Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces

Molecular Cancer Research

Volumn 6, Issue 9, 2008, Pages 1410-1420

  Rösel, Daniel ^a   Brábek, Jan ^a   Tolde, Ondřej ^a   Mierke, Claudia T ^c   Zitterbart, Daniel P ^c   Raupach, Carina ^c   Bicanová, Kristýna ^a   Kollmannsberger, Philip ^c   Paňková, Daniela ^a   Veselý, Pavel ^b   Folk, Petr ^a   Fabry, Ben ^c  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN LIGHT CHAIN; RHO ASSOCIATED PROTEIN KINASE 1; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER INVASION; CARCINOMA CELL; CELL INVASION; CELL LINE; CONFOCAL MICROSCOPY; CYTOSKELETON; MESENCHYME CELL; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMA CELL;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; CYTOSKELETON; LIM KINASES; MAGNETICS; MATRIX METALLOPROTEINASE 2; MESENCHYMAL STEM CELLS; MICROSCOPY, FLUORESCENCE; MYOSIN LIGHT CHAINS; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; RATS; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SARCOMA; UP-REGULATION;

EID: 53349127603     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-07-2174     Document Type: Article

References (40)

1. Ahmad A, Hart IR. Mechanisms of metastasis. Crit Rev Oncol Hematol 1997;26:163-73.
2. Sahai E. Mechanisms of cancer cell invasion. Curr Opin Genet Dev 2005;15:87-96.
3. Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 2003;5:711-9.
4. Wolf K, Mazo I, Leung H, et al. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 2003;160:267-77.
5. Wyckoff JB, Pinner SE, Gschmeissner S, Condeelis JS, Sahai E. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo . Curr Biol 2006;16:1515-23.
6. Vial E, Sahai E, Marshall CJ. ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell 2003;4:67-79.
7. Cavanna T, Pokorna E, Vesely P, Gray C, Zicha D. Evidence for protein 4.1B acting as a metastasis suppressor. J Cell Sci 2007;120:606-16.
8. Carragher NO, Walker SM, Scott Carragher LA, et al. Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene 2006;25:5726-40.
9. Brabek J, Constancio SS, Shin NY, Pozzi A, Weaver AM, Hanks SK. CAS promotes invasiveness of Src-transformed cells. Oncogene 2004;23:7406-15.
10. Zhao ZS, Manser E. PAK and other Rho-associated kinases - effectors with surprisingly diverse mechanisms of regulation. Biochem J 2005;386:201-14.
11. Ishizaki T, Maekawa M, Fujisawa K, et al. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J 1996;15:1885-93.
12. Sahai E, Marshall CJ. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol 2002;4:408-15.
13. Danley DE, Chuang TH, Bokoch GM. Defective Rho GTPase regulation by IL-1β-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor. J Immunol 1996;157:500-3.
14. Kimura K, Ito M, Amano M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996;273:245-8.
15. Amano M, Chihara K, Kimura K, et al. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 1997;275:1308-11.
16. Bursac P, Lenormand G, Fabry B, et al. Cytoskeletal remodelling and slow dynamics in the living cell. Nat Mater 2005;4:557-61.
17. Alenghat FJ, Fabry B, Tsai KY, Goldmann WH, Ingber DE. Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer. Biochem Biophys Res Commun 2000;277:93-9.
18. Mierke CT, Kollmannsberger P, Zitterbart DP, Smith J, Fabry B, Goldmann WH. Mechano-coupling and regulation of contractility by the vinculin tail domain. Biophys J 2008;94:661-70.
19. Vesely P, Chaloupkova A, Urbanec P, et al. Patterns of in vitro behaviour characterizing cells of spontaneously metastasizing K2M rat sarcoma. Folia Biol Praha 1987;33:307-24.
20. Laevsky G, Knecht DA. Cross-linking of actin filaments by myosin II is a major contributor to cortical integrity and cell motility in restrictive environments. J Cell Sci 2003;116:3761-70.
21. Mierke CT, Zitterbart DP, Kollmannsberger P, et al. Breakdown of the endothelial barrier function in tumor cell transmigration. Biophys J 2008;94:2832-46.
22. Zheng Y, Mak AF. Effective elastic properties for lower limb soft tissues from manual indentation experiment. IEEE Trans Rehabil Eng 1999;7:257-67.
23. Samani A, Plewes D. An inverse problem solution for measuring the elastic modulus of intact ex vivo breast tissue tumours. Phys Med Biol 2007;52:1247-60.
24. Butler JP, Tolic-Norrelykke IM, Fabry B, Fredberg JJ. Traction fields, moments, and strain energy that cells exert on their surroundings. Am J Physiol Cell Physiol 2002;282:C595-605.
25. Wyckoff JB, Jones JG, Condeelis JS, Segall JE. A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer Res 2000;60:2504-11.
26. Wang W, Wyckoff JB, Frohlich VC, et al. Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res 2002;62:6278-88.
27. Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 1999;5:221-5.
28. Takamura M, Sakamoto M, Genda T, Ichida T, Asakura H, Hirohashi S. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. Hepatology 2001;33:577-81.
29. Mierke CT, Rosel D, Fabry B, Brabek J. Contractile forces in tumor cell migration. Eur J Cell Biol 2008;87:669-76.
30. Fukuda T, Kido A, Kajino K, et al. Cloning of differentially expressed genes in highly and low metastatic rat osteosarcomas by a modified cDNA-AFLP method. Biochem Biophys Res Commun 1999;261:35-40.
31. Banyard J, Anand-Apte B, Symons M, Zetter BR. Motility and invasion are differentially modulated by Rho family GTPases. Oncogene 2000;19:580-91.
32. Nakajima M, Katayama K, Tamechika I, et al. WF-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility. Clin Exp Pharmacol Physiol 2003;30:457-63.
33. Ying H, Biroc SL, Li WW, et al. The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models. Mol Cancer Ther 2006;5:2158-64.
34. Vesely P, Weiss RA. Cell locomotion and contact inhibition of normal and neoplastic rat cells. Int J Cancer 1973;11:64-76.
35. Heit B, Kubes P. Measuring chemotaxis and chemokinesis: the under-agarose cell migration assay. Sci STKE 2003;2003:L5.
36. Pozzi A, Moberg PE, Miles LA, Wagner S, Soloway P, Gardner HA. Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci U S A 2000;97:2202-7.
37. Fabry B, Maksym GN, Shore SA, et al. Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells. J Appl Physiol 2001;91:986-94.
38. Raupach C, Zitterbart DP, Mierke CT, Metzner C, Muller FA, Fabry B. Stress fluctuations and motion of cytoskeletal-bound markers. Phys Rev E Stat Nonlin Soft Matter Phys 2007;76:011918.
39. Hildebrandt J. Comparison of mathematical models for cat lung and viscoelastic balloon derived by Laplace transform methods from pressure-volume data. Bull Math Biophys 1969;31:651-67.
40. Wang YL, Pelham RJ, Jr. Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells. Methods Enzymol 1998;298:489-96.