conductance. Int. J. Obes. Relat. Metab. Disord. 23(Suppl. 6), S4-S11 (1999).
    • (1999) Int. J. Obes. Relat. Metab. Disord. , vol.23 , Issue.6 SUPPL.
    • Brand, M.D.1
  • 19
    • 0029561581 scopus 로고
    • Thyroid hormone control of thermogenesis and energy balance
    • Silva, J. F. Thyroid hormone control of thermogenesis and energy balance. Thyroid 5, 481-492 (1995.).
    • (1995) Thyroid , vol.5 , pp. 481-492
    • Silva, J.F.1
  • 20
    • 0029910416 scopus 로고    scopus 로고
    • Enhanced thermogenesis during recovery from diet-induced weight gain in the rat
    • Almeida, N. G., Levitsky, D. A. & Strupp, B. Enhanced thermogenesis during recovery from diet-induced weight gain in the rat. Am. J. Physiol. 271, R1380-R1387 (1996).
    • (1996) Am. J. Physiol. , vol.271
    • Almeida, N.G.1    Levitsky, D.A.2    Strupp, B.3
  • 21
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima, R. S. et al. Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252 (1996).
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1
  • 22
    • 0000659858 scopus 로고    scopus 로고
    • Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
    • Legradi, G., Emerson, C. H., Ahima, R. S., Flier, J. S. & Lechan, R. M. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 138, 2569-2576 (1997).
    • (1997) Endocrinology , vol.138 , pp. 2569-2576
    • Legradi, G.1    Emerson, C.H.2    Ahima, R.S.3    Flier, J.S.4    Lechan, R.M.5
  • 23
    • 0030854715 scopus 로고    scopus 로고
    • Cellular energy utilization and molecular origin of standard metabolic rate in mammals
    • Rolfe, D. F. & Brown, G. C. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol. Rev. 77, 731-758 (1997).
    • (1997) Physiol. Rev. , vol.77 , pp. 731-758
    • Rolfe, D.F.1    Brown, G.C.2
  • 24
    • 0031799482 scopus 로고    scopus 로고
    • Regulation of energy transduction and electron transfer in cytochrome c oxidase by adenine nucleotides
    • Kadenbach, B. et al. Regulation of energy transduction and electron transfer in cytochrome c oxidase by adenine nucleotides. J. Bioenerg. Biomembr. 30, 25-33 (1998).
    • (1998) J. Bioenerg. Biomembr. , vol.30 , pp. 25-33
    • Kadenbach, B.1
  • 25
    • 0025787873 scopus 로고
    • Abnormal brown and white fat development in transgenic mice overexpressing glycerol 3-phosphate dehydrogenase
    • Kozak, L. P., Kozak, U. C. & Clarke, G. T. Abnormal brown and white fat development in transgenic mice overexpressing glycerol 3-phosphate dehydrogenase. Genes Dev. 5, 2256-2264 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 2256-2264
    • Kozak, L.P.1    Kozak, U.C.2    Clarke, G.T.3
  • 26
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls, D. G. & Locke, R. M. Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1-64 (1984).
    • (1984) Physiol. Rev. , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 27
    • 0032901360 scopus 로고    scopus 로고
    • Structure and function of the uncoupling protein from brown adipose tissue
    • Klingenberg, M. & Huang, S. G. Structure and function of the uncoupling protein from brown adipose tissue. Biochim. Biophys. Acta 1415, 271-296 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1415 , pp. 271-296
    • Klingenberg, M.1    Huang, S.G.2
  • 28
    • 1842409029 scopus 로고    scopus 로고
    • Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
    • Enerback, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (1997).
    • (1997) Nature , vol.387 , pp. 90-94
    • Enerback, S.1
  • 29
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
    • Fleury, C. et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genet. 15, 269-272 (1997).
    • (1997) Nature Genet. , vol.15 , pp. 269-272
    • Fleury, C.1
  • 30
    • 15144356206 scopus 로고    scopus 로고
    • Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
    • Gimeno, R. E. et al. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46, 900-906 (1997).
    • (1997) Diabetes , vol.46 , pp. 900-906
    • Gimeno, R.E.1
  • 31
    • 0030988140 scopus 로고    scopus 로고
    • Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
    • Boss, O. et al. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408, 39-42 (1997).
    • (1997) FEBS Lett. , vol.408 , pp. 39-42
    • Boss, O.1
  • 32
    • 0031560941 scopus 로고    scopus 로고
    • UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem
    • Vidal-Puig, A., Solanes, G., Grujic, D., Flier, J. S. & Lowell, B. B. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem. Biophys. Res. Commun. 235, 79-32 (1997).
    • (1997) Biophys. Res. Commun. , vol.235 , pp. 79-132
    • Vidal-Puig, A.1    Solanes, G.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 33
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
    • Gong, D. W., He, Y., Karas, M. & Reitman, M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J. Biol. Chem. 272, 24129-24132 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24129-24132
    • Gong, D.W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 34
    • 0033039965 scopus 로고    scopus 로고
    • Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells
    • Hinz, W., Faller, B., Gruninger, S., Gazzotti, P. & Chiesi, M. Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells. FEBS Lett. 448, 57-61 (1999).
    • (1999) FEBS Lett. , vol.448 , pp. 57-61
    • Hinz, W.1    Faller, B.2    Gruninger, S.3    Gazzotti, P.4    Chiesi, M.5
  • 35
    • 0032907853 scopus 로고    scopus 로고
    • Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system
    • Zhang, C.Y., Hagen, T., Mootha, V.K., Slieker, L.J. & Lowell, B. B. Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system. FEBS Lett. 449, 129-134 (1999).
    • (1999) FEBS Lett. , vol.449 , pp. 129-134
    • Zhang, C.Y.1    Hagen, T.2    Mootha, V.K.3    Slieker, L.J.4    Lowell, B.B.5
  • 36
    • 0037773721 scopus 로고    scopus 로고
    • Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
    • Iaburek, M. et al. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J. Biol. Chem. 274, 26003-26007 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 26003-26007
    • Iaburek, M.1
  • 37
    • 0032545458 scopus 로고    scopus 로고
    • BMCPI, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
    • Sanchis, D. et al. BMCPI, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J. Biol. Chem. 273, 34611-34615 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 34611-34615
    • Sanchis, D.1
  • 38
    • 0032998265 scopus 로고    scopus 로고
    • UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    • Mao, W. et al. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443, 326-330 (1999).
    • (1999) FEBS Lett. , vol.443 , pp. 326-330
    • Mao, W.1
  • 39
    • 0030804677 scopus 로고    scopus 로고
    • Tissue-dependent upregulationof rat uncoupling protein-2 expression in response to fasting or cold
    • Boss, O. et al. Tissue-dependent upregulationof rat uncoupling protein-2 expression in response to fasting or cold. FEBS Lett. 412, 111-114 (1997).
    • (1997) FEBS Lett. , vol.412 , pp. 111-114
    • Boss, O.1
  • 40
    • 0031915045 scopus 로고    scopus 로고
    • Elevated free fatty acids induce uncoupling protein 3 expression in muscle: A potential explanation for the effect of fasting
    • Weigle, D. S. et al. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Diabetes 47, 298-302 (1998).
    • (1998) Diabetes , vol.47 , pp. 298-302
    • Weigle, D.S.1
  • 41
    • 0014370572 scopus 로고
    • Oxidative metabolism in cells isolated from brown adipose tissue. 2. Catecholamine regulated respiratory control
    • Prusiner, S. B., Cannon, B., Ching, T. M. & Lindberg, O. Oxidative metabolism in cells isolated from brown adipose tissue. 2. Catecholamine regulated respiratory control. Eur. J. Biochem. 7, 51-57 (1968).
    • (1968) Eur. J. Biochem. , vol.7 , pp. 51-57
    • Prusiner, S.B.1    Cannon, B.2    Ching, T.M.3    Lindberg, O.4
  • 42
    • 0019814864 scopus 로고
    • Metabolic relationships between lipolysis and respiration in rat brown adipocytes. the role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis
    • Bukowiecki, I. J., Follea, N., Lupien, J. & Paradis, A. Metabolic relationships between lipolysis and respiration in rat brown adipocytes. The role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis. J. Biol. Chem. 256, 12840-12848 (1981).
    • (1981) J. Biol. Chem. , vol.256 , pp. 12840-12848
    • Bukowiecki, I.J.1    Follea, N.2    Lupien, J.3    Paradis, A.4
  • 43
    • 0040931083 scopus 로고    scopus 로고
    • Fatty acid cycling mechanism and mitochondrial uncoupling proteins
    • Jezek, P. et al. Fatty acid cycling mechanism and mitochondrial uncoupling proteins. Biochim. Biophys. Acta 1365, 319-327 (1998).
    • (1998) Biochim. Biophys. Acta , vol.1365 , pp. 319-327
    • Jezek, P.1
  • 44
    • 0021363316 scopus 로고
    • Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
    • Arch, J. R. et al. Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309, 163-165 (1984).
    • (1984) Nature , vol.309 , pp. 163-165
    • Arch, J.R.1
  • 45
    • 0030273411 scopus 로고    scopus 로고
    • Function and regulation of the beta 3-adrenoceptor
    • Strosberg, A. D. & Pietri-Rouxel, F. Function and regulation of the beta 3-adrenoceptor. Trends Pharmacol. Sci. 17, 373-381 (1996).
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 373-381
    • Strosberg, A.D.1    Pietri-Rouxel, F.2
  • 46
    • 0028838836 scopus 로고
    • Targeted disruption of the beta 3-adrenergic receptor gene
    • Susulic, V. S. et al. Targeted disruption of the beta 3-adrenergic receptor gene. J. Biol. Chem. 270, 29483-29492 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 29483-29492
    • Susulic, V.S.1
  • 47
    • 0025836657 scopus 로고
    • Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs
    • Champigny, O. et al. Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs. Proc. Natl Acad. Sci. USA 88, 10774-10777 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 10774-10777
    • Champigny, O.1
  • 48
    • 0032081279 scopus 로고    scopus 로고
    • A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkey
    • Fisher, M. H. et al. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkey. J. Clin. Invest. 101, 2387-2393 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 2387-2393
    • Fisher, M.H.1
  • 49
    • 0026562272 scopus 로고
    • Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans
    • Garruti, G. & Ricquier, D. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int. J. Obes. Relat. Metab. Disord. 16, 383-390 (1992).
    • (1992) Int. J. Obes. Relat. Metab. Disord. , vol.16 , pp. 383-390
    • Garruti, G.1    Ricquier, D.2
  • 50
    • 0028224485 scopus 로고
    • Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats
    • Himms-Hagen, J. et al. Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am. J. Physiol 266, R1371-1382 (1994).
    • (1994) Am. J. Physiol , vol.266
    • Himms-Hagen, J.1
  • 51
    • 0031025546 scopus 로고    scopus 로고
    • Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice
    • Collins, S., Daniel, K. W., Petro, A. F. & Surwit, R. S. Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138, 405-413 (1997).
    • (1997) Endocrinology , vol.138 , pp. 405-413
    • Collins, S.1    Daniel, K.W.2    Petro, A.F.3    Surwit, R.S.4
  • 52
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in while fat in mice is under genetic control. Effects on body weight and adiposity
    • Guerra, C., Koza, R. A., Yamashita, H., Walsh, K. & Kozak, L. P. Emergence of brown adipocytes in while fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102, 412-420 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 53
    • 15844409555 scopus 로고    scopus 로고
    • Role of leptin in fat regulation
    • Collins, S. et a. Role of leptin in fat regulation. Nature 380, 677 (1996).
    • (1996) Nature , vol.380 , pp. 677
    • Collins, S.1
  • 55
    • 0030759687 scopus 로고    scopus 로고
    • Leptin increases uncoupling protein expression and energy expenditure
    • Scarpace, P. J., Matheny, M., Pollock, B. H. & Turner, N. Leptin increases uncoupling protein expression and energy expenditure. Am. J. Physiol. 273, E226-E230 (1997).
    • (1997) Am. J. Physiol. , vol.273
    • Scarpace, P.J.1    Matheny, M.2    Pollock, B.H.3    Turner, N.4
  • 56
    • 0032547042 scopus 로고    scopus 로고
    • Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
    • Satoh, N. et al. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci. Lett. 249, 107-110 (1998).
    • (1998) Neurosci. Lett. , vol.249 , pp. 107-110
    • Satoh, N.1
  • 57
    • 0031748933 scopus 로고    scopus 로고
    • Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins
    • Cusin, I. et al. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes 47, 1014-1019 (1998).
    • (1998) Diabetes , vol.47 , pp. 1014-1019
    • Cusin, I.1
  • 58
    • 0025613080 scopus 로고
    • Effects of fasting and refeeding on the level of uncoupling protein mRNA in rat brown adipose tissue: Evidence for diet-induced and cold-induced responses
    • Champigny, O. & Ricquier, D. Effects of fasting and refeeding on the level of uncoupling protein mRNA in rat brown adipose tissue: evidence for diet-induced and cold-induced responses. J. Nutr. 120, 1730-1736 (1990).
    • (1990) J. Nutr. , vol.120 , pp. 1730-1736
    • Champigny, O.1    Ricquier, D.2
  • 59
    • 0027731309 scopus 로고
    • Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    • Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993).
    • (1993) Nature , vol.366 , pp. 740-742
    • Lowell, B.B.1
  • 60
    • 0031958087 scopus 로고    scopus 로고
    • Temperature-dependent feeding: Lack of role for leptin and defect in brown adipose tissue-ablated obese mice
    • Melnyk, A. & Himms-Hagen, J. Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice. Am. J. Physiol. 274, R1131-1135 (1998).
    • (1998) Am. J. Physiol. , vol.274
    • Melnyk, A.1    Himms-Hagen, J.2
  • 61
    • 0023851885 scopus 로고
    • Reduced rate of energy expenditure as a risk factor for body-weight gain
    • Ravussin, E. et al. Reduced rate of energy expenditure as a risk factor for body-weight gain. N. Engl. J. Med. 318, 467-472 (1988).
    • (1988) N. Engl. J. Med. , vol.318 , pp. 467-472
    • Ravussin, E.1
  • 62
    • 0023869784 scopus 로고
    • A. Energy expenditure and intake in infants born to lean and overweight mothers
    • Roberts, S. B., Savage, J., Coward, W. A., Chew, B. & Lucas, A. Energy expenditure and intake in infants born to lean and overweight mothers. N. Engl. J. Med. 318, 461-466 (1988).
    • (1988) N. Engl. J. Med. , vol.318 , pp. 461-466
    • Roberts, S.B.1    Savage, J.2    Coward, W.A.3    Chew, B.4    Lucas, A.5
  • 63
    • 0025047553 scopus 로고
    • Skeletal muscle metabolism is a major determinant of resting energy expenditure
    • Zurlo, F., Larson, K., Bogardus, C. & Ravussin, E. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J. Clin. Invest. 86, 1423-1427 (1990).
    • (1990) J. Clin. Invest. , vol.86 , pp. 1423-1427
    • Zurlo, F.1    Larson, K.2    Bogardus, C.3    Ravussin, E.4
  • 64
    • 0026443844 scopus 로고
    • Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue
    • Simonsen, L., Bulow, J., Madsen, J. & Christensen, N. J. Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue. Am. J. Physiol. 263, E850-E855 (1992).
    • (1992) Am. J. Physiol. , vol.263
    • Simonsen, L.1    Bulow, J.2    Madsen, J.3    Christensen, N.J.4
  • 65
    • 0029791552 scopus 로고    scopus 로고
    • Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription
    • Gugneja, S., Virbasius, C. M. & Scarpulla, R. C. Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription. Mol. Cell. Biol. 16, 5708-5716 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5708-5716
    • Gugneja, S.1    Virbasius, C.M.2    Scarpulla, R.C.3
  • 66
    • 0028011017 scopus 로고
    • Activation of the human mitochondrial transcription factor a gene by nuclear respiratory factors: A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis
    • Virbasius, J. V. & Scarpulla, R. C. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc. Natl. Acad. Sci. USA 91, 1309-1313 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1309-1313
    • Virbasius, J.V.1    Scarpulla, R.C.2
  • 67
    • 0032055908 scopus 로고    scopus 로고
    • Regulation of mitochondrial biogenesis in brown adipose tissue nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase beta subunit
    • Villena, J. A. et al. Regulation of mitochondrial biogenesis in brown adipose tissue nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase beta subunit. Biochem. J. 331, 121-127 (1998).
    • (1998) Biochem. J. , vol.331 , pp. 121-127
    • Villena, J.A.1
  • 68
    • 0029975942 scopus 로고    scopus 로고
    • Mitochondrial genes as sites of primary action of steroid hormones
    • Demonacos, C. V. et al. Mitochondrial genes as sites of primary action of steroid hormones. Steroids 61, 226-232 (1996).
    • (1996) Steroids , vol.61 , pp. 226-232
    • Demonacos, C.V.1
  • 69
    • 0027300035 scopus 로고
    • Tissue-specific and beta-adrenergic regulation of the mitochondrial uncoupling protein gene: Control by cis-acting elements in the 5′-flanking region
    • Cassard-Doulcier, A. M. et al. Tissue-specific and beta-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 5′-flanking region. Mol. Endocrinol. 7, 497-506 (1993).
    • (1993) Mol. Endocrinol. , vol.7 , pp. 497-506
    • Cassard-Doulcier, A.M.1
  • 70
    • 0028153698 scopus 로고
    • An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene
    • Kozak, U. C. et al. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol. Cell. Biol. 14, 59-67 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 59-67
    • Kozak, U.C.1
  • 71
    • 0029737861 scopus 로고    scopus 로고
    • Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A
    • Cummings, D. E. et al. Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 382, 622-626 (1996).
    • (1996) Nature , vol.382 , pp. 622-626
    • Cummings, D.E.1
  • 72
    • 0029941669 scopus 로고    scopus 로고
    • Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: Regulation by peroxisome proliferator-activated receptor gamma
    • Sears, I. B., MacGinnitie, M. A., Kovacs, L. G. & Graves, R. A. Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma. Mol. Cell. Biol. 16, 3410-3419 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3410-3419
    • Sears, I.B.1    MacGinnitie, M.A.2    Kovacs, L.G.3    Graves, R.A.4
  • 73
    • 0030582447 scopus 로고    scopus 로고
    • Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent
    • Foellmi-Adams, L. A., Wyse, B. M., Herron, D., Nedergaard, J. & Kletzen, R. F. Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent. Biochem. Pharmacol. 52, 693-701 (1996).
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 693-701
    • Foellmi-Adams, L.A.1    Wyse, B.M.2    Herron, D.3    Nedergaard, J.4    Kletzen, R.F.5
  • 74
    • 10544229796 scopus 로고    scopus 로고
    • Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation
    • Tai, T. A. C. et al. Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation. J. Biol. Chem. 271, 29909-29914 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 29909-29914
    • Tai, T.A.C.1
  • 75
    • 0344915176 scopus 로고    scopus 로고
    • Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: A potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth
    • Brun, S. et al. Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth. Diabetes 48, 1217-1222 (1999).
    • (1999) Diabetes , vol.48 , pp. 1217-1222
    • Brun, S.1
  • 76
    • 0031577549 scopus 로고    scopus 로고
    • Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells
    • Aubert, J. et al. Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. Biochem. Biophys. Res. Commun. 238, 606-611 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.238 , pp. 606-611
    • Aubert, J.1
  • 77
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998).
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1
  • 78
    • 0033546748 scopus 로고    scopus 로고
    • Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1
    • Boss, O. et al. Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1. Biochem. Biophys. Res. Commun. 261, 870-876 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.261 , pp. 870-876
    • Boss, O.1
  • 79
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124 (1999).
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1
  • 80
    • 0033305326 scopus 로고    scopus 로고
    • Repression and regulation of type II iodothyronine deiodinase in cultured human skeletal muscle cells
    • Hosoi, Y. et al. Repression and regulation of type II iodothyronine deiodinase in cultured human skeletal muscle cells. J. Clin. Endocrinol. Metab. 84, 3293-3300 (1999).
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3293-3300
    • Hosoi, Y.1
  • 81
    • 0030744190 scopus 로고    scopus 로고
    • Physiological approach to maturation of brown adipocytes in primary cell culture
    • Encke, D, Ely, M., Heldmaier, G. & Klaus, S. Physiological approach to maturation of brown adipocytes in primary cell culture. Biochim. Biophys. Acta 1357, 339-347 (1997).
    • (1997) Biochim. Biophys. Acta , vol.1357 , pp. 339-347
    • Encke, D.1    Ely, M.2    Heldmaier, G.3    Klaus, S.4
  • 82
    • 85047681858 scopus 로고    scopus 로고
    • Characterization of the 5′-flanking and 5′-untranslated regions of the cyclic adenosine 3′,5′-monophosphate-responsive human type 2 iodothyronine deiodinase gene
    • Bartha, T. et al. Characterization of the 5′-flanking and 5′-untranslated regions of the cyclic adenosine 3′,5′-monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology 141, 229-237 (2000).
    • (2000) Endocrinology , vol.141 , pp. 229-237
    • Bartha, T.1
  • 83
    • 0027480085 scopus 로고
    • 1 leak in mitochondria and its relevance to metabolic rate
    • 1 leak in mitochondria and its relevance to metabolic rate. Nature 362, 628-630 (1993).
    • (1993) Nature , vol.362 , pp. 628-630
    • Porter, R.K.1    Brand, M.D.2
  • 85
    • 0018784261 scopus 로고
    • Keilin's respiratory chain concept and its chemiosmotic consequences
    • Mitchell, P. Keilin's respiratory chain concept and its chemiosmotic consequences. Science 206, 1148-1159 (1979).
    • (1979) Science , vol.206 , pp. 1148-1159
    • Mitchell, P.1
  • 86
    • 0025343842 scopus 로고
    • Regulation of oxidative phosphorylation in the mammalian cell
    • Balaban, R. S. Regulation of oxidative phosphorylation in the mammalian cell. Am. J. Physiol. 258, C377-C389 (1990).
    • (1990) Am. J. Physiol. , vol.258
    • Balaban, R.S.1
  • 87
    • 0033607168 scopus 로고    scopus 로고
    • The metabolic implications of intracellular circulation
    • Hochachka, P. W. The metabolic implications of intracellular circulation. Proc. Natl Acad. Sci. USA 96, 12233-12239 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 12233-12239
    • Hochachka, P.W.1
  • 88
    • 0025319665 scopus 로고
    • Role of calcium ions in regulation of mammalian intramitochondrial metabolism
    • McCormack, J. G., Halestrap, A. P. & Denton, R. M. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol. Rev. 70, 391-425 (1990).
    • (1990) Physiol. Rev. , vol.70 , pp. 391-425
    • McCormack, J.G.1    Halestrap, A.P.2    Denton, R.M.3
  • 89
    • 0026549468 scopus 로고
    • Control of respiration and ATP synthesis in mammalian mitochondria and cells
    • Brown, G. C. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem. J. 284, 1-13 (1992).
    • (1992) Biochem. J. , vol.284 , pp. 1-13
    • Brown, G.C.1
  • 90
    • 0028314350 scopus 로고
    • Thermogenesis in muscle
    • Block, B. A. Thermogenesis in muscle. Annu. Rev. Physiol. 36, 535-577 (1994).
    • (1994) Annu. Rev. Physiol. , vol.36 , pp. 535-577
    • Block, B.A.1
  • 91
    • 2342561101 scopus 로고    scopus 로고
    • 2+ on oxidative phosphorylation in mitochondria from the thermogenic organ of marlin
    • 2+ on oxidative phosphorylation in mitochondria from the thermogenic organ of marlin. J. Exp. Biol. 199, 2679-2687 (1996).
    • (1996) J. Exp. Biol. , vol.199 , pp. 2679-2687
    • O'Brien, J.1    Block, B.A.2
  • 92
    • 0032480548 scopus 로고    scopus 로고
    • Malignant hyperthermia
    • Denborough, M. Malignant hyperthermia. Lancet 352, 1131-1136 (1998).
    • (1998) Lancet , vol.352 , pp. 1131-1136
    • Denborough, M.1


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