Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation

Science

Volumn 302, Issue 5651, 2003, Pages 1775-1779

  Wang, Hong Rui ^a   Zhang, Yue ^a   Ozdamar, Barish ^a,b   Ogunjimi, Abiodun A ^a   Alexandrova, Evguenia ^c   Thomsen, Gerald H ^c   Wrana, Jeffrey L ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; PROTEINS; SIGNALING; TUMORS;

POLARITY;

CELLS;

GUANOSINE TRIPHOSPHATASE; PROTEIN; PROTEIN CDC42; PROTEIN KINASE C ZETA; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; SMURF1 PROTEIN; UNCLASSIFIED DRUG;

BIOLOGY; DEGRADATION; MEMBRANE; PROTEIN;

ANIMAL CELL; ARTICLE; CELL MOTILITY; CELL POLARITY; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TUMOR CELL;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CELL POLARITY; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; CYTOSKELETON; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTERCELLULAR JUNCTIONS; MICE; NIH 3T3 CELLS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PSEUDOPODIA; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 0344758986     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090772     Document Type: Article

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36. We thank L. Attisano and members of the Wrana laboratory for discussion and comments on the manuscript; S. Elowe, D. Lin, T. Pawson, I. B. Weinstein, D. Bohmann, J. Sheng, and A. Varshavsky for providing reagents; S, Kulkarni for help with deconvolution microscopy and time-lapse imaging; and L. Locke for advice on the motility assay. We are indebted to J. Trimmer and L. Buckwalder for help in preparation of monoclonal antibodies. This work was supported by grants from the Canadian Cancer Society and the Canadian Institutes of Health Research (J.L.W.) and NIH grant HD32429 and Carol M. Baldwin Breast Cancer Foundation (G.H.T.). Y.Z. and B.O. are supported by a Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship and Doctoral Studentship awards, respectively, and E.A. is the recipient of an Institute for Cell and Developmental Biology Predoctoral Fellowship from Stony Brook University. J.L.W. is a CIHR Investigator and an International Scholar of the Howard Hughes Medical Institute.