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Volumn 7, Issue 18, 2016, Pages 25022-25049

Cell polarity signaling in the plasticity of cancer cell invasiveness

Author keywords

AMT; EMT; Invasion; Plasticity; Polarity

Indexed keywords

BETA1 INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UVOMORULIN; VIMENTIN;

EID: 84967000235     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7214     Document Type: Article
Times cited : (108)

References (264)
  • 1
    • 28444472417 scopus 로고    scopus 로고
    • The great escape: when cancer cells hijack the genes for chemotaxis and motility
    • Condeelis J, Singer RH, Segall JE. The great escape: when cancer cells hijack the genes for chemotaxis and motility. Annu Rev Cell Dev Biol. 2005; 21:695-718.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 695-718
    • Condeelis, J.1    Singer, R.H.2    Segall, J.E.3
  • 2
    • 84885352426 scopus 로고    scopus 로고
    • Origins of metastatic traits
    • Vanharanta S, Massagué J. Origins of metastatic traits. Cancer Cell. 2013; 24:410-21.
    • (2013) Cancer Cell , vol.24 , pp. 410-421
    • Vanharanta, S.1    Massagué, J.2
  • 3
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: molecular insights and evolving paradigms
    • Valastyan S, Weinberg R a. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011; 147:275-92.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 4
    • 77951238830 scopus 로고    scopus 로고
    • Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity
    • Nelson WJ. Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol. 2009; 1:1-19.
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , pp. 1-19
    • Nelson, W.J.1
  • 5
    • 0141533034 scopus 로고    scopus 로고
    • Roles of Rho-family GTPases in cell polarisation and directional migration
    • Fukata M, Nakagawa M, Kaibuchi K. Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol. 2003; 15:590-7.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 590-597
    • Fukata, M.1    Nakagawa, M.2    Kaibuchi, K.3
  • 6
    • 84902663108 scopus 로고    scopus 로고
    • Polarised cell migration: intrinsic and extrinsic drivers
    • Woodham EF, Machesky LM. Polarised cell migration: intrinsic and extrinsic drivers. Curr Opin Cell Biol. 2014; 30C: 25-32.
    • (2014) Curr Opin Cell Biol , vol.30C , pp. 25-32
    • Woodham, E.F.1    Machesky, L.M.2
  • 7
    • 80051724097 scopus 로고    scopus 로고
    • Epithelial cell polarity: a major gatekeeper against cancer?
    • Royer C, Lu X. Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ. 2011; 18: 1470-7.
    • (2011) Cell Death Differ , vol.18 , pp. 1470-1477
    • Royer, C.1    Lu, X.2
  • 8
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-Mesenchymal Transitions in Development and Disease
    • Thiery JP, Acloque H, Huang RYJ, Nieto MA. Epithelial-Mesenchymal Transitions in Development and Disease. Cell. 2009; 139:871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 9
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg R. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.2
  • 10
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009; 9:265-73.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 11
    • 1642282882 scopus 로고    scopus 로고
    • Prespecification and plasticity: shifting mechanisms of cell migration
    • Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol. 2004; 16:14-23.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 14-23
    • Friedl, P.1
  • 12
    • 39849100440 scopus 로고    scopus 로고
    • Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
    • Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008; 1778:660-9.
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 660-669
    • Hartsock, A.1    Nelson, W.J.2
  • 13
    • 35348841509 scopus 로고    scopus 로고
    • Tight junctions/adherens junctions: basic structure and function
    • Niessen CM. Tight junctions/adherens junctions: basic structure and function. J Invest Dermatol. 2007; 127:2525-32.
    • (2007) J Invest Dermatol , vol.127 , pp. 2525-2532
    • Niessen, C.M.1
  • 14
    • 0043204760 scopus 로고    scopus 로고
    • Epithelium-the primary building block for metazoan complexity
    • Tyler S. Epithelium-the primary building block for metazoan complexity. Integr Comp Biol. 2003; 43:55-63.
    • (2003) Integr Comp Biol , vol.43 , pp. 55-63
    • Tyler, S.1
  • 15
    • 85019197347 scopus 로고    scopus 로고
    • Rewiring cell polarity signaling in cancer
    • Halaoui R, McCaffrey L. Rewiring cell polarity signaling in cancer. Oncogene. 2014; 1-12.
    • (2014) Oncogene , pp. 1-12
    • Halaoui, R.1    McCaffrey, L.2
  • 16
    • 84910658384 scopus 로고    scopus 로고
    • Cell biology in development: The cell biology of planar cell polarity
    • Devenport D. Cell biology in development: The cell biology of planar cell polarity. J Cell Biol. 2014; 207:171-9.
    • (2014) J Cell Biol , vol.207 , pp. 171-179
    • Devenport, D.1
  • 17
    • 84908192337 scopus 로고    scopus 로고
    • Insight into planar cell polarity
    • Sebbagh M, Borg J-P. Insight into planar cell polarity. Exp Cell Res. 2014; 328:284-95.
    • (2014) Exp Cell Res , vol.328 , pp. 284-295
    • Sebbagh, M.1    Borg, J.-P.2
  • 18
    • 4043170088 scopus 로고    scopus 로고
    • Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors
    • Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 2004; 18:1909-25.
    • (2004) Genes Dev , vol.18 , pp. 1909-1925
    • Bilder, D.1
  • 20
    • 2942729619 scopus 로고    scopus 로고
    • LKB1 tumor suppressor protein: PARtaker in cell polarity
    • Baas AF, Smit L, Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol. 2004; 14:312-9.
    • (2004) Trends Cell Biol , vol.14 , pp. 312-319
    • Baas, A.F.1    Smit, L.2    Clevers, H.3
  • 22
    • 67449114979 scopus 로고    scopus 로고
    • Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells
    • Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S. Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci. 2009; 122:1595-606.
    • (2009) J Cell Sci , vol.122 , pp. 1595-1606
    • Horikoshi, Y.1    Suzuki, A.2    Yamanaka, T.3    Sasaki, K.4    Mizuno, K.5    Sawada, H.6    Yonemura, S.7    Ohno, S.8
  • 23
    • 0034253536 scopus 로고    scopus 로고
    • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    • Joberty G, Petersen C, Gao L, Macara IG. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000; 2:531-9.
    • (2000) Nat Cell Biol , vol.2 , pp. 531-539
    • Joberty, G.1    Petersen, C.2    Gao, L.3    Macara, I.G.4
  • 24
    • 0032487494 scopus 로고    scopus 로고
    • An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3
    • Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T, Tabuse Y, Kemphues KJ, Ohno S. An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3 . J Cell Biol. 1998; 143:95-106.
    • (1998) J Cell Biol , vol.143 , pp. 95-106
    • Izumi, Y.1    Hirose, T.2    Tamai, Y.3    Hirai, S.4    Nagashima, Y.5    Fujimoto, T.6    Tabuse, Y.7    Kemphues, K.J.8    Ohno, S.9
  • 25
    • 0037222950 scopus 로고    scopus 로고
    • Cell polarity: Par6, aPKC and cytoskeletal crosstalk
    • Etienne-Manneville S, Hall A. Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr Opin Cell Biol. 2003; 15:67-72.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 67-72
    • Etienne-Manneville, S.1    Hall, A.2
  • 26
    • 54549104845 scopus 로고    scopus 로고
    • Crosstalk between small GTPases and polarity proteins in cell polarization
    • Iden S, Collard J. Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol cell Biol. 2008; 9:846-59.
    • (2008) Nat Rev Mol cell Biol , vol.9 , pp. 846-859
    • Iden, S.1    Collard, J.2
  • 27
    • 0037434790 scopus 로고    scopus 로고
    • Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
    • Etienne-Manneville S, Hall A. Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature. 2003; 421:753-6.
    • (2003) Nature , vol.421 , pp. 753-756
    • Etienne-Manneville, S.1    Hall, A.2
  • 28
    • 56349123945 scopus 로고    scopus 로고
    • Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts
    • Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell. 2008; 135:948-59.
    • (2008) Cell , vol.135 , pp. 948-959
    • Meng, W.1    Mushika, Y.2    Ichii, T.3    Takeichi, M.4
  • 29
    • 14744289370 scopus 로고    scopus 로고
    • Par-3 controls tight junction assembly through the Rac exchange factor Tiam1
    • Chen X, Macara IG. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol. 2005; 7:262-9.
    • (2005) Nat Cell Biol , vol.7 , pp. 262-269
    • Chen, X.1    Macara, I.G.2
  • 30
    • 0042090214 scopus 로고    scopus 로고
    • Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
    • Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene. 2003; 22:4752-6.
    • (2003) Oncogene , vol.22 , pp. 4752-4756
    • Spicer, J.1    Rayter, S.2    Young, N.3    Elliott, R.4    Ashworth, A.5    Smith, D.6
  • 31
    • 33846448743 scopus 로고    scopus 로고
    • Activation of PAR-1 Kinase and Stimulation of Tau Phosphorylation by Diverse Signals Require the Tumor Suppressor Protein LKB1
    • Wang J-W, Imai Y, Lu B. Activation of PAR-1 Kinase and Stimulation of Tau Phosphorylation by Diverse Signals Require the Tumor Suppressor Protein LKB1. J Neurosci. 2007; 27 : 574-81.
    • (2007) J Neurosci , vol.27 , pp. 574-581
    • Wang, J.-W.1    Imai, Y.2    Lu, B.3
  • 32
    • 84907870409 scopus 로고    scopus 로고
    • Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function
    • Gan R-Y, Li H-B. Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function. Int J Mol Sci. 2014; 15:16698-718.
    • (2014) Int J Mol Sci , vol.15 , pp. 16698-16718
    • Gan, R.-Y.1    Li, H.-B.2
  • 34
    • 3042649049 scopus 로고    scopus 로고
    • LKB1 kinase: master and commander of metabolism and polarity
    • Spicer J, Ashworth A. LKB1 kinase: master and commander of metabolism and polarity. Curr Biol. 2004; 14:R383-5.
    • (2004) Curr Biol , vol.14 , pp. R383-R385
    • Spicer, J.1    Ashworth, A.2
  • 35
    • 0037178864 scopus 로고    scopus 로고
    • The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions
    • Roh MH, Liu C-J, Laurinec S, Margolis B. The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. J Biol Chem. 2002; 277:27501-9.
    • (2002) J Biol Chem , vol.277 , pp. 27501-27509
    • Roh, M.H.1    Liu, C.-J.2    Laurinec, S.3    Margolis, B.4
  • 36
    • 1642464585 scopus 로고    scopus 로고
    • Loss of PALS1 expression leads to tight junction and polarity defects
    • Straight S, Shin K, Fogg V. Loss of PALS1 expression leads to tight junction and polarity defects. Mol Biol Cell. 2004; 15:1981-90.
    • (2004) Mol Biol Cell , vol.15 , pp. 1981-1990
    • Straight, S.1    Shin, K.2    Fogg, V.3
  • 37
    • 0037319350 scopus 로고    scopus 로고
    • Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
    • Hurd TW, Gao L, Roh MH, Macara IG, Margolis B. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol. 2003; 5:137-42.
    • (2003) Nat Cell Biol , vol.5 , pp. 137-142
    • Hurd, T.W.1    Gao, L.2    Roh, M.H.3    Macara, I.G.4    Margolis, B.5
  • 38
    • 84905473528 scopus 로고    scopus 로고
    • Establishment of epithelial polarity - GEF who's minding the GAP?
    • Ngok SP, Lin W-H, Anastasiadis PZ. Establishment of epithelial polarity - GEF who's minding the GAP? J Cell Sci. 2014; 127: 3205-15.
    • (2014) J Cell Sci , vol.127 , pp. 3205-3215
    • Ngok, S.P.1    Lin, W.-H.2    Anastasiadis, P.Z.3
  • 40
    • 24944577909 scopus 로고    scopus 로고
    • Cdc42 and Par6-PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
    • Etienne-Manneville S, Manneville J, Nicholls S, Ferenczi MA, Hall A. Cdc42 and Par6-PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization. J Cell Biol. 2005; 170:895-901.
    • (2005) J Cell Biol , vol.170 , pp. 895-901
    • Etienne-Manneville, S.1    Manneville, J.2    Nicholls, S.3    Ferenczi, M.A.4    Hall, A.5
  • 41
    • 84862529698 scopus 로고    scopus 로고
    • A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains
    • Sotelo NS, Valiente M, Gil A, Pulido R. A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains. J Cell Biochem. 2012; 113:2661-70.
    • (2012) J Cell Biochem , vol.113 , pp. 2661-2670
    • Sotelo, N.S.1    Valiente, M.2    Gil, A.3    Pulido, R.4
  • 42
    • 84867058207 scopus 로고    scopus 로고
    • Regulation of the DLG tumor suppressor by β-catenin
    • Subbaiah VK, Narayan N, Massimi P, Banks L. Regulation of the DLG tumor suppressor by β-catenin. Int J Cancer. 2012; 131:2223-33.
    • (2012) Int J Cancer , vol.131 , pp. 2223-2233
    • Subbaiah, V.K.1    Narayan, N.2    Massimi, P.3    Banks, L.4
  • 43
    • 29144469472 scopus 로고    scopus 로고
    • The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
    • Qin Y, Capaldo C, Gumbiner BM, Macara IG. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J Cell Biol. 2005; 171:1061-71.
    • (2005) J Cell Biol , vol.171 , pp. 1061-1071
    • Qin, Y.1    Capaldo, C.2    Gumbiner, B.M.3    Macara, I.G.4
  • 44
    • 83155181734 scopus 로고    scopus 로고
    • Wnt5a: its signalling, functions and implication in diseases
    • Kikuchi A, Yamamoto H, Sato A, Matsumoto S. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol. 2012; 204:17-33.
    • (2012) Acta Physiol , vol.204 , pp. 17-33
    • Kikuchi, A.1    Yamamoto, H.2    Sato, A.3    Matsumoto, S.4
  • 46
    • 85027933832 scopus 로고    scopus 로고
    • Pointing in the right direction: new developments in the field of planar cell polarity
    • Bayly R, Axelrod JD. Pointing in the right direction: new developments in the field of planar cell polarity. Nat Rev Genet. 2011; 12:385-91.
    • (2011) Nat Rev Genet , vol.12 , pp. 385-391
    • Bayly, R.1    Axelrod, J.D.2
  • 47
    • 34547604466 scopus 로고    scopus 로고
    • Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity
    • Schlessinger K, McManus EJ, Hall A. Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. J Cell Biol. 2007; 178:355-61.
    • (2007) J Cell Biol , vol.178 , pp. 355-361
    • Schlessinger, K.1    McManus, E.J.2    Hall, A.3
  • 49
    • 0344663968 scopus 로고    scopus 로고
    • Phosphorylation-Dependent Binding of 14-3-3 to the Polarity Protein Par3 Regulates Cell Polarity in Mammalian Epithelia
    • Hurd TW, Fan S, Liu CJ, Kweon HK, Hakansson K, Margolis B. Phosphorylation-Dependent Binding of 14-3-3 to the Polarity Protein Par3 Regulates Cell Polarity in Mammalian Epithelia. Curr Biol. 2003; 13:2082-90.
    • (2003) Curr Biol , vol.13 , pp. 2082-2090
    • Hurd, T.W.1    Fan, S.2    Liu, C.J.3    Kweon, H.K.4    Hakansson, K.5    Margolis, B.6
  • 50
    • 4143119015 scopus 로고    scopus 로고
    • DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    • Sotillos S, Díaz-Meco M. DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol. 2004; 166:549-57.
    • (2004) J Cell Biol , vol.166 , pp. 549-557
    • Sotillos, S.1    Díaz-Meco, M.2
  • 51
    • 19944372081 scopus 로고    scopus 로고
    • Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development
    • Ossipova O, Dhawan S, Sokol S, Green JBA. Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev Cell. 2005; 8:829-41.
    • (2005) Dev Cell , vol.8 , pp. 829-841
    • Ossipova, O.1    Dhawan, S.2    Sokol, S.3    Green, J.B.A.4
  • 53
    • 58149185543 scopus 로고    scopus 로고
    • Planar cell polarity signaling: from fly development to human disease
    • Simons M, Mlodzik M. Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet. 2008; 42:517.
    • (2008) Annu Rev Genet , vol.42 , pp. 517
    • Simons, M.1    Mlodzik, M.2
  • 54
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014; 15:178-96.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 55
    • 35548974844 scopus 로고    scopus 로고
    • The transcription factor ZEB1 ( δ EF1 ) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    • Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M. The transcription factor ZEB1 ( δ EF1 ) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene. 2010; 26:6979-88.
    • (2010) Oncogene , vol.26 , pp. 6979-6988
    • Aigner, K.1    Dampier, B.2    Descovich, L.3    Mikula, M.4    Sultan, A.5    Schreiber, M.6
  • 57
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani S, Donaher J. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 2004; 117:927-39.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.2    Donaher, J.3
  • 58
    • 0028058712 scopus 로고
    • Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer
    • Umbas R, Isaacs W, Bringuier P. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res. 1994; 54:3929-33.
    • (1994) Cancer Res , vol.54 , pp. 3929-3933
    • Umbas, R.1    Isaacs, W.2    Bringuier, P.3
  • 59
    • 45549105086 scopus 로고    scopus 로고
    • The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes
    • Whiteman EL, Liu C-J, Fearon ER, Margolis B. The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes. Oncogene. 2008; 27:3875-9.
    • (2008) Oncogene , vol.27 , pp. 3875-3879
    • Whiteman, E.L.1    Liu, C.-J.2    Fearon, E.R.3    Margolis, B.4
  • 61
    • 84905568827 scopus 로고    scopus 로고
    • An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential
    • Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Mol Cell. 2014; 55:436-50.
    • (2014) Mol Cell , vol.55 , pp. 436-450
    • Goodwin, J.M.1    Svensson, R.U.2    Lou, H.J.3    Winslow, M.M.4    Turk, B.E.5    Shaw, R.J.6
  • 62
    • 39149135251 scopus 로고    scopus 로고
    • Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells
    • Wang X, Nie J, Zhou Q, Liu W, Zhu F, Chen W, Mao H, Luo N, Dong X, Yu X. Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells. Biochim Biophys Acta. 2008; 1782:51-9.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 51-59
    • Wang, X.1    Nie, J.2    Zhou, Q.3    Liu, W.4    Zhu, F.5    Chen, W.6    Mao, H.7    Luo, N.8    Dong, X.9    Yu, X.10
  • 63
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • Ozdamar B, Bose R, Barrios-Rodiles M, Wang H-R, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science. 2005; 307:1603-9.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.-R.4    Zhang, Y.5    Wrana, J.L.6
  • 64
    • 77954256913 scopus 로고    scopus 로고
    • TGF-beta signaling specifies axons during brain development
    • Yi JJ, Barnes AP, Hand R, Polleux F, Michael D. TGF-beta signaling specifies axons during brain development. Cell. 2010; 142:144-57.
    • (2010) Cell , vol.142 , pp. 144-157
    • Yi, J.J.1    Barnes, A.P.2    Hand, R.3    Polleux, F.4    Michael, D.5
  • 65
    • 84883359231 scopus 로고    scopus 로고
    • Par6 is phosphorylated by aPKC to facilitate EMT
    • Gunaratne A, Di Guglielmo GM. Par6 is phosphorylated by aPKC to facilitate EMT. Cell Adh Migr. 2013; 7:357-61.
    • (2013) Cell Adh Migr , vol.7 , pp. 357-361
    • Gunaratne, A.1    Di Guglielmo, G.M.2
  • 67
    • 65249103982 scopus 로고    scopus 로고
    • Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway
    • Shin S-Y, Rath O, Choo S-M, Fee F, McFerran B, Kolch W, Cho K-H. Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J Cell Sci. 2009; 122:425-35.
    • (2009) J Cell Sci , vol.122 , pp. 425-435
    • Shin, S.-Y.1    Rath, O.2    Choo, S.-M.3    Fee, F.4    McFerran, B.5    Kolch, W.6    Cho, K.-H.7
  • 68
    • 84884723730 scopus 로고    scopus 로고
    • ERK and RSK regulate distinct steps of a cellular program that induces transition from multicellular epithelium to single cell phenotype
    • Čáslavský J, Klímová Z, Vomastek T. ERK and RSK regulate distinct steps of a cellular program that induces transition from multicellular epithelium to single cell phenotype. Cell Signal. 2013; 25:2743-51.
    • (2013) Cell Signal , vol.25 , pp. 2743-2751
    • Čáslavský, J.1    Klímová, Z.2    Vomastek, T.3
  • 72
    • 70350452554 scopus 로고    scopus 로고
    • New evidence for tumour embolism as a mode of metastasis
    • Hart IR. New evidence for tumour embolism as a mode of metastasis. J Pathol. 2009; 219:275-6.
    • (2009) J Pathol , vol.219 , pp. 275-276
    • Hart, I.R.1
  • 73
    • 0032831099 scopus 로고    scopus 로고
    • Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets
    • Nabeshima K, Inoue T, Shimao Y, Kataoka H, Koono M. Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets. Histol Histopathol. 1999; 14:1183-97.
    • (1999) Histol Histopathol , vol.14 , pp. 1183-1197
    • Nabeshima, K.1    Inoue, T.2    Shimao, Y.3    Kataoka, H.4    Koono, M.5
  • 76
    • 0034234278 scopus 로고    scopus 로고
    • Front-Cell-specific Expression of Membrane-Type 1 Matrix Metalloproteinase and Gelatinase A during Cohort Migration of Colon Carcinoma Cells Induced by Hepatocyte Growth Factor/Scatter Factor
    • Nabeshima K, Inoue T, Shimao Y, Okada Y, Itoh Y, Seiki M, Koono M. Front-Cell-specific Expression of Membrane-Type 1 Matrix Metalloproteinase and Gelatinase A during Cohort Migration of Colon Carcinoma Cells Induced by Hepatocyte Growth Factor/Scatter Factor. Cancer Res. 2000; 60 : 3364-9.
    • (2000) Cancer Res , vol.60 , pp. 3364-3369
    • Nabeshima, K.1    Inoue, T.2    Shimao, Y.3    Okada, Y.4    Itoh, Y.5    Seiki, M.6    Koono, M.7
  • 77
    • 84895466196 scopus 로고    scopus 로고
    • Rho-directed forces in collective migration
    • Friedl P, Wolf K, Zegers MM. Rho-directed forces in collective migration. Nat Cell Biol. 2014; 16:208-10.
    • (2014) Nat Cell Biol , vol.16 , pp. 208-210
    • Friedl, P.1    Wolf, K.2    Zegers, M.M.3
  • 78
    • 84923817507 scopus 로고    scopus 로고
    • Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K
    • Yamaguchi N, Mizutani T, Kawabata K, Haga H. Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K. Sci Rep. 2015; 5:7656.
    • (2015) Sci Rep , vol.5 , pp. 7656
    • Yamaguchi, N.1    Mizutani, T.2    Kawabata, K.3    Haga, H.4
  • 79
    • 84857345144 scopus 로고    scopus 로고
    • Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions
    • Omelchenko T, Hall A. Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Curr Biol. 2012; 22:278-88.
    • (2012) Curr Biol , vol.22 , pp. 278-288
    • Omelchenko, T.1    Hall, A.2
  • 82
    • 77953539835 scopus 로고    scopus 로고
    • Keeping in touch with contact inhibition of locomotion
    • Mayor R, Carmona-Fontaine C. Keeping in touch with contact inhibition of locomotion. Trends Cell Biol. 2010; 20:319-28.
    • (2010) Trends Cell Biol , vol.20 , pp. 319-328
    • Mayor, R.1    Carmona-Fontaine, C.2
  • 84
    • 14044271408 scopus 로고    scopus 로고
    • Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement
    • Farooqui R, Fenteany G. Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement. J Cell Sci. 2005; 118:51-63.
    • (2005) J Cell Sci , vol.118 , pp. 51-63
    • Farooqui, R.1    Fenteany, G.2
  • 85
    • 84940467386 scopus 로고    scopus 로고
    • Collective cell migration: guidance principles and hierarchies
    • Haeger A, Wolf K, Zegers MM, Friedl P. Collective cell migration: guidance principles and hierarchies. Trends Cell Biol. 2015; 25:556-66.
    • (2015) Trends Cell Biol , vol.25 , pp. 556-566
    • Haeger, A.1    Wolf, K.2    Zegers, M.M.3    Friedl, P.4
  • 86
    • 36749013537 scopus 로고    scopus 로고
    • Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    • Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol. 2007; 9:1392-400.
    • (2007) Nat Cell Biol , vol.9 , pp. 1392-1400
    • Gaggioli, C.1    Hooper, S.2    Hidalgo-Carcedo, C.3    Grosse, R.4    Marshall, J.F.5    Harrington, K.6    Sahai, E.7
  • 89
    • 77956064817 scopus 로고    scopus 로고
    • Cell adhesion: integrating cytoskeletal dynamics and cellular tension
    • Parsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol cell Biol. 2010; 11:633-43.
    • (2010) Nat Rev Mol cell Biol , vol.11 , pp. 633-643
    • Parsons, J.T.1    Horwitz, A.R.2    Schwartz, M.A.3
  • 90
    • 84885654506 scopus 로고    scopus 로고
    • Actin stress fibre subtypes in mesenchymal-migrating cells
    • Vallenius T. Actin stress fibre subtypes in mesenchymal-migrating cells. Open Biol. 2013; 3:130001.
    • (2013) Open Biol , vol.3
    • Vallenius, T.1
  • 92
    • 36849058617 scopus 로고    scopus 로고
    • RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility
    • Vomastek T, Iwanicki MP, Schaeffer H-J, Tarcsafalvi A, Parsons JT, Weber MJ. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol. 2007; 27:8296-305.
    • (2007) Mol Cell Biol , vol.27 , pp. 8296-8305
    • Vomastek, T.1    Iwanicki, M.P.2    Schaeffer, H.-J.3    Tarcsafalvi, A.4    Parsons, J.T.5    Weber, M.J.6
  • 93
    • 0029995797 scopus 로고    scopus 로고
    • Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
    • Chrzanowska-Wodnicka M, Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol. 1996; 133:1403-15.
    • (1996) J Cell Biol , vol.133 , pp. 1403-1415
    • Chrzanowska-Wodnicka, M.1    Burridge, K.2
  • 95
    • 80054031825 scopus 로고    scopus 로고
    • Degrading devices: invadosomes in proteolytic cell invasion
    • Linder S, Wiesner C, Himmel M. Degrading devices: invadosomes in proteolytic cell invasion. Annu Rev Cell Dev Biol. 2011; 27:185-211.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 185-211
    • Linder, S.1    Wiesner, C.2    Himmel, M.3
  • 96
    • 84920611863 scopus 로고    scopus 로고
    • Digging a little deeper: the stages of invadopodium formation and maturation
    • Beaty BT, Condeelis J. Digging a little deeper: the stages of invadopodium formation and maturation. Eur J Cell Biol. 2014; 93:438-44.
    • (2014) Eur J Cell Biol , vol.93 , pp. 438-444
    • Beaty, B.T.1    Condeelis, J.2
  • 97
    • 33645507413 scopus 로고    scopus 로고
    • Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function
    • Artym V V, Zhang Y, Seillier-Moiseiwitsch F, Yamada KM, Mueller SC. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res. 2006; 66:3034-43.
    • (2006) Cancer Res , vol.66 , pp. 3034-3043
    • Artym, V.V.1    Zhang, Y.2    Seillier-Moiseiwitsch, F.3    Yamada, K.M.4    Mueller, S.C.5
  • 101
    • 54749146365 scopus 로고    scopus 로고
    • Tube travel: the role of proteases in individual and collective cancer cell invasion
    • Friedl P, Wolf K. Tube travel: the role of proteases in individual and collective cancer cell invasion. Cancer Res. 2008; 68:7247-9.
    • (2008) Cancer Res , vol.68 , pp. 7247-7249
    • Friedl, P.1    Wolf, K.2
  • 103
    • 18844421896 scopus 로고    scopus 로고
    • Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis
    • Poola I, DeWitty RL, Marshalleck JJ, Bhatnagar R, Abraham J, Leffall LD. Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis. Nat Med. 2005; 11:481-3.
    • (2005) Nat Med , vol.11 , pp. 481-483
    • Poola, I.1    DeWitty, R.L.2    Marshalleck, J.J.3    Bhatnagar, R.4    Abraham, J.5    Leffall, L.D.6
  • 104
    • 79961208848 scopus 로고    scopus 로고
    • Initial steps of metastasis: cell invasion and endothelial transmigration
    • Zijl F Van, Krupitza G, Mikulits W. Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res Mutat. 2011; 728:23-34.
    • (2011) Mutat Res Mutat , vol.728 , pp. 23-34
    • Van, Z.F.1    Krupitza, G.2    Mikulits, W.3
  • 106
    • 80053339433 scopus 로고    scopus 로고
    • Orientation and function of the nuclear-centrosomal axis during cell migration
    • Luxton GWG, Gundersen GG. Orientation and function of the nuclear-centrosomal axis during cell migration. Curr Opin Cell Biol. 2011; 23:579-88.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 579-588
    • Luxton, G.W.G.1    Gundersen, G.G.2
  • 107
    • 84897533668 scopus 로고    scopus 로고
    • Emerging role for nuclear rotation and orientation in cell migration
    • Maninova M, Iwanicki MP, Vomastek T. Emerging role for nuclear rotation and orientation in cell migration. Cell Adh Migr. 2014; 8:42-8.
    • (2014) Cell Adh Migr , vol.8 , pp. 42-48
    • Maninova, M.1    Iwanicki, M.P.2    Vomastek, T.3
  • 108
    • 2342432240 scopus 로고    scopus 로고
    • Cdc42-the centre of polarity
    • Etienne-Manneville S. Cdc42-the centre of polarity. J Cell Sci. 2004; 117:1291-300.
    • (2004) J Cell Sci , vol.117 , pp. 1291-1300
    • Etienne-Manneville, S.1
  • 109
    • 84877692922 scopus 로고    scopus 로고
    • The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts
    • Maninová M, Klímová Z, Parsons JT, Weber MJ, Iwanicki MP, Vomastek T. The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts. J Mol Biol. 2013; 425:2039-55.
    • (2013) J Mol Biol , vol.425 , pp. 2039-2055
    • Maninová, M.1    Klímová, Z.2    Parsons, J.T.3    Weber, M.J.4    Iwanicki, M.P.5    Vomastek, T.6
  • 110
    • 38749118958 scopus 로고    scopus 로고
    • LARG and mDia1 link Gα12/13 to cell polarity and microtubule dynamics
    • Goulimari P, Knieling H, Engel U, Grosse R. LARG and mDia1 link Gα12/13 to cell polarity and microtubule dynamics. Mol Biol Cell. 2008; 19:30-40.
    • (2008) Mol Biol Cell , vol.19 , pp. 30-40
    • Goulimari, P.1    Knieling, H.2    Engel, U.3    Grosse, R.4
  • 112
  • 115
    • 33750948427 scopus 로고    scopus 로고
    • Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis
    • Mouneimne G, DesMarais V, Sidani M, Scemes E, Wang W, Song X, Eddy R, Condeelis J. Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis. Curr Biol. 2006; 16:2193-205.
    • (2006) Curr Biol , vol.16 , pp. 2193-2205
    • Mouneimne, G.1    DesMarais, V.2    Sidani, M.3    Scemes, E.4    Wang, W.5    Song, X.6    Eddy, R.7    Condeelis, J.8
  • 117
    • 0031456065 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
    • Shaw LM, Rabinovitz I, Wang HH, Toker a, Mercurio a M. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell. 1997; 91:949-60.
    • (1997) Cell , vol.91 , pp. 949-960
    • Shaw, L.M.1    Rabinovitz, I.2    Wang, H.H.3    Toker, A.4    Mercurio, A.M.5
  • 118
    • 0034306279 scopus 로고    scopus 로고
    • Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components
    • Fleming IN, Gray A, Downes CP. Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J. 2000; 351:173.
    • (2000) Biochem J , vol.351 , pp. 173
    • Fleming, I.N.1    Gray, A.2    Downes, C.P.3
  • 121
    • 77956459044 scopus 로고    scopus 로고
    • Rac and Rho GTPases in cancer cell motility control
    • Parri M, Chiarugi P. Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal. 2010; 8:23.
    • (2010) Cell Commun Signal , vol.8 , pp. 23
    • Parri, M.1    Chiarugi, P.2
  • 123
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of Cancer : The Next Generation
    • Hanahan D, Weinberg RA. Hallmarks of Cancer : The Next Generation. Cell. 2011; 144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 129
    • 36248969983 scopus 로고    scopus 로고
    • Actin stress fibres
    • Pellegrin S, Mellor H. Actin stress fibres. J Cell Sci. 2007; 120:3491-9.
    • (2007) J Cell Sci , vol.120 , pp. 3491-3499
    • Pellegrin, S.1    Mellor, H.2
  • 130
    • 79955516270 scopus 로고    scopus 로고
    • Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells
    • Vicente-Manzanares M, Newell-Litwa K, Bachir AI, Whitmore L a, Horwitz AR. Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol. 2011; 193:381-96.
    • (2011) J Cell Biol , vol.193 , pp. 381-396
    • Vicente-Manzanares, M.1    Newell-Litwa, K.2    Bachir, A.I.3    Whitmore, L.A.4    Horwitz, A.R.5
  • 133
    • 33646197411 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of RhoA activity in migrating cells
    • Pertz O, Hodgson L, Klemke RL, Hahn KM. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 2006; 440:1069-72.
    • (2006) Nature , vol.440 , pp. 1069-1072
    • Pertz, O.1    Hodgson, L.2    Klemke, R.L.3    Hahn, K.M.4
  • 136
    • 24344482090 scopus 로고    scopus 로고
    • Localized RhoA activation as a requirement for the induction of membrane ruffling
    • Kurokawa K, Matsuda M. Localized RhoA activation as a requirement for the induction of membrane ruffling. Mol Biol Cell. 2005; 16:4294-303.
    • (2005) Mol Biol Cell , vol.16 , pp. 4294-4303
    • Kurokawa, K.1    Matsuda, M.2
  • 138
    • 79955425392 scopus 로고    scopus 로고
    • A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia
    • Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, Condeelis J. A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol. 2011; 21:635-44.
    • (2011) Curr Biol , vol.21 , pp. 635-644
    • Bravo-Cordero, J.J.1    Oser, M.2    Chen, X.3    Eddy, R.4    Hodgson, L.5    Condeelis, J.6
  • 141
    • 70349314647 scopus 로고    scopus 로고
    • Mechanical modes of "amoeboid" cell migration
    • Lämmermann T, Sixt M. Mechanical modes of "amoeboid" cell migration. Curr Opin Cell Biol. 2009; 21:636-44.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 636-644
    • Lämmermann, T.1    Sixt, M.2
  • 142
    • 50149095564 scopus 로고    scopus 로고
    • Blebs lead the way: how to migrate without lamellipodia
    • Charras G, Paluch E. Blebs lead the way: how to migrate without lamellipodia. Nat Rev Mol Cell Biol. 2008; 9:730-6.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 730-736
    • Charras, G.1    Paluch, E.2
  • 143
    • 0042354574 scopus 로고    scopus 로고
    • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    • Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol. 2003; 5:711-9.
    • (2003) Nat Cell Biol , vol.5 , pp. 711-719
    • Sahai, E.1    Marshall, C.J.2
  • 144
    • 50649115103 scopus 로고    scopus 로고
    • Imaging amoeboid cancer cell motility in vivo
    • Pinner S, Sahai E. Imaging amoeboid cancer cell motility in vivo. J Microsc. 2008; 231:441-5.
    • (2008) J Microsc , vol.231 , pp. 441-445
    • Pinner, S.1    Sahai, E.2
  • 148
    • 14744304060 scopus 로고    scopus 로고
    • Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
    • Wilkinson S, Paterson HF, Marshall CJ. Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol. 2005; 7:255-61.
    • (2005) Nat Cell Biol , vol.7 , pp. 255-261
    • Wilkinson, S.1    Paterson, H.F.2    Marshall, C.J.3
  • 149
    • 33746562929 scopus 로고    scopus 로고
    • ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo
    • Wyckoff JB, Pinner SE, Gschmeissner S, Condeelis JS, Sahai E. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol. 2006; 16:1515-23.
    • (2006) Curr Biol , vol.16 , pp. 1515-1523
    • Wyckoff, J.B.1    Pinner, S.E.2    Gschmeissner, S.3    Condeelis, J.S.4    Sahai, E.5
  • 151
    • 77951587879 scopus 로고    scopus 로고
    • Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
    • Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. Oncogene. 2010; 29:2441-8.
    • (2010) Oncogene , vol.29 , pp. 2441-2448
    • Kitzing, T.M.1    Wang, Y.2    Pertz, O.3    Copeland, J.W.4    Grosse, R.5
  • 152
    • 0033605738 scopus 로고    scopus 로고
    • Inhibition of myosin light chain kinase by p21-activated kinase
    • Sanders L, Matsumura F, Bokoch G, Lanerolle P De. Inhibition of myosin light chain kinase by p21-activated kinase. Science. 1999; 283:2083-5.
    • (1999) Science , vol.283 , pp. 2083-2085
    • Sanders, L.1    Matsumura, F.2    Bokoch, G.3    De, L.P.4
  • 153
    • 53249143863 scopus 로고    scopus 로고
    • DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells
    • Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol. 2008; 18:1456-65.
    • (2008) Curr Biol , vol.18 , pp. 1456-1465
    • Gadea, G.1    Sanz-Moreno, V.2    Self, A.3    Godi, A.4    Marshall, C.J.5
  • 154
    • 0037205265 scopus 로고    scopus 로고
    • Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
    • Funamoto S, Meili R, Lee S, Parry L, Firtel R. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell. 2002; 109:611-23.
    • (2002) Cell , vol.109 , pp. 611-623
    • Funamoto, S.1    Meili, R.2    Lee, S.3    Parry, L.4    Firtel, R.5
  • 155
    • 67649464358 scopus 로고    scopus 로고
    • PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells
    • Pramanik MK, Iijima M, Iwadate Y, Yumura S. PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells. Genes Cells. 2009; 14:821-34.
    • (2009) Genes Cells , vol.14 , pp. 821-834
    • Pramanik, M.K.1    Iijima, M.2    Iwadate, Y.3    Yumura, S.4
  • 156
    • 8444221934 scopus 로고    scopus 로고
    • Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
    • Sasaki AT, Chun C, Takeda K, Firtel R a. Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol. 2004; 167:505-18.
    • (2004) J Cell Biol , vol.167 , pp. 505-518
    • Sasaki, A.T.1    Chun, C.2    Takeda, K.3    Firtel, R.A.4
  • 157
    • 84905278337 scopus 로고    scopus 로고
    • Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells
    • Falke JJ, Ziemba BP. Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells. Chem Phys Lipids. 2014; 182:73-9.
    • (2014) Chem Phys Lipids , vol.182 , pp. 73-79
    • Falke, J.J.1    Ziemba, B.P.2
  • 158
    • 79953156598 scopus 로고    scopus 로고
    • An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells
    • Lorentzen A, Bamber J, Sadok A, Elson-Schwab I, Marshall CJ. An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells. J Cell Sci. 2011; 124:1256-67.
    • (2011) J Cell Sci , vol.124 , pp. 1256-1267
    • Lorentzen, A.1    Bamber, J.2    Sadok, A.3    Elson-Schwab, I.4    Marshall, C.J.5
  • 159
    • 84865957893 scopus 로고    scopus 로고
    • Cell mechanics control rapid transitions between blebs and lamellipodia during migration
    • Bergert M, Chandradoss SD, Desai R a, Paluch E. Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Proc Natl Acad Sci U S A. 2012; 109:14434-9.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 14434-14439
    • Bergert, M.1    Chandradoss, S.D.2    Desai, R.A.3    Paluch, E.4
  • 161
    • 84918507471 scopus 로고    scopus 로고
    • The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes
    • Crespo CL, Vernieri C, Keller PJ, Garre M, Bender JR, Wittbrodt J, Pardi R. The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes. J Cell Sci. 2014; 127:4381-95.
    • (2014) J Cell Sci , vol.127 , pp. 4381-4395
    • Crespo, C.L.1    Vernieri, C.2    Keller, P.J.3    Garre, M.4    Bender, J.R.5    Wittbrodt, J.6    Pardi, R.7
  • 162
    • 73749086570 scopus 로고    scopus 로고
    • The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
    • Panková K, Rösel D, Novotný M, Brábek J. The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci. 2010; 67:63-71.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 63-71
    • Panková, K.1    Rösel, D.2    Novotný, M.3    Brábek, J.4
  • 163
    • 84923382712 scopus 로고    scopus 로고
    • The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition
    • Huang B, Lu M, Jolly MK, Tsarfaty I, Onuchic J, Ben-Jacob E. The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition. Sci Rep. 2014; 4:6449.
    • (2014) Sci Rep , vol.4 , pp. 6449
    • Huang, B.1    Lu, M.2    Jolly, M.K.3    Tsarfaty, I.4    Onuchic, J.5    Ben-Jacob, E.6
  • 164
    • 77956472212 scopus 로고    scopus 로고
    • The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
    • Brábek J, Mierke CT, Rösel D, Veselý P, Fabry B. The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal. 2010; 8:22.
    • (2010) Cell Commun Signal , vol.8 , pp. 22
    • Brábek, J.1    Mierke, C.T.2    Rösel, D.3    Veselý, P.4    Fabry, B.5
  • 165
    • 0025886995 scopus 로고
    • Mathematical model for the effects of adhesion and mechanics on cell migration speed
    • DiMilla P, Barbee K, Lauffenburger D. Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys J. 1991; 60:15-37.
    • (1991) Biophys J , vol.60 , pp. 15-37
    • DiMilla, P.1    Barbee, K.2    Lauffenburger, D.3
  • 166
    • 58149332179 scopus 로고    scopus 로고
    • Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization
    • Provenzano PP, Inman DR, Eliceiri KW, Trier SM, Keely PJ. Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J. 2008; 95:5374-84.
    • (2008) Biophys J , vol.95 , pp. 5374-5384
    • Provenzano, P.P.1    Inman, D.R.2    Eliceiri, K.W.3    Trier, S.M.4    Keely, P.J.5
  • 167
    • 76249088362 scopus 로고    scopus 로고
    • Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures
    • Van Goethem E, Poincloux R, Gauffre F, Maridonneau-Parini I, Le Cabec V. Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures. J Immunol. 2010; 184:1049-61.
    • (2010) J Immunol , vol.184 , pp. 1049-1061
    • Van Goethem, E.1    Poincloux, R.2    Gauffre, F.3    Maridonneau-Parini, I.4    Le Cabec, V.5
  • 169
    • 33846014269 scopus 로고    scopus 로고
    • Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility
    • Sahai E, Garcia-Medina R, Pouysségur J, Vial E. Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol. 2007; 176:35-42.
    • (2007) J Cell Biol , vol.176 , pp. 35-42
    • Sahai, E.1    Garcia-Medina, R.2    Pouysségur, J.3    Vial, E.4
  • 173
    • 0034602959 scopus 로고    scopus 로고
    • Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop
    • Ohashi K. Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop. J Biol Chem. 2000; 275:3577-82.
    • (2000) J Biol Chem , vol.275 , pp. 3577-3582
    • Ohashi, K.1
  • 174
    • 0033611107 scopus 로고    scopus 로고
    • Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho-and Cdc42-activated LIM-kinase 2
    • Sumi T, Matsumoto K. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho-and Cdc42-activated LIM-kinase 2. J Cell Biol. 1999; 147:1519-32.
    • (1999) J Cell Biol , vol.147 , pp. 1519-1532
    • Sumi, T.1    Matsumoto, K.2
  • 175
    • 0032565769 scopus 로고    scopus 로고
    • Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
    • Yang N, Higuchi O, Ohashi K, Nagata K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature. 1998; 1171:809-12.
    • (1998) Nature , vol.1171 , pp. 809-812
    • Yang, N.1    Higuchi, O.2    Ohashi, K.3    Nagata, K.4
  • 176
    • 76749126470 scopus 로고    scopus 로고
    • LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices
    • Mishima T, Naotsuka M, Horita Y, Sato M, Ohashi K, Mizuno K. LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices. Biochem Biophys Res Commun. 2010; 392:577-81.
    • (2010) Biochem Biophys Res Commun , vol.392 , pp. 577-581
    • Mishima, T.1    Naotsuka, M.2    Horita, Y.3    Sato, M.4    Ohashi, K.5    Mizuno, K.6
  • 177
    • 0036532136 scopus 로고    scopus 로고
    • Collective Cell Movement in Primary Melanoma Explants: Plasticity of Cell-Cell Interaction, (beta)1-Integrin Function, and Migration Strategies
    • Hegerfeldt Y, Tusch M, Bröcker E, Strategies M, Friedl P, Brocker E-B. Collective Cell Movement in Primary Melanoma Explants: Plasticity of Cell-Cell Interaction, (beta)1-Integrin Function, and Migration Strategies. Cancer Res. 2002; 62:2125-30.
    • (2002) Cancer Res , vol.62 , pp. 2125-2130
    • Hegerfeldt, Y.1    Tusch, M.2    Bröcker, E.3    Strategies, M.4    Friedl, P.5    Brocker, E.-B.6
  • 179
    • 79551612886 scopus 로고    scopus 로고
    • Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
    • Terry SJ, Zihni C, Elbediwy A, Vitiello E, San IVLC, Balda MS, Matter K. Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nat Cell Biol. 2011; 13:159-66.
    • (2011) Nat Cell Biol , vol.13 , pp. 159-166
    • Terry, S.J.1    Zihni, C.2    Elbediwy, A.3    Vitiello, E.4    San, I.V.L.C.5    Balda, M.S.6    Matter, K.7
  • 181
    • 41649118421 scopus 로고    scopus 로고
    • Transforming growth factor β controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin
    • Binamé F, Lassus P, Hibner U. Transforming growth factor β controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin. Mol Biol Cell. 2008; 19:945-56.
    • (2008) Mol Biol Cell , vol.19 , pp. 945-956
    • Binamé, F.1    Lassus, P.2    Hibner, U.3
  • 184
    • 84880769933 scopus 로고    scopus 로고
    • Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble
    • Elsum IA, Humbert PO. Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble. Cells Tissues Organs. 2013; 198:1-11.
    • (2013) Cells Tissues Organs , vol.198 , pp. 1-11
    • Elsum, I.A.1    Humbert, P.O.2
  • 186
    • 84896036461 scopus 로고    scopus 로고
    • Apico-basal polarity complex and cancer
    • Khursheed M, Bashyam MD. Apico-basal polarity complex and cancer. J Biosci. 2014; 39:145-55.
    • (2014) J Biosci , vol.39 , pp. 145-155
    • Khursheed, M.1    Bashyam, M.D.2
  • 189
    • 0035943401 scopus 로고    scopus 로고
    • Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
    • Etienne-Manneville S, Hall A. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell. 2001; 106:489-98.
    • (2001) Cell , vol.106 , pp. 489-498
    • Etienne-Manneville, S.1    Hall, A.2
  • 190
    • 67349256860 scopus 로고    scopus 로고
    • Bringing up the rear: defining the roles of the uropod
    • Sánchez-Madrid F, Serrador JM. Bringing up the rear: defining the roles of the uropod. Nat Rev Mol Cell Biol. 2009; 10:353-9.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 353-359
    • Sánchez-Madrid, F.1    Serrador, J.M.2
  • 191
    • 0000202186 scopus 로고    scopus 로고
    • A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
    • Lin D, Edwards a S, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000; 2:540-7.
    • (2000) Nat Cell Biol , vol.2 , pp. 540-547
    • Lin, D.1    Edwards, A.S.2    Fawcett, J.P.3    Mbamalu, G.4    Scott, J.D.5    Pawson, T.6
  • 193
    • 84890526139 scopus 로고    scopus 로고
    • The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity
    • Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013; 24:3857-68.
    • (2013) Mol Biol Cell , vol.24 , pp. 3857-3868
    • Narayanan, A.S.1    Reyes, S.B.2    Um, K.3    McCarty, J.H.4    Tolias, K.F.5
  • 196
    • 77957735280 scopus 로고    scopus 로고
    • LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity
    • Xu X, Omelchenko T, Hall A. LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity. BMC Cell Biol. 2010; 11:77.
    • (2010) BMC Cell Biol , vol.11 , pp. 77
    • Xu, X.1    Omelchenko, T.2    Hall, A.3
  • 197
    • 38849204971 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
    • Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res. 2008; 68:740-8.
    • (2008) Cancer Res , vol.68 , pp. 740-748
    • Zhang, S.1    Schafer-Hales, K.2    Khuri, F.R.3    Zhou, W.4    Vertino, P.M.5    Marcus, A.I.6
  • 198
    • 2642547462 scopus 로고    scopus 로고
    • Mammalian Scribble forms a tight complex with the βPIX exchange factor
    • Audebert S, Navarro C, Nourry C. Mammalian Scribble forms a tight complex with the βPIX exchange factor. Curr Biol. 2004; 14:987-95.
    • (2004) Curr Biol , vol.14 , pp. 987-995
    • Audebert, S.1    Navarro, C.2    Nourry, C.3
  • 199
    • 84906907631 scopus 로고    scopus 로고
    • An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration
    • Kutys ML, Yamada KM. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014; 16.
    • (2014) Nat Cell Biol , pp. 16
    • Kutys, M.L.1    Yamada, K.M.2
  • 200
    • 34147094240 scopus 로고    scopus 로고
    • The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge
    • Dow LE, Kauffman JS, Caddy J, Zarbalis K, Peterson a S, Jane SM, Russell SM, Humbert PO. The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene. 2007; 26:2272-82.
    • (2007) Oncogene , vol.26 , pp. 2272-2282
    • Dow, L.E.1    Kauffman, J.S.2    Caddy, J.3    Zarbalis, K.4    Peterson, A.S.5    Jane, S.M.6    Russell, S.M.7    Humbert, P.O.8
  • 201
    • 67449124591 scopus 로고    scopus 로고
    • Vimentin regulates scribble activity by protecting it from proteasomal degradation
    • Phua DCY, Humbert PO, Hunziker W. Vimentin regulates scribble activity by protecting it from proteasomal degradation. Mol Biol Cell. 2009; 20:2841-55.
    • (2009) Mol Biol Cell , vol.20 , pp. 2841-2855
    • Phua, D.C.Y.1    Humbert, P.O.2    Hunziker, W.3
  • 202
    • 83355163339 scopus 로고    scopus 로고
    • Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)
    • O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall R a, Newton AC. Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011; 286:43559-68.
    • (2011) J Biol Chem , vol.286 , pp. 43559-43568
    • O'Neill, A.K.1    Gallegos, L.L.2    Justilien, V.3    Garcia, E.L.4    Leitges, M.5    Fields, A.P.6    Hall, R.A.7    Newton, A.C.8
  • 203
    • 84857217053 scopus 로고    scopus 로고
    • The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration
    • Dahan I, Yearim A, Touboul Y, Ravid S. The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration. Mol Biol Cell. 2012; 23:591-601.
    • (2012) Mol Biol Cell , vol.23 , pp. 591-601
    • Dahan, I.1    Yearim, A.2    Touboul, Y.3    Ravid, S.4
  • 204
    • 84892518329 scopus 로고    scopus 로고
    • The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation
    • Dahan I, Petrov D, Cohen-Kfir E, Ravid S. The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation. J Cell Sci. 2014; 127:295-304.
    • (2014) J Cell Sci , vol.127 , pp. 295-304
    • Dahan, I.1    Petrov, D.2    Cohen-Kfir, E.3    Ravid, S.4
  • 205
    • 67149133634 scopus 로고    scopus 로고
    • Pivotal Advance: PKCzeta is required for migration of macrophages
    • Guo H, Ma Y, Zhang B, Sun B, Niu R, Ying G, Zhang N. Pivotal Advance: PKCzeta is required for migration of macrophages. J Leukoc Biol. 2009; 85:911-8.
    • (2009) J Leukoc Biol , vol.85 , pp. 911-918
    • Guo, H.1    Ma, Y.2    Zhang, B.3    Sun, B.4    Niu, R.5    Ying, G.6    Zhang, N.7
  • 206
    • 67649238892 scopus 로고    scopus 로고
    • Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2
    • Vandenberg AL, Sassoon DA. Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2. Development. 2009; 136:1559-70.
    • (2009) Development , vol.136 , pp. 1559-1570
    • Vandenberg, A.L.1    Sassoon, D.A.2
  • 208
    • 84864956480 scopus 로고    scopus 로고
    • A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression
    • Anastas JN, Biechele TL, Robitaille M, Muster J, Allison KH, Angers S, Moon RT. A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene. 2012; 31:3696-708.
    • (2012) Oncogene , vol.31 , pp. 3696-3708
    • Anastas, J.N.1    Biechele, T.L.2    Robitaille, M.3    Muster, J.4    Allison, K.H.5    Angers, S.6    Moon, R.T.7
  • 210
    • 72049111230 scopus 로고    scopus 로고
    • The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion
    • Cantrell VA, Jessen JR. The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion. Cancer Lett. 2010; 287:54-61.
    • (2010) Cancer Lett , vol.287 , pp. 54-61
    • Cantrell, V.A.1    Jessen, J.R.2
  • 213
    • 77950526433 scopus 로고    scopus 로고
    • Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells
    • Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A. Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 2010; 29:1192-204.
    • (2010) EMBO J , vol.29 , pp. 1192-1204
    • Matsumoto, S.1    Fumoto, K.2    Okamoto, T.3    Kaibuchi, K.4    Kikuchi, A.5
  • 214
    • 84861395028 scopus 로고    scopus 로고
    • Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration
    • Zhu Y, Tian Y, Du J, Hu Z, Yang L, Liu J, Gu L. Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PLoS One. 2012; 7:e37823.
    • (2012) PLoS One , vol.7
    • Zhu, Y.1    Tian, Y.2    Du, J.3    Hu, Z.4    Yang, L.5    Liu, J.6    Gu, L.7
  • 215
    • 33846270032 scopus 로고    scopus 로고
    • PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42
    • Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell. 2007; 128:383-97.
    • (2007) Cell , vol.128 , pp. 383-397
    • Martin-Belmonte, F.1    Gassama, A.2    Datta, A.3    Yu, W.4    Rescher, U.5    Gerke, V.6    Mostov, K.7
  • 216
    • 0343183328 scopus 로고    scopus 로고
    • Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
    • Liliental J, Moon SY, Lesche R, Mamillapalli R, Li D, Zheng Y, Sun H, Wu H. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10:401-4.
    • (2000) Curr Biol , vol.10 , pp. 401-404
    • Liliental, J.1    Moon, S.Y.2    Lesche, R.3    Mamillapalli, R.4    Li, D.5    Zheng, Y.6    Sun, H.7    Wu, H.8
  • 217
    • 0033575287 scopus 로고    scopus 로고
    • PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
    • Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem. 1999; 274:20693-703.
    • (1999) J Biol Chem , vol.274 , pp. 20693-20703
    • Tamura, M.1    Gu, J.2    Danen, E.H.3    Takino, T.4    Miyamoto, S.5    Yamada, K.M.6
  • 218
    • 0031459917 scopus 로고    scopus 로고
    • Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
    • Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise L V. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature. 1997; 390:632-6.
    • (1997) Nature , vol.390 , pp. 632-636
    • Keely, P.J.1    Westwick, J.K.2    Whitehead, I.P.3    Der, C.J.4    Parise, L.V.5
  • 219
    • 33748199154 scopus 로고    scopus 로고
    • Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells
    • Gassama-Diagne A, Yu W, ter Beest M, Martin-Belmonte F, Kierbel A, Engel J, Mostov K. Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat Cell Biol. 2006; 8:963-70.
    • (2006) Nat Cell Biol , vol.8 , pp. 963-970
    • Gassama-Diagne, A.1    Yu, W.2    Ter Beest, M.3    Martin-Belmonte, F.4    Kierbel, A.5    Engel, J.6    Mostov, K.7
  • 220
    • 84860295783 scopus 로고    scopus 로고
    • Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism
    • Welf ES, Ahmed S, Johnson HE, Melvin AT, Haugh JM. Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism. J Cell Biol. 2012; 197:105-14.
    • (2012) J Cell Biol , vol.197 , pp. 105-114
    • Welf, E.S.1    Ahmed, S.2    Johnson, H.E.3    Melvin, A.T.4    Haugh, J.M.5
  • 222
    • 84860414367 scopus 로고    scopus 로고
    • Phosphoinositide binding by par-3 involved in par-3 localization
    • Horikoshi Y, Hamada S, Ohno S, Suetsugu S. Phosphoinositide binding by par-3 involved in par-3 localization. Cell Struct Funct. 2011; 36:97-102.
    • (2011) Cell Struct Funct , vol.36 , pp. 97-102
    • Horikoshi, Y.1    Hamada, S.2    Ohno, S.3    Suetsugu, S.4
  • 223
    • 84858001709 scopus 로고    scopus 로고
    • Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration
    • Majumder P, Aranjuez G, Amick J, McDonald J. Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration. Curr Biol. 2012; 22:363-72.
    • (2012) Curr Biol , vol.22 , pp. 363-372
    • Majumder, P.1    Aranjuez, G.2    Amick, J.3    McDonald, J.4
  • 224
    • 78650512223 scopus 로고    scopus 로고
    • Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
    • Hidalgo-Carcedo C, Hooper S, Chaudhry SI, Williamson P, Harrington K, Leitinger B, Sahai E. Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol. 2011; 13:49-58.
    • (2011) Nat Cell Biol , vol.13 , pp. 49-58
    • Hidalgo-Carcedo, C.1    Hooper, S.2    Chaudhry, S.I.3    Williamson, P.4    Harrington, K.5    Leitinger, B.6    Sahai, E.7
  • 225
    • 41549155540 scopus 로고    scopus 로고
    • Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
    • Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR. Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol. 2008; 180:1277-89.
    • (2008) J Cell Biol , vol.180 , pp. 1277-1289
    • Shintani, Y.1    Fukumoto, Y.2    Chaika, N.3    Svoboda, R.4    Wheelock, M.J.5    Johnson, K.R.6
  • 227
    • 84873410310 scopus 로고    scopus 로고
    • Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion
    • Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK. Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol. 2013; 15:189-200.
    • (2013) Nat Cell Biol , vol.15 , pp. 189-200
    • Xue, B.1    Krishnamurthy, K.2    Allred, D.C.3    Muthuswamy, S.K.4
  • 228
    • 84869000970 scopus 로고    scopus 로고
    • Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis
    • McCaffrey LM, Montalbano J, Mihai C, Macara IG. Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell. 2012; 22:601-14.
    • (2012) Cancer Cell , vol.22 , pp. 601-614
    • McCaffrey, L.M.1    Montalbano, J.2    Mihai, C.3    Macara, I.G.4
  • 230
    • 84966910133 scopus 로고    scopus 로고
    • Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition
    • Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu H, Gao W. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 2015;
    • (2015) Oncogene
    • Zhang, K.1    Zhao, H.2    Ji, Z.3    Zhang, C.4    Zhou, P.5    Wang, L.6    Chen, Q.7    Wang, J.8    Zhang, P.9    Chen, Z.10    Zhu, H.11    Gao, W.12
  • 231
    • 84896720981 scopus 로고    scopus 로고
    • Overexpression of the polarity protein PAR3 in clear cell renal cell carcinoma is associated with poor prognosis
    • Dugay F, Goff X. Overexpression of the polarity protein PAR3 in clear cell renal cell carcinoma is associated with poor prognosis. Int J Cancer. 2013; 134:2051-60.
    • (2013) Int J Cancer , vol.134 , pp. 2051-2060
    • Dugay, F.1    Goff, X.2
  • 232
    • 84878667715 scopus 로고    scopus 로고
    • Expression of partitioning defective 3 (par-3) for predicting extrahepatic metastasis and survival with hepatocellular carcinoma
    • Jan Y-J, Ko B-S, Liu T-A, Wu Y-M, Liang S-M, Chen S-C, Wang J, Liou J-Y. Expression of partitioning defective 3 (par-3) for predicting extrahepatic metastasis and survival with hepatocellular carcinoma. Int J Mol Sci. 2013; 14:1684-97.
    • (2013) Int J Mol Sci , vol.14 , pp. 1684-1697
    • Jan, Y.-J.1    Ko, B.-S.2    Liu, T.-A.3    Wu, Y.-M.4    Liang, S.-M.5    Chen, S.-C.6    Wang, J.7    Liou, J.-Y.8
  • 233
    • 49649126819 scopus 로고    scopus 로고
    • Matrix metalloproteinase-10 is a critical effector of protein kinase C iota-Par6 alpha-mediated lung cancer
    • Frederick L a, Matthews J a, Jamieson L, Justilien V, Thompson E a, Radisky DC, Fields a P. Matrix metalloproteinase-10 is a critical effector of protein kinase C iota-Par6 alpha-mediated lung cancer. Oncogene. 2008; 27:4841-53.
    • (2008) Oncogene , vol.27 , pp. 4841-4853
    • La, F.1    Ja, M.2    Jamieson, L.3    Justilien, V.4    Thompson, E.A.5    Radisky, D.C.6    Fields, A.P.7
  • 235
    • 78649734292 scopus 로고    scopus 로고
    • The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation
    • Xiao H, Bai X-H, Kapus A, Lu W-Y, Mak AS, Liu M. The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation. Mol Cell Biol. 2010; 30:5545-61.
    • (2010) Mol Cell Biol , vol.30 , pp. 5545-5561
    • Xiao, H.1    Bai, X.-H.2    Kapus, A.3    Lu, W.-Y.4    Mak, A.S.5    Liu, M.6
  • 239
    • 84907915831 scopus 로고    scopus 로고
    • Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion
    • Li J, Liu J, Li P, Mao X, Li W, Yang J, Liu P. Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion. J Exp Clin Cancer Res. 2014; 33:70.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 70
    • Li, J.1    Liu, J.2    Li, P.3    Mao, X.4    Li, W.5    Yang, J.6    Liu, P.7
  • 240
    • 84880693771 scopus 로고    scopus 로고
    • LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation
    • Xu X, Jin D, Durgan J, Hall A. LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation. Mol Cell Biol. 2013; 33:2671-82.
    • (2013) Mol Cell Biol , vol.33 , pp. 2671-2682
    • Xu, X.1    Jin, D.2    Durgan, J.3    Hall, A.4
  • 241
    • 33845332753 scopus 로고    scopus 로고
    • Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential
    • Zhuang Z-G, Di G-H, Shen Z-Z, Ding J, Shao Z-M. Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential. Mol Cancer Res. 2006; 4:843-9.
    • (2006) Mol Cancer Res , vol.4 , pp. 843-849
    • Zhuang, Z.-G.1    Di, G.-H.2    Shen, Z.-Z.3    Ding, J.4    Shao, Z.-M.5
  • 242
    • 3042659106 scopus 로고    scopus 로고
    • KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer
    • Lee JH, Park SR, Chay K-O, Seo Y-W, Kook H, Ahn KY, Kim YJ, Kim KK. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. Cancer Res. 2004; 64:4235-43.
    • (2004) Cancer Res , vol.64 , pp. 4235-4243
    • Lee, J.H.1    Park, S.R.2    Chay, K.-O.3    Seo, Y.-W.4    Kook, H.5    Ahn, K.Y.6    Kim, Y.J.7    Kim, K.K.8
  • 243
    • 60049091422 scopus 로고    scopus 로고
    • KITENIN recruits Dishevelled/PKCδ to form a functional complex and controls the migration and invasiveness of colorectal cancer cells
    • Kho DH, Bae JA, Lee JH, Cho HJ, Cho SH, Seo YW, Ahn KY, Chung IJ, Kim KK. KITENIN recruits Dishevelled/PKCδ to form a functional complex and controls the migration and invasiveness of colorectal cancer cells. Gut. 2009; 58:509-19.
    • (2009) Gut , vol.58 , pp. 509-519
    • Kho, D.H.1    Bae, J.A.2    Lee, J.H.3    Cho, H.J.4    Cho, S.H.5    Seo, Y.W.6    Ahn, K.Y.7    Chung, I.J.8    Kim, K.K.9
  • 244
    • 32944470373 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells
    • Stallings-Mann M, Jamieson L, Regala RP, Weems C, Murray NR, Fields AP. A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Cancer Res. 2006; 66:1767-74.
    • (2006) Cancer Res , vol.66 , pp. 1767-1774
    • Stallings-Mann, M.1    Jamieson, L.2    Regala, R.P.3    Weems, C.4    Murray, N.R.5    Fields, A.P.6
  • 245
    • 84885390091 scopus 로고    scopus 로고
    • Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small cell lung cancer, ovarian cancer and pancreatic cancer
    • Mansfield AS, Fields AP, Jatoi A, Qi Y, Adjei AA, Erlichman C, Molina JR. Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small cell lung cancer, ovarian cancer and pancreatic cancer. Anticancer Drugs. 2013; 24:1079.
    • (2013) Anticancer Drugs , vol.24 , pp. 1079
    • Mansfield, A.S.1    Fields, A.P.2    Jatoi, A.3    Qi, Y.4    Adjei, A.A.5    Erlichman, C.6    Molina, J.R.7
  • 247
    • 84949045216 scopus 로고    scopus 로고
    • En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition
    • Aceto N, Toner M, Maheswaran S, Haber DA. En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition. Trends in Cancer. 2015; 1:44-52.
    • (2015) Trends in Cancer , vol.1 , pp. 44-52
    • Aceto, N.1    Toner, M.2    Maheswaran, S.3    Haber, D.A.4
  • 249
    • 84885424897 scopus 로고    scopus 로고
    • Twist: a molecular target in cancer therapeutics
    • Khan MA, Chen H, Zhang D, Fu J. Twist: a molecular target in cancer therapeutics. Tumour Biol. 2013; 34:2497-506.
    • (2013) Tumour Biol , vol.34 , pp. 2497-2506
    • Khan, M.A.1    Chen, H.2    Zhang, D.3    Fu, J.4
  • 250
    • 34249276569 scopus 로고    scopus 로고
    • New potential therapeutic targets to combat epithelial tumor invasion
    • Peinado H, Cano a. New potential therapeutic targets to combat epithelial tumor invasion. Clin Transl Oncol. 2006; 8:851-7.
    • (2006) Clin Transl Oncol , vol.8 , pp. 851-857
    • Peinado, H.1    Cano, A.2
  • 252
    • 84899881227 scopus 로고    scopus 로고
    • Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways
    • Pal HC, Sharma S, Strickland LR, Katiyar SK, Ballestas ME, Athar M, Elmets C a, Afaq F. Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways. PLoS One. 2014; 9:e86338.
    • (2014) PLoS One , vol.9
    • Pal, H.C.1    Sharma, S.2    Strickland, L.R.3    Katiyar, S.K.4    Ballestas, M.E.5    Athar, M.6    Elmets, C.A.7    Afaq, F.8
  • 253
    • 77950667079 scopus 로고    scopus 로고
    • ROCK inhibitors as emerging therapeutic candidates for sarcomas
    • Micuda S, Rosel D, Ryska A, Brabek J. ROCK inhibitors as emerging therapeutic candidates for sarcomas. Curr Cancer Drug Targets. 2010; 10:127-34.
    • (2010) Curr Cancer Drug Targets , vol.10 , pp. 127-134
    • Micuda, S.1    Rosel, D.2    Ryska, A.3    Brabek, J.4
  • 255
    • 84881481410 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
    • Hadler-Olsen E, Winberg J-O, Uhlin-Hansen L. Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biol. 2013; 34:2041-51.
    • (2013) Tumour Biol , vol.34 , pp. 2041-2051
    • Hadler-Olsen, E.1    Winberg, J.-O.2    Uhlin-Hansen, L.3
  • 256
    • 84879924314 scopus 로고    scopus 로고
    • Drugs for solid cancer: The productivity crisis prompts a rethink
    • Rösel D, Brábek J, Veselý P, Fernandes M. Drugs for solid cancer: The productivity crisis prompts a rethink. Onco Targets Ther. 2013; 6:767-77.
    • (2013) Onco Targets Ther , vol.6 , pp. 767-777
    • Rösel, D.1    Brábek, J.2    Veselý, P.3    Fernandes, M.4
  • 257
    • 84939877182 scopus 로고    scopus 로고
    • Translation in solid cancer: are size-based response criteria an anachronism?
    • Fernandes M, Rosel D, Brabek J. Translation in solid cancer: are size-based response criteria an anachronism? Clin Transl Oncol. 2015; 17: 1-10.
    • (2015) Clin Transl Oncol , vol.17 , pp. 1-10
    • Fernandes, M.1    Rosel, D.2    Brabek, J.3
  • 258
    • 84918544201 scopus 로고    scopus 로고
    • Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma
    • Mao X, Li P, Ren Y, Li J, Zhou C, Yang J, Liu P. Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma. Int J Oncol. 2015; 46:657-66.
    • (2015) Int J Oncol , vol.46 , pp. 657-666
    • Mao, X.1    Li, P.2    Ren, Y.3    Li, J.4    Zhou, C.5    Yang, J.6    Liu, P.7
  • 260
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2011; 17:320-9.
    • (2011) Nat Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 262
    • 75749146306 scopus 로고    scopus 로고
    • Plasticity of cell migration: a multiscale tuning model
    • Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol. 2010; 188:11-9.
    • (2010) J Cell Biol , vol.188 , pp. 11-19
    • Friedl, P.1    Wolf, K.2
  • 263
    • 84875580811 scopus 로고    scopus 로고
    • At the leading edge of three-dimensional cell migration
    • Petrie RJ, Yamada KM. At the leading edge of three-dimensional cell migration. J Cell Sci. 2012; 125:5917-26.
    • (2012) J Cell Sci , vol.125 , pp. 5917-5926
    • Petrie, R.J.1    Yamada, K.M.2
  • 264
    • 84910136913 scopus 로고    scopus 로고
    • Three-dimensional organotypic culture: experimental models of mammalian biology and disease
    • Shamir ER, Ewald AJ. Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nat Rev Mol Cell Biol. 2014; 15: 647-64.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 647-664
    • Shamir, E.R.1    Ewald, A.J.2


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