-
1
-
-
28444472417
-
The great escape: when cancer cells hijack the genes for chemotaxis and motility
-
Condeelis J, Singer RH, Segall JE. The great escape: when cancer cells hijack the genes for chemotaxis and motility. Annu Rev Cell Dev Biol. 2005; 21:695-718.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 695-718
-
-
Condeelis, J.1
Singer, R.H.2
Segall, J.E.3
-
2
-
-
84885352426
-
Origins of metastatic traits
-
Vanharanta S, Massagué J. Origins of metastatic traits. Cancer Cell. 2013; 24:410-21.
-
(2013)
Cancer Cell
, vol.24
, pp. 410-421
-
-
Vanharanta, S.1
Massagué, J.2
-
3
-
-
80054686286
-
Tumor metastasis: molecular insights and evolving paradigms
-
Valastyan S, Weinberg R a. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011; 147:275-92.
-
(2011)
Cell
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
4
-
-
77951238830
-
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity
-
Nelson WJ. Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol. 2009; 1:1-19.
-
(2009)
Cold Spring Harb Perspect Biol
, vol.1
, pp. 1-19
-
-
Nelson, W.J.1
-
5
-
-
0141533034
-
Roles of Rho-family GTPases in cell polarisation and directional migration
-
Fukata M, Nakagawa M, Kaibuchi K. Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol. 2003; 15:590-7.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 590-597
-
-
Fukata, M.1
Nakagawa, M.2
Kaibuchi, K.3
-
6
-
-
84902663108
-
Polarised cell migration: intrinsic and extrinsic drivers
-
Woodham EF, Machesky LM. Polarised cell migration: intrinsic and extrinsic drivers. Curr Opin Cell Biol. 2014; 30C: 25-32.
-
(2014)
Curr Opin Cell Biol
, vol.30C
, pp. 25-32
-
-
Woodham, E.F.1
Machesky, L.M.2
-
7
-
-
80051724097
-
Epithelial cell polarity: a major gatekeeper against cancer?
-
Royer C, Lu X. Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ. 2011; 18: 1470-7.
-
(2011)
Cell Death Differ
, vol.18
, pp. 1470-1477
-
-
Royer, C.1
Lu, X.2
-
8
-
-
70450198396
-
Epithelial-Mesenchymal Transitions in Development and Disease
-
Thiery JP, Acloque H, Huang RYJ, Nieto MA. Epithelial-Mesenchymal Transitions in Development and Disease. Cell. 2009; 139:871-90.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.J.3
Nieto, M.A.4
-
9
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri R, Weinberg R. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119:1420-8.
-
(2009)
J Clin Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.2
-
10
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
-
Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009; 9:265-73.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
11
-
-
1642282882
-
Prespecification and plasticity: shifting mechanisms of cell migration
-
Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol. 2004; 16:14-23.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 14-23
-
-
Friedl, P.1
-
12
-
-
39849100440
-
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
-
Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008; 1778:660-9.
-
(2008)
Biochim Biophys Acta
, vol.1778
, pp. 660-669
-
-
Hartsock, A.1
Nelson, W.J.2
-
13
-
-
35348841509
-
Tight junctions/adherens junctions: basic structure and function
-
Niessen CM. Tight junctions/adherens junctions: basic structure and function. J Invest Dermatol. 2007; 127:2525-32.
-
(2007)
J Invest Dermatol
, vol.127
, pp. 2525-2532
-
-
Niessen, C.M.1
-
14
-
-
0043204760
-
Epithelium-the primary building block for metazoan complexity
-
Tyler S. Epithelium-the primary building block for metazoan complexity. Integr Comp Biol. 2003; 43:55-63.
-
(2003)
Integr Comp Biol
, vol.43
, pp. 55-63
-
-
Tyler, S.1
-
15
-
-
85019197347
-
Rewiring cell polarity signaling in cancer
-
Halaoui R, McCaffrey L. Rewiring cell polarity signaling in cancer. Oncogene. 2014; 1-12.
-
(2014)
Oncogene
, pp. 1-12
-
-
Halaoui, R.1
McCaffrey, L.2
-
16
-
-
84910658384
-
Cell biology in development: The cell biology of planar cell polarity
-
Devenport D. Cell biology in development: The cell biology of planar cell polarity. J Cell Biol. 2014; 207:171-9.
-
(2014)
J Cell Biol
, vol.207
, pp. 171-179
-
-
Devenport, D.1
-
17
-
-
84908192337
-
Insight into planar cell polarity
-
Sebbagh M, Borg J-P. Insight into planar cell polarity. Exp Cell Res. 2014; 328:284-95.
-
(2014)
Exp Cell Res
, vol.328
, pp. 284-295
-
-
Sebbagh, M.1
Borg, J.-P.2
-
18
-
-
4043170088
-
Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors
-
Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 2004; 18:1909-25.
-
(2004)
Genes Dev
, vol.18
, pp. 1909-1925
-
-
Bilder, D.1
-
19
-
-
49249121662
-
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
-
Karp CM, Tan TT, Mathew R, Nelson D, Mukherjee C, Degenhardt K, Karantza-Wadsworth V, White E. Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. Cancer Res. 2008; 68:4105-15.
-
(2008)
Cancer Res
, vol.68
, pp. 4105-4115
-
-
Karp, C.M.1
Tan, T.T.2
Mathew, R.3
Nelson, D.4
Mukherjee, C.5
Degenhardt, K.6
Karantza-Wadsworth, V.7
White, E.8
-
20
-
-
2942729619
-
LKB1 tumor suppressor protein: PARtaker in cell polarity
-
Baas AF, Smit L, Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol. 2004; 14:312-9.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 312-319
-
-
Baas, A.F.1
Smit, L.2
Clevers, H.3
-
22
-
-
67449114979
-
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells
-
Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S. Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci. 2009; 122:1595-606.
-
(2009)
J Cell Sci
, vol.122
, pp. 1595-1606
-
-
Horikoshi, Y.1
Suzuki, A.2
Yamanaka, T.3
Sasaki, K.4
Mizuno, K.5
Sawada, H.6
Yonemura, S.7
Ohno, S.8
-
23
-
-
0034253536
-
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
-
Joberty G, Petersen C, Gao L, Macara IG. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000; 2:531-9.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 531-539
-
-
Joberty, G.1
Petersen, C.2
Gao, L.3
Macara, I.G.4
-
24
-
-
0032487494
-
An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3
-
Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T, Tabuse Y, Kemphues KJ, Ohno S. An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3 . J Cell Biol. 1998; 143:95-106.
-
(1998)
J Cell Biol
, vol.143
, pp. 95-106
-
-
Izumi, Y.1
Hirose, T.2
Tamai, Y.3
Hirai, S.4
Nagashima, Y.5
Fujimoto, T.6
Tabuse, Y.7
Kemphues, K.J.8
Ohno, S.9
-
25
-
-
0037222950
-
Cell polarity: Par6, aPKC and cytoskeletal crosstalk
-
Etienne-Manneville S, Hall A. Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr Opin Cell Biol. 2003; 15:67-72.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 67-72
-
-
Etienne-Manneville, S.1
Hall, A.2
-
26
-
-
54549104845
-
Crosstalk between small GTPases and polarity proteins in cell polarization
-
Iden S, Collard J. Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol cell Biol. 2008; 9:846-59.
-
(2008)
Nat Rev Mol cell Biol
, vol.9
, pp. 846-859
-
-
Iden, S.1
Collard, J.2
-
27
-
-
0037434790
-
Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
-
Etienne-Manneville S, Hall A. Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature. 2003; 421:753-6.
-
(2003)
Nature
, vol.421
, pp. 753-756
-
-
Etienne-Manneville, S.1
Hall, A.2
-
28
-
-
56349123945
-
Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts
-
Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell. 2008; 135:948-59.
-
(2008)
Cell
, vol.135
, pp. 948-959
-
-
Meng, W.1
Mushika, Y.2
Ichii, T.3
Takeichi, M.4
-
29
-
-
14744289370
-
Par-3 controls tight junction assembly through the Rac exchange factor Tiam1
-
Chen X, Macara IG. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol. 2005; 7:262-9.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 262-269
-
-
Chen, X.1
Macara, I.G.2
-
30
-
-
0042090214
-
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
-
Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene. 2003; 22:4752-6.
-
(2003)
Oncogene
, vol.22
, pp. 4752-4756
-
-
Spicer, J.1
Rayter, S.2
Young, N.3
Elliott, R.4
Ashworth, A.5
Smith, D.6
-
31
-
-
33846448743
-
Activation of PAR-1 Kinase and Stimulation of Tau Phosphorylation by Diverse Signals Require the Tumor Suppressor Protein LKB1
-
Wang J-W, Imai Y, Lu B. Activation of PAR-1 Kinase and Stimulation of Tau Phosphorylation by Diverse Signals Require the Tumor Suppressor Protein LKB1. J Neurosci. 2007; 27 : 574-81.
-
(2007)
J Neurosci
, vol.27
, pp. 574-581
-
-
Wang, J.-W.1
Imai, Y.2
Lu, B.3
-
32
-
-
84907870409
-
Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function
-
Gan R-Y, Li H-B. Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function. Int J Mol Sci. 2014; 15:16698-718.
-
(2014)
Int J Mol Sci
, vol.15
, pp. 16698-16718
-
-
Gan, R.-Y.1
Li, H.-B.2
-
34
-
-
3042649049
-
LKB1 kinase: master and commander of metabolism and polarity
-
Spicer J, Ashworth A. LKB1 kinase: master and commander of metabolism and polarity. Curr Biol. 2004; 14:R383-5.
-
(2004)
Curr Biol
, vol.14
, pp. R383-R385
-
-
Spicer, J.1
Ashworth, A.2
-
35
-
-
0037178864
-
The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions
-
Roh MH, Liu C-J, Laurinec S, Margolis B. The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. J Biol Chem. 2002; 277:27501-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 27501-27509
-
-
Roh, M.H.1
Liu, C.-J.2
Laurinec, S.3
Margolis, B.4
-
36
-
-
1642464585
-
Loss of PALS1 expression leads to tight junction and polarity defects
-
Straight S, Shin K, Fogg V. Loss of PALS1 expression leads to tight junction and polarity defects. Mol Biol Cell. 2004; 15:1981-90.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1981-1990
-
-
Straight, S.1
Shin, K.2
Fogg, V.3
-
37
-
-
0037319350
-
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
-
Hurd TW, Gao L, Roh MH, Macara IG, Margolis B. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol. 2003; 5:137-42.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 137-142
-
-
Hurd, T.W.1
Gao, L.2
Roh, M.H.3
Macara, I.G.4
Margolis, B.5
-
38
-
-
84905473528
-
Establishment of epithelial polarity - GEF who's minding the GAP?
-
Ngok SP, Lin W-H, Anastasiadis PZ. Establishment of epithelial polarity - GEF who's minding the GAP? J Cell Sci. 2014; 127: 3205-15.
-
(2014)
J Cell Sci
, vol.127
, pp. 3205-3215
-
-
Ngok, S.P.1
Lin, W.-H.2
Anastasiadis, P.Z.3
-
39
-
-
33646136870
-
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
-
Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell. 2006; 125:535-48.
-
(2006)
Cell
, vol.125
, pp. 535-548
-
-
Wells, C.D.1
Fawcett, J.P.2
Traweger, A.3
Yamanaka, Y.4
Goudreault, M.5
Elder, K.6
Kulkarni, S.7
Gish, G.8
Virag, C.9
Lim, C.10
-
40
-
-
24944577909
-
Cdc42 and Par6-PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
-
Etienne-Manneville S, Manneville J, Nicholls S, Ferenczi MA, Hall A. Cdc42 and Par6-PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization. J Cell Biol. 2005; 170:895-901.
-
(2005)
J Cell Biol
, vol.170
, pp. 895-901
-
-
Etienne-Manneville, S.1
Manneville, J.2
Nicholls, S.3
Ferenczi, M.A.4
Hall, A.5
-
41
-
-
84862529698
-
A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains
-
Sotelo NS, Valiente M, Gil A, Pulido R. A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains. J Cell Biochem. 2012; 113:2661-70.
-
(2012)
J Cell Biochem
, vol.113
, pp. 2661-2670
-
-
Sotelo, N.S.1
Valiente, M.2
Gil, A.3
Pulido, R.4
-
43
-
-
29144469472
-
The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
-
Qin Y, Capaldo C, Gumbiner BM, Macara IG. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J Cell Biol. 2005; 171:1061-71.
-
(2005)
J Cell Biol
, vol.171
, pp. 1061-1071
-
-
Qin, Y.1
Capaldo, C.2
Gumbiner, B.M.3
Macara, I.G.4
-
44
-
-
83155181734
-
Wnt5a: its signalling, functions and implication in diseases
-
Kikuchi A, Yamamoto H, Sato A, Matsumoto S. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol. 2012; 204:17-33.
-
(2012)
Acta Physiol
, vol.204
, pp. 17-33
-
-
Kikuchi, A.1
Yamamoto, H.2
Sato, A.3
Matsumoto, S.4
-
45
-
-
33646941288
-
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals
-
Montcouquiol M, Sans N, Huss D, Kach J, Dickman JD, Forge A, Rachel R a, Copeland NG, Jenkins N a, Bogani D, Murdoch J, Warchol ME, Wenthold RJ, et al. Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci. 2006; 26:5265-75.
-
(2006)
J Neurosci
, vol.26
, pp. 5265-5275
-
-
Montcouquiol, M.1
Sans, N.2
Huss, D.3
Kach, J.4
Dickman, J.D.5
Forge, A.6
Rachel, R.A.7
Copeland, N.G.8
Jenkins, N.A.9
Bogani, D.10
Murdoch, J.11
Warchol, M.E.12
Wenthold, R.J.13
-
46
-
-
85027933832
-
Pointing in the right direction: new developments in the field of planar cell polarity
-
Bayly R, Axelrod JD. Pointing in the right direction: new developments in the field of planar cell polarity. Nat Rev Genet. 2011; 12:385-91.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 385-391
-
-
Bayly, R.1
Axelrod, J.D.2
-
47
-
-
34547604466
-
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity
-
Schlessinger K, McManus EJ, Hall A. Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. J Cell Biol. 2007; 178:355-61.
-
(2007)
J Cell Biol
, vol.178
, pp. 355-361
-
-
Schlessinger, K.1
McManus, E.J.2
Hall, A.3
-
48
-
-
0037385561
-
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl
-
Plant PJ, Fawcett JP, Lin DCC, Holdorf AD, Binns K, Kulkarni S, Pawson T. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol. 2003; 5:301-8.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 301-308
-
-
Plant, P.J.1
Fawcett, J.P.2
Lin, D.C.C.3
Holdorf, A.D.4
Binns, K.5
Kulkarni, S.6
Pawson, T.7
-
49
-
-
0344663968
-
Phosphorylation-Dependent Binding of 14-3-3 to the Polarity Protein Par3 Regulates Cell Polarity in Mammalian Epithelia
-
Hurd TW, Fan S, Liu CJ, Kweon HK, Hakansson K, Margolis B. Phosphorylation-Dependent Binding of 14-3-3 to the Polarity Protein Par3 Regulates Cell Polarity in Mammalian Epithelia. Curr Biol. 2003; 13:2082-90.
-
(2003)
Curr Biol
, vol.13
, pp. 2082-2090
-
-
Hurd, T.W.1
Fan, S.2
Liu, C.J.3
Kweon, H.K.4
Hakansson, K.5
Margolis, B.6
-
50
-
-
4143119015
-
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
-
Sotillos S, Díaz-Meco M. DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol. 2004; 166:549-57.
-
(2004)
J Cell Biol
, vol.166
, pp. 549-557
-
-
Sotillos, S.1
Díaz-Meco, M.2
-
51
-
-
19944372081
-
Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development
-
Ossipova O, Dhawan S, Sokol S, Green JBA. Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev Cell. 2005; 8:829-41.
-
(2005)
Dev Cell
, vol.8
, pp. 829-841
-
-
Ossipova, O.1
Dhawan, S.2
Sokol, S.3
Green, J.B.A.4
-
52
-
-
4344659154
-
Polarity proteins control ciliogenesis via kinesin motor interactions
-
Fan S, Hurd TW, Liu C-J, Straight SW, Weimbs T, Hurd EA, Domino SE, Margolis B. Polarity proteins control ciliogenesis via kinesin motor interactions. Curr Biol. 2004; 14:1451-61.
-
(2004)
Curr Biol
, vol.14
, pp. 1451-1461
-
-
Fan, S.1
Hurd, T.W.2
Liu, C.-J.3
Straight, S.W.4
Weimbs, T.5
Hurd, E.A.6
Domino, S.E.7
Margolis, B.8
-
53
-
-
58149185543
-
Planar cell polarity signaling: from fly development to human disease
-
Simons M, Mlodzik M. Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet. 2008; 42:517.
-
(2008)
Annu Rev Genet
, vol.42
, pp. 517
-
-
Simons, M.1
Mlodzik, M.2
-
54
-
-
84894593599
-
Molecular mechanisms of epithelial-mesenchymal transition
-
Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014; 15:178-96.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 178-196
-
-
Lamouille, S.1
Xu, J.2
Derynck, R.3
-
55
-
-
35548974844
-
The transcription factor ZEB1 ( δ EF1 ) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
-
Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M. The transcription factor ZEB1 ( δ EF1 ) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene. 2010; 26:6979-88.
-
(2010)
Oncogene
, vol.26
, pp. 6979-6988
-
-
Aigner, K.1
Dampier, B.2
Descovich, L.3
Mikula, M.4
Sultan, A.5
Schreiber, M.6
-
56
-
-
6044231839
-
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
-
Barberà MJ, Puig I, Domínguez D, Julien-Grille S, Guaita-Esteruelas S, Peiró S, Baulida J, Francí C, Dedhar S, Larue L, García de Herreros A. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene. 2004; 23:7345-54.
-
(2004)
Oncogene
, vol.23
, pp. 7345-7354
-
-
Barberà, M.J.1
Puig, I.2
Domínguez, D.3
Julien-Grille, S.4
Guaita-Esteruelas, S.5
Peiró, S.6
Baulida, J.7
Francí, C.8
Dedhar, S.9
Larue, L.10
García de Herreros, A.11
-
57
-
-
2942707848
-
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
-
Yang J, Mani S, Donaher J. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 2004; 117:927-39.
-
(2004)
Cell
, vol.117
, pp. 927-939
-
-
Yang, J.1
Mani, S.2
Donaher, J.3
-
58
-
-
0028058712
-
Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer
-
Umbas R, Isaacs W, Bringuier P. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res. 1994; 54:3929-33.
-
(1994)
Cancer Res
, vol.54
, pp. 3929-3933
-
-
Umbas, R.1
Isaacs, W.2
Bringuier, P.3
-
59
-
-
45549105086
-
The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes
-
Whiteman EL, Liu C-J, Fearon ER, Margolis B. The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes. Oncogene. 2008; 27:3875-9.
-
(2008)
Oncogene
, vol.27
, pp. 3875-3879
-
-
Whiteman, E.L.1
Liu, C.-J.2
Fearon, E.R.3
Margolis, B.4
-
60
-
-
84875212117
-
The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis
-
Kashyap a, Zimmerman T, Ergül N, Bosserhoff a, Hartman U, Alla V, Bataille F, Galle PR, Strand S, Strand D. The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis. Oncogene. 2013; 32:1396-407.
-
(2013)
Oncogene
, vol.32
, pp. 1396-1407
-
-
Kashyap, A.1
Zimmerman, T.2
Ergül, N.3
Bosserhoff, A.4
Hartman, U.5
Alla, V.6
Bataille, F.7
Galle, P.R.8
Strand, S.9
Strand, D.10
-
61
-
-
84905568827
-
An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential
-
Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Mol Cell. 2014; 55:436-50.
-
(2014)
Mol Cell
, vol.55
, pp. 436-450
-
-
Goodwin, J.M.1
Svensson, R.U.2
Lou, H.J.3
Winslow, M.M.4
Turk, B.E.5
Shaw, R.J.6
-
62
-
-
39149135251
-
Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells
-
Wang X, Nie J, Zhou Q, Liu W, Zhu F, Chen W, Mao H, Luo N, Dong X, Yu X. Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells. Biochim Biophys Acta. 2008; 1782:51-9.
-
(2008)
Biochim Biophys Acta
, vol.1782
, pp. 51-59
-
-
Wang, X.1
Nie, J.2
Zhou, Q.3
Liu, W.4
Zhu, F.5
Chen, W.6
Mao, H.7
Luo, N.8
Dong, X.9
Yu, X.10
-
63
-
-
14844364701
-
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
-
Ozdamar B, Bose R, Barrios-Rodiles M, Wang H-R, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science. 2005; 307:1603-9.
-
(2005)
Science
, vol.307
, pp. 1603-1609
-
-
Ozdamar, B.1
Bose, R.2
Barrios-Rodiles, M.3
Wang, H.-R.4
Zhang, Y.5
Wrana, J.L.6
-
64
-
-
77954256913
-
TGF-beta signaling specifies axons during brain development
-
Yi JJ, Barnes AP, Hand R, Polleux F, Michael D. TGF-beta signaling specifies axons during brain development. Cell. 2010; 142:144-57.
-
(2010)
Cell
, vol.142
, pp. 144-157
-
-
Yi, J.J.1
Barnes, A.P.2
Hand, R.3
Polleux, F.4
Michael, D.5
-
65
-
-
84883359231
-
Par6 is phosphorylated by aPKC to facilitate EMT
-
Gunaratne A, Di Guglielmo GM. Par6 is phosphorylated by aPKC to facilitate EMT. Cell Adh Migr. 2013; 7:357-61.
-
(2013)
Cell Adh Migr
, vol.7
, pp. 357-361
-
-
Gunaratne, A.1
Di Guglielmo, G.M.2
-
66
-
-
33750505436
-
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
-
Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, Pawson T, Muthuswamy SK. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol. 2006; 8:1235-45.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1235-1245
-
-
Aranda, V.1
Haire, T.2
Nolan, M.E.3
Calarco, J.P.4
Rosenberg, A.Z.5
Fawcett, J.P.6
Pawson, T.7
Muthuswamy, S.K.8
-
67
-
-
65249103982
-
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway
-
Shin S-Y, Rath O, Choo S-M, Fee F, McFerran B, Kolch W, Cho K-H. Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J Cell Sci. 2009; 122:425-35.
-
(2009)
J Cell Sci
, vol.122
, pp. 425-435
-
-
Shin, S.-Y.1
Rath, O.2
Choo, S.-M.3
Fee, F.4
McFerran, B.5
Kolch, W.6
Cho, K.-H.7
-
68
-
-
84884723730
-
ERK and RSK regulate distinct steps of a cellular program that induces transition from multicellular epithelium to single cell phenotype
-
Čáslavský J, Klímová Z, Vomastek T. ERK and RSK regulate distinct steps of a cellular program that induces transition from multicellular epithelium to single cell phenotype. Cell Signal. 2013; 25:2743-51.
-
(2013)
Cell Signal
, vol.25
, pp. 2743-2751
-
-
Čáslavský, J.1
Klímová, Z.2
Vomastek, T.3
-
69
-
-
68949210380
-
RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate, pro-motile/invasive gene program and phenotype in epithelial cells
-
Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen J V, Cohen MS, Johansen J V, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, et al. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate, pro-motile/invasive gene program and phenotype in epithelial cells. Mol Cell. 2009; 35:511-22.
-
(2009)
Mol Cell
, vol.35
, pp. 511-522
-
-
Doehn, U.1
Hauge, C.2
Frank, S.R.3
Jensen, C.J.4
Duda, K.5
Nielsen, J.V.6
Cohen, M.S.7
Johansen, J.V.8
Winther, B.R.9
Lund, L.R.10
Winther, O.11
Taunton, J.12
Hansen, S.H.13
-
70
-
-
84876950650
-
Targeting tumor cell motility as a strategy against invasion and metastasis
-
Wells A, Grahovac J, Wheeler S, Ma B, Lauffenburger D. Targeting tumor cell motility as a strategy against invasion and metastasis. Trends Pharmacol Sci. 2013; 34:283-9.
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 283-289
-
-
Wells, A.1
Grahovac, J.2
Wheeler, S.3
Ma, B.4
Lauffenburger, D.5
-
71
-
-
0035964349
-
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
-
Brabletz T, Jung a, Reu S, Porzner M, Hlubek F, Kunz-Schughart L a, Knuechel R, Kirchner T. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A. 2001; 98:10356-61.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10356-10361
-
-
Brabletz, T.1
Jung, A.2
Reu, S.3
Porzner, M.4
Hlubek, F.5
Kunz-Schughart, L.A.6
Knuechel, R.7
Kirchner, T.8
-
72
-
-
70350452554
-
New evidence for tumour embolism as a mode of metastasis
-
Hart IR. New evidence for tumour embolism as a mode of metastasis. J Pathol. 2009; 219:275-6.
-
(2009)
J Pathol
, vol.219
, pp. 275-276
-
-
Hart, I.R.1
-
73
-
-
0032831099
-
Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets
-
Nabeshima K, Inoue T, Shimao Y, Kataoka H, Koono M. Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets. Histol Histopathol. 1999; 14:1183-97.
-
(1999)
Histol Histopathol
, vol.14
, pp. 1183-1197
-
-
Nabeshima, K.1
Inoue, T.2
Shimao, Y.3
Kataoka, H.4
Koono, M.5
-
74
-
-
84890567148
-
Epithelial bridges maintain tissue integrity during collective cell migration
-
Vedula SRK, Hirata H, Nai MH, Brugués A, Toyama Y, Trepat X, Lim CT, Ladoux B. Epithelial bridges maintain tissue integrity during collective cell migration. Nat Mater. 2014; 13:87-96.
-
(2014)
Nat Mater
, vol.13
, pp. 87-96
-
-
Vedula, S.R.K.1
Hirata, H.2
Nai, M.H.3
Brugués, A.4
Toyama, Y.5
Trepat, X.6
Lim, C.T.7
Ladoux, B.8
-
76
-
-
0034234278
-
Front-Cell-specific Expression of Membrane-Type 1 Matrix Metalloproteinase and Gelatinase A during Cohort Migration of Colon Carcinoma Cells Induced by Hepatocyte Growth Factor/Scatter Factor
-
Nabeshima K, Inoue T, Shimao Y, Okada Y, Itoh Y, Seiki M, Koono M. Front-Cell-specific Expression of Membrane-Type 1 Matrix Metalloproteinase and Gelatinase A during Cohort Migration of Colon Carcinoma Cells Induced by Hepatocyte Growth Factor/Scatter Factor. Cancer Res. 2000; 60 : 3364-9.
-
(2000)
Cancer Res
, vol.60
, pp. 3364-3369
-
-
Nabeshima, K.1
Inoue, T.2
Shimao, Y.3
Okada, Y.4
Itoh, Y.5
Seiki, M.6
Koono, M.7
-
77
-
-
84895466196
-
Rho-directed forces in collective migration
-
Friedl P, Wolf K, Zegers MM. Rho-directed forces in collective migration. Nat Cell Biol. 2014; 16:208-10.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 208-210
-
-
Friedl, P.1
Wolf, K.2
Zegers, M.M.3
-
78
-
-
84923817507
-
Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K
-
Yamaguchi N, Mizutani T, Kawabata K, Haga H. Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K. Sci Rep. 2015; 5:7656.
-
(2015)
Sci Rep
, vol.5
, pp. 7656
-
-
Yamaguchi, N.1
Mizutani, T.2
Kawabata, K.3
Haga, H.4
-
79
-
-
84857345144
-
Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions
-
Omelchenko T, Hall A. Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Curr Biol. 2012; 22:278-88.
-
(2012)
Curr Biol
, vol.22
, pp. 278-288
-
-
Omelchenko, T.1
Hall, A.2
-
80
-
-
0141480029
-
Rho-dependent formation of epithelial "leader" cells during wound healing
-
Omelchenko T, Vasiliev JM, Gelfand IM, Feder HH, Bonder EM. Rho-dependent formation of epithelial "leader" cells during wound healing. Proc Natl Acad Sci. 2003; 100 : 10788-93.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 10788-10793
-
-
Omelchenko, T.1
Vasiliev, J.M.2
Gelfand, I.M.3
Feder, H.H.4
Bonder, E.M.5
-
81
-
-
84895479294
-
Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells
-
Reffay M, Parrini MC, Cochet-Escartin O, Ladoux B, Buguin A, Coscoy S, Amblard F, Camonis J, Silberzan P. Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells. Nat Cell Biol. 2014; 16:217-23.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 217-223
-
-
Reffay, M.1
Parrini, M.C.2
Cochet-Escartin, O.3
Ladoux, B.4
Buguin, A.5
Coscoy, S.6
Amblard, F.7
Camonis, J.8
Silberzan, P.9
-
82
-
-
77953539835
-
Keeping in touch with contact inhibition of locomotion
-
Mayor R, Carmona-Fontaine C. Keeping in touch with contact inhibition of locomotion. Trends Cell Biol. 2010; 20:319-28.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 319-328
-
-
Mayor, R.1
Carmona-Fontaine, C.2
-
83
-
-
84884974729
-
Collective migration and cell jamming
-
Sadati M, Qazvini NT, Krishnan R, Park CY, Fredberg JJ. Collective migration and cell jamming. Differentiation. 2013; 86:121-5.
-
(2013)
Differentiation
, vol.86
, pp. 121-125
-
-
Sadati, M.1
Qazvini, N.T.2
Krishnan, R.3
Park, C.Y.4
Fredberg, J.J.5
-
84
-
-
14044271408
-
Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement
-
Farooqui R, Fenteany G. Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement. J Cell Sci. 2005; 118:51-63.
-
(2005)
J Cell Sci
, vol.118
, pp. 51-63
-
-
Farooqui, R.1
Fenteany, G.2
-
85
-
-
84940467386
-
Collective cell migration: guidance principles and hierarchies
-
Haeger A, Wolf K, Zegers MM, Friedl P. Collective cell migration: guidance principles and hierarchies. Trends Cell Biol. 2015; 25:556-66.
-
(2015)
Trends Cell Biol
, vol.25
, pp. 556-566
-
-
Haeger, A.1
Wolf, K.2
Zegers, M.M.3
Friedl, P.4
-
86
-
-
36749013537
-
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
-
Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol. 2007; 9:1392-400.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1392-1400
-
-
Gaggioli, C.1
Hooper, S.2
Hidalgo-Carcedo, C.3
Grosse, R.4
Marshall, J.F.5
Harrington, K.6
Sahai, E.7
-
87
-
-
84923614059
-
Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface
-
Bronsert P, Enderle-Ammour K, Bader M, Timme S, Kuehs M, Csanadi A, Kayser G, Kohler I, Bausch D, Hoeppner J, Hopt U, Keck T, Stickeler E, et al. Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface. J Pathol. 2014; 234:410-22.
-
(2014)
J Pathol
, vol.234
, pp. 410-422
-
-
Bronsert, P.1
Enderle-Ammour, K.2
Bader, M.3
Timme, S.4
Kuehs, M.5
Csanadi, A.6
Kayser, G.7
Kohler, I.8
Bausch, D.9
Hoeppner, J.10
Hopt, U.11
Keck, T.12
Stickeler, E.13
-
88
-
-
84881474341
-
Dynamics and morphology of focal adhesions in complex 3D environment
-
Tolde O, Rosel D, Janostiak R, Vesely P, Brabek J. Dynamics and morphology of focal adhesions in complex 3D environment. Folia Biol (Praha). 2012; 58:177-84.
-
(2012)
Folia Biol (Praha)
, vol.58
, pp. 177-184
-
-
Tolde, O.1
Rosel, D.2
Janostiak, R.3
Vesely, P.4
Brabek, J.5
-
89
-
-
77956064817
-
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
-
Parsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol cell Biol. 2010; 11:633-43.
-
(2010)
Nat Rev Mol cell Biol
, vol.11
, pp. 633-643
-
-
Parsons, J.T.1
Horwitz, A.R.2
Schwartz, M.A.3
-
90
-
-
84885654506
-
Actin stress fibre subtypes in mesenchymal-migrating cells
-
Vallenius T. Actin stress fibre subtypes in mesenchymal-migrating cells. Open Biol. 2013; 3:130001.
-
(2013)
Open Biol
, vol.3
-
-
Vallenius, T.1
-
91
-
-
1642586962
-
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
-
Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol. 2004; 6:154-61.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 154-161
-
-
Webb, D.J.1
Donais, K.2
Whitmore, L.A.3
Thomas, S.M.4
Turner, C.E.5
Parsons, J.T.6
Horwitz, A.F.7
-
92
-
-
36849058617
-
RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility
-
Vomastek T, Iwanicki MP, Schaeffer H-J, Tarcsafalvi A, Parsons JT, Weber MJ. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol. 2007; 27:8296-305.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8296-8305
-
-
Vomastek, T.1
Iwanicki, M.P.2
Schaeffer, H.-J.3
Tarcsafalvi, A.4
Parsons, J.T.5
Weber, M.J.6
-
93
-
-
0029995797
-
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
-
Chrzanowska-Wodnicka M, Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol. 1996; 133:1403-15.
-
(1996)
J Cell Biol
, vol.133
, pp. 1403-1415
-
-
Chrzanowska-Wodnicka, M.1
Burridge, K.2
-
94
-
-
42549105514
-
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
-
Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci. 2008; 121:895-905.
-
(2008)
J Cell Sci
, vol.121
, pp. 895-905
-
-
Iwanicki, M.P.1
Vomastek, T.2
Tilghman, R.W.3
Martin, K.H.4
Banerjee, J.5
Wedegaertner, P.B.6
Parsons, J.T.7
-
95
-
-
80054031825
-
Degrading devices: invadosomes in proteolytic cell invasion
-
Linder S, Wiesner C, Himmel M. Degrading devices: invadosomes in proteolytic cell invasion. Annu Rev Cell Dev Biol. 2011; 27:185-211.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 185-211
-
-
Linder, S.1
Wiesner, C.2
Himmel, M.3
-
96
-
-
84920611863
-
Digging a little deeper: the stages of invadopodium formation and maturation
-
Beaty BT, Condeelis J. Digging a little deeper: the stages of invadopodium formation and maturation. Eur J Cell Biol. 2014; 93:438-44.
-
(2014)
Eur J Cell Biol
, vol.93
, pp. 438-444
-
-
Beaty, B.T.1
Condeelis, J.2
-
97
-
-
33645507413
-
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function
-
Artym V V, Zhang Y, Seillier-Moiseiwitsch F, Yamada KM, Mueller SC. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res. 2006; 66:3034-43.
-
(2006)
Cancer Res
, vol.66
, pp. 3034-3043
-
-
Artym, V.V.1
Zhang, Y.2
Seillier-Moiseiwitsch, F.3
Yamada, K.M.4
Mueller, S.C.5
-
98
-
-
0033609816
-
A Novel Protease-docking Function of Integrin at Invadopodia
-
Mueller SC, Ghersi G, Akiyama SK, Sang Q-XA, Howard L, Pineiro-Sanchez M, Nakahara H, Yeh Y, Chen W-T, Steven K. A Novel Protease-docking Function of Integrin at Invadopodia. J Biol Chem. 1999; 274:24947-52.
-
(1999)
J Biol Chem
, vol.274
, pp. 24947-24952
-
-
Mueller, S.C.1
Ghersi, G.2
Akiyama, S.K.3
Sang, Q.-X.A.4
Howard, L.5
Pineiro-Sanchez, M.6
Nakahara, H.7
Yeh, Y.8
Chen, W.-T.9
Steven, K.10
-
99
-
-
0037455576
-
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis
-
Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, Deryugina EI, Strongin AY, Bröcker E-B, Friedl P. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol. 2003; 160:267-77.
-
(2003)
J Cell Biol
, vol.160
, pp. 267-277
-
-
Wolf, K.1
Mazo, I.2
Leung, H.3
Engelke, K.4
von Andrian, U.H.5
Deryugina, E.I.6
Strongin, A.Y.7
Bröcker, E.-B.8
Friedl, P.9
-
100
-
-
77954958925
-
The structure of invadopodia in a complex 3D environment
-
Tolde O, Rösel D, Veselý P, Folk P, Brábek J. The structure of invadopodia in a complex 3D environment. Eur J Cell Biol. 2010; 89:674-80.
-
(2010)
Eur J Cell Biol
, vol.89
, pp. 674-680
-
-
Tolde, O.1
Rösel, D.2
Veselý, P.3
Folk, P.4
Brábek, J.5
-
101
-
-
54749146365
-
Tube travel: the role of proteases in individual and collective cancer cell invasion
-
Friedl P, Wolf K. Tube travel: the role of proteases in individual and collective cancer cell invasion. Cancer Res. 2008; 68:7247-9.
-
(2008)
Cancer Res
, vol.68
, pp. 7247-7249
-
-
Friedl, P.1
Wolf, K.2
-
102
-
-
33645669923
-
Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer
-
Lubbe WJ, Zhou ZY, Fu W, Zuzga D, Schulz S, Fridman R, Muschel RJ, Waldman S, Pitari GM. Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer. Clin Cancer Res. 2006; 12:1876-82.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1876-1882
-
-
Lubbe, W.J.1
Zhou, Z.Y.2
Fu, W.3
Zuzga, D.4
Schulz, S.5
Fridman, R.6
Muschel, R.J.7
Waldman, S.8
Pitari, G.M.9
-
103
-
-
18844421896
-
Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis
-
Poola I, DeWitty RL, Marshalleck JJ, Bhatnagar R, Abraham J, Leffall LD. Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis. Nat Med. 2005; 11:481-3.
-
(2005)
Nat Med
, vol.11
, pp. 481-483
-
-
Poola, I.1
DeWitty, R.L.2
Marshalleck, J.J.3
Bhatnagar, R.4
Abraham, J.5
Leffall, L.D.6
-
104
-
-
79961208848
-
Initial steps of metastasis: cell invasion and endothelial transmigration
-
Zijl F Van, Krupitza G, Mikulits W. Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res Mutat. 2011; 728:23-34.
-
(2011)
Mutat Res Mutat
, vol.728
, pp. 23-34
-
-
Van, Z.F.1
Krupitza, G.2
Mikulits, W.3
-
105
-
-
0344305784
-
Cell migration: integrating signals from front to back
-
Ridley AJ, Schwartz M a, Burridge K, Firtel R a, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science. 2003; 302:1704-9.
-
(2003)
Science
, vol.302
, pp. 1704-1709
-
-
Ridley, A.J.1
Schwartz, M.A.2
Burridge, K.3
Firtel, R.A.4
Ginsberg, M.H.5
Borisy, G.6
Parsons, J.T.7
Horwitz, A.R.8
-
106
-
-
80053339433
-
Orientation and function of the nuclear-centrosomal axis during cell migration
-
Luxton GWG, Gundersen GG. Orientation and function of the nuclear-centrosomal axis during cell migration. Curr Opin Cell Biol. 2011; 23:579-88.
-
(2011)
Curr Opin Cell Biol
, vol.23
, pp. 579-588
-
-
Luxton, G.W.G.1
Gundersen, G.G.2
-
107
-
-
84897533668
-
Emerging role for nuclear rotation and orientation in cell migration
-
Maninova M, Iwanicki MP, Vomastek T. Emerging role for nuclear rotation and orientation in cell migration. Cell Adh Migr. 2014; 8:42-8.
-
(2014)
Cell Adh Migr
, vol.8
, pp. 42-48
-
-
Maninova, M.1
Iwanicki, M.P.2
Vomastek, T.3
-
108
-
-
2342432240
-
Cdc42-the centre of polarity
-
Etienne-Manneville S. Cdc42-the centre of polarity. J Cell Sci. 2004; 117:1291-300.
-
(2004)
J Cell Sci
, vol.117
, pp. 1291-1300
-
-
Etienne-Manneville, S.1
-
109
-
-
84877692922
-
The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts
-
Maninová M, Klímová Z, Parsons JT, Weber MJ, Iwanicki MP, Vomastek T. The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts. J Mol Biol. 2013; 425:2039-55.
-
(2013)
J Mol Biol
, vol.425
, pp. 2039-2055
-
-
Maninová, M.1
Klímová, Z.2
Parsons, J.T.3
Weber, M.J.4
Iwanicki, M.P.5
Vomastek, T.6
-
110
-
-
38749118958
-
LARG and mDia1 link Gα12/13 to cell polarity and microtubule dynamics
-
Goulimari P, Knieling H, Engel U, Grosse R. LARG and mDia1 link Gα12/13 to cell polarity and microtubule dynamics. Mol Biol Cell. 2008; 19:30-40.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 30-40
-
-
Goulimari, P.1
Knieling, H.2
Engel, U.3
Grosse, R.4
-
111
-
-
33748659504
-
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src
-
Yamana N, Arakawa Y, Nishino T, Kurokawa K, Tanji M, Itoh RE, Monypenny J, Ishizaki T, Bito H, Nozaki K, Hashimoto N, Matsuda M, Narumiya S. The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol. 2006; 26:6844-58.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6844-6858
-
-
Yamana, N.1
Arakawa, Y.2
Nishino, T.3
Kurokawa, K.4
Tanji, M.5
Itoh, R.E.6
Monypenny, J.7
Ishizaki, T.8
Bito, H.9
Nozaki, K.10
Hashimoto, N.11
Matsuda, M.12
Narumiya, S.13
-
112
-
-
2342436150
-
Cofilin promotes actin polymerization and defines the direction of cell motility
-
Ghosh M, Song X, Mouneimne G, Sidani M, Lawrence DS, Condeelis JS. Cofilin promotes actin polymerization and defines the direction of cell motility. Science. 2004; 304:743-6.
-
(2004)
Science
, vol.304
, pp. 743-746
-
-
Ghosh, M.1
Song, X.2
Mouneimne, G.3
Sidani, M.4
Lawrence, D.S.5
Condeelis, J.S.6
-
113
-
-
84879417563
-
Functions of cofilin in cell locomotion and invasion
-
Bravo-Cordero JJ, Magalhaes M a O, Eddy RJ, Hodgson L, Condeelis J. Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol. 2013; 14:405-15.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 405-415
-
-
Bravo-Cordero, J.J.1
Magalhaes, M.A.O.2
Eddy, R.J.3
Hodgson, L.4
Condeelis, J.5
-
114
-
-
36348968323
-
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
-
Sidani M, Wessels D, Mouneimne G, Ghosh M, Goswami S, Sarmiento C, Wang W, Kuhl S, El-Sibai M, Backer JM, Eddy R, Soll D, Condeelis J. Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol. 2007; 179:777-91.
-
(2007)
J Cell Biol
, vol.179
, pp. 777-791
-
-
Sidani, M.1
Wessels, D.2
Mouneimne, G.3
Ghosh, M.4
Goswami, S.5
Sarmiento, C.6
Wang, W.7
Kuhl, S.8
El-Sibai, M.9
Backer, J.M.10
Eddy, R.11
Soll, D.12
Condeelis, J.13
-
115
-
-
33750948427
-
Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis
-
Mouneimne G, DesMarais V, Sidani M, Scemes E, Wang W, Song X, Eddy R, Condeelis J. Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis. Curr Biol. 2006; 16:2193-205.
-
(2006)
Curr Biol
, vol.16
, pp. 2193-2205
-
-
Mouneimne, G.1
DesMarais, V.2
Sidani, M.3
Scemes, E.4
Wang, W.5
Song, X.6
Eddy, R.7
Condeelis, J.8
-
116
-
-
84899538936
-
Cofilin drives cell-invasive and metastatic responses to TGF-β in prostate cancer
-
Collazo J, Zhu B, Larkin S, Martin SK, Pu H, Horbinski C, Koochekpour S, Kyprianou N. Cofilin drives cell-invasive and metastatic responses to TGF-β in prostate cancer. Cancer Res. 2014; 74:2362-73.
-
(2014)
Cancer Res
, vol.74
, pp. 2362-2373
-
-
Collazo, J.1
Zhu, B.2
Larkin, S.3
Martin, S.K.4
Pu, H.5
Horbinski, C.6
Koochekpour, S.7
Kyprianou, N.8
-
117
-
-
0031456065
-
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
-
Shaw LM, Rabinovitz I, Wang HH, Toker a, Mercurio a M. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell. 1997; 91:949-60.
-
(1997)
Cell
, vol.91
, pp. 949-960
-
-
Shaw, L.M.1
Rabinovitz, I.2
Wang, H.H.3
Toker, A.4
Mercurio, A.M.5
-
118
-
-
0034306279
-
Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components
-
Fleming IN, Gray A, Downes CP. Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J. 2000; 351:173.
-
(2000)
Biochem J
, vol.351
, pp. 173
-
-
Fleming, I.N.1
Gray, A.2
Downes, C.P.3
-
119
-
-
33745550075
-
Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization
-
Ten Klooster JP, Evers EE, Janssen L, Machesky LM, Michiels F, Hordijk P, Collard JG. Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization. Biochem J. 2006; 397:39-45.
-
(2006)
Biochem J
, vol.397
, pp. 39-45
-
-
Ten Klooster, J.P.1
Evers, E.E.2
Janssen, L.3
Machesky, L.M.4
Michiels, F.5
Hordijk, P.6
Collard, J.G.7
-
120
-
-
54549088877
-
Rac activation and inactivation control plasticity of tumor cell movement
-
Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, Sahai E, Marshall CJ. Rac activation and inactivation control plasticity of tumor cell movement. Cell. 2008; 135:510-23.
-
(2008)
Cell
, vol.135
, pp. 510-523
-
-
Sanz-Moreno, V.1
Gadea, G.2
Ahn, J.3
Paterson, H.4
Marra, P.5
Pinner, S.6
Sahai, E.7
Marshall, C.J.8
-
121
-
-
77956459044
-
Rac and Rho GTPases in cancer cell motility control
-
Parri M, Chiarugi P. Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal. 2010; 8:23.
-
(2010)
Cell Commun Signal
, vol.8
, pp. 23
-
-
Parri, M.1
Chiarugi, P.2
-
123
-
-
79952284127
-
Hallmarks of Cancer : The Next Generation
-
Hanahan D, Weinberg RA. Hallmarks of Cancer : The Next Generation. Cell. 2011; 144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
125
-
-
20244379418
-
Regulation of PTEN by Rho small GTPases
-
Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Regulation of PTEN by Rho small GTPases. Nat Cell Biol. 2005; 7:399-404.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 399-404
-
-
Li, Z.1
Dong, X.2
Dong, X.3
Wang, Z.4
Liu, W.5
Deng, N.6
Ding, Y.7
Tang, L.8
Hla, T.9
Zeng, R.10
Li, L.11
Wu, D.12
-
126
-
-
33644870152
-
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane
-
Vazquez F, Matsuoka S, Sellers WR, Yanagida T, Ueda M, Devreotes PN. Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A. 2006; 103:3633-8.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3633-3638
-
-
Vazquez, F.1
Matsuoka, S.2
Sellers, W.R.3
Yanagida, T.4
Ueda, M.5
Devreotes, P.N.6
-
127
-
-
9444242736
-
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
-
Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase). Sci . 1996; 273 : 245-8.
-
(1996)
Sci
, vol.273
, pp. 245-248
-
-
Kimura, K.1
Ito, M.2
Amano, M.3
Chihara, K.4
Fukata, Y.5
Nakafuku, M.6
Yamamori, B.7
Feng, J.8
Nakano, T.9
Okawa, K.10
Iwamatsu, A.11
Kaibuchi, K.12
-
128
-
-
0029786313
-
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
-
Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K. Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase). J Biol Chem. 1996; 271:20246-9.
-
(1996)
J Biol Chem
, vol.271
, pp. 20246-20249
-
-
Amano, M.1
Ito, M.2
Kimura, K.3
Fukata, Y.4
Chihara, K.5
Nakano, T.6
Matsuura, Y.7
Kaibuchi, K.8
-
129
-
-
36248969983
-
Actin stress fibres
-
Pellegrin S, Mellor H. Actin stress fibres. J Cell Sci. 2007; 120:3491-9.
-
(2007)
J Cell Sci
, vol.120
, pp. 3491-3499
-
-
Pellegrin, S.1
Mellor, H.2
-
130
-
-
79955516270
-
Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells
-
Vicente-Manzanares M, Newell-Litwa K, Bachir AI, Whitmore L a, Horwitz AR. Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol. 2011; 193:381-96.
-
(2011)
J Cell Biol
, vol.193
, pp. 381-396
-
-
Vicente-Manzanares, M.1
Newell-Litwa, K.2
Bachir, A.I.3
Whitmore, L.A.4
Horwitz, A.R.5
-
131
-
-
56149095489
-
Segregation and activation of myosin IIB creates a rear in migrating cells
-
Vicente-Manzanares M, Koach MA, Whitmore L, Lamers ML, Horwitz AF. Segregation and activation of myosin IIB creates a rear in migrating cells. J Cell Biol. 2008; 183:543-54.
-
(2008)
J Cell Biol
, vol.183
, pp. 543-554
-
-
Vicente-Manzanares, M.1
Koach, M.A.2
Whitmore, L.3
Lamers, M.L.4
Horwitz, A.F.5
-
132
-
-
29644433350
-
Gα12/13 is essential for directed cell migration and localized Rho-Dia1 function
-
Goulimari P, Kitzing TM, Knieling H, Brandt DT, Offermanns S, Grosse R. Gα12/13 is essential for directed cell migration and localized Rho-Dia1 function. J Biol Chem. 2005; 280:42242-51.
-
(2005)
J Biol Chem
, vol.280
, pp. 42242-42251
-
-
Goulimari, P.1
Kitzing, T.M.2
Knieling, H.3
Brandt, D.T.4
Offermanns, S.5
Grosse, R.6
-
133
-
-
33646197411
-
Spatiotemporal dynamics of RhoA activity in migrating cells
-
Pertz O, Hodgson L, Klemke RL, Hahn KM. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 2006; 440:1069-72.
-
(2006)
Nature
, vol.440
, pp. 1069-1072
-
-
Pertz, O.1
Hodgson, L.2
Klemke, R.L.3
Hahn, K.M.4
-
134
-
-
77957227956
-
A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo
-
Kardash E, Reichman-Fried M, Maître J-L, Boldajipour B, Papusheva E, Messerschmidt E-M, Heisenberg C-P, Raz E. A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol. 2010; 12:47-53.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 47-53
-
-
Kardash, E.1
Reichman-Fried, M.2
Maître, J.-L.3
Boldajipour, B.4
Papusheva, E.5
Messerschmidt, E.-M.6
Heisenberg, C.-P.7
Raz, E.8
-
135
-
-
69949185998
-
Coordination of Rho GTPase activities during cell protrusion
-
Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, Abell A, Johnson GL, Hahn KM, Danuser G. Coordination of Rho GTPase activities during cell protrusion. Nature. 2009; 461:99-103.
-
(2009)
Nature
, vol.461
, pp. 99-103
-
-
Machacek, M.1
Hodgson, L.2
Welch, C.3
Elliott, H.4
Pertz, O.5
Nalbant, P.6
Abell, A.7
Johnson, G.L.8
Hahn, K.M.9
Danuser, G.10
-
136
-
-
24344482090
-
Localized RhoA activation as a requirement for the induction of membrane ruffling
-
Kurokawa K, Matsuda M. Localized RhoA activation as a requirement for the induction of membrane ruffling. Mol Biol Cell. 2005; 16:4294-303.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4294-4303
-
-
Kurokawa, K.1
Matsuda, M.2
-
137
-
-
84893087001
-
The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration
-
Dachsel JC, Ngok SP, Lewis-Tuffin LJ, Kourtidis A, Geyer R, Johnston L, Feathers R, Anastasiadis PZ. The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration. Mol Cell Biol. 2013; 33:4909-18.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4909-4918
-
-
Dachsel, J.C.1
Ngok, S.P.2
Lewis-Tuffin, L.J.3
Kourtidis, A.4
Geyer, R.5
Johnston, L.6
Feathers, R.7
Anastasiadis, P.Z.8
-
138
-
-
79955425392
-
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia
-
Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, Condeelis J. A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol. 2011; 21:635-44.
-
(2011)
Curr Biol
, vol.21
, pp. 635-644
-
-
Bravo-Cordero, J.J.1
Oser, M.2
Chen, X.3
Eddy, R.4
Hodgson, L.5
Condeelis, J.6
-
140
-
-
84867405335
-
NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells
-
Paňková D, Jobe N, Kratochvílová M, Buccione R, Brábek J, Rösel D. NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells. Eur J Cell Biol. 2012; 91:969-77.
-
(2012)
Eur J Cell Biol
, vol.91
, pp. 969-977
-
-
Paňková, D.1
Jobe, N.2
Kratochvílová, M.3
Buccione, R.4
Brábek, J.5
Rösel, D.6
-
141
-
-
70349314647
-
Mechanical modes of "amoeboid" cell migration
-
Lämmermann T, Sixt M. Mechanical modes of "amoeboid" cell migration. Curr Opin Cell Biol. 2009; 21:636-44.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 636-644
-
-
Lämmermann, T.1
Sixt, M.2
-
142
-
-
50149095564
-
Blebs lead the way: how to migrate without lamellipodia
-
Charras G, Paluch E. Blebs lead the way: how to migrate without lamellipodia. Nat Rev Mol Cell Biol. 2008; 9:730-6.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 730-736
-
-
Charras, G.1
Paluch, E.2
-
143
-
-
0042354574
-
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
-
Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol. 2003; 5:711-9.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 711-719
-
-
Sahai, E.1
Marshall, C.J.2
-
144
-
-
50649115103
-
Imaging amoeboid cancer cell motility in vivo
-
Pinner S, Sahai E. Imaging amoeboid cancer cell motility in vivo. J Microsc. 2008; 231:441-5.
-
(2008)
J Microsc
, vol.231
, pp. 441-445
-
-
Pinner, S.1
Sahai, E.2
-
145
-
-
84899431982
-
Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells
-
Taddei ML, Giannoni E, Morandi A, Ippolito L, Ramazzotti M, Callari M, Gandellini P, Chiarugi P. Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells. Cell Commun Signal. 2014; 12:24.
-
(2014)
Cell Commun Signal
, vol.12
, pp. 24
-
-
Taddei, M.L.1
Giannoni, E.2
Morandi, A.3
Ippolito, L.4
Ramazzotti, M.5
Callari, M.6
Gandellini, P.7
Chiarugi, P.8
-
146
-
-
84864338902
-
Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells
-
Borrull A, Ghislin S, Deshayes F, Lauriol J, Alcaide-Loridan C, Middendorp S. Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells. J Cancer Res Clin Oncol. 2012; 138:1145-54.
-
(2012)
J Cancer Res Clin Oncol
, vol.138
, pp. 1145-1154
-
-
Borrull, A.1
Ghislin, S.2
Deshayes, F.3
Lauriol, J.4
Alcaide-Loridan, C.5
Middendorp, S.6
-
147
-
-
33947537278
-
ROCK1 phosphorylates and activates zipper-interacting protein kinase
-
Hagerty L, Weitzel DH, Chambers J, Fortner CN, Brush MH, Loiselle D, Hosoya H, Haystead TA. ROCK1 phosphorylates and activates zipper-interacting protein kinase. J Biol Chem. 2007; 282:4884-93.
-
(2007)
J Biol Chem
, vol.282
, pp. 4884-4893
-
-
Hagerty, L.1
Weitzel, D.H.2
Chambers, J.3
Fortner, C.N.4
Brush, M.H.5
Loiselle, D.6
Hosoya, H.7
Haystead, T.A.8
-
148
-
-
14744304060
-
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
-
Wilkinson S, Paterson HF, Marshall CJ. Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol. 2005; 7:255-61.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 255-261
-
-
Wilkinson, S.1
Paterson, H.F.2
Marshall, C.J.3
-
149
-
-
33746562929
-
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo
-
Wyckoff JB, Pinner SE, Gschmeissner S, Condeelis JS, Sahai E. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol. 2006; 16:1515-23.
-
(2006)
Curr Biol
, vol.16
, pp. 1515-1523
-
-
Wyckoff, J.B.1
Pinner, S.E.2
Gschmeissner, S.3
Condeelis, J.S.4
Sahai, E.5
-
150
-
-
53349127603
-
Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces
-
Rösel D, Brábek J, Tolde O, Mierke CT, Zitterbart DP, Raupach C, Bicanová K, Kollmannsberger P, Panková D, Vesely P, Folk P, Fabry B. Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces. Mol Cancer Res. 2008; 6:1410-20.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1410-1420
-
-
Rösel, D.1
Brábek, J.2
Tolde, O.3
Mierke, C.T.4
Zitterbart, D.P.5
Raupach, C.6
Bicanová, K.7
Kollmannsberger, P.8
Panková, D.9
Vesely, P.10
Folk, P.11
Fabry, B.12
-
151
-
-
77951587879
-
Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
-
Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. Oncogene. 2010; 29:2441-8.
-
(2010)
Oncogene
, vol.29
, pp. 2441-2448
-
-
Kitzing, T.M.1
Wang, Y.2
Pertz, O.3
Copeland, J.W.4
Grosse, R.5
-
152
-
-
0033605738
-
Inhibition of myosin light chain kinase by p21-activated kinase
-
Sanders L, Matsumura F, Bokoch G, Lanerolle P De. Inhibition of myosin light chain kinase by p21-activated kinase. Science. 1999; 283:2083-5.
-
(1999)
Science
, vol.283
, pp. 2083-2085
-
-
Sanders, L.1
Matsumura, F.2
Bokoch, G.3
De, L.P.4
-
153
-
-
53249143863
-
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells
-
Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol. 2008; 18:1456-65.
-
(2008)
Curr Biol
, vol.18
, pp. 1456-1465
-
-
Gadea, G.1
Sanz-Moreno, V.2
Self, A.3
Godi, A.4
Marshall, C.J.5
-
154
-
-
0037205265
-
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
-
Funamoto S, Meili R, Lee S, Parry L, Firtel R. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell. 2002; 109:611-23.
-
(2002)
Cell
, vol.109
, pp. 611-623
-
-
Funamoto, S.1
Meili, R.2
Lee, S.3
Parry, L.4
Firtel, R.5
-
155
-
-
67649464358
-
PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells
-
Pramanik MK, Iijima M, Iwadate Y, Yumura S. PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells. Genes Cells. 2009; 14:821-34.
-
(2009)
Genes Cells
, vol.14
, pp. 821-834
-
-
Pramanik, M.K.1
Iijima, M.2
Iwadate, Y.3
Yumura, S.4
-
156
-
-
8444221934
-
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
-
Sasaki AT, Chun C, Takeda K, Firtel R a. Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol. 2004; 167:505-18.
-
(2004)
J Cell Biol
, vol.167
, pp. 505-518
-
-
Sasaki, A.T.1
Chun, C.2
Takeda, K.3
Firtel, R.A.4
-
157
-
-
84905278337
-
Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells
-
Falke JJ, Ziemba BP. Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells. Chem Phys Lipids. 2014; 182:73-9.
-
(2014)
Chem Phys Lipids
, vol.182
, pp. 73-79
-
-
Falke, J.J.1
Ziemba, B.P.2
-
158
-
-
79953156598
-
An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells
-
Lorentzen A, Bamber J, Sadok A, Elson-Schwab I, Marshall CJ. An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells. J Cell Sci. 2011; 124:1256-67.
-
(2011)
J Cell Sci
, vol.124
, pp. 1256-1267
-
-
Lorentzen, A.1
Bamber, J.2
Sadok, A.3
Elson-Schwab, I.4
Marshall, C.J.5
-
159
-
-
84865957893
-
Cell mechanics control rapid transitions between blebs and lamellipodia during migration
-
Bergert M, Chandradoss SD, Desai R a, Paluch E. Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Proc Natl Acad Sci U S A. 2012; 109:14434-9.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 14434-14439
-
-
Bergert, M.1
Chandradoss, S.D.2
Desai, R.A.3
Paluch, E.4
-
160
-
-
20444445916
-
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
-
Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ETY, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, Ellis S, Smyth MJ, et al. A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity. 2005; 22:737-48.
-
(2005)
Immunity
, vol.22
, pp. 737-748
-
-
Ludford-Menting, M.J.1
Oliaro, J.2
Sacirbegovic, F.3
Cheah, E.T.Y.4
Pedersen, N.5
Thomas, S.J.6
Pasam, A.7
Iazzolino, R.8
Dow, L.E.9
Waterhouse, N.J.10
Murphy, A.11
Ellis, S.12
Smyth, M.J.13
-
161
-
-
84918507471
-
The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes
-
Crespo CL, Vernieri C, Keller PJ, Garre M, Bender JR, Wittbrodt J, Pardi R. The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes. J Cell Sci. 2014; 127:4381-95.
-
(2014)
J Cell Sci
, vol.127
, pp. 4381-4395
-
-
Crespo, C.L.1
Vernieri, C.2
Keller, P.J.3
Garre, M.4
Bender, J.R.5
Wittbrodt, J.6
Pardi, R.7
-
162
-
-
73749086570
-
The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
-
Panková K, Rösel D, Novotný M, Brábek J. The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci. 2010; 67:63-71.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 63-71
-
-
Panková, K.1
Rösel, D.2
Novotný, M.3
Brábek, J.4
-
163
-
-
84923382712
-
The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition
-
Huang B, Lu M, Jolly MK, Tsarfaty I, Onuchic J, Ben-Jacob E. The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition. Sci Rep. 2014; 4:6449.
-
(2014)
Sci Rep
, vol.4
, pp. 6449
-
-
Huang, B.1
Lu, M.2
Jolly, M.K.3
Tsarfaty, I.4
Onuchic, J.5
Ben-Jacob, E.6
-
164
-
-
77956472212
-
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
-
Brábek J, Mierke CT, Rösel D, Veselý P, Fabry B. The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal. 2010; 8:22.
-
(2010)
Cell Commun Signal
, vol.8
, pp. 22
-
-
Brábek, J.1
Mierke, C.T.2
Rösel, D.3
Veselý, P.4
Fabry, B.5
-
165
-
-
0025886995
-
Mathematical model for the effects of adhesion and mechanics on cell migration speed
-
DiMilla P, Barbee K, Lauffenburger D. Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys J. 1991; 60:15-37.
-
(1991)
Biophys J
, vol.60
, pp. 15-37
-
-
DiMilla, P.1
Barbee, K.2
Lauffenburger, D.3
-
166
-
-
58149332179
-
Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization
-
Provenzano PP, Inman DR, Eliceiri KW, Trier SM, Keely PJ. Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J. 2008; 95:5374-84.
-
(2008)
Biophys J
, vol.95
, pp. 5374-5384
-
-
Provenzano, P.P.1
Inman, D.R.2
Eliceiri, K.W.3
Trier, S.M.4
Keely, P.J.5
-
167
-
-
76249088362
-
Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures
-
Van Goethem E, Poincloux R, Gauffre F, Maridonneau-Parini I, Le Cabec V. Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures. J Immunol. 2010; 184:1049-61.
-
(2010)
J Immunol
, vol.184
, pp. 1049-1061
-
-
Van Goethem, E.1
Poincloux, R.2
Gauffre, F.3
Maridonneau-Parini, I.4
Le Cabec, V.5
-
168
-
-
84903286861
-
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration
-
Orgaz JL, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A, Albrengues J, Nestle FO, Ridley AJ, Gaggioli C. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun. 2014; 5.
-
(2014)
Nat Commun
, pp. 5
-
-
Orgaz, J.L.1
Pandya, P.2
Dalmeida, R.3
Karagiannis, P.4
Sanchez-Laorden, B.5
Viros, A.6
Albrengues, J.7
Nestle, F.O.8
Ridley, A.J.9
Gaggioli, C.10
-
169
-
-
33846014269
-
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility
-
Sahai E, Garcia-Medina R, Pouysségur J, Vial E. Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol. 2007; 176:35-42.
-
(2007)
J Cell Biol
, vol.176
, pp. 35-42
-
-
Sahai, E.1
Garcia-Medina, R.2
Pouysségur, J.3
Vial, E.4
-
170
-
-
34250738935
-
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion
-
Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Großhans J, Grosse R. Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev. 2007; 21:1478-83.
-
(2007)
Genes Dev
, vol.21
, pp. 1478-1483
-
-
Kitzing, T.M.1
Sahadevan, A.S.2
Brandt, D.T.3
Knieling, H.4
Hannemann, S.5
Fackler, O.T.6
Großhans, J.7
Grosse, R.8
-
171
-
-
66149139847
-
Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells
-
Lizárraga F, Poincloux R, Romão M, Montagnac G, Le Dez G, Bonne I, Rigaill G, Raposo G, Chavrier P. Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res. 2009; 69:2792-800.
-
(2009)
Cancer Res
, vol.69
, pp. 2792-2800
-
-
Lizárraga, F.1
Poincloux, R.2
Romão, M.3
Montagnac, G.4
Le Dez, G.5
Bonne, I.6
Rigaill, G.7
Raposo, G.8
Chavrier, P.9
-
172
-
-
84864823696
-
DIAPH3 governs the cellular transition to the amoeboid tumour phenotype
-
Hager MH, Morley S, Bielenberg DR, Gao S, Morello M, Holcomb IN, Liu W, Mouneimne G, Demichelis F, Kim J, Solomon KR, Adam RM, Isaacs WB, et al. DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. EMBO Mol Med. 2012; 4:743-60.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 743-760
-
-
Hager, M.H.1
Morley, S.2
Bielenberg, D.R.3
Gao, S.4
Morello, M.5
Holcomb, I.N.6
Liu, W.7
Mouneimne, G.8
Demichelis, F.9
Kim, J.10
Solomon, K.R.11
Adam, R.M.12
Isaacs, W.B.13
-
173
-
-
0034602959
-
Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop
-
Ohashi K. Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop. J Biol Chem. 2000; 275:3577-82.
-
(2000)
J Biol Chem
, vol.275
, pp. 3577-3582
-
-
Ohashi, K.1
-
174
-
-
0033611107
-
Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho-and Cdc42-activated LIM-kinase 2
-
Sumi T, Matsumoto K. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho-and Cdc42-activated LIM-kinase 2. J Cell Biol. 1999; 147:1519-32.
-
(1999)
J Cell Biol
, vol.147
, pp. 1519-1532
-
-
Sumi, T.1
Matsumoto, K.2
-
175
-
-
0032565769
-
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
-
Yang N, Higuchi O, Ohashi K, Nagata K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature. 1998; 1171:809-12.
-
(1998)
Nature
, vol.1171
, pp. 809-812
-
-
Yang, N.1
Higuchi, O.2
Ohashi, K.3
Nagata, K.4
-
176
-
-
76749126470
-
LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices
-
Mishima T, Naotsuka M, Horita Y, Sato M, Ohashi K, Mizuno K. LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices. Biochem Biophys Res Commun. 2010; 392:577-81.
-
(2010)
Biochem Biophys Res Commun
, vol.392
, pp. 577-581
-
-
Mishima, T.1
Naotsuka, M.2
Horita, Y.3
Sato, M.4
Ohashi, K.5
Mizuno, K.6
-
177
-
-
0036532136
-
Collective Cell Movement in Primary Melanoma Explants: Plasticity of Cell-Cell Interaction, (beta)1-Integrin Function, and Migration Strategies
-
Hegerfeldt Y, Tusch M, Bröcker E, Strategies M, Friedl P, Brocker E-B. Collective Cell Movement in Primary Melanoma Explants: Plasticity of Cell-Cell Interaction, (beta)1-Integrin Function, and Migration Strategies. Cancer Res. 2002; 62:2125-30.
-
(2002)
Cancer Res
, vol.62
, pp. 2125-2130
-
-
Hegerfeldt, Y.1
Tusch, M.2
Bröcker, E.3
Strategies, M.4
Friedl, P.5
Brocker, E.-B.6
-
178
-
-
84877626308
-
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion
-
Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiäinen M, Gstaiger M, Lehti K. EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion. J Cell Biol. 2013; 201:467-84.
-
(2013)
J Cell Biol
, vol.201
, pp. 467-484
-
-
Sugiyama, N.1
Gucciardo, E.2
Tatti, O.3
Varjosalo, M.4
Hyytiäinen, M.5
Gstaiger, M.6
Lehti, K.7
-
179
-
-
79551612886
-
Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
-
Terry SJ, Zihni C, Elbediwy A, Vitiello E, San IVLC, Balda MS, Matter K. Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nat Cell Biol. 2011; 13:159-66.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 159-166
-
-
Terry, S.J.1
Zihni, C.2
Elbediwy, A.3
Vitiello, E.4
San, I.V.L.C.5
Balda, M.S.6
Matter, K.7
-
180
-
-
84869850079
-
Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion
-
Terry SJ, Elbediwy A, Zihni C, Harris AR, Bailly M, Charras GT, Balda MS, Matter K. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. PLoS One. 2012; 7:e50188.
-
(2012)
PLoS One
, vol.7
-
-
Terry, S.J.1
Elbediwy, A.2
Zihni, C.3
Harris, A.R.4
Bailly, M.5
Charras, G.T.6
Balda, M.S.7
Matter, K.8
-
181
-
-
41649118421
-
Transforming growth factor β controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin
-
Binamé F, Lassus P, Hibner U. Transforming growth factor β controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin. Mol Biol Cell. 2008; 19:945-56.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 945-956
-
-
Binamé, F.1
Lassus, P.2
Hibner, U.3
-
182
-
-
77950280030
-
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
-
Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, et al. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010; 70:2158-64.
-
(2010)
Cancer Res
, vol.70
, pp. 2158-2164
-
-
Rothenberg, S.M.1
Mohapatra, G.2
Rivera, M.N.3
Winokur, D.4
Greninger, P.5
Nitta, M.6
Sadow, P.M.7
Sooriyakumar, G.8
Brannigan, B.W.9
Ulman, M.J.10
Perera, R.M.11
Wang, R.12
Tam, A.13
-
183
-
-
84896733184
-
Atypical Protein Kinase C i as a human oncogene and therapeutic target
-
Parker PJ, Justilien V, Riou P, Linch M, Fields AP. Atypical Protein Kinase C i as a human oncogene and therapeutic target. Biochem Pharmacol. 2014; 88:1-11.
-
(2014)
Biochem Pharmacol
, vol.88
, pp. 1-11
-
-
Parker, P.J.1
Justilien, V.2
Riou, P.3
Linch, M.4
Fields, A.P.5
-
184
-
-
84880769933
-
Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble
-
Elsum IA, Humbert PO. Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble. Cells Tissues Organs. 2013; 198:1-11.
-
(2013)
Cells Tissues Organs
, vol.198
, pp. 1-11
-
-
Elsum, I.A.1
Humbert, P.O.2
-
185
-
-
84902176984
-
Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer
-
Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol J a, Cardiff RD, Muthuswamy SK. Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Res. 2014; 74:3180-94.
-
(2014)
Cancer Res
, vol.74
, pp. 3180-3194
-
-
Feigin, M.E.1
Akshinthala, S.D.2
Araki, K.3
Rosenberg, A.Z.4
Muthuswamy, L.B.5
Martin, B.6
Lehmann, B.D.7
Berman, H.K.8
Pietenpol, J.A.9
Cardiff, R.D.10
Muthuswamy, S.K.11
-
186
-
-
84896036461
-
Apico-basal polarity complex and cancer
-
Khursheed M, Bashyam MD. Apico-basal polarity complex and cancer. J Biosci. 2014; 39:145-55.
-
(2014)
J Biosci
, vol.39
, pp. 145-155
-
-
Khursheed, M.1
Bashyam, M.D.2
-
189
-
-
0035943401
-
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
-
Etienne-Manneville S, Hall A. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell. 2001; 106:489-98.
-
(2001)
Cell
, vol.106
, pp. 489-498
-
-
Etienne-Manneville, S.1
Hall, A.2
-
190
-
-
67349256860
-
Bringing up the rear: defining the roles of the uropod
-
Sánchez-Madrid F, Serrador JM. Bringing up the rear: defining the roles of the uropod. Nat Rev Mol Cell Biol. 2009; 10:353-9.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 353-359
-
-
Sánchez-Madrid, F.1
Serrador, J.M.2
-
191
-
-
0000202186
-
A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
-
Lin D, Edwards a S, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000; 2:540-7.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 540-547
-
-
Lin, D.1
Edwards, A.S.2
Fawcett, J.P.3
Mbamalu, G.4
Scott, J.D.5
Pawson, T.6
-
192
-
-
34848869140
-
The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity
-
Pegtel DM, Ellenbroek SIJ, Mertens AEE, van der Kammen R a, de Rooij J, Collard JG. The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol. 2007; 17:1623-34.
-
(2007)
Curr Biol
, vol.17
, pp. 1623-1634
-
-
Pegtel, D.M.1
Ellenbroek, S.I.J.2
Mertens, A.E.E.3
van der Kammen, R.A.4
de Rooij, J.5
Collard, J.G.6
-
193
-
-
84890526139
-
The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity
-
Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013; 24:3857-68.
-
(2013)
Mol Biol Cell
, vol.24
, pp. 3857-3868
-
-
Narayanan, A.S.1
Reyes, S.B.2
Um, K.3
McCarty, J.H.4
Tolias, K.F.5
-
194
-
-
0344758986
-
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
-
Wang H-R, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science. 2003; 302:1775-9.
-
(2003)
Science
, vol.302
, pp. 1775-1779
-
-
Wang, H.-R.1
Zhang, Y.2
Ozdamar, B.3
Ogunjimi, A.A.4
Alexandrova, E.5
Thomsen, G.H.6
Wrana, J.L.7
-
195
-
-
38849122774
-
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation
-
Nakayama M, Goto TM, Sugimoto M, Nishimura T, Shinagawa T, Ohno S, Amano M, Kaibuchi K. Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell. 2008; 14:205-15.
-
(2008)
Dev Cell
, vol.14
, pp. 205-215
-
-
Nakayama, M.1
Goto, T.M.2
Sugimoto, M.3
Nishimura, T.4
Shinagawa, T.5
Ohno, S.6
Amano, M.7
Kaibuchi, K.8
-
196
-
-
77957735280
-
LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity
-
Xu X, Omelchenko T, Hall A. LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity. BMC Cell Biol. 2010; 11:77.
-
(2010)
BMC Cell Biol
, vol.11
, pp. 77
-
-
Xu, X.1
Omelchenko, T.2
Hall, A.3
-
197
-
-
38849204971
-
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
-
Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res. 2008; 68:740-8.
-
(2008)
Cancer Res
, vol.68
, pp. 740-748
-
-
Zhang, S.1
Schafer-Hales, K.2
Khuri, F.R.3
Zhou, W.4
Vertino, P.M.5
Marcus, A.I.6
-
198
-
-
2642547462
-
Mammalian Scribble forms a tight complex with the βPIX exchange factor
-
Audebert S, Navarro C, Nourry C. Mammalian Scribble forms a tight complex with the βPIX exchange factor. Curr Biol. 2004; 14:987-95.
-
(2004)
Curr Biol
, vol.14
, pp. 987-995
-
-
Audebert, S.1
Navarro, C.2
Nourry, C.3
-
199
-
-
84906907631
-
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration
-
Kutys ML, Yamada KM. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014; 16.
-
(2014)
Nat Cell Biol
, pp. 16
-
-
Kutys, M.L.1
Yamada, K.M.2
-
200
-
-
34147094240
-
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge
-
Dow LE, Kauffman JS, Caddy J, Zarbalis K, Peterson a S, Jane SM, Russell SM, Humbert PO. The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene. 2007; 26:2272-82.
-
(2007)
Oncogene
, vol.26
, pp. 2272-2282
-
-
Dow, L.E.1
Kauffman, J.S.2
Caddy, J.3
Zarbalis, K.4
Peterson, A.S.5
Jane, S.M.6
Russell, S.M.7
Humbert, P.O.8
-
201
-
-
67449124591
-
Vimentin regulates scribble activity by protecting it from proteasomal degradation
-
Phua DCY, Humbert PO, Hunziker W. Vimentin regulates scribble activity by protecting it from proteasomal degradation. Mol Biol Cell. 2009; 20:2841-55.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 2841-2855
-
-
Phua, D.C.Y.1
Humbert, P.O.2
Hunziker, W.3
-
202
-
-
83355163339
-
Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)
-
O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall R a, Newton AC. Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011; 286:43559-68.
-
(2011)
J Biol Chem
, vol.286
, pp. 43559-43568
-
-
O'Neill, A.K.1
Gallegos, L.L.2
Justilien, V.3
Garcia, E.L.4
Leitges, M.5
Fields, A.P.6
Hall, R.A.7
Newton, A.C.8
-
203
-
-
84857217053
-
The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration
-
Dahan I, Yearim A, Touboul Y, Ravid S. The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration. Mol Biol Cell. 2012; 23:591-601.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 591-601
-
-
Dahan, I.1
Yearim, A.2
Touboul, Y.3
Ravid, S.4
-
204
-
-
84892518329
-
The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation
-
Dahan I, Petrov D, Cohen-Kfir E, Ravid S. The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation. J Cell Sci. 2014; 127:295-304.
-
(2014)
J Cell Sci
, vol.127
, pp. 295-304
-
-
Dahan, I.1
Petrov, D.2
Cohen-Kfir, E.3
Ravid, S.4
-
205
-
-
67149133634
-
Pivotal Advance: PKCzeta is required for migration of macrophages
-
Guo H, Ma Y, Zhang B, Sun B, Niu R, Ying G, Zhang N. Pivotal Advance: PKCzeta is required for migration of macrophages. J Leukoc Biol. 2009; 85:911-8.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 911-918
-
-
Guo, H.1
Ma, Y.2
Zhang, B.3
Sun, B.4
Niu, R.5
Ying, G.6
Zhang, N.7
-
206
-
-
67649238892
-
Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2
-
Vandenberg AL, Sassoon DA. Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2. Development. 2009; 136:1559-70.
-
(2009)
Development
, vol.136
, pp. 1559-1570
-
-
Vandenberg, A.L.1
Sassoon, D.A.2
-
207
-
-
76649084891
-
Vang-like protein 2 and Rac1 interact to regulate adherens junctions
-
Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T. Vang-like protein 2 and Rac1 interact to regulate adherens junctions. J Cell Sci. 2010; 123:472-83.
-
(2010)
J Cell Sci
, vol.123
, pp. 472-483
-
-
Lindqvist, M.1
Horn, Z.2
Bryja, V.3
Schulte, G.4
Papachristou, P.5
Ajima, R.6
Dyberg, C.7
Arenas, E.8
Yamaguchi, T.P.9
Lagercrantz, H.10
Ringstedt, T.11
-
208
-
-
84864956480
-
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression
-
Anastas JN, Biechele TL, Robitaille M, Muster J, Allison KH, Angers S, Moon RT. A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene. 2012; 31:3696-708.
-
(2012)
Oncogene
, vol.31
, pp. 3696-3708
-
-
Anastas, J.N.1
Biechele, T.L.2
Robitaille, M.3
Muster, J.4
Allison, K.H.5
Angers, S.6
Moon, R.T.7
-
209
-
-
84862883479
-
VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration
-
Williams BB, Cantrell VA, Mundell N a, Bennett AC, Quick RE, Jessen JR. VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. J Cell Sci. 2012; 125:2141-7.
-
(2012)
J Cell Sci
, vol.125
, pp. 2141-2147
-
-
Williams, B.B.1
Cantrell, V.A.2
Mundell, N.A.3
Bennett, A.C.4
Quick, R.E.5
Jessen, J.R.6
-
210
-
-
72049111230
-
The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion
-
Cantrell VA, Jessen JR. The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion. Cancer Lett. 2010; 287:54-61.
-
(2010)
Cancer Lett
, vol.287
, pp. 54-61
-
-
Cantrell, V.A.1
Jessen, J.R.2
-
212
-
-
84928662409
-
Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway
-
Kaucká M, Petersen J, Janovská P, Radaszkiewicz T, Smyčková L, Daulat AM, Borg J-P, Schulte G, Bryja V. Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway. Cell Commun Signal. 2015; 13:2.
-
(2015)
Cell Commun Signal
, vol.13
, pp. 2
-
-
Kaucká, M.1
Petersen, J.2
Janovská, P.3
Radaszkiewicz, T.4
Smyčková, L.5
Daulat, A.M.6
Borg, J.-P.7
Schulte, G.8
Bryja, V.9
-
213
-
-
77950526433
-
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells
-
Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A. Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 2010; 29:1192-204.
-
(2010)
EMBO J
, vol.29
, pp. 1192-1204
-
-
Matsumoto, S.1
Fumoto, K.2
Okamoto, T.3
Kaibuchi, K.4
Kikuchi, A.5
-
214
-
-
84861395028
-
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration
-
Zhu Y, Tian Y, Du J, Hu Z, Yang L, Liu J, Gu L. Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PLoS One. 2012; 7:e37823.
-
(2012)
PLoS One
, vol.7
-
-
Zhu, Y.1
Tian, Y.2
Du, J.3
Hu, Z.4
Yang, L.5
Liu, J.6
Gu, L.7
-
215
-
-
33846270032
-
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42
-
Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell. 2007; 128:383-97.
-
(2007)
Cell
, vol.128
, pp. 383-397
-
-
Martin-Belmonte, F.1
Gassama, A.2
Datta, A.3
Yu, W.4
Rescher, U.5
Gerke, V.6
Mostov, K.7
-
216
-
-
0343183328
-
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
-
Liliental J, Moon SY, Lesche R, Mamillapalli R, Li D, Zheng Y, Sun H, Wu H. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10:401-4.
-
(2000)
Curr Biol
, vol.10
, pp. 401-404
-
-
Liliental, J.1
Moon, S.Y.2
Lesche, R.3
Mamillapalli, R.4
Li, D.5
Zheng, Y.6
Sun, H.7
Wu, H.8
-
217
-
-
0033575287
-
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
-
Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem. 1999; 274:20693-703.
-
(1999)
J Biol Chem
, vol.274
, pp. 20693-20703
-
-
Tamura, M.1
Gu, J.2
Danen, E.H.3
Takino, T.4
Miyamoto, S.5
Yamada, K.M.6
-
218
-
-
0031459917
-
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
-
Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise L V. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature. 1997; 390:632-6.
-
(1997)
Nature
, vol.390
, pp. 632-636
-
-
Keely, P.J.1
Westwick, J.K.2
Whitehead, I.P.3
Der, C.J.4
Parise, L.V.5
-
219
-
-
33748199154
-
Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells
-
Gassama-Diagne A, Yu W, ter Beest M, Martin-Belmonte F, Kierbel A, Engel J, Mostov K. Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat Cell Biol. 2006; 8:963-70.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 963-970
-
-
Gassama-Diagne, A.1
Yu, W.2
Ter Beest, M.3
Martin-Belmonte, F.4
Kierbel, A.5
Engel, J.6
Mostov, K.7
-
220
-
-
84860295783
-
Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism
-
Welf ES, Ahmed S, Johnson HE, Melvin AT, Haugh JM. Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism. J Cell Biol. 2012; 197:105-14.
-
(2012)
J Cell Biol
, vol.197
, pp. 105-114
-
-
Welf, E.S.1
Ahmed, S.2
Johnson, H.E.3
Melvin, A.T.4
Haugh, J.M.5
-
221
-
-
0037415640
-
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
-
Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K, Kalman D, Bourne HR. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol. 2003; 160:375-85.
-
(2003)
J Cell Biol
, vol.160
, pp. 375-385
-
-
Srinivasan, S.1
Wang, F.2
Glavas, S.3
Ott, A.4
Hofmann, F.5
Aktories, K.6
Kalman, D.7
Bourne, H.R.8
-
223
-
-
84858001709
-
Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration
-
Majumder P, Aranjuez G, Amick J, McDonald J. Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration. Curr Biol. 2012; 22:363-72.
-
(2012)
Curr Biol
, vol.22
, pp. 363-372
-
-
Majumder, P.1
Aranjuez, G.2
Amick, J.3
McDonald, J.4
-
224
-
-
78650512223
-
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
-
Hidalgo-Carcedo C, Hooper S, Chaudhry SI, Williamson P, Harrington K, Leitinger B, Sahai E. Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol. 2011; 13:49-58.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 49-58
-
-
Hidalgo-Carcedo, C.1
Hooper, S.2
Chaudhry, S.I.3
Williamson, P.4
Harrington, K.5
Leitinger, B.6
Sahai, E.7
-
225
-
-
41549155540
-
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
-
Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR. Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol. 2008; 180:1277-89.
-
(2008)
J Cell Biol
, vol.180
, pp. 1277-1289
-
-
Shintani, Y.1
Fukumoto, Y.2
Chaika, N.3
Svoboda, R.4
Wheelock, M.J.5
Johnson, K.R.6
-
226
-
-
74049086695
-
The Tight Junction Protein , Occludin , Regulates the Directional Migration of Epithelial Cells
-
Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, Huang Q, Zhang F, Bao H, Jia L, Wu X, Zhu X, Zhang X, et al. The Tight Junction Protein , Occludin , Regulates the Directional Migration of Epithelial Cells. Dev Cell. 2010; 18:52-63.
-
(2010)
Dev Cell
, vol.18
, pp. 52-63
-
-
Du, D.1
Xu, F.2
Yu, L.3
Zhang, C.4
Lu, X.5
Yuan, H.6
Huang, Q.7
Zhang, F.8
Bao, H.9
Jia, L.10
Wu, X.11
Zhu, X.12
Zhang, X.13
-
227
-
-
84873410310
-
Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion
-
Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK. Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol. 2013; 15:189-200.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 189-200
-
-
Xue, B.1
Krishnamurthy, K.2
Allred, D.C.3
Muthuswamy, S.K.4
-
228
-
-
84869000970
-
Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis
-
McCaffrey LM, Montalbano J, Mihai C, Macara IG. Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell. 2012; 22:601-14.
-
(2012)
Cancer Cell
, vol.22
, pp. 601-614
-
-
McCaffrey, L.M.1
Montalbano, J.2
Mihai, C.3
Macara, I.G.4
-
229
-
-
84941640699
-
PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion
-
Bonastre E, Verdura S, Zondervan I, Facchinetti F, Lantuejoul S, Chiara MD, Rodrigo JP, Carretero J, Condom E, Vidal A, Sidransky D, Villanueva A, Roz L, et al. PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion. Cancer Res. 2015; 75:1287-97.
-
(2015)
Cancer Res
, vol.75
, pp. 1287-1297
-
-
Bonastre, E.1
Verdura, S.2
Zondervan, I.3
Facchinetti, F.4
Lantuejoul, S.5
Chiara, M.D.6
Rodrigo, J.P.7
Carretero, J.8
Condom, E.9
Vidal, A.10
Sidransky, D.11
Villanueva, A.12
Roz, L.13
-
230
-
-
84966910133
-
Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition
-
Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu H, Gao W. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 2015;
-
(2015)
Oncogene
-
-
Zhang, K.1
Zhao, H.2
Ji, Z.3
Zhang, C.4
Zhou, P.5
Wang, L.6
Chen, Q.7
Wang, J.8
Zhang, P.9
Chen, Z.10
Zhu, H.11
Gao, W.12
-
231
-
-
84896720981
-
Overexpression of the polarity protein PAR3 in clear cell renal cell carcinoma is associated with poor prognosis
-
Dugay F, Goff X. Overexpression of the polarity protein PAR3 in clear cell renal cell carcinoma is associated with poor prognosis. Int J Cancer. 2013; 134:2051-60.
-
(2013)
Int J Cancer
, vol.134
, pp. 2051-2060
-
-
Dugay, F.1
Goff, X.2
-
232
-
-
84878667715
-
Expression of partitioning defective 3 (par-3) for predicting extrahepatic metastasis and survival with hepatocellular carcinoma
-
Jan Y-J, Ko B-S, Liu T-A, Wu Y-M, Liang S-M, Chen S-C, Wang J, Liou J-Y. Expression of partitioning defective 3 (par-3) for predicting extrahepatic metastasis and survival with hepatocellular carcinoma. Int J Mol Sci. 2013; 14:1684-97.
-
(2013)
Int J Mol Sci
, vol.14
, pp. 1684-1697
-
-
Jan, Y.-J.1
Ko, B.-S.2
Liu, T.-A.3
Wu, Y.-M.4
Liang, S.-M.5
Chen, S.-C.6
Wang, J.7
Liou, J.-Y.8
-
233
-
-
49649126819
-
Matrix metalloproteinase-10 is a critical effector of protein kinase C iota-Par6 alpha-mediated lung cancer
-
Frederick L a, Matthews J a, Jamieson L, Justilien V, Thompson E a, Radisky DC, Fields a P. Matrix metalloproteinase-10 is a critical effector of protein kinase C iota-Par6 alpha-mediated lung cancer. Oncogene. 2008; 27:4841-53.
-
(2008)
Oncogene
, vol.27
, pp. 4841-4853
-
-
La, F.1
Ja, M.2
Jamieson, L.3
Justilien, V.4
Thompson, E.A.5
Radisky, D.C.6
Fields, A.P.7
-
234
-
-
84899800579
-
Control of MT1-MMP transport by atypical PKC during breast-cancer progression
-
Rossé C, Lodillinsky C, Fuhrmann L, Nourieh M, Monteiro P, Irondelle M, Lagoutte E, Vacher S, Waharte F, Paul-Gilloteaux P, Romao M, Sengmanivong L, Linch M, et al. Control of MT1-MMP transport by atypical PKC during breast-cancer progression. Proc Natl Acad Sci U S A. 2014; 111:E1872-9.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. E1872-E1879
-
-
Rossé, C.1
Lodillinsky, C.2
Fuhrmann, L.3
Nourieh, M.4
Monteiro, P.5
Irondelle, M.6
Lagoutte, E.7
Vacher, S.8
Waharte, F.9
Paul-Gilloteaux, P.10
Romao, M.11
Sengmanivong, L.12
Linch, M.13
-
235
-
-
78649734292
-
The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation
-
Xiao H, Bai X-H, Kapus A, Lu W-Y, Mak AS, Liu M. The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation. Mol Cell Biol. 2010; 30:5545-61.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5545-5561
-
-
Xiao, H.1
Bai, X.-H.2
Kapus, A.3
Lu, W.-Y.4
Mak, A.S.5
Liu, M.6
-
236
-
-
84898410495
-
Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression
-
Imamura N, Horikoshi Y, Matsuzaki T, Toriumi K, Kitatani K, Ogura G, Masuda R, Nakamura N, Takekoshi S, Iwazaki M. Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression. Tokai J Exp Clin Med. 2013; 38:146-58.
-
(2013)
Tokai J Exp Clin Med
, vol.38
, pp. 146-158
-
-
Imamura, N.1
Horikoshi, Y.2
Matsuzaki, T.3
Toriumi, K.4
Kitatani, K.5
Ogura, G.6
Masuda, R.7
Nakamura, N.8
Takekoshi, S.9
Iwazaki, M.10
-
237
-
-
21044453012
-
Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
-
Schimanski CC, Schmitz G, Kashyap A, Bosserhoff AK, Bataille F, Schafer SC, Lehr HA, Berger MR, Galle PR, Strand S, Strand D. Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. Oncogene. 2005; 24:3100-9.
-
(2005)
Oncogene
, vol.24
, pp. 3100-3109
-
-
Schimanski, C.C.1
Schmitz, G.2
Kashyap, A.3
Bosserhoff, A.K.4
Bataille, F.5
Schafer, S.C.6
Lehr, H.A.7
Berger, M.R.8
Galle, P.R.9
Strand, S.10
Strand, D.11
-
238
-
-
84857132136
-
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
-
Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJP, Kovanen PE, Makela TP, Werb Z, Klefstrom J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A. 2012; 109:E388-97.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E388-E397
-
-
Partanen, J.I.1
Tervonen, T.A.2
Myllynen, M.3
Lind, E.4
Imai, M.5
Katajisto, P.6
Dijkgraaf, G.J.P.7
Kovanen, P.E.8
Makela, T.P.9
Werb, Z.10
Klefstrom, J.11
-
239
-
-
84907915831
-
Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion
-
Li J, Liu J, Li P, Mao X, Li W, Yang J, Liu P. Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion. J Exp Clin Cancer Res. 2014; 33:70.
-
(2014)
J Exp Clin Cancer Res
, vol.33
, pp. 70
-
-
Li, J.1
Liu, J.2
Li, P.3
Mao, X.4
Li, W.5
Yang, J.6
Liu, P.7
-
240
-
-
84880693771
-
LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation
-
Xu X, Jin D, Durgan J, Hall A. LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation. Mol Cell Biol. 2013; 33:2671-82.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 2671-2682
-
-
Xu, X.1
Jin, D.2
Durgan, J.3
Hall, A.4
-
241
-
-
33845332753
-
Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential
-
Zhuang Z-G, Di G-H, Shen Z-Z, Ding J, Shao Z-M. Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential. Mol Cancer Res. 2006; 4:843-9.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 843-849
-
-
Zhuang, Z.-G.1
Di, G.-H.2
Shen, Z.-Z.3
Ding, J.4
Shao, Z.-M.5
-
242
-
-
3042659106
-
KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer
-
Lee JH, Park SR, Chay K-O, Seo Y-W, Kook H, Ahn KY, Kim YJ, Kim KK. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. Cancer Res. 2004; 64:4235-43.
-
(2004)
Cancer Res
, vol.64
, pp. 4235-4243
-
-
Lee, J.H.1
Park, S.R.2
Chay, K.-O.3
Seo, Y.-W.4
Kook, H.5
Ahn, K.Y.6
Kim, Y.J.7
Kim, K.K.8
-
243
-
-
60049091422
-
KITENIN recruits Dishevelled/PKCδ to form a functional complex and controls the migration and invasiveness of colorectal cancer cells
-
Kho DH, Bae JA, Lee JH, Cho HJ, Cho SH, Seo YW, Ahn KY, Chung IJ, Kim KK. KITENIN recruits Dishevelled/PKCδ to form a functional complex and controls the migration and invasiveness of colorectal cancer cells. Gut. 2009; 58:509-19.
-
(2009)
Gut
, vol.58
, pp. 509-519
-
-
Kho, D.H.1
Bae, J.A.2
Lee, J.H.3
Cho, H.J.4
Cho, S.H.5
Seo, Y.W.6
Ahn, K.Y.7
Chung, I.J.8
Kim, K.K.9
-
244
-
-
32944470373
-
A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells
-
Stallings-Mann M, Jamieson L, Regala RP, Weems C, Murray NR, Fields AP. A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Cancer Res. 2006; 66:1767-74.
-
(2006)
Cancer Res
, vol.66
, pp. 1767-1774
-
-
Stallings-Mann, M.1
Jamieson, L.2
Regala, R.P.3
Weems, C.4
Murray, N.R.5
Fields, A.P.6
-
245
-
-
84885390091
-
Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small cell lung cancer, ovarian cancer and pancreatic cancer
-
Mansfield AS, Fields AP, Jatoi A, Qi Y, Adjei AA, Erlichman C, Molina JR. Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small cell lung cancer, ovarian cancer and pancreatic cancer. Anticancer Drugs. 2013; 24:1079.
-
(2013)
Anticancer Drugs
, vol.24
, pp. 1079
-
-
Mansfield, A.S.1
Fields, A.P.2
Jatoi, A.3
Qi, Y.4
Adjei, A.A.5
Erlichman, C.6
Molina, J.R.7
-
246
-
-
84939890096
-
Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells
-
Kyjacova L, Hubackova S, Krejcikova K, Strauss R, Hanzlikova H, Dzijak R, Imrichova T, Simova J, Reinis M, Bartek J, Hodný Z. Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells. Cell Death Differ. 2015; 22:898-911.
-
(2015)
Cell Death Differ
, vol.22
, pp. 898-911
-
-
Kyjacova, L.1
Hubackova, S.2
Krejcikova, K.3
Strauss, R.4
Hanzlikova, H.5
Dzijak, R.6
Imrichova, T.7
Simova, J.8
Reinis, M.9
Bartek, J.10
Hodný, Z.11
-
247
-
-
84949045216
-
En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition
-
Aceto N, Toner M, Maheswaran S, Haber DA. En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition. Trends in Cancer. 2015; 1:44-52.
-
(2015)
Trends in Cancer
, vol.1
, pp. 44-52
-
-
Aceto, N.1
Toner, M.2
Maheswaran, S.3
Haber, D.A.4
-
248
-
-
84884582960
-
Therapeutic targets associated to E-cadherin dysfunction in gastric cancer
-
Carneiro P, Figueiredo J, Bordeira-Carriço R, Fernandes MS, Carvalho J, Oliveira C, Seruca R. Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. Expert Opin Ther Targets. 2013; 17:1187-201.
-
(2013)
Expert Opin Ther Targets
, vol.17
, pp. 1187-1201
-
-
Carneiro, P.1
Figueiredo, J.2
Bordeira-Carriço, R.3
Fernandes, M.S.4
Carvalho, J.5
Oliveira, C.6
Seruca, R.7
-
249
-
-
84885424897
-
Twist: a molecular target in cancer therapeutics
-
Khan MA, Chen H, Zhang D, Fu J. Twist: a molecular target in cancer therapeutics. Tumour Biol. 2013; 34:2497-506.
-
(2013)
Tumour Biol
, vol.34
, pp. 2497-2506
-
-
Khan, M.A.1
Chen, H.2
Zhang, D.3
Fu, J.4
-
250
-
-
34249276569
-
New potential therapeutic targets to combat epithelial tumor invasion
-
Peinado H, Cano a. New potential therapeutic targets to combat epithelial tumor invasion. Clin Transl Oncol. 2006; 8:851-7.
-
(2006)
Clin Transl Oncol
, vol.8
, pp. 851-857
-
-
Peinado, H.1
Cano, A.2
-
251
-
-
84922668738
-
Targeting the TGFβ pathway for cancer therapy
-
Neuzillet C, Tijeras-Raballand A, Cohen R, Cros J, Faivre S, Raymond E, de Gramont A. Targeting the TGFβ pathway for cancer therapy. Pharmacol Ther. 2015; 147:22-31.
-
(2015)
Pharmacol Ther
, vol.147
, pp. 22-31
-
-
Neuzillet, C.1
Tijeras-Raballand, A.2
Cohen, R.3
Cros, J.4
Faivre, S.5
Raymond, E.6
de Gramont, A.7
-
252
-
-
84899881227
-
Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways
-
Pal HC, Sharma S, Strickland LR, Katiyar SK, Ballestas ME, Athar M, Elmets C a, Afaq F. Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways. PLoS One. 2014; 9:e86338.
-
(2014)
PLoS One
, vol.9
-
-
Pal, H.C.1
Sharma, S.2
Strickland, L.R.3
Katiyar, S.K.4
Ballestas, M.E.5
Athar, M.6
Elmets, C.A.7
Afaq, F.8
-
254
-
-
84946818704
-
A novel pharmacologic activity of ketorolac for therapeutic benefit in ovarian cancer patients
-
clincanres - 0461
-
Guo Y, Kenney SR, Cook LS, Adams SF, Rutledge T, Romero E, Oprea T, Sklar LA, Bedrick E, Wiggins CL. A novel pharmacologic activity of ketorolac for therapeutic benefit in ovarian cancer patients. Clin Cancer Res. 2015; clincanres - 0461.
-
(2015)
Clin Cancer Res
-
-
Guo, Y.1
Kenney, S.R.2
Cook, L.S.3
Adams, S.F.4
Rutledge, T.5
Romero, E.6
Oprea, T.7
Sklar, L.A.8
Bedrick, E.9
Wiggins, C.L.10
-
255
-
-
84881481410
-
Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
-
Hadler-Olsen E, Winberg J-O, Uhlin-Hansen L. Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biol. 2013; 34:2041-51.
-
(2013)
Tumour Biol
, vol.34
, pp. 2041-2051
-
-
Hadler-Olsen, E.1
Winberg, J.-O.2
Uhlin-Hansen, L.3
-
256
-
-
84879924314
-
Drugs for solid cancer: The productivity crisis prompts a rethink
-
Rösel D, Brábek J, Veselý P, Fernandes M. Drugs for solid cancer: The productivity crisis prompts a rethink. Onco Targets Ther. 2013; 6:767-77.
-
(2013)
Onco Targets Ther
, vol.6
, pp. 767-777
-
-
Rösel, D.1
Brábek, J.2
Veselý, P.3
Fernandes, M.4
-
257
-
-
84939877182
-
Translation in solid cancer: are size-based response criteria an anachronism?
-
Fernandes M, Rosel D, Brabek J. Translation in solid cancer: are size-based response criteria an anachronism? Clin Transl Oncol. 2015; 17: 1-10.
-
(2015)
Clin Transl Oncol
, vol.17
, pp. 1-10
-
-
Fernandes, M.1
Rosel, D.2
Brabek, J.3
-
258
-
-
84918544201
-
Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma
-
Mao X, Li P, Ren Y, Li J, Zhou C, Yang J, Liu P. Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma. Int J Oncol. 2015; 46:657-66.
-
(2015)
Int J Oncol
, vol.46
, pp. 657-666
-
-
Mao, X.1
Li, P.2
Ren, Y.3
Li, J.4
Zhou, C.5
Yang, J.6
Liu, P.7
-
259
-
-
84913537715
-
Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration
-
ra112
-
Pignatelli J, Goswami S, Jones JG, Rohan TE, Pieri E, Chen X, Adler E, Cox D, Maleki S, Bresnick A, Gertler FB, Condeelis JS, Oktay MH. Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration. Sci Signal. 2014; 7:ra112.
-
(2014)
Sci Signal
, vol.7
-
-
Pignatelli, J.1
Goswami, S.2
Jones, J.G.3
Rohan, T.E.4
Pieri, E.5
Chen, X.6
Adler, E.7
Cox, D.8
Maleki, S.9
Bresnick, A.10
Gertler, F.B.11
Condeelis, J.S.12
Oktay, M.H.13
-
260
-
-
79952392467
-
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
-
Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2011; 17:320-9.
-
(2011)
Nat Med
, vol.17
, pp. 320-329
-
-
Bissell, M.J.1
Hines, W.C.2
-
262
-
-
75749146306
-
Plasticity of cell migration: a multiscale tuning model
-
Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol. 2010; 188:11-9.
-
(2010)
J Cell Biol
, vol.188
, pp. 11-19
-
-
Friedl, P.1
Wolf, K.2
-
263
-
-
84875580811
-
At the leading edge of three-dimensional cell migration
-
Petrie RJ, Yamada KM. At the leading edge of three-dimensional cell migration. J Cell Sci. 2012; 125:5917-26.
-
(2012)
J Cell Sci
, vol.125
, pp. 5917-5926
-
-
Petrie, R.J.1
Yamada, K.M.2
-
264
-
-
84910136913
-
Three-dimensional organotypic culture: experimental models of mammalian biology and disease
-
Shamir ER, Ewald AJ. Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nat Rev Mol Cell Biol. 2014; 15: 647-64.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 647-664
-
-
Shamir, E.R.1
Ewald, A.J.2
|