메뉴 건너뛰기




Volumn 55, Issue 3, 2014, Pages 436-450

An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls snail1 and metastatic potential

Author keywords

[No Author keywords available]

Indexed keywords

DIXDC1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE LKB1; SCAFFOLD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SNAIL1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84905568827     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.06.021     Document Type: Article
Times cited : (110)

References (44)
  • 4
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer C.L., Weinberg R.A. A perspective on cancer cell metastasis. Science 2011, 331:1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 9
    • 84893181929 scopus 로고    scopus 로고
    • Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer
    • Gyorffy B., Surowiak P., Budczies J., Lánczky A. Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS ONE 2013, 8:e82241.
    • (2013) PLoS ONE , vol.8
    • Gyorffy, B.1    Surowiak, P.2    Budczies, J.3    Lánczky, A.4
  • 10
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 84876320551 scopus 로고    scopus 로고
    • LKB1 and AMPK and the cancer-metabolism link - ten years after
    • Hardie D.G., Alessi D.R. LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biol. 2013, 11:36.
    • (2013) BMC Biol. , vol.11 , pp. 36
    • Hardie, D.G.1    Alessi, D.R.2
  • 12
    • 33644503878 scopus 로고    scopus 로고
    • Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling
    • Hoffman L.M., Jensen C.C., Kloeker S., Wang C.L., Yoshigi M., Beckerle M.C. Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J. Cell Biol. 2006, 172:771-782.
    • (2006) J. Cell Biol. , vol.172 , pp. 771-782
    • Hoffman, L.M.1    Jensen, C.C.2    Kloeker, S.3    Wang, C.L.4    Yoshigi, M.5    Beckerle, M.C.6
  • 13
    • 67650898228 scopus 로고    scopus 로고
    • LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism
    • Jansen M., Ten Klooster J.P., Offerhaus G.J., Clevers H. LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol. Rev. 2009, 89:777-798.
    • (2009) Physiol. Rev. , vol.89 , pp. 777-798
    • Jansen, M.1    Ten Klooster, J.P.2    Offerhaus, G.J.3    Clevers, H.4
  • 15
    • 79952555964 scopus 로고    scopus 로고
    • Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome
    • Lai C., Robinson J., Clark S., Stamp G., Poulsom R., Silver A. Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome. J. Pathol. 2011, 223:584-592.
    • (2011) J. Pathol. , vol.223 , pp. 584-592
    • Lai, C.1    Robinson, J.2    Clark, S.3    Stamp, G.4    Poulsom, R.5    Silver, A.6
  • 18
    • 77950526433 scopus 로고    scopus 로고
    • Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells
    • Matsumoto S., Fumoto K., Okamoto T., Kaibuchi K., Kikuchi A. Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 2010, 29:1192-1204.
    • (2010) EMBO J. , vol.29 , pp. 1192-1204
    • Matsumoto, S.1    Fumoto, K.2    Okamoto, T.3    Kaibuchi, K.4    Kikuchi, A.5
  • 20
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova M.M., Shaw R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat. Cell Biol. 2011, 13:1016-1023.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 22
    • 84866116442 scopus 로고    scopus 로고
    • Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1
    • Mise N., Savai R., Yu H., Schwarz J., Kaminski N., Eickelberg O. Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1. J. Biol. Chem. 2012, 287:31393-31405.
    • (2012) J. Biol. Chem. , vol.287 , pp. 31393-31405
    • Mise, N.1    Savai, R.2    Yu, H.3    Schwarz, J.4    Kaminski, N.5    Eickelberg, O.6
  • 23
    • 33750358078 scopus 로고    scopus 로고
    • Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition
    • Moreno-Bueno G., Cubillo E., Sarrió D., Peinado H., Rodríguez-Pinilla S.M., Villa S., Bolós V., Jordá M., Fabra A., Portillo F., et al. Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res. 2006, 66:9543-9556.
    • (2006) Cancer Res. , vol.66 , pp. 9543-9556
    • Moreno-Bueno, G.1    Cubillo, E.2    Sarrió, D.3    Peinado, H.4    Rodríguez-Pinilla, S.M.5    Villa, S.6    Bolós, V.7    Jordá, M.8    Fabra, A.9    Portillo, F.10
  • 24
    • 83455245205 scopus 로고    scopus 로고
    • The tumor suppressor kinase LKB1: lessons from mouse models
    • Ollila S., Mäkelä T.P. The tumor suppressor kinase LKB1: lessons from mouse models. J. Mol. Cell Biol. 2011, 3:330-340.
    • (2011) J. Mol. Cell Biol. , vol.3 , pp. 330-340
    • Ollila, S.1    Mäkelä, T.P.2
  • 26
    • 79951896236 scopus 로고    scopus 로고
    • Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition
    • Ren D., Minami Y., Nishita M. Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition. Genes Cells 2011, 16:304-315.
    • (2011) Genes Cells , vol.16 , pp. 304-315
    • Ren, D.1    Minami, Y.2    Nishita, M.3
  • 27
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
    • Shackelford D.B., Shaw R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 2009, 9:563-575.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 29
    • 66249131630 scopus 로고    scopus 로고
    • Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin
    • Shan Y., Yu L., Li Y., Pan Y., Zhang Q., Wang F., Chen J., Zhu X. Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. PLoS Biol. 2009, 7:e1000116.
    • (2009) PLoS Biol. , vol.7
    • Shan, Y.1    Yu, L.2    Li, Y.3    Pan, Y.4    Zhang, Q.5    Wang, F.6    Chen, J.7    Zhu, X.8
  • 30
  • 31
    • 67649849871 scopus 로고    scopus 로고
    • Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
    • Shibue T., Weinberg R.A. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc. Natl. Acad. Sci. USA 2009, 106:10290-10295.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 10290-10295
    • Shibue, T.1    Weinberg, R.A.2
  • 32
    • 0037425625 scopus 로고    scopus 로고
    • Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning
    • Shiomi K., Uchida H., Keino-Masu K., Masu M. Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning. Curr. Biol. 2003, 13:73-77.
    • (2003) Curr. Biol. , vol.13 , pp. 73-77
    • Shiomi, K.1    Uchida, H.2    Keino-Masu, K.3    Masu, M.4
  • 33
    • 77954504217 scopus 로고    scopus 로고
    • Dixdc1 is a critical regulator of DISC1 and embryonic cortical development
    • Singh K.K., Ge X., Mao Y., Drane L., Meletis K., Samuels B.A., Tsai L.H. Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron 2010, 67:33-48.
    • (2010) Neuron , vol.67 , pp. 33-48
    • Singh, K.K.1    Ge, X.2    Mao, Y.3    Drane, L.4    Meletis, K.5    Samuels, B.A.6    Tsai, L.H.7
  • 35
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 36
    • 84890036078 scopus 로고    scopus 로고
    • Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module
    • Toettcher J.E., Weiner O.D., Lim W.A. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell 2013, 155:1422-1434.
    • (2013) Cell , vol.155 , pp. 1422-1434
    • Toettcher, J.E.1    Weiner, O.D.2    Lim, W.A.3
  • 37
    • 34250638276 scopus 로고    scopus 로고
    • Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates
    • Turk B.E., Hutti J.E., Cantley L.C. Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates. Nat. Protoc. 2006, 1:375-379.
    • (2006) Nat. Protoc. , vol.1 , pp. 375-379
    • Turk, B.E.1    Hutti, J.E.2    Cantley, L.C.3
  • 39
    • 84857686971 scopus 로고    scopus 로고
    • Structure and function of focal adhesions
    • Wehrle-Haller B. Structure and function of focal adhesions. Curr. Opin. Cell Biol. 2012, 24:116-124.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 116-124
    • Wehrle-Haller, B.1
  • 41
    • 4544384021 scopus 로고    scopus 로고
    • The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms
    • Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.C. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. J. Biol. Chem. 2004, 279:39366-39373.
    • (2004) J. Biol. Chem. , vol.279 , pp. 39366-39373
    • Wong, C.K.1    Luo, W.2    Deng, Y.3    Zou, H.4    Ye, Z.5    Lin, S.C.6
  • 42
    • 0344465841 scopus 로고    scopus 로고
    • Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells
    • Zaidel-Bar R., Ballestrem C., Kam Z., Geiger B. Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J. Cell Sci. 2003, 116:4605-4613.
    • (2003) J. Cell Sci. , vol.116 , pp. 4605-4613
    • Zaidel-Bar, R.1    Ballestrem, C.2    Kam, Z.3    Geiger, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.