-
1
-
-
56749102128
-
Par complex in cancer: A regulator of normal cell polarity joins the dark side
-
Aranda V, Nolan ME, Muthuswamy SK (2008). Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene 27, 6878-6887.
-
(2008)
Oncogene
, vol.27
, pp. 6878-6887
-
-
Aranda, V.1
Nolan, M.E.2
Muthuswamy, S.K.3
-
2
-
-
21644460380
-
Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways
-
Cau J, Hall A (2005). Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways. J Cell Sci 118, 2579-2587.
-
(2005)
J Cell Sci
, vol.118
, pp. 2579-2587
-
-
Cau, J.1
Hall, A.2
-
3
-
-
33750681355
-
The polarity protein par-3 directly interacts with p75ntr to regulate myelination
-
Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M (2006). The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. Science 314, 832-836.
-
(2006)
Science
, vol.314
, pp. 832-836
-
-
Chan, J.R.1
Jolicoeur, C.2
Yamauchi, J.3
Elliott, J.4
Fawcett, J.P.5
Ng, B.K.6
Cayouette, M.7
-
4
-
-
14744289370
-
Par-3 controls tight junction assembly through the rac exchange factor tiam1
-
Chen X, Macara IG (2005). Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol 7, 262-269.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 262-269
-
-
Chen, X.1
Macara, I.G.2
-
5
-
-
33846615059
-
Abr and bcr, two homologous rac gtpase-Activating proteins, control multiple cellular functions of murine macrophages
-
Cho YJ, Cunnick JM, Yi SJ, Kaartinen V, Groffen J, Heisterkamp N (2007). Abr and Bcr, two homologous Rac GTPase-Activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol 27, 899-911.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 899-911
-
-
Cho, Y.J.1
Cunnick, J.M.2
Yi, S.J.3
Kaartinen, V.4
Groffen, J.5
Heisterkamp, N.6
-
6
-
-
84885789025
-
Par6b is required for tight junction formation and activated pkcζ localization in breast cancer
-
Cunliffe HE, Jiang Y, Fornace KM, Yang F, Meltzer PS (2012). PAR6B is required for tight junction formation and activated PKCζ localization in breast cancer. Am J Cancer Res 2, 478-491.
-
(2012)
Am J Cancer Res
, vol.2
, pp. 478-491
-
-
Cunliffe, H.E.1
Jiang, Y.2
Fornace, K.M.3
Yang, F.4
Meltzer, P.S.5
-
7
-
-
24644490121
-
Atypical pkcι contributes to poor prognosis through loss of apical-basal polarity and cyclin e overexpression in ovarian cancer
-
Eder AM et al. (2005). Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci USA 102, 12519-12524.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 12519-12524
-
-
Eder, A.M.1
-
9
-
-
84875808443
-
The rac activator tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network
-
Ellenbroek SI, Iden S, Collard JG (2012b). The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network. Small GTPases 3, 4-14.
-
(2012)
Small GTPases
, vol.3
, pp. 4-14
-
-
Ellenbroek, S.I.1
Iden, S.2
Collard, J.G.3
-
10
-
-
2342432240
-
Cdc42 -The centre of polarity
-
Etienne-Manneville S (2004). Cdc42 -the centre of polarity. J Cell Sci 117, 1291-1300.
-
(2004)
J Cell Sci
, vol.117
, pp. 1291-1300
-
-
Etienne-Manneville, S.1
-
11
-
-
32144442590
-
In vitro assay of primary astrocyte migration as a tool to study rho gtpase function in cell polarization
-
Etienne-Manneville S (2006). In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization. Methods Enzymol 406, 565-578.
-
(2006)
Methods Enzymol
, vol.406
, pp. 565-578
-
-
Etienne-Manneville, S.1
-
12
-
-
56249139409
-
Polarity proteins in glial cell functions
-
Etienne-Manneville S (2008). Polarity proteins in glial cell functions. Curr Opin Neurobiol 18, 488-494.
-
(2008)
Curr Opin Neurobiol
, vol.18
, pp. 488-494
-
-
Etienne-Manneville, S.1
-
13
-
-
0035943401
-
Integrin-mediated activation of cdc42 controls cell polarity in migrating astrocytes through pkcζ
-
Etienne-Manneville S, Hall A (2001). Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCζ. Cell 106, 489-498.
-
(2001)
Cell
, vol.106
, pp. 489-498
-
-
Etienne-Manneville, S.1
Hall, A.2
-
14
-
-
0037069690
-
Rho gtpases in cell biology
-
Etienne-Manneville S, Hall A (2002). Rho GTPases in cell biology. Nature 420, 629-635.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
15
-
-
0037434790
-
Cdc42 regulates gsk-3β and adenomatous polyposis coli to control cell polarity
-
Etienne-Manneville S, Hall A (2003a). Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature 421, 753-756.
-
(2003)
Nature
, vol.421
, pp. 753-756
-
-
Etienne-Manneville, S.1
Hall, A.2
-
16
-
-
0037222950
-
Cell polarity: Par6, apkc and cytoskeletal crosstalk
-
Etienne-Manneville S, Hall A (2003b). Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr Opin Cell Biol 15, 67-72.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 67-72
-
-
Etienne-Manneville, S.1
Hall, A.2
-
17
-
-
2442664118
-
Rational design and characterization of a rac gtpase-specific small molecule inhibitor
-
Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y (2004). Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101, 7618-7623.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 7618-7623
-
-
Gao, Y.1
Dickerson, J.B.2
Guo, F.3
Zheng, J.4
Zheng, Y.5
-
18
-
-
0036898598
-
Spatial and temporal analysis of rac activation during live neutrophil chemotaxis
-
Gardiner EM, Pestonjamasp KN, Bohl BP, Chamberlain C, Hahn KM, Bokoch GM (2002). Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Curr Biol 12, 2029-2034.
-
(2002)
Curr Biol
, vol.12
, pp. 2029-2034
-
-
Gardiner, E.M.1
Pestonjamasp, K.N.2
Bohl, B.P.3
Chamberlain, C.4
Hahn, K.M.5
Bokoch, G.M.6
-
19
-
-
17844379382
-
Nuclear movement regulated by cdc42, mrck, myosin, and actin flow establishes mtoc polarization in migrating cells
-
Gomes ER, Jani S, Gundersen GG (2005). Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell 121, 451-463.
-
(2005)
Cell
, vol.121
, pp. 451-463
-
-
Gomes, E.R.1
Jani, S.2
Gundersen, G.G.3
-
21
-
-
0031214960
-
Involvement of phosphatidylinositide 3′-kinase and rac in platelet-derived growth factor-induced actin reorganization and chemotaxis
-
Hooshmand-Rad R, Claesson-Welsh L, Wennstrom S, Yokote K, Siegbahn A, Heldin CH (1997). Involvement of phosphatidylinositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. Exp Cell Res 234, 434-441.
-
(1997)
Exp Cell Res
, vol.234
, pp. 434-441
-
-
Hooshmand-Rad, R.1
Claesson-Welsh, L.2
Wennstrom, S.3
Yokote, K.4
Siegbahn, A.5
Heldin, C.H.6
-
22
-
-
54549104845
-
Crosstalk between small gtpases and polarity proteins in cell polarization
-
Iden S, Collard JG (2008). Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol Cell Biol 9, 846-859.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 846-859
-
-
Iden, S.1
Collard, J.G.2
-
23
-
-
0034644603
-
Localized rac activation dynamics visualized in living cells
-
Kraynov VS, Chamberlain C, Bokoch GM, Schwartz MA, Slabaugh S, Hahn KM (2000). Localized Rac activation dynamics visualized in living cells. Science 290, 333-337.
-
(2000)
Science
, vol.290
, pp. 333-337
-
-
Kraynov, V.S.1
Chamberlain, C.2
Bokoch, G.M.3
Schwartz, M.A.4
Slabaugh, S.5
Hahn, K.M.6
-
24
-
-
0033517102
-
Axin and frat1 interact with dvl and gsk, bridging dvl to gsk in wnt-mediated regulation of lef-1
-
Li L, Yuan H, Weaver CD, Mao J, Farr GH, III, Sussman DJ, Jonkers J, Kimelman D, Wu D (1999). Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J 18, 4233-4240.
-
(1999)
EMBO J
, vol.18
, pp. 4233-4240
-
-
Li, L.1
Yuan, H.2
Weaver, C.D.3
Mao, J.4
Farr III, G.H.5
Sussman, D.J.6
Jonkers, J.7
Kimelman, D.8
Wu, D.9
-
25
-
-
84857296427
-
Targeting rho gtpase signaling for cancer therapy
-
Mardilovich K, Olson MF, Baugh M (2012). Targeting Rho GTPase signaling for cancer therapy. Future Oncol 8, 165-177.
-
(2012)
Future Oncol
, vol.8
, pp. 165-177
-
-
Mardilovich, K.1
Olson, M.F.2
Baugh, M.3
-
27
-
-
0037205007
-
The promise and perils of wnt signaling through β-catenin
-
Moon RT, Bowerman B, Boutros M, Perrimon N (2002). The promise and perils of Wnt signaling through β-catenin. Science 296, 1644-1646.
-
(2002)
Science
, vol.296
, pp. 1644-1646
-
-
Moon, R.T.1
Bowerman, B.2
Boutros, M.3
Perrimon, N.4
-
28
-
-
38849122774
-
Rho-kinase phosphorylates par-3 and disrupts par complex formation
-
Nakayama M, Goto TM, Sugimoto M, Nishimura T, Shinagawa T, Ohno S, Amano M, Kaibuchi K (2008). Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell 14, 205-215.
-
(2008)
Dev Cell
, vol.14
, pp. 205-215
-
-
Nakayama, M.1
Goto, T.M.2
Sugimoto, M.3
Nishimura, T.4
Shinagawa, T.5
Ohno, S.6
Amano, M.7
Kaibuchi, K.8
-
29
-
-
14744300477
-
Par-6-par-3 mediates cdc42-induced rac activation through the rac gefs stef/tiam1
-
Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K (2005). PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol 7, 270-277.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 270-277
-
-
Nishimura, T.1
Yamaguchi, T.2
Kato, K.3
Yoshizawa, M.4
Nabeshima, Y.5
Ohno, S.6
Hoshino, M.7
Kaibuchi, K.8
-
30
-
-
34848869140
-
The par-tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity
-
Pegtel DM, Ellenbroek SI, Mertens AE, van der Kammen RA, de Rooij J, Collard JG (2007). The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol 17, 1623-1634.
-
(2007)
Curr Biol
, vol.17
, pp. 1623-1634
-
-
Pegtel, D.M.1
Ellenbroek, S.I.2
Mertens, A.E.3
Van Der Kammen, R.A.4
De Rooij, J.5
Collard, J.G.6
-
31
-
-
0034659420
-
A human homolog of the c. Elegans polarity determinant par-6 links rac and cdc42 to pkcζ signaling and cell transformation
-
Qiu RG, Abo A, Steven Martin G (2000). A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation. Curr Biol 10, 697-707.
-
(2000)
Curr Biol
, vol.10
, pp. 697-707
-
-
Qiu, R.G.1
Abo, A.2
Steven Martin, G.3
-
32
-
-
79959559880
-
Role of rho gtpases and their regulators in cancer progression
-
Rathinam R, Berrier A, Alahari SK (2011). Role of Rho GTPases and their regulators in cancer progression. Front Biosci (Landmark Ed) 16, 2561-2571.
-
(2011)
Front Biosci (Landmark Ed)
, Issue.16
, pp. 2561-2571
-
-
Rathinam, R.1
Berrier, A.2
Alahari, S.K.3
-
33
-
-
24744469442
-
Atypical protein kinase cι plays a critical role in human lung cancer cell growth and tumorigenicity
-
Regala RP, Weems C, Jamieson L, Copland JA, Thompson EA, Fields AP (2005a). Atypical protein kinase Cι plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem 280, 31109-31115.
-
(2005)
J Biol Chem
, vol.280
, pp. 31109-31115
-
-
Regala, R.P.1
Weems, C.2
Jamieson, L.3
Copland, J.A.4
Thompson, E.A.5
Fields, A.P.6
-
34
-
-
25444531988
-
Atypical protein kinase cι is an oncogene in human non-small cell lung cancer
-
Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM, Fields AP (2005b). Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer. Cancer Res 65, 8905-8911.
-
(2005)
Cancer Res
, vol.65
, pp. 8905-8911
-
-
Regala, R.P.1
Weems, C.2
Jamieson, L.3
Khoor, A.4
Edell, E.S.5
Lohse, C.M.6
Fields, A.P.7
-
35
-
-
0034865456
-
Rho gtpases and cell migration
-
Ridley AJ (2001). Rho GTPases and cell migration. J Cell Sci 114, 2713-2722.
-
(2001)
J Cell Sci
, vol.114
, pp. 2713-2722
-
-
Ridley, A.J.1
-
36
-
-
2442477424
-
New synaptic bouton formation is disrupted by misregulation of microtubule stability in apkc mutants
-
Ruiz-Canada C, Ashley J, Moeckel-Cole S, Drier E, Yin J, Budnik V (2004). New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants. Neuron 42, 567-580.
-
(2004)
Neuron
, vol.42
, pp. 567-580
-
-
Ruiz-Canada, C.1
Ashley, J.2
Moeckel-Cole, S.3
Drier, E.4
Yin, J.5
Budnik, V.6
-
37
-
-
0032583205
-
Matrix-dependent tiam1/rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
-
Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F, Collard JG (1998). Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol 143, 1385-1398.
-
(1998)
J Cell Biol
, vol.143
, pp. 1385-1398
-
-
Sander, E.E.1
Van Delft, S.2
Ten Klooster, J.P.3
Reid, T.4
Van Der Kammen, R.A.5
Michiels, F.6
Collard, J.G.7
-
38
-
-
0036644975
-
Guanine nucleotide exchange factors for rho gtpases: Turning on the switch
-
Schmidt A, Hall A (2002). Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16, 1587-1609.
-
(2002)
Genes Dev
, vol.16
, pp. 1587-1609
-
-
Schmidt, A.1
Hall, A.2
-
39
-
-
9244249219
-
Apc and gsk-3β are involved in mpar3 targeting to the nascent axon and establishment of neuronal polarity
-
Shi SH, Cheng T, Jan LY, Jan YN (2004). APC and GSK-3β are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr Biol 14, 2025-2032.
-
(2004)
Curr Biol
, vol.14
, pp. 2025-2032
-
-
Shi, S.H.1
Cheng, T.2
Jan, L.Y.3
Jan, Y.N.4
-
40
-
-
0034704104
-
Activation of atypical protein kinase c ζ by caspase processing and degradation by the ubiquitin-proteasome system
-
Smith L, Chen L, Reyland ME, DeVries TA, Talanian RV, Omura S, Smith JB (2000). Activation of atypical protein kinase C ζ by caspase processing and degradation by the ubiquitin-proteasome system. J Biol Chem 275, 40620-40627.
-
(2000)
J Biol Chem
, vol.275
, pp. 40620-40627
-
-
Smith, L.1
Chen, L.2
Reyland, M.E.3
DeVries, T.A.4
Talanian, R.V.5
Omura, S.6
Smith, J.B.7
-
42
-
-
33846969965
-
Current knowledge of the large rhogap family of proteins
-
Tcherkezian J, Lamarche-Vane N (2007). Current knowledge of the large RhoGAP family of proteins. Biol Cell 99, 67-86.
-
(2007)
Biol Cell
, vol.99
, pp. 67-86
-
-
Tcherkezian, J.1
Lamarche-Vane, N.2
-
43
-
-
13844253719
-
The rac1-gef tiam1 couples the nmda receptor to the activity-dependent development of dendritic arbors and spines
-
Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME (2005). The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron 45, 525-538.
-
(2005)
Neuron
, vol.45
, pp. 525-538
-
-
Tolias, K.F.1
Bikoff, J.B.2
Burette, A.3
Paradis, S.4
Harrar, D.5
Tavazoie, S.6
Weinberg, R.J.7
Greenberg, M.E.8
-
44
-
-
34249856693
-
The rac1 guanine nucleotide exchange factor tiam1 mediates ephb receptor-dependent dendritic spine development
-
Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME (2007). The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Nat Acad Sci USA 104, 7265-7270.
-
(2007)
Proc Nat Acad Sci USA
, vol.104
, pp. 7265-7270
-
-
Tolias, K.F.1
Bikoff, J.B.2
Kane, C.G.3
Tolias, C.S.4
Hu, L.5
Greenberg, M.E.6
-
45
-
-
41549086261
-
Phosphatidylinositol-3-kinase-Atypical protein kinase c signaling is required for wnt attraction and anterior-posterior axon guidance
-
Wolf AM, Lyuksyutova AI, Fenstermaker AG, Shafer B, Lo CG, Zou Y (2008). Phosphatidylinositol-3-kinase-Atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. J Neurosci 28, 3456-3467.
-
(2008)
J Neurosci
, vol.28
, pp. 3456-3467
-
-
Wolf, A.M.1
Lyuksyutova, A.I.2
Fenstermaker, A.G.3
Shafer, B.4
Lo, C.G.5
Zou, Y.6
-
46
-
-
33644747349
-
The polarity protein par-3 and tiam1 cooperate in dendritic spine morphogenesis
-
Zhang H, Macara IG (2006). The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Nat Cell Biol 8, 227-237.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 227-237
-
-
Zhang, H.1
Macara, I.G.2
-
47
-
-
38849119148
-
The par-6 polarity protein regulates dendritic spine morphogenesis through p190 rhogap and the rho gtpase
-
Zhang H, Macara IG (2008). The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase. Dev Cell 14, 216-226.
-
(2008)
Dev Cell
, vol.14
, pp. 216-226
-
-
Zhang, H.1
Macara, I.G.2
|