Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

Cell

Volumn 109, Issue 5, 2002, Pages 611-623

  Funamoto, Satoru ^a   Meili, Ruedi ^a   Lee, Susan ^a   Parry, Lisa ^a   Firtel, Richard A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; CELL MEMBRANE; CHEMOTAXIS; CONTROLLED STUDY; DICTYOSTELIUM DISCOIDEUM; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; NEGIBACTERIA;

EID: 0037205265     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00755-9     Document Type: Article

References (36)

1. Efficient control of gene expression by a tetracycline-dependent transactivator in single Dictyostelium discoideum cells
2. PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis
3. Signaling pathways controlling cell polarity and chemotaxis
4. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
5. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities
6. The molecular genetics of chemotaxis: Sensing and responding to chemoattractant gradients
7. Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity
8. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
9. Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
10. Tight control of gene expression in mammalian cells by teracycline-responsive elements
11. Spatial sensing in fibroblasts mediated by 3′ phosphoinositides
12. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
13. Localization of the G protein βγ complex in living cells during chemotaxis
14. Signal transduction in neutrophil chemotaxis
15. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
16. A novel Ras interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium
17. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
18. RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation
19. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipd second messenger, phosphatidylinositol 3,4,5-trisphosphate
20. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
21. A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium
22. Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
23. A cell's sense of direction
24. G protein signaling events are activated at the leading edge of chemotactic cells
25. Leukocytes navigate by compass: Roles of PI3K-γ and its lipid products
26. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
27. Leukocyte polarization in cell migration and immune interactions
28. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
29. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
30. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
31. Dictyostelium RasG is required for normal motility and cytokinesis, but not growth
32. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
33. Synthesis and function of 3-phosphorylated inositol lipids
34. Computer-assisted characterization of the behavioral defects of cytoskeletal mutants of Dictyostelium discoideum
35. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation
36. A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: Biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development