A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation

New England Journal of Medicine

Volumn 339, Issue 11, 1998, Pages 719-724

  Jick, Hershel ^a   Vasilakis, Catherine ^a   Weinrauch, Larry A ^b,c   Meier, Christoph R ^a   Jick, Susan S ^a   Derby, Laura E ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b MOUNT AUBURN HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANOREXIGENIC AGENT; DEXFENFLURAMINE; FENFLURAMINE; PHENTERMINE;

ADULT; AORTA VALVE REGURGITATION; ARTICLE; COHORT ANALYSIS; ECHOCARDIOGRAPHY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MITRAL VALVE REGURGITATION; OBESITY; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; VALVULAR HEART DISEASE;

ADULT; AGED; AORTIC VALVE INSUFFICIENCY; APPETITE DEPRESSANTS; CASE-CONTROL STUDIES; DRUG COMBINATIONS; FEMALE; FENFLURAMINE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MITRAL VALVE INSUFFICIENCY; OBESITY; PHENTERMINE; RISK; SURVIVAL ANALYSIS;

EID: 0032504983     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199809103391102     Document Type: Article

References (13)

1. Connolly HM, Crary JL, McGoon MD, et al. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997;337:581-8 [Erratum, N Engl J Med 1997;337:1783.]
2. Graham DJ, Green L. Further cases of valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997;337:635.
3. Kurz X, Van Ermen A. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997;337:1172-3.
4. Rasmussen S, Corya BC, Glassman RD. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997;337:1773.
5. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997. MMWR Morb Mortal Wkly Rep 1997;46:1061-6.
6. Jick H, Jick SS, Derby LE. Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ 1991;302:766-8.
7. Jick H, Terris BZ, Derby LE, Jick SS. Further validation of information recorded on a general practitioner-based computerized data resource in the United Kingdom. Pharmacoepidemiol Drug Saf 1992;1:347-9.
8. Jick H. A database worth saving. Lancet 1997;350:1045-6.
9. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
10. Rothman KJ. Estimation of confidence limits for the cumulative probability of survival in life table analysis. J Chronic Dis 1978;31:557-60.
11. Rothman KJ, Boice JD Jr. Epidemiologic analysis with a programmable calculator. Washington, D.C.: National Institutes of Health, 1979.
12. Abenheim L, Moride Y, Brenot F, et al. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N Engl J Med 1996;335: 609-16.
13. Weissman NJ, Tighe JF Jr, Gottdiener JS, Gwynne JT. An assessment of heart-valve abnormalities in obese patients taking dexfenfluramine, sustained-release dexfenfluramine, or placebo. N Engl J Med 1998;339:725-32.