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Volumn 24, Issue 24, 2013, Pages 3857-3868

The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; BREAKPOINT CLUSTER REGION PROTEIN; BROXURIDINE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAC PROTEIN; BCR PROTEIN, MOUSE; CELL ADHESION MOLECULE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NEUROPEPTIDE; PAR6 PROTEIN, MOUSE; PARD3 PROTEIN, MOUSE; PROTEIN KINASE C; PROTEIN KINASE C ZETA; RAC1 PROTEIN; RAC1 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TIAM1 PROTEIN, MOUSE;

EID: 84890526139     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E13-06-0333     Document Type: Article
Times cited : (21)

References (47)
  • 1
    • 56749102128 scopus 로고    scopus 로고
    • Par complex in cancer: A regulator of normal cell polarity joins the dark side
    • Aranda V, Nolan ME, Muthuswamy SK (2008). Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene 27, 6878-6887.
    • (2008) Oncogene , vol.27 , pp. 6878-6887
    • Aranda, V.1    Nolan, M.E.2    Muthuswamy, S.K.3
  • 2
    • 21644460380 scopus 로고    scopus 로고
    • Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways
    • Cau J, Hall A (2005). Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways. J Cell Sci 118, 2579-2587.
    • (2005) J Cell Sci , vol.118 , pp. 2579-2587
    • Cau, J.1    Hall, A.2
  • 4
    • 14744289370 scopus 로고    scopus 로고
    • Par-3 controls tight junction assembly through the rac exchange factor tiam1
    • Chen X, Macara IG (2005). Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol 7, 262-269.
    • (2005) Nat Cell Biol , vol.7 , pp. 262-269
    • Chen, X.1    Macara, I.G.2
  • 5
    • 33846615059 scopus 로고    scopus 로고
    • Abr and bcr, two homologous rac gtpase-Activating proteins, control multiple cellular functions of murine macrophages
    • Cho YJ, Cunnick JM, Yi SJ, Kaartinen V, Groffen J, Heisterkamp N (2007). Abr and Bcr, two homologous Rac GTPase-Activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol 27, 899-911.
    • (2007) Mol Cell Biol , vol.27 , pp. 899-911
    • Cho, Y.J.1    Cunnick, J.M.2    Yi, S.J.3    Kaartinen, V.4    Groffen, J.5    Heisterkamp, N.6
  • 6
    • 84885789025 scopus 로고    scopus 로고
    • Par6b is required for tight junction formation and activated pkcζ localization in breast cancer
    • Cunliffe HE, Jiang Y, Fornace KM, Yang F, Meltzer PS (2012). PAR6B is required for tight junction formation and activated PKCζ localization in breast cancer. Am J Cancer Res 2, 478-491.
    • (2012) Am J Cancer Res , vol.2 , pp. 478-491
    • Cunliffe, H.E.1    Jiang, Y.2    Fornace, K.M.3    Yang, F.4    Meltzer, P.S.5
  • 7
    • 24644490121 scopus 로고    scopus 로고
    • Atypical pkcι contributes to poor prognosis through loss of apical-basal polarity and cyclin e overexpression in ovarian cancer
    • Eder AM et al. (2005). Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci USA 102, 12519-12524.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12519-12524
    • Eder, A.M.1
  • 9
    • 84875808443 scopus 로고    scopus 로고
    • The rac activator tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network
    • Ellenbroek SI, Iden S, Collard JG (2012b). The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network. Small GTPases 3, 4-14.
    • (2012) Small GTPases , vol.3 , pp. 4-14
    • Ellenbroek, S.I.1    Iden, S.2    Collard, J.G.3
  • 10
    • 2342432240 scopus 로고    scopus 로고
    • Cdc42 -The centre of polarity
    • Etienne-Manneville S (2004). Cdc42 -the centre of polarity. J Cell Sci 117, 1291-1300.
    • (2004) J Cell Sci , vol.117 , pp. 1291-1300
    • Etienne-Manneville, S.1
  • 11
    • 32144442590 scopus 로고    scopus 로고
    • In vitro assay of primary astrocyte migration as a tool to study rho gtpase function in cell polarization
    • Etienne-Manneville S (2006). In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization. Methods Enzymol 406, 565-578.
    • (2006) Methods Enzymol , vol.406 , pp. 565-578
    • Etienne-Manneville, S.1
  • 12
    • 56249139409 scopus 로고    scopus 로고
    • Polarity proteins in glial cell functions
    • Etienne-Manneville S (2008). Polarity proteins in glial cell functions. Curr Opin Neurobiol 18, 488-494.
    • (2008) Curr Opin Neurobiol , vol.18 , pp. 488-494
    • Etienne-Manneville, S.1
  • 13
    • 0035943401 scopus 로고    scopus 로고
    • Integrin-mediated activation of cdc42 controls cell polarity in migrating astrocytes through pkcζ
    • Etienne-Manneville S, Hall A (2001). Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCζ. Cell 106, 489-498.
    • (2001) Cell , vol.106 , pp. 489-498
    • Etienne-Manneville, S.1    Hall, A.2
  • 14
    • 0037069690 scopus 로고    scopus 로고
    • Rho gtpases in cell biology
    • Etienne-Manneville S, Hall A (2002). Rho GTPases in cell biology. Nature 420, 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 15
    • 0037434790 scopus 로고    scopus 로고
    • Cdc42 regulates gsk-3β and adenomatous polyposis coli to control cell polarity
    • Etienne-Manneville S, Hall A (2003a). Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature 421, 753-756.
    • (2003) Nature , vol.421 , pp. 753-756
    • Etienne-Manneville, S.1    Hall, A.2
  • 16
    • 0037222950 scopus 로고    scopus 로고
    • Cell polarity: Par6, apkc and cytoskeletal crosstalk
    • Etienne-Manneville S, Hall A (2003b). Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr Opin Cell Biol 15, 67-72.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 67-72
    • Etienne-Manneville, S.1    Hall, A.2
  • 17
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a rac gtpase-specific small molecule inhibitor
    • Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y (2004). Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101, 7618-7623.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 19
    • 17844379382 scopus 로고    scopus 로고
    • Nuclear movement regulated by cdc42, mrck, myosin, and actin flow establishes mtoc polarization in migrating cells
    • Gomes ER, Jani S, Gundersen GG (2005). Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell 121, 451-463.
    • (2005) Cell , vol.121 , pp. 451-463
    • Gomes, E.R.1    Jani, S.2    Gundersen, G.G.3
  • 21
    • 0031214960 scopus 로고    scopus 로고
    • Involvement of phosphatidylinositide 3′-kinase and rac in platelet-derived growth factor-induced actin reorganization and chemotaxis
    • Hooshmand-Rad R, Claesson-Welsh L, Wennstrom S, Yokote K, Siegbahn A, Heldin CH (1997). Involvement of phosphatidylinositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. Exp Cell Res 234, 434-441.
    • (1997) Exp Cell Res , vol.234 , pp. 434-441
    • Hooshmand-Rad, R.1    Claesson-Welsh, L.2    Wennstrom, S.3    Yokote, K.4    Siegbahn, A.5    Heldin, C.H.6
  • 22
    • 54549104845 scopus 로고    scopus 로고
    • Crosstalk between small gtpases and polarity proteins in cell polarization
    • Iden S, Collard JG (2008). Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol Cell Biol 9, 846-859.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 846-859
    • Iden, S.1    Collard, J.G.2
  • 25
    • 84857296427 scopus 로고    scopus 로고
    • Targeting rho gtpase signaling for cancer therapy
    • Mardilovich K, Olson MF, Baugh M (2012). Targeting Rho GTPase signaling for cancer therapy. Future Oncol 8, 165-177.
    • (2012) Future Oncol , vol.8 , pp. 165-177
    • Mardilovich, K.1    Olson, M.F.2    Baugh, M.3
  • 27
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of wnt signaling through β-catenin
    • Moon RT, Bowerman B, Boutros M, Perrimon N (2002). The promise and perils of Wnt signaling through β-catenin. Science 296, 1644-1646.
    • (2002) Science , vol.296 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 30
    • 34848869140 scopus 로고    scopus 로고
    • The par-tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity
    • Pegtel DM, Ellenbroek SI, Mertens AE, van der Kammen RA, de Rooij J, Collard JG (2007). The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol 17, 1623-1634.
    • (2007) Curr Biol , vol.17 , pp. 1623-1634
    • Pegtel, D.M.1    Ellenbroek, S.I.2    Mertens, A.E.3    Van Der Kammen, R.A.4    De Rooij, J.5    Collard, J.G.6
  • 31
    • 0034659420 scopus 로고    scopus 로고
    • A human homolog of the c. Elegans polarity determinant par-6 links rac and cdc42 to pkcζ signaling and cell transformation
    • Qiu RG, Abo A, Steven Martin G (2000). A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation. Curr Biol 10, 697-707.
    • (2000) Curr Biol , vol.10 , pp. 697-707
    • Qiu, R.G.1    Abo, A.2    Steven Martin, G.3
  • 32
    • 79959559880 scopus 로고    scopus 로고
    • Role of rho gtpases and their regulators in cancer progression
    • Rathinam R, Berrier A, Alahari SK (2011). Role of Rho GTPases and their regulators in cancer progression. Front Biosci (Landmark Ed) 16, 2561-2571.
    • (2011) Front Biosci (Landmark Ed) , Issue.16 , pp. 2561-2571
    • Rathinam, R.1    Berrier, A.2    Alahari, S.K.3
  • 33
    • 24744469442 scopus 로고    scopus 로고
    • Atypical protein kinase cι plays a critical role in human lung cancer cell growth and tumorigenicity
    • Regala RP, Weems C, Jamieson L, Copland JA, Thompson EA, Fields AP (2005a). Atypical protein kinase Cι plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem 280, 31109-31115.
    • (2005) J Biol Chem , vol.280 , pp. 31109-31115
    • Regala, R.P.1    Weems, C.2    Jamieson, L.3    Copland, J.A.4    Thompson, E.A.5    Fields, A.P.6
  • 35
    • 0034865456 scopus 로고    scopus 로고
    • Rho gtpases and cell migration
    • Ridley AJ (2001). Rho GTPases and cell migration. J Cell Sci 114, 2713-2722.
    • (2001) J Cell Sci , vol.114 , pp. 2713-2722
    • Ridley, A.J.1
  • 36
    • 2442477424 scopus 로고    scopus 로고
    • New synaptic bouton formation is disrupted by misregulation of microtubule stability in apkc mutants
    • Ruiz-Canada C, Ashley J, Moeckel-Cole S, Drier E, Yin J, Budnik V (2004). New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants. Neuron 42, 567-580.
    • (2004) Neuron , vol.42 , pp. 567-580
    • Ruiz-Canada, C.1    Ashley, J.2    Moeckel-Cole, S.3    Drier, E.4    Yin, J.5    Budnik, V.6
  • 37
    • 0032583205 scopus 로고    scopus 로고
    • Matrix-dependent tiam1/rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
    • Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F, Collard JG (1998). Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol 143, 1385-1398.
    • (1998) J Cell Biol , vol.143 , pp. 1385-1398
    • Sander, E.E.1    Van Delft, S.2    Ten Klooster, J.P.3    Reid, T.4    Van Der Kammen, R.A.5    Michiels, F.6    Collard, J.G.7
  • 38
    • 0036644975 scopus 로고    scopus 로고
    • Guanine nucleotide exchange factors for rho gtpases: Turning on the switch
    • Schmidt A, Hall A (2002). Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16, 1587-1609.
    • (2002) Genes Dev , vol.16 , pp. 1587-1609
    • Schmidt, A.1    Hall, A.2
  • 39
    • 9244249219 scopus 로고    scopus 로고
    • Apc and gsk-3β are involved in mpar3 targeting to the nascent axon and establishment of neuronal polarity
    • Shi SH, Cheng T, Jan LY, Jan YN (2004). APC and GSK-3β are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr Biol 14, 2025-2032.
    • (2004) Curr Biol , vol.14 , pp. 2025-2032
    • Shi, S.H.1    Cheng, T.2    Jan, L.Y.3    Jan, Y.N.4
  • 40
    • 0034704104 scopus 로고    scopus 로고
    • Activation of atypical protein kinase c ζ by caspase processing and degradation by the ubiquitin-proteasome system
    • Smith L, Chen L, Reyland ME, DeVries TA, Talanian RV, Omura S, Smith JB (2000). Activation of atypical protein kinase C ζ by caspase processing and degradation by the ubiquitin-proteasome system. J Biol Chem 275, 40620-40627.
    • (2000) J Biol Chem , vol.275 , pp. 40620-40627
    • Smith, L.1    Chen, L.2    Reyland, M.E.3    DeVries, T.A.4    Talanian, R.V.5    Omura, S.6    Smith, J.B.7
  • 41
    • 33750962238 scopus 로고    scopus 로고
    • Mpar6α controls neuronal migration
    • Solecki DJ, Govek EE, Hatten ME (2006). mPar6α controls neuronal migration. J Neurosci 26, 10624-10625.
    • (2006) J Neurosci , vol.26 , pp. 10624-10625
    • Solecki, D.J.1    Govek, E.E.2    Hatten, M.E.3
  • 42
    • 33846969965 scopus 로고    scopus 로고
    • Current knowledge of the large rhogap family of proteins
    • Tcherkezian J, Lamarche-Vane N (2007). Current knowledge of the large RhoGAP family of proteins. Biol Cell 99, 67-86.
    • (2007) Biol Cell , vol.99 , pp. 67-86
    • Tcherkezian, J.1    Lamarche-Vane, N.2
  • 44
    • 34249856693 scopus 로고    scopus 로고
    • The rac1 guanine nucleotide exchange factor tiam1 mediates ephb receptor-dependent dendritic spine development
    • Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME (2007). The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Nat Acad Sci USA 104, 7265-7270.
    • (2007) Proc Nat Acad Sci USA , vol.104 , pp. 7265-7270
    • Tolias, K.F.1    Bikoff, J.B.2    Kane, C.G.3    Tolias, C.S.4    Hu, L.5    Greenberg, M.E.6
  • 45
    • 41549086261 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase-Atypical protein kinase c signaling is required for wnt attraction and anterior-posterior axon guidance
    • Wolf AM, Lyuksyutova AI, Fenstermaker AG, Shafer B, Lo CG, Zou Y (2008). Phosphatidylinositol-3-kinase-Atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. J Neurosci 28, 3456-3467.
    • (2008) J Neurosci , vol.28 , pp. 3456-3467
    • Wolf, A.M.1    Lyuksyutova, A.I.2    Fenstermaker, A.G.3    Shafer, B.4    Lo, C.G.5    Zou, Y.6
  • 46
    • 33644747349 scopus 로고    scopus 로고
    • The polarity protein par-3 and tiam1 cooperate in dendritic spine morphogenesis
    • Zhang H, Macara IG (2006). The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Nat Cell Biol 8, 227-237.
    • (2006) Nat Cell Biol , vol.8 , pp. 227-237
    • Zhang, H.1    Macara, I.G.2
  • 47
    • 38849119148 scopus 로고    scopus 로고
    • The par-6 polarity protein regulates dendritic spine morphogenesis through p190 rhogap and the rho gtpase
    • Zhang H, Macara IG (2008). The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase. Dev Cell 14, 216-226.
    • (2008) Dev Cell , vol.14 , pp. 216-226
    • Zhang, H.1    Macara, I.G.2


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