A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression

Oncogene

Volumn 31, Issue 32, 2012, Pages 3696-3708

  Anastas, J N ^a   Biechele, T L ^a   Robitaille, M ^b,c   Muster, J ^a   Allison, K H ^a   Angers, S ^b,c   Moon, R T ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

migration; NOS1AP; PCP; SCRIB; VANGL1

Indexed keywords

P21 ACTIVATED KINASE; PROTEIN; PROTEIN ARHGEF; PROTEIN GIT; PROTEIN NOS1AP; PROTEIN SCRIB; PROTEIN VANGL1; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER GROWTH; CELL JUNCTION; CELL MIGRATION; CELL POLARITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TUMOR XENOGRAFT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BREAST NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL POLARITY; CELL PROLIFERATION; CELL SURFACE EXTENSIONS; DISEASE PROGRESSION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MEMBRANE PROTEINS; MICE; MICE, NUDE; MULTIPROTEIN COMPLEXES; NEOPLASM TRANSPLANTATION; PROTEIN INTERACTION MAPPING; PROTEIN INTERACTION MAPS; PROTEIN TRANSPORT; RNA INTERFERENCE; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEINS;

EID: 84864956480     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.528     Document Type: Article

References (34)

1. Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ et al. (2006). The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol 8: 348-357.
2. Audebert S, Navarro C, Nourry C, Chasserot-Golaz S, Lécine P, Bellaiche Y et al. (2004). Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Curr Biol 14: 987-995.
3. Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D et al. (2006). Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439: 353-357.
4. Bilder D, Li M, Perrimon N. (2000). Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289: 113-116.
5. Bilder D, Perrimon N. (2000). Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403: 676-680.
6. Bilder D, Schober M, Perrimon N. (2003). Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol 5: 53-58.
7. Carrel D, Du Y, Komlos D, Hadzimichalis NM, Kwon M, Wang B et al. (2009). NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway. J Neurosci 29: 8248-8258.
8. Cordero JB, Macagno JP, Stefanatos RK, Strathdee KE, Cagan RL, Vidal M. (2010). Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter. Developmental Cell 18: 999-1011.
9. Courbard J-R, Djiane A, Wu J, Mlodzik M. (2009). The apical/basal- polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. Dev Biol 333: 67-77.
10. Dow LE, Kauffman JS, Caddy J, Zarbalis K, Peterson AS, Jane SM et al. (2007). The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene 26: 2272-2282.
11. Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH. (2000). Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 28: 183-193.
12. Harvey JM, Clark GM, Osborne CK, Allred DC. (1999). Estrogen receptor status by immunohistochemistry is superior to the ligandbinding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol 17: 1474-1481.
13. Ivanov AI, Young C, Den Beste K, Capaldo CT, Humbert PO, Brennwald P et al. (2010). Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium. Am J Pathol 176: 134-145.
14. Jaffrey SR. (2002). Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Proc Natl Acad Sci USA 99: 3199-3204.
15. Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH. (1998). CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron 20: 115-124.
16. Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C et al. (2007). Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 316: 1043-1046.
17. Métais J-Y, Navarro C, Santoni M-J, Audebert S, Borg JP. (2005). hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells. FEBS Lett 579: 3725-3730.
18. Montcouquiol M, Rachel RA, Lanford PJ, Copeland NG, Jenkins NA, Kelley MW. (2003). Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423: 173-177.
19. Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME et al. (2010). The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function. J Neurosci 30: 9738-9752.
20. Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C et al. (2003). Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet 12: 87-98.
21. Murdoch JN, Rachel RA, Shah S, Beermann F, Stanier P, Mason CA et al. (2001). Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation. Genomics 78: 55-63.
22. Nobes CD. (1999). Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 144: 1235-1244.
23. Nola S, Sebbagh M, Marchetto S, Osmani N, Nourry C, Audebert S et al. (2008). Scrib regulates PAK activity during the cell migration process. Hum Mol Genet 17: 3552-3565.
24. Navarro C, Nola S, Audebert S, Santoni M-J, Arsanto J-P, Ginestier C et al. (2005). Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene 24: 4330-4339.
25. Osmani N, Vitale N, Borg J-P, Etienne-Manneville S. (2006). Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration. Curr Biol 16: 2395-2405.
26. Petit MMR, Crombez KRMO, Vervenne HBVK, Weyns N, Van de Ven WJM. (2005a). The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. FEBS Lett 579: 5061-5068.
27. Petit MMR,Meulemans SMP, Alen P, Ayoubi TAY, Jansen E, Van de Ven WJM. (2005b). The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. BMC Cell Biol 6: 1.
28. Phua DCY, Humbert PO, Hunziker W. (2009). Vimentin regulates scribble activity by protecting it from proteasomal degradation. Mol Biol Cell 20: 2841-2855.
29. Qin Y, Capaldo C, Gumbiner BM, Macara IG. (2005). The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E cadherin. J Cell Biol 171: 1061-1071.
30. Richier L, Williton K, Clattenburg L, Colwill K, O'Brien M, Tsang C et al. (2010). NOS1AP associates with Scribble and regulates dendritic spine development. J Neurosci 30: 4796-4805.
31. Vervenne HBVK, Crombez KRMO, Lambaerts K, Carvalho L, Kö ppen M, Heisenberg CP et al. (2008). Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Dev Biol 320: 267-277.
32. Wada H, Iwasaki M, Sato T, Masai I, Nishiwaki Y, Tanaka H et al. (2005). Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos. Development 132: 2273-2285.
33. Wang Y, Klijn JGM, Zhang Y, Sieuwerts AM, Look MP, Yang F et al. (2005). Gene expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365: 671-679.
34. Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB et al. (2008). Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135: 865-878.