메뉴 건너뛰기




Volumn 17, Issue 3, 2011, Pages 320-329

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Author keywords

[No Author keywords available]

Indexed keywords

8 [(4 AMINOBUTYL)(2 BENZIMIDAZOLYLMETHYL)AMINO] 1,2,3,4 TETRAHYDROQUINOLINE; ANASTROZOLE; AVE 1642; B RAF KINASE; BEVACIZUMAB; BGJ 398; BORTEZOMIB; CAVEOLIN 1; CELECOXIB; DENOSUMAB; DX 2400; ENDOSTAR; ENDOSTATIN; GLYCOSIDASE INHIBITOR; HYALURONIDASE; IPI 926; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MK 2461; ODANACATIB; PEGPH 20; PEGPH20; PG 545; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE INHIBITOR; PROTEIN LYSINE 6 OXIDASE; REACTIVE OXYGEN METABOLITE; SORAFENIB; TRABEDERSEN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLEDRONIC ACID;

EID: 79952392467     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2328     Document Type: Review
Times cited : (1219)

References (140)
  • 3
    • 1542319129 scopus 로고    scopus 로고
    • Cancer without disease
    • DOI 10.1038/427787a
    • Folkman, J. & Kalluri, R. Cancer without disease. Nature 427, 787 (2004). (Pubitemid 38297724)
    • (2004) Nature , vol.427 , Issue.6977 , pp. 787
    • Folkman, J.1    Kalluri, R.2
  • 4
    • 0001372301 scopus 로고
    • On the frequency of occurrence of occult carcinoma of the prostate
    • Rich, A.R. On the frequency of occurrence of occult carcinoma of the prostate. J. Urol. 33, 215-223 (1935).
    • (1935) J. Urol. , vol.33 , pp. 215-223
    • Rich, A.R.1
  • 5
    • 34447315787 scopus 로고    scopus 로고
    • On the frequency of occurrence of occult carcinoma of the prostrate
    • DOI 10.1093/ije/dym050
    • Rich, A.R. On the frequency of occurrence of occult carcinoma of the prostrate. Int. J. Epidemiol. 36, 274-277 (2007). (Pubitemid 47062836)
    • (2007) International Journal of Epidemiology , vol.36 , Issue.2 , pp. 274-277
    • Rich, A.R.1
  • 6
    • 0027244510 scopus 로고
    • The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients
    • Sakr, W.A., Haas, G.P., Cassin, B.F., Pontes, J.E. & Crissman, J.D. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J. Urol. 150, 379-385 (1993). (Pubitemid 23215874)
    • (1993) Journal of Urology , vol.150 , Issue.2 , pp. 379-385
    • Sakr, W.A.1    Haas, G.P.2    Cassin, B.F.3    Pontes, J.E.4    Crissman, J.D.5
  • 7
    • 0023589208 scopus 로고
    • Breast cancer and atypia among young and middle-aged women: A study of 110 medicolegal autopsies
    • Nielsen, M., Thomsen, J.L., Primdahl, S., Dyreborg, U. & Andersen, J.A. Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies. Br. J. Cancer 56, 814-819 (1987). (Pubitemid 18048359)
    • (1987) British Journal of Cancer , vol.56 , Issue.6 , pp. 814-819
    • Nielsen, M.1    Thomsen, J.L.2    Primdahl, S.3    Dyreborg, U.4    Andersen, J.A.5
  • 8
    • 0021809472 scopus 로고
    • Occult papillary carcinoma of the thyroid. A 'normal' finding in Finland. A systematic autopsy study
    • DOI 10.1002/1097-0142(19850801)56:3<531::AID-CNCR2820560321>3.0. CO;2-3
    • Harach, H.R., Franssila, K.O. & Wasenius, V.M. Occult papillary carcinoma of the thyroid. A "normal" finding in Finland. A systematic autopsy study. Cancer 56, 531-538 (1985). (Pubitemid 15035581)
    • (1985) Cancer , vol.56 , Issue.3 , pp. 531-538
    • Harach, H.R.1    Franssila, K.O.2    Wasenius, V.-M.3
  • 9
    • 14844297320 scopus 로고    scopus 로고
    • Incidental lung cancers identified at coronial autopsy: Implications for overdiagnosis of lung cancer by screening
    • DOI 10.1016/j.rmed.2004.08.017, PII S095461110400335X
    • Manser, R.L., Dodd, M., Byrnes, G., Irving, L.B. & Campbell, D.A. Incidental lung cancers identified at coronial autopsy: implications for overdiagnosis of lung cancer by screening. Respir. Med. 99, 501-507 (2005). (Pubitemid 40347835)
    • (2005) Respiratory Medicine , vol.99 , Issue.4 , pp. 501-507
    • Manser, R.L.1    Dodd, M.2    Byrnes, G.3    Irving, L.B.4    Campbell, D.A.5
  • 10
    • 0029954751 scopus 로고    scopus 로고
    • Very low level of major BCR-ABL expression in blood of some healthy individuals
    • Biernaux, C., Sels, A., Huez, G. & Stryckmans, P. Very low level of major BCRABL expression in blood of some healthy individuals. Bone Marrow Transplant. 3, S45-S47 (1996). (Pubitemid 26181608)
    • (1996) Bone Marrow Transplantation , vol.17 , Issue.SUPPL. 3
    • Biernaux, C.1    Sels, A.2    Huez, G.3    Stryckmans, P.4
  • 11
    • 79952413390 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia
    • eds Lowy A.M. Leach S.D. and Philip P.A.) (Springer New York New York
    • Hruban, R., Brune, K., Fukushima, N. & Maitra, A. Pancreatic intraepithelial neoplasia. in Pancreatic Cancer (eds. Lowy, A.M., Leach, S.D. and Philip, P.A.) (Springer, New York, New York, 2008).
    • (2008) Pancreatic Cancer
    • Hruban, R.1    Brune, K.2    Fukushima, N.3    Maitra, A.4
  • 12
    • 0032211172 scopus 로고    scopus 로고
    • The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease
    • Bose, S., Deininger, M., Gora-Tybor, J., Goldman, J.M. & Melo, J.V. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 92, 3362-3367 (1998). (Pubitemid 28492345)
    • (1998) Blood , vol.92 , Issue.9 , pp. 3362-3367
    • Bose, S.1    Deininger, M.2    Gora-Tybor, J.3    Goldman, J.M.4    Melo, J.V.5
  • 13
    • 0019419121 scopus 로고
    • Axillary lymph node metastasis from an occult breast cancer
    • DOI 10.1002/1097-0142(19810615)47:12<2923::AID-CNCR2820471231>3.0. CO;2-N
    • Patel, J., Nemoto, T., Rosner, D., Dao, T.L. & Pickren, J.W. Axillary lymph node metastasis from an occult breast cancer. Cancer 47, 2923-2927 (1981). (Pubitemid 11066892)
    • (1981) Cancer , vol.47 , Issue.12 , pp. 2923-2927
    • Patel, J.1    Nemoto, T.2    Rosner, D.3
  • 14
    • 34249315487 scopus 로고    scopus 로고
    • Morphogens morphostats, microarchitecture and malignancy
    • Potter, J.D. Morphogens, morphostats, microarchitecture and malignancy. Nat. Rev. Cancer 7, 464-474 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 464-474
    • Potter, J.D.1
  • 15
    • 79952372186 scopus 로고
    • Extracellular materials and tissue interactions
    • ed Benjamin, W.A. (Benjamin/Cummings Publishing, Menlo Park, California
    • Wessels, N.K. Extracellular materials and tissue interactions. in Tissue Interaction and Development (ed. Benjamin, W.A.) (Benjamin/Cummings Publishing, Menlo Park, California, 1977).
    • (1977) Tissue Interaction and Development
    • Wessels, N.K.1
  • 16
    • 0030589664 scopus 로고    scopus 로고
    • The extracellular matrix in epithelial biology: Shared molecules and common themes in distant phyla
    • Ashkenas, J., Muschler, J. & Bissell, M. The extracellular matrix in epithelial biology: shared molecules and common themes in distant phyla. Dev. Biol. 180, 433 (1996).
    • (1996) Dev. Biol. , vol.180 , pp. 433
    • Ashkenas, J.1    Muschler, J.2    Bissell, M.3
  • 19
    • 84965831127 scopus 로고
    • The cocarcinogenic action of croton resin
    • Berenblum, I. The cocarcinogenic action of croton resin. Cancer Res. 1, 44-48 (1941).
    • (1941) Cancer Res. , vol.1 , pp. 44-48
    • Berenblum, I.1
  • 20
    • 78651011011 scopus 로고
    • An experimental study of the initiating state of carcinogenesis and a re-examination of the somatic cell mutation theory of cancer
    • Berenblum, I. & Shubik, P. An experimental study of the initiating state of carcinogenesis and a re-examination of the somatic cell mutation theory of cancer. Br. J. Cancer 3, 109-118 (1949).
    • (1949) Br. J. Cancer , vol.3 , pp. 109-118
    • Berenblum, I.1    Shubik, P.2
  • 21
    • 0020643375 scopus 로고
    • Overview of tumor promotion in animals
    • Slaga, T.J. Overview of tumor promotion in animals. Environ. Health Perspect. 50, 3-14 (1983). (Pubitemid 13040421)
    • (1983) Environmental Health Perspectives , vol.50 , pp. 3-14
    • Slaga, T.J.1
  • 22
    • 79952409063 scopus 로고
    • The part played by injury and repair in the development of cancer, with some remarks on the growth of experimental cancers
    • Deelman, H.T. The part played by injury and repair in the development of cancer, with some remarks on the growth of experimental cancers. Proc. R. Soc. Med. 20, 1157-1158 (1927).
    • (1927) Proc. R. Soc. Med. , vol.20 , pp. 1157-1158
    • Deelman, H.T.1
  • 23
    • 85013554449 scopus 로고
    • The initiating and promoting elements in tumor production: An analysis of the effects of tar, benzpyrene and methylcholanthrene on rabbit skin
    • Friedewald, W.F. & Rous, P. The initiating and promoting elements in tumor production: an analysis of the effects of tar, benzpyrene and methylcholanthrene on rabbit skin. J. Exp. Med. 80, 101-126 (1944).
    • (1944) J. Exp. Med. , vol.80 , pp. 101-126
    • Friedewald, W.F.1    Rous, P.2
  • 24
    • 0007796227 scopus 로고
    • A speculative review; The probable nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis
    • Berenblum, I. A speculative review; the probable nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis. Cancer Res. 14, 471-477 (1954).
    • (1954) Cancer Res. , vol.14 , pp. 471-477
    • Berenblum, I.1
  • 25
    • 0022397711 scopus 로고
    • Wounding and its role in RSV-mediated tumor formation
    • Dolberg, D.S., Hollingsworth, R., Hertle, M. & Bissell, M.J. Wounding and its role in RSV-mediated tumor formation. Science 230, 676-678 (1985). (Pubitemid 16190963)
    • (1985) Science , vol.230 , Issue.4726 , pp. 676-678
    • Dolberg, D.S.1    Hollingsworth, R.2    Hertle, M.3    Bissell, M.J.4
  • 26
    • 0028251039 scopus 로고
    • The tumor-promoting effect of wounding: A possible role for TGF-induced stromal alterations
    • Sieweke, M.H. & Bissell, M.J. The tumor-promoting effect of wounding: a possible role for TGF-induced stromal alterations. Crit. Rev. Oncog. 5, 297-311 (1994).
    • (1994) Crit. Rev. Oncog. , vol.5 , pp. 297-311
    • Sieweke, M.H.1    Bissell, M.J.2
  • 27
    • 0014933756 scopus 로고
    • Rous sarcoma virus: A function required for the maintenance of the transformed state
    • Martin, G.S. Rous sarcoma virus: a function required for the maintenance of the transformed state. Nature 227, 1021-1023 (1970).
    • (1970) Nature , vol.227 , pp. 1021-1023
    • Martin, G.S.1
  • 29
    • 0013465445 scopus 로고
    • A hemorrhagic disease occurring in chicks inoculated with the Rous and Fuginami viruses
    • Duran-Reynals, F. A hemorrhagic disease occurring in chicks inoculated with the Rous and Fuginami viruses. Yale J. Biol. Med. 13, 77-98 (1940).
    • (1940) Yale J. Biol. Med. , vol.13 , pp. 77-98
    • Duran-Reynals, F.1
  • 30
    • 84979948588 scopus 로고
    • A sarcoma of the fowl transmissible by an agent separable from the tumor cells
    • Rous, P. A sarcoma of the fowl transmissible by an agent separable from the tumor cells. J. Exp. Med. 13, 397-411 (1911).
    • (1911) J. Exp. Med. , vol.13 , pp. 397-411
    • Rous, P.1
  • 31
    • 0021190160 scopus 로고
    • Inability of Rous sarcoma virus to cause sarcomas in the avian embryo
    • Dolberg, D.S. & Bissell, M.J. Inability of Rous sarcoma virus to cause sarcomas in the avian embryo. Nature 309, 552-556 (1984). (Pubitemid 14109376)
    • (1984) Nature , vol.309 , Issue.5968 , pp. 552-556
    • Dolberg, D.S.1    Bissell, M.J.2
  • 32
    • 0025336260 scopus 로고
    • The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia
    • Stoker, A.W., Hatier, C. & Bissell, M.J. The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia. J. Cell Biol. 111, 217-228 (1990).
    • (1990) J. Cell Biol. , vol.111 , pp. 217-228
    • Stoker, A.W.1    Hatier, C.2    Bissell, M.J.3
  • 33
    • 0025354027 scopus 로고
    • Mediation of woundrelated Rous sarcoma virus tumorigenesis by TGF
    • Sieweke, M.H., Thompson, N.L., Sporn, M.B. & Bissell, M.J. Mediation of woundrelated Rous sarcoma virus tumorigenesis by TGF-. Science 248, 1656-1660 (1990).
    • (1990) Science , vol.248 , pp. 1656-1660
    • Sieweke, M.H.1    Thompson, N.L.2    Sporn, M.B.3    Bissell, M.J.4
  • 34
    • 0008776253 scopus 로고
    • Ultrastructural analysis of the early development of teratocarcinomas
    • Pierce, G.B., Stevens, L.C. & Nakane, P.K. Ultrastructural analysis of the early development of teratocarcinomas. J. Natl. Cancer Inst. 39, 755-773 (1967).
    • (1967) J. Natl. Cancer Inst. , vol.39 , pp. 755-773
    • Pierce, G.B.1    Stevens, L.C.2    Nakane, P.K.3
  • 35
    • 0014156312 scopus 로고
    • Teratocarcinoma: Model for a developmental concept of cancer
    • Pierce, G.B. Teratocarcinoma: model for a developmental concept of cancer. Curr. Top. Dev. Biol. 2, 223-246 (1967).
    • (1967) Curr. Top. Dev. Biol. , vol.2 , pp. 223-246
    • Pierce, G.B.1
  • 36
    • 0014758977 scopus 로고
    • The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos
    • Stevens, L.C. The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos. Dev. Biol. 21, 364-382 (1970).
    • (1970) Dev. Biol. , vol.21 , pp. 364-382
    • Stevens, L.C.1
  • 37
    • 0014168076 scopus 로고
    • The biology of teratomas
    • Stevens, L.C. The biology of teratomas. Adv. Morphog. 6, 1-31 (1967).
    • (1967) Adv. Morphog. , vol.6 , pp. 1-31
    • Stevens, L.C.1
  • 38
    • 0016174481 scopus 로고
    • The effect of cells transferred into the mouse blastocyst on subsequent development
    • Brinster, R.L. The effect of cells transferred into the mouse blastocyst on subsequent development. J. Exp. Med. 140, 1049-1056 (1974).
    • (1974) J. Exp. Med. , vol.140 , pp. 1049-1056
    • Brinster, R.L.1
  • 39
    • 0345366593 scopus 로고
    • Normal genetically mosaic mice produced from malignant teratocarcinoma cells
    • Mintz, B. & Illmensee, K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc. Natl. Acad. Sci. USA 72, 3585-3589 (1975).
    • (1975) Proc. Natl. Acad. Sci. USA , vol.72 , pp. 3585-3589
    • Mintz, B.1    Illmensee, K.2
  • 40
    • 2042435768 scopus 로고
    • Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts
    • Illmensee, K. & Mintz, B. Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. Proc. Natl. Acad. Sci. USA 73, 549-553 (1976).
    • (1976) Proc. Natl. Acad. Sci. USA , vol.73 , pp. 549-553
    • Illmensee, K.1    Mintz, B.2
  • 42
    • 0020470231 scopus 로고
    • The induction of adenocarcinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inductor
    • Fujii, H., Cunha, G.R. & Norman, J.T. The induction of adenocarcinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inductor. J. Urol. 128, 858-861 (1982). (Pubitemid 13236382)
    • (1982) Journal of Urology , vol.128 , Issue.4 , pp. 858-861
    • Fujii, H.1    Cunha, G.R.2    Norman, J.T.3
  • 43
    • 0025297609 scopus 로고
    • Influence of male genital tract mesenchymes on differentiation of Dunning prostatic adenocarcinoma
    • Hayashi, N., Cunha, G.R. & Wong, Y.C. Influence of male genital tract mesenchymes on differentiation of Dunning prostatic adenocarcinoma. Cancer Res. 50, 4747-4754 (1990). (Pubitemid 20230424)
    • (1990) Cancer Research , vol.50 , Issue.15 , pp. 4747-4754
    • Hayashi, N.1    Cunha, G.R.2    Wong, Y.C.3
  • 44
    • 0026738947 scopus 로고
    • Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells
    • Petersen, O.W., Ronnov-Jessen, L., Howlett, A.R. & Bissell, M.J. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc. Natl. Acad. Sci. USA 89, 9064-9068 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9064-9068
    • Petersen, O.W.1    Ronnov-Jessen, L.2    Howlett, A.R.3    Bissell, M.J.4
  • 45
    • 0028576840 scopus 로고
    • A novel function for the nm23-H1 gene: Overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest
    • Howlett, A.R., Petersen, O.W., Steeg, P.S. & Bissell, M.J. A novel function for the nm23-H1 gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J. Natl. Cancer Inst. 86, 1838-1844 (1994).
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1838-1844
    • Howlett, A.R.1    Petersen, O.W.2    Steeg, P.S.3    Bissell, M.J.4
  • 46
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three- dimensional culture and in vivo by integrin blocking antibodies
    • DOI 10.1083/jcb.137.1.231
    • Weaver, V.M. et al. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J. Cell Biol. 137, 231-245 (1997). (Pubitemid 27167310)
    • (1997) Journal of Cell Biology , vol.137 , Issue.1 , pp. 231-245
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3    Larabell, C.A.4    Briand, P.5    Damsky, C.6    Bissell, M.J.7
  • 47
  • 50
    • 33744990640 scopus 로고    scopus 로고
    • A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells
    • DOI 10.1634/stemcells.2005-0459
    • Postovit, L.M., Seftor, E.A., Seftor, R.E. & Hendrix, M.J. A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells 24, 501-505 (2006). (Pubitemid 44464753)
    • (2006) Stem Cells , vol.24 , Issue.3 , pp. 501-505
    • Postovit, L.-M.1    Seftor, E.A.2    Seftor, R.E.B.3    Hendrix, M.J.C.4
  • 52
    • 0027613594 scopus 로고
    • Cell-matrix interactions in liver
    • Maher, J.J. & Bissell, D.M. Cell-matrix interactions in liver. Semin. Cell Biol. 4, 189-201 (1993).
    • (1993) Semin. Cell Biol. , vol.4 , pp. 189-201
    • Maher, J.J.1    Bissell, D.M.2
  • 53
    • 0017082939 scopus 로고
    • Risk for breast cancer development determined by mammographic parenchymal pattern
    • Wolfe, J.N. Risk for breast cancer development determined by mammographic parenchymal pattern. Cancer 37, 2486-2492 (1976).
    • (1976) Cancer , vol.37 , pp. 2486-2492
    • Wolfe, J.N.1
  • 55
    • 33846590533 scopus 로고    scopus 로고
    • Wolfe mammographic parenchymal patterns and breast cancer risk
    • DOI 10.2214/AJR.06.0635
    • Sickles, E.A. Wolfe mammographic parenchymal patterns and breast cancer risk. AJR Am. J. Roentgenol. 188, 301-303 (2007). (Pubitemid 46170751)
    • (2007) American Journal of Roentgenology , vol.188 , Issue.2 , pp. 301-303
    • Sickles, E.A.1
  • 57
    • 0036153330 scopus 로고    scopus 로고
    • Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition
    • Gudjonsson, T. et al. Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J. Cell Sci. 115, 39-50 (2002). (Pubitemid 34105527)
    • (2002) Journal of Cell Science , vol.115 , Issue.1 , pp. 39-50
    • Gudjonsson, T.1    Ronnov-Jessen, L.2    Villadsen, R.3    Rank, F.4    Bissell, M.J.5    Petersen, O.W.6
  • 58
    • 78650220991 scopus 로고    scopus 로고
    • Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo
    • Beliveau, A. et al. Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo. Genes Dev. 24, 2800-2811 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2800-2811
    • Beliveau, A.1
  • 59
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce, J.A. & Pollard, J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9, 239-252 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 60
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian, B.Z. & Pollard, J.W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39-51 (2010).
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 61
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - Bipolar effects of the tumour stroma in cancer
    • DOI 10.1038/nrc1477
    • Mueller, M.M. & Fusenig, N.E. Friends or foes-bipolar effects of the tumour stroma in cancer. Nat. Rev. Cancer 4, 839-849 (2004). (Pubitemid 39472951)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.11 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 63
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • DOI 10.1038/nature03096
    • Bhowmick, N.A., Neilson, E.G. & Moses, H.L. Stromal fibroblasts in cancer initiation and progression. Nature 432, 332-337 (2004). (Pubitemid 39551661)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 64
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29, 15-18 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 15-18
    • Folkman, J.1
  • 65
    • 0029312344 scopus 로고
    • Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1
    • Sympson, C.J., Bissell, M.J. & Werb, Z. Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1. Semin. Cancer Biol. 6, 159-163 (1995).
    • (1995) Semin. Cancer Biol. , vol.6 , pp. 159-163
    • Sympson, C.J.1    Bissell, M.J.2    Werb, Z.3
  • 70
    • 0021893245 scopus 로고
    • Adult, foetal and transformed fibroblasts display different migratory phenotypes on collagen gels: Evidence for an isoformic transition during foetal development
    • Schor, S.L., Schor, A.M., Rushton, G. & Smith, L. Adult, foetal and transformed fibroblasts display different migratory phenotypes on collagen gels: evidence for an isoformic transition during foetal development. J. Cell Sci. 73, 221-234 (1985). (Pubitemid 15055072)
    • (1985) Journal of Cell Science , vol.VOL. 73 , pp. 221-234
    • Schor, S.L.1    Schor, A.M.2    Rushton, G.3    Smith, L.4
  • 71
    • 0021893246 scopus 로고
    • Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels
    • Schor, S.L., Schor, A.M., Durning, P. & Rushton, G. Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels. J. Cell Sci. 73, 235-244 (1985). (Pubitemid 15055073)
    • (1985) Journal of Cell Science , vol.VOL. 73 , pp. 235-244
    • Schor, S.L.1    Schor, A.M.2    Durning, P.3    Rushton, G.4
  • 72
    • 0023722312 scopus 로고
    • Fibroblasts from cancer patients display a mixture of both foetal and adult-like phenotypic characteristics
    • Schor, S.L., Schor, A.M. & Rushton, G. Fibroblasts from cancer patients display a mixture of both foetal and adult-like phenotypic characteristics. J. Cell Sci. 90, 401-407 (1988).
    • (1988) J. Cell Sci. , vol.90 , pp. 401-407
    • Schor, S.L.1    Schor, A.M.2    Rushton, G.3
  • 74
    • 0025103317 scopus 로고
    • Fibroblast-mediated acceleration of human epithelial tumor growth in vivo
    • Camps, J.L. et al. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc. Natl. Acad. Sci. USA 87, 75-79 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 75-79
    • Camps, J.L.1
  • 76
    • 0034161922 scopus 로고    scopus 로고
    • Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
    • Barcellos-Hoff, M.H. & Ravani, S.A. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 60, 1254-1260 (2000). (Pubitemid 30151992)
    • (2000) Cancer Research , vol.60 , Issue.5 , pp. 1254-1260
    • Barcellos-Hoff, M.H.1    Ravani, S.A.2
  • 78
    • 0027161705 scopus 로고
    • Induction of α-smooth muscle actin by transforming growth factor-β1 in quiescent human breast gland fibroblasts
    • Rønnov-Jessen, L. & Petersen, O.W. Induction of -smooth muscle actin by transforming growth factor-1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab. Invest. 68, 696-707 (1993). (Pubitemid 23202798)
    • (1993) Laboratory Investigation , vol.68 , Issue.6 , pp. 696-707
    • Ronnov-Jessen, L.1    Petersen, O.W.2
  • 79
    • 0030051051 scopus 로고    scopus 로고
    • Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
    • Rønnov-Jessen, L., Petersen, O.W. & Bissell, M.J. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol. Rev. 76, 69-125 (1996). (Pubitemid 26048279)
    • (1996) Physiological Reviews , vol.76 , Issue.1 , pp. 69-125
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Bissell, M.J.3
  • 80
    • 0028890174 scopus 로고
    • The origin of the myofibroblasts in breast cancer Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells
    • Rønnov-Jessen, L., Petersen, O.W., Koteliansky, V.E. & Bissell, M.J. The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. J. Clin. Invest. 95, 859-873 (1995).
    • (1995) J. Clin. Invest. , vol.95 , pp. 859-873
    • Rønnov-Jessen, L.1    Petersen, O.W.2    Koteliansky, V.E.3    Bissell, M.J.4
  • 81
    • 19344363035 scopus 로고    scopus 로고
    • Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds
    • Chang, H.Y. et al. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol. 2, E7 (2004).
    • (2004) PLoS Biol. , vol.2
    • Chang, H.Y.1
  • 84
    • 77954600493 scopus 로고    scopus 로고
    • Oxidative stress promotes myofibroblast differentiation and tumour spreading
    • Toullec, A. et al. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol. Med. 2, 211-230 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , pp. 211-230
    • Toullec, A.1
  • 86
    • 50849090319 scopus 로고    scopus 로고
    • Macrophages define the invasive microenvironment in breast cancer
    • Pollard, J.W. Macrophages define the invasive microenvironment in breast cancer. J. Leukoc. Biol. 84, 623-630 (2008).
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 623-630
    • Pollard, J.W.1
  • 87
    • 0035495401 scopus 로고    scopus 로고
    • Putting tumours in context
    • Bissell, M.J. & Radisky, D. Putting tumours in context. Nat. Rev. Cancer 1, 46-54 (2001). (Pubitemid 33741880)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.1 , pp. 46-54
    • Bissell, M.J.1    Radisky, D.2
  • 88
    • 0023946119 scopus 로고
    • Tumors as caricatures of the process of tissue renewal: Prospects for therapy by directing differentiation
    • Pierce, G.B. & Speers, W.C. Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation. Cancer Res. 48, 1996-2004 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 1996-2004
    • Pierce, G.B.1    Speers, W.C.2
  • 89
    • 0017379403 scopus 로고
    • Relationship between differentiation and carcinogenesis
    • Pierce, G.B. Relationship between differentiation and carcinogenesis. J. Toxicol. Environ. Health 2, 1335-1342 (1977). (Pubitemid 8151322)
    • (1977) Journal of Toxicology and Environmental Health , vol.2 , Issue.6 , pp. 1335-1342
    • Pierce, G.B.1
  • 90
    • 34347221196 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment
    • Kenny, P.A., Lee, G.Y. & Bissell, M.J. Targeting the tumor microenvironment. Front. Biosci. 12, 3468-3474 (2007).
    • (2007) Front. Biosci. , vol.12 , pp. 3468-3474
    • Kenny, P.A.1    Lee, G.Y.2    Bissell, M.J.3
  • 91
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing
    • Dvorak, H.F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650-1659 (1986). (Pubitemid 17052899)
    • (1986) New England Journal of Medicine , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 92
    • 78149298209 scopus 로고    scopus 로고
    • Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein
    • Kraman, M. et al. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-. Science 330, 827-830 (2010).
    • (2010) Science , vol.330 , pp. 827-830
    • Kraman, M.1
  • 94
    • 76649134465 scopus 로고    scopus 로고
    • Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers
    • Saadi, A. et al. Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers. Proc. Natl. Acad. Sci. USA 107, 2177-2182 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 2177-2182
    • Saadi, A.1
  • 95
    • 58149334773 scopus 로고    scopus 로고
    • A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    • Farmer, P. et al. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat. Med. 15, 68-74 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 68-74
    • Farmer, P.1
  • 96
    • 0028953271 scopus 로고
    • Reduction of caveolin and caveolae in oncogenically transformed cells
    • Koleske, A.J., Baltimore, D. & Lisanti, M.P. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc. Natl. Acad. Sci. USA 92, 1381-1385 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1381-1385
    • Koleske, A.J.1    Baltimore, D.2    Lisanti, M.P.3
  • 98
    • 66549114050 scopus 로고    scopus 로고
    • An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
    • Witkiewicz, A.K. et al. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am. J. Pathol. 174, 2023-2034 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 2023-2034
    • Witkiewicz, A.K.1
  • 99
    • 66749106907 scopus 로고    scopus 로고
    • Stromal cell expression of caveolin-1 predicts outcome in breast cancer
    • Sloan, E.K. et al. Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am. J. Pathol. 174, 2035-2043 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 2035-2043
    • Sloan, E.K.1
  • 100
    • 67649975270 scopus 로고    scopus 로고
    • Prognostic significance of stromal platelet-derived growth factor receptor expression in human breast cancer
    • Paulsson, J. et al. Prognostic significance of stromal platelet-derived growth factor receptor expression in human breast cancer. Am. J. Pathol. 175, 334-341 (2009).
    • (2009) Am. J. Pathol. , vol.175 , pp. 334-341
    • Paulsson, J.1
  • 101
    • 77956425361 scopus 로고    scopus 로고
    • Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
    • Barry-Hamilton, V. et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat. Med. 16, 1009-1017 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 1009-1017
    • Barry-Hamilton, V.1
  • 102
    • 0037116626 scopus 로고    scopus 로고
    • Evolution of anticancer drug discovery and the role of cell-based screening
    • Balis, F.M. Evolution of anticancer drug discovery and the role of cell-based screening. J. Natl. Cancer Inst. 94, 78-79 (2002). (Pubitemid 34121279)
    • (2002) Journal of the National Cancer Institute , vol.94 , Issue.2 , pp. 78-79
    • Balis, F.M.1
  • 103
    • 34147167656 scopus 로고    scopus 로고
    • Achievements in systemic therapies in the pregenomic era in metastatic breast cancer
    • DOI 10.1634/theoncologist.12-3-253
    • Colozza, M. et al. Achievements in systemic therapies in the pregenomic era in metastatic breast cancer. Oncologist 12, 253-270 (2007). (Pubitemid 46556792)
    • (2007) Oncologist , vol.12 , Issue.3 , pp. 253-270
    • Colozza, M.1    De Azambuja, E.2    Personeni, N.3    Lebrun, F.4    Piccart, M.J.5    Cardoso, F.6
  • 105
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside, T.L. The tumor microenvironment and its role in promoting tumor growth. Oncogene 27, 5904-5912 (2008).
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 106
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • DOI 10.1038/nature01322
    • Coussens, L.M. & Werb, Z. Inflammation and cancer. Nature 420, 860-867 (2002). (Pubitemid 36019639)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 107
    • 0036726312 scopus 로고    scopus 로고
    • β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    • DOI 10.1016/S1535-6108(02)00125-3
    • Weaver, V.M. et al. 4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2, 205-216 (2002). (Pubitemid 41043976)
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 205-216
    • Weaver, V.M.1    Lelievre, S.2    Lakins, J.N.3    Chrenek, M.A.4    Jones, J.C.R.5    Giancotti, F.6    Werb, Z.7    Bissell, M.J.8
  • 108
    • 77953540958 scopus 로고    scopus 로고
    • HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    • Weigelt, B., Lo, A.T., Park, C.C., Gray, J.W. & Bissell, M.J. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res. Treat. 122, 35-43 (2010).
    • (2010) Breast Cancer Res. Treat. , vol.122 , pp. 35-43
    • Weigelt, B.1    Lo, A.T.2    Park, C.C.3    Gray, J.W.4    Bissell, M.J.5
  • 109
    • 77956497324 scopus 로고    scopus 로고
    • Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice
    • Polo, M.L. et al. Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice. PLoS ONE 5, e10786 (2010).
    • (2010) PLoS ONE , vol.5
    • Polo, M.L.1
  • 111
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • DOI 10.1038/ncb0901-785
    • Muthuswamy, S.K., Li, D., Lelievre, S., Bissell, M.J. & Brugge, J.S. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat. Cell Biol. 3, 785-792 (2001). (Pubitemid 32842683)
    • (2001) Nature Cell Biology , vol.3 , Issue.9 , pp. 785-792
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 112
    • 32944469169 scopus 로고    scopus 로고
    • 1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo
    • DOI 10.1158/0008-5472.CAN-05-3071
    • Park, C.C. et al. 1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res. 66, 1526-1535 (2006). (Pubitemid 43259934)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1526-1535
    • Park, C.C.1    Zhang, H.2    Pallavicini, M.3    Gray, J.W.4    Baehner, F.5    Park, C.J.6    Bissell, M.J.7
  • 113
    • 49249107671 scopus 로고    scopus 로고
    • Integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts
    • Park, C.C., Zhang, H.J., Yao, E.S., Park, C.J. & Bissell, M.J. 1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res. 68, 4398-4405 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 4398-4405
    • Park, C.C.1    Zhang, H.J.2    Yao, E.S.3    Park, C.J.4    Bissell, M.J.5
  • 114
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive, K.P. et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461 (2009).
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1
  • 115
    • 78649638780 scopus 로고    scopus 로고
    • Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models
    • Thompson, C.B. et al. Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models. Mol. Cancer Ther. 9, 3052-3064 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 3052-3064
    • Thompson, C.B.1
  • 116
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • Levental, K.R. et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139, 891-906 (2009).
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1
  • 117
    • 59849098041 scopus 로고    scopus 로고
    • Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function
    • Xu, R. et al. Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J. Cell Biol. 184, 57-66 (2009).
    • (2009) J. Cell Biol. , vol.184 , pp. 57-66
    • Xu, R.1
  • 118
    • 33746417036 scopus 로고    scopus 로고
    • Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: The role of extracellular matrix and its degrading enzymes
    • DOI 10.1101/sqb.2005.70.013
    • Bissell, M.J., Kenny, P.A. & Radisky, D.C. Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb. Symp. Quant. Biol. 70, 343-356 (2005). (Pubitemid 44124889)
    • (2005) Cold Spring Harbor Symposia on Quantitative Biology , vol.70 , pp. 343-356
    • Bissell, M.J.1    Kenny, P.A.2    Radisky, D.C.3
  • 119
    • 77950542260 scopus 로고    scopus 로고
    • Tumor cell-specific bioluminescence platform to identify stromainduced changes to anticancer drug activity
    • McMillin, D.W. et al. Tumor cell-specific bioluminescence platform to identify stromainduced changes to anticancer drug activity. Nat. Med. 16, 483-489 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 483-489
    • McMillin, D.W.1
  • 120
    • 69249110820 scopus 로고    scopus 로고
    • Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity
    • Chen, A. et al. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 69, 6721-6729 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 6721-6729
    • Chen, A.1
  • 122
    • 79952070774 scopus 로고    scopus 로고
    • The secreted factors responsible for premetastatic niche formation: Old sayings and new thoughts
    • 18 January published online doi:10.1016/j.semcancer. 2011.01.002
    • Peinado, H., Lavothskin, S. & Lyden, D. The secreted factors responsible for premetastatic niche formation: old sayings and new thoughts. Semin. Cancer. Biol. published online, doi:10.1016/j.semcancer. 2011.01.002 (18 January 2011).
    • (2011) Semin. Cancer. Biol.
    • Peinado, H.1    Lavothskin, S.2    Lyden, D.3
  • 123
    • 33748967069 scopus 로고    scopus 로고
    • Of extracellular matrix, scaffolds and signaling: Tissue architecture regulates development, homeostasis, and cancer
    • Nelson, C.M. & Bissell, M.J. Of extracellular matrix, scaffolds and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 22, 287-309 (2006).
    • (2006) Annu. Rev. Cell Dev. Biol. , vol.22 , pp. 287-309
    • Nelson, C.M.1    Bissell, M.J.2
  • 124
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget, S. The distribution of secondary growths in cancer of the breast. Lancet 1, 571-573 (1889).
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 126
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N., Hillan, K.J., Gerber, H.P. & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3, 391-400 (2004). (Pubitemid 38618122)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.5 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.-P.3    Novotny, W.4
  • 127
    • 32944478104 scopus 로고    scopus 로고
    • Results of a phase i trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors, including colorectal cancer
    • Kupsch, P. et al. Results of a phase I trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors, including colorectal cancer. Clin. Colorectal Cancer 5, 188-196 (2005).
    • (2005) Clin. Colorectal Cancer , vol.5 , pp. 188-196
    • Kupsch, P.1
  • 128
    • 76749097199 scopus 로고    scopus 로고
    • MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor
    • Pan, B.S. et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 70, 1524-1533 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 1524-1533
    • Pan, B.S.1
  • 129
    • 33748804427 scopus 로고    scopus 로고
    • The effect of zoledronic acid on the function and differentiation of myeloid cells
    • Wolf, A.M. et al. The effect of zoledronic acid on the function and differentiation of myeloid cells. Haematologica 91, 1165-1171 (2006). (Pubitemid 44408425)
    • (2006) Haematologica , vol.91 , Issue.9 , pp. 1165-1171
    • Wolf, A.M.1    Rumpold, H.2    Tilg, H.3    Gastl, G.4    Gunsilius, E.5    Wolf, D.6
  • 130
    • 77955982989 scopus 로고    scopus 로고
    • Zoledronic acid impairs myeloid differentiation to tumourassociated macrophages in mesothelioma
    • Veltman, J.D. et al. Zoledronic acid impairs myeloid differentiation to tumourassociated macrophages in mesothelioma. Br. J. Cancer 103, 629-641 (2010).
    • (2010) Br. J. Cancer , vol.103 , pp. 629-641
    • Veltman, J.D.1
  • 131
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum, S.L. Bone resorption by osteoclasts. Science 289, 1504-1508 (2000).
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 132
    • 9244252016 scopus 로고    scopus 로고
    • The molecular triad OPG/RANK/RANKL: Involvement in the orchestration of pathophysiological bone remodeling
    • DOI 10.1016/j.cytogfr.2004.06.004, PII S1359610104000747
    • Theoleyre, S. et al. The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. Cytokine Growth Factor Rev. 15, 457-475 (2004). (Pubitemid 39550455)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.6 , pp. 457-475
    • Theoleyre, S.1    Wittrant, Y.2    Tat, S.K.3    Fortun, Y.4    Redini, F.5    Heymann, D.6
  • 133
    • 58249100053 scopus 로고    scopus 로고
    • CXCR4 antagonists: Targeting the microenvironment in leukemia and other cancers
    • Burger, J.A. & Peled, A. CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 23, 43-52 (2009).
    • (2009) Leukemia , vol.23 , pp. 43-52
    • Burger, J.A.1    Peled, A.2
  • 134
    • 36849073658 scopus 로고    scopus 로고
    • MMPs as therapeutic targets-Still a viable option?
    • DOI 10.1016/j.semcdb.2007.06.006, PII S1084952107000912, Matrix Metalloproteinases
    • Fingleton, B. MMPs as therapeutic targets-still a viable option? Semin. Cell Dev. Biol. 19, 61-68 (2008). (Pubitemid 350235985)
    • (2008) Seminars in Cell and Developmental Biology , vol.19 , Issue.1 , pp. 61-68
    • Fingleton, B.1
  • 135
    • 37549070672 scopus 로고    scopus 로고
    • Cysteine cathepsin proteases as pharmacological targets in cancer
    • Palermo, C. & Joyce, J.A. Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol. Sci. 29, 22-28 (2008).
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 22-28
    • Palermo, C.1    Joyce, J.A.2
  • 136
    • 34547640302 scopus 로고    scopus 로고
    • Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer
    • DOI 10.1158/0008-5472.CAN-07-0602
    • Bell-McGuinn, K.M., Garfall, A.L., Bogyo, M., Hanahan, D. & Joyce, J.A. Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res. 67, 7378-7385 (2007). (Pubitemid 47206568)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7378-7385
    • Bell-McGuinn, K.M.1    Garfall, A.L.2    Bogyo, M.3    Hanahan, D.4    Joyce, J.A.5
  • 137
    • 77954954369 scopus 로고    scopus 로고
    • Cancer and inflammation: Promise for biologic therapy
    • Demaria, S. et al. Cancer and inflammation: promise for biologic therapy. J. Immunother. 33, 335-351 (2010).
    • (2010) J. Immunother. , vol.33 , pp. 335-351
    • Demaria, S.1
  • 138
    • 0348227655 scopus 로고    scopus 로고
    • Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells
    • DOI 10.1182/blood-2003-06-2066
    • Qiang, Y.W., Yao, L., Tosato, G. & Rudikoff, S. Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells. Blood 103, 301-308 (2004). (Pubitemid 38029952)
    • (2004) Blood , vol.103 , Issue.1 , pp. 301-308
    • Qiang, Y.-W.1    Yao, L.2    Tosato, G.3    Rudikoff, S.4
  • 139
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • DOI 10.1038/nrc2189, PII NRC2189
    • Hideshima, T., Mitsiades, C., Tonon, G., Richardson, P.G. & Anderson, K.C. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat. Rev. Cancer 7, 585-598 (2007). (Pubitemid 47106630)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 140
    • 14544303662 scopus 로고    scopus 로고
    • Proteasome inhibition as a novel therapeutic target in human cancer
    • DOI 10.1200/JCO.2005.11.030
    • Rajkumar, S.V., Richardson, P.G., Hideshima, T. & Anderson, K.C. Proteasome inhibition as a novel therapeutic target in human cancer. J. Clin. Oncol. 23, 630-639 (2005). (Pubitemid 46224241)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.3 , pp. 630-639
    • Rajkumar, S.V.1    Richardson, P.G.2    Hideshima, T.3    Anderson, K.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.