메뉴 건너뛰기




Volumn 86, Issue 5, 2014, Pages 479-484

Odd sibling: Features of β3-adrenoceptor pharmacology

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; MESSENGER RNA; NADOLOL; PROPRANOLOL; LIGAND;

EID: 84907433555     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.092817     Document Type: Article
Times cited : (70)

References (67)
  • 1
    • 84922243411 scopus 로고    scopus 로고
    • Combination treatment with mirabegron and solifenacin in patients with overactive bladder: Efficacy and safety results from a randomised, double-blind, dose-ranging, phase 2 study (Symphony)
    • [published ahead of print]
    • Abrams P, Kelleher C, Staskin D, Rechberger T, Kay R, Martina R, Newgreen D, Paireddy A, van Maanen R, and Ridder A (2014) Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomised, double-blind, dose-ranging, phase 2 study (Symphony). Eur Urol DOI: 10.1016/j.eururo.2014.02.012 [published ahead of print].
    • (2014) Eur Urol
    • Abrams, P.1    Kelleher, C.2    Staskin, D.3    Rechberger, T.4    Kay, R.5    Martina, R.6    Newgreen, D.7    Paireddy, A.8    Van Maanen, R.9    Ridder, A.10
  • 2
    • 0029670132 scopus 로고    scopus 로고
    • 3-adrenoceptor agonist induces increased pancreatic islet blood flow and insulin secretion in rats
    • Atef N, Lafontan M, Doublé A, Hélary C, Ktorza A, and Pénicaud L (1996) A specific β3-adrenoceptor agonist induces increased pancreatic islet blood flow and insulin secretion in rats. Eur J Pharmacol 298:287-292.
    • (1996) Eur J Pharmacol , vol.298 , pp. 287-292
    • Atef, N.1    Lafontan, M.2    Doublé, A.3    Hélary, C.4    Ktorza, A.5    Pénicaud, L.6
  • 3
    • 14644421602 scopus 로고    scopus 로고
    • The selectivity of b-adrenoceptor antagonists at the human b1, b2 and b3 adrenoceptors
    • Baker JG (2005) The selectivity of b-adrenoceptor antagonists at the human b1, b2 and b3 adrenoceptors. Br J Pharmacol 144:317-322.
    • (2005) Br J Pharmacol , vol.144 , pp. 317-322
    • Baker, J.G.1
  • 4
    • 77953185520 scopus 로고    scopus 로고
    • 3-adrenoceptors
    • Baker JG (2010) The selectivity of b-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors. Br J Pharmacol 160:1048-1061.
    • (2010) Br J Pharmacol , vol.160 , pp. 1048-1061
    • Baker, J.G.1
  • 6
    • 0030299965 scopus 로고    scopus 로고
    • 3adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor
    • Bengtsson T, Redegren K, Strosberg AD, Nedergaard J, and Cannon B (1996) Downregulation of β3 adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor. J Biol Chem271:33366-33375.
    • (1996) J Biol Chem , vol.271 , pp. 33366-33375
    • Bengtsson, T.1    Redegren, K.2    Strosberg, A.D.3    Nedergaard, J.4    Cannon, B.5
  • 8
    • 0027761394 scopus 로고
    • 3-adrenergic receptor
    • Blin N, Camoin L, Maigret B, and Strosberg AD (1993) Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor. Mol Pharmacol 44:1094-1104.
    • (1993) Mol Pharmacol , vol.44 , pp. 1094-1104
    • Blin, N.1    Camoin, L.2    Maigret, B.3    Strosberg, A.D.4
  • 12
    • 0027494518 scopus 로고
    • Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion
    • Carpéné C, Galitzky J, Collon P, Esclapez F, Dauzats M, and Lafontan M (1993) Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion. J Pharmacol Exp Ther 265:237-247.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 237-247
    • Carpéné, C.1    Galitzky, J.2    Collon, P.3    Esclapez, F.4    Dauzats, M.5    Lafontan, M.6
  • 14
    • 0028172071 scopus 로고
    • 3-adrenoceptor refractory to down-regulation
    • Chambers J, Park J, Cronk D, Chapman C, Kennedy FR, Wilson S, and Milligan G (1994) β3-adrenoceptor agonist-induced down-regulation of Gs a and functional desensitization in a Chinese hamster ovary cell line expressing a β3-adrenoceptor refractory to down-regulation. Biochem J 303:973-978.
    • (1994) Biochem J , vol.303 , pp. 973-978
    • Chambers, J.1    Park, J.2    Cronk, D.3    Chapman, C.4    Kennedy, F.R.5    Wilson, S.6    Milligan, G.7
  • 15
  • 16
    • 0028061556 scopus 로고
    • 3-adrenergic receptor
    • Chaudhry A and Granneman JG (1994) Influence of cell type upon the desensitization of the β3-adrenergic receptor. J Pharmacol Exp Ther 271:1253-1258.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1253-1258
    • Chaudhry, A.1    Granneman, J.G.2
  • 18
    • 0030221713 scopus 로고    scopus 로고
    • 3- but not b 1-adrenergic receptors are resistant to agonist-mediated regulation in human SK-N-MC neurotumor cells
    • Curran PK and Fishman PH (1996) Endogenous β3- but not b 1-adrenergic receptors are resistant to agonist-mediated regulation in human SK-N-MC neurotumor cells. Cell Signal 8:355-364.
    • (1996) Cell Signal , vol.8 , pp. 355-364
    • Curran, P.K.1    Fishman, P.H.2
  • 19
    • 84897431084 scopus 로고    scopus 로고
    • The pharmacological rationale for combining muscarinic receptor antagonists and b-adrenoceptor agonists in the treatment of airway and bladder disease
    • Dale PR, Cernecka H, Schmidt M, Dowling MR, Charlton SJ, Pieper MP, and Michel MC (2014) The pharmacological rationale for combining muscarinic receptor antagonists and b-adrenoceptor agonists in the treatment of airway and bladder disease. Curr Opin Pharmacol 16C:31-42.
    • (2014) Curr Opin Pharmacol , vol.16 C , pp. 31-42
    • Dale, P.R.1    Cernecka, H.2    Schmidt, M.3    Dowling, M.R.4    Charlton, S.J.5    Pieper, M.P.6    Michel, M.C.7
  • 21
    • 84904680346 scopus 로고    scopus 로고
    • Polymorphic variants of adrenoceptors: Physiology, pharmacology and role in disease
    • in press
    • Engelhardt S and Ahles A (2014) Polymorphic variants of adrenoceptors: physiology, pharmacology and role in disease. Pharmacol Rev (in press).
    • (2014) Pharmacol Rev
    • Engelhardt, S.1    Ahles, A.2
  • 24
    • 0026555798 scopus 로고
    • 3-adrenoreceptor messenger ribonucleic acids in adipose tissues
    • Granneman JG and Lahners KN (1992) Differential adrenergic regulation of β1- and β3-adrenoreceptor messenger ribonucleic acids in adipose tissues. Endocrinology 130:109-114.
    • (1992) Endocrinology , vol.130 , pp. 109-114
    • Granneman, J.G.1    Lahners, K.N.2
  • 26
    • 1442349847 scopus 로고    scopus 로고
    • Comparative pharmacology of human b-adrenergic receptor subtypes-characterization of stably transfected receptors in CHO cells
    • Hoffmann C, Leitz MR, Oberdorf-Maass S, Lohse MJ, and Klotz K-N (2004) Comparative pharmacology of human b-adrenergic receptor subtypes-characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol 369:151-159.
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , pp. 151-159
    • Hoffmann, C.1    Leitz, M.R.2    Oberdorf-Maass, S.3    Lohse, M.J.4    Klotz, K.-N.5
  • 27
    • 0035937457 scopus 로고    scopus 로고
    • Agonist activity of SR59230A at atypical betaadrenoceptors in guinea pig gastric fundus and duodenum
    • Horinouchi T and Koike K (2001) Agonist activity of SR59230A at atypical betaadrenoceptors in guinea pig gastric fundus and duodenum. Eur J Pharmacol 416:165-168
    • (2001) Eur J Pharmacol , vol.416 , pp. 165-168
    • Horinouchi, T.1    Koike, K.2
  • 28
    • 0034021934 scopus 로고    scopus 로고
    • 3)-adrenoceptor regulation and relaxation responses in mouse ileum
    • Hutchinson DS, Evans BA, and Summers RJ (2000) β(3)-adrenoceptor regulation and relaxation responses in mouse ileum. Br J Pharmacol 129:1251-1259.
    • (2000) Br J Pharmacol , vol.129 , pp. 1251-1259
    • Hutchinson, D.S.1    Evans, B.A.2    Summers, R.J.3
  • 29
    • 14344261394 scopus 로고    scopus 로고
    • 3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1, 2, 3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate]
    • Hutchinson DS, Sato M, Evans BA, Christopoulos A, and Summers RJ (2005) Evidence for pleiotropic signaling at the mouse β3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate]. J Pharmacol Exp Ther 312:1064-1074.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 1064-1074
    • Hutchinson, D.S.1    Sato, M.2    Evans, B.A.3    Christopoulos, A.4    Summers, R.J.5
  • 30
    • 84877917378 scopus 로고    scopus 로고
    • 3-adrenoceptor agonists in clinical development for the treatment of overactive bladder syndrome
    • Igawa Y and Michel MC (2013) Pharmacological profile of β3-adrenoceptor agonists in clinical development for the treatment of overactive bladder syndrome. Naunyn Schmiedebergs Arch Pharmacol 386:177-183.
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , pp. 177-183
    • Igawa, Y.1    Michel, M.C.2
  • 33
    • 0027080192 scopus 로고
    • 3-adrenergic receptors: Differential agonist activation of recombinant receptors in Chinese hamster ovary cells
    • Liggett SB (1992) Functional properties of the rat and human β3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells. Mol Pharmacol 42:634-637.
    • (1992) Mol Pharmacol , vol.42 , pp. 634-637
    • Liggett, S.B.1
  • 36
    • 84896708299 scopus 로고    scopus 로고
    • Do β-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder?
    • Michel MC (2014) Do β-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder? Naunyn Schmiedebergs Arch Pharmacol 387:215-224.
    • (2014) Naunyn Schmiedebergs Arch Pharmacol , vol.387 , pp. 215-224
    • Michel, M.C.1
  • 37
    • 39549119348 scopus 로고    scopus 로고
    • Physiological and pathological regulation of the autonomic control of urinary bladder contractility
    • Michel MC and BarendrechtMM(2008) Physiological and pathological regulation of the autonomic control of urinary bladder contractility. Pharmacol Ther 117:297-312.
    • (2008) Pharmacol Ther , vol.117 , pp. 297-312
    • Michel, M.C.1    Barendrecht, M.M.2
  • 39
    • 71249116156 scopus 로고    scopus 로고
    • Effect of pre-contraction on b-adrenoceptor-mediated relaxation of rat urinary bladder
    • Michel MC and Sand C (2009) Effect of pre-contraction on b-adrenoceptor-mediated relaxation of rat urinary bladder. World J Urol 27:711-715.
    • (2009) World J Urol , vol.27 , pp. 711-715
    • Michel, M.C.1    Sand, C.2
  • 40
    • 84907426789 scopus 로고    scopus 로고
    • 3-Adrenergic receptor gene polymorphisms: Comparison of human with chimpanzee and Rhesus macaque
    • Michel MC, Teitsma CA, Vrydag W, Bontrop R, de la Rosette JJMCH, and Baas F (2008) β3-Adrenergic receptor gene polymorphisms: comparison of human with chimpanzee and Rhesus macaque. FASEB J 22:1134.3.
    • (2008) FASEB J , vol.22 , pp. 1134-1143
    • Michel, M.C.1    Teitsma, C.A.2    Vrydag, W.3    Bontrop, R.4    De La Rosette, J.J.M.C.H.5    Baas, F.6
  • 41
    • 32544437708 scopus 로고    scopus 로고
    • α1-, α2- and β -adrenoceptors in the urinary bladder, urethra and prostate
    • Michel MC and Vrydag W (2006) α1-, α2- and β -adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol 147 (Suppl 2):S88-S119.
    • (2006) Br J Pharmacol , vol.147 , pp. S88-S119
    • Michel, M.C.1    Vrydag, W.2
  • 42
    • 84884673071 scopus 로고    scopus 로고
    • 3-adrenoceptors expressed in human embryonic kidney cells
    • Michel-Reher MB and Michel MC (2013) Agonist-induced desensitization of human β3-adrenoceptors expressed in human embryonic kidney cells. Naunyn Schmiedebergs Arch Pharmacol 386:843-851.
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , pp. 843-851
    • Michel-Reher, M.B.1    Michel, M.C.2
  • 45
    • 0025940707 scopus 로고
    • 3-adrenergic receptor: Relationship with the atypical receptor of adipocytes
    • Nahmias C, Blin N, Elalouf J-M, Mattei MG, Strosberg AD, and Emorine LJ (1991) Molecular characterization of the mouse β3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J 10:3721-3727.
    • (1991) EMBO J , vol.10 , pp. 3721-3727
    • Nahmias, C.1    Blin, N.2    Elalouf, J.-M.3    Mattei, M.G.4    Strosberg, A.D.5    Emorine, L.J.6
  • 47
    • 0017365232 scopus 로고
    • Characterization of the adrenergic beta-receptor in the urinary bladder of man and cat
    • Nergårdh A, Boréus LO, and Naglo AS (1977) Characterization of the adrenergic beta-receptor in the urinary bladder of man and cat. Acta Pharmacol Toxicol (Copenh) 40:14-21.
    • (1977) Acta Pharmacol Toxicol (Copenh) , vol.40 , pp. 14-21
    • Nergårdh, A.1    Boréus, L.O.2    Naglo, A.S.3
  • 48
    • 84883232108 scopus 로고    scopus 로고
    • 2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling
    • Ngala RA, O'Dowd JF, Stocker CJ, Cawthorne MA, and Arch JRS (2013) β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling. Naunyn Schmiedebergs Arch Pharmacol 386:761-773.
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , pp. 761-773
    • Ngala, R.A.1    O'dowd, J.F.2    Stocker, C.J.3    Cawthorne, M.A.4    Arch, J.R.S.5
  • 50
    • 84867064355 scopus 로고    scopus 로고
    • 3-adrenoceptor agonist solabegron for overactive bladder
    • Ohlstein EH, von Keitz A, and Michel MC (2012) A multicenter, double-blind, randomized, placebo-controlled trial of the β3-adrenoceptor agonist solabegron for overactive bladder. Eur Urol 62:834-840.
    • (2012) Eur Urol , vol.62 , pp. 834-840
    • Ohlstein, E.H.1    Von Keitz, A.2    Michel, M.C.3
  • 53
    • 54549087794 scopus 로고    scopus 로고
    • Anatomical profiling of G proteincoupled receptor expression
    • Regard JB, Sato IT, and Coughlin SR (2008) Anatomical profiling of G proteincoupled receptor expression. Cell 135:561-571.
    • (2008) Cell , vol.135 , pp. 561-571
    • Regard, J.B.1    Sato, I.T.2    Coughlin, S.R.3
  • 55
    • 35548946776 scopus 로고    scopus 로고
    • Liganddirected signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1, S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists
    • Sato M, Horinouchi T, Hutchinson DS, Evans BA, and Summers RJ (2007) Liganddirected signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1, S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists. Mol Pharmacol 74:1359-1368.
    • (2007) Mol Pharmacol , vol.74 , pp. 1359-1368
    • Sato, M.1    Horinouchi, T.2    Hutchinson, D.S.3    Evans, B.A.4    Summers, R.J.5
  • 56
    • 54449101252 scopus 로고    scopus 로고
    • 3-adrenoceptor agonist
    • 3-adrenoceptor
    • Sato M, Hutchinson DS, Evans BA, and Summers RJ (2008) The β3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy) propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4- [2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl] benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human β3-adrenoceptor. Mol Pharmacol 74: 1417-1428.
    • (2008) Mol Pharmacol , vol.74 , pp. 1417-1428
    • Sato, M.1    Hutchinson, D.S.2    Evans, B.A.3    Summers, R.J.4
  • 58
    • 0032961616 scopus 로고    scopus 로고
    • 3- adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats
    • Scarpace PJ, Matheny M, and Tümer N (1999) Differential down-regulation of β3- adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats. Pflugers Arch 437:479-483.
    • (1999) Pflugers Arch , vol.437 , pp. 479-483
    • Scarpace, P.J.1    Matheny, M.2    Tümer, N.3
  • 59
    • 2442708970 scopus 로고    scopus 로고
    • Signal transduction underlying carbachol-induced contraction of human urinary bladder
    • Schneider T, Fetscher C, Krege S, and Michel MC (2004) Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther 309:1148-1153.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 1148-1153
    • Schneider, T.1    Fetscher, C.2    Krege, S.3    Michel, M.C.4
  • 62
    • 84875382377 scopus 로고    scopus 로고
    • 3)-adrenoceptor gene associated with an altered bladder function?
    • Teitsma CA, de la Rosette JJMCH, and Michel MC (2013) Are polymorphisms of the β (3)-adrenoceptor gene associated with an altered bladder function? Neurourol Urodyn 32:276-280.
    • (2013) Neurourol Urodyn , vol.32 , pp. 276-280
    • Teitsma, C.A.1    De La Rosette, J.J.M.C.H.2    Michel, M.C.3
  • 63
    • 0027417325 scopus 로고
    • 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human
    • Thomas RF and Liggett SB (1993) Lack of β3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. Mol Pharmacol 43: 343-348.
    • (1993) Mol Pharmacol , vol.43 , pp. 343-348
    • Thomas, R.F.1    Liggett, S.B.2
  • 65
    • 65549144124 scopus 로고    scopus 로고
    • 3-adrenoceptors?
    • Vrydag W, Alewijnse AE, and Michel MC (2009) Do gene polymorphisms alone or in combination affect the function of human β3-adrenoceptors? Br J Pharmacol 156: 127-134.
    • (2009) Br J Pharmacol , vol.156 , pp. 127-134
    • Vrydag, W.1    Alewijnse, A.E.2    Michel, M.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.