Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

Journal of Cell Science

Volumn 122, Issue 3, 2009, Pages 425-435

  Shin, Sung Young ^a   Rath, Oliver ^b   Choo, Sang Mok ^c   Fee, Frances ^b   McFerran, Brian ^b,d   Kolch, Walter ^b,e   Cho, Kwang Hyun ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c University of Ulsan   (South Korea)

^d MERCK RESEARCH LABORATORIES   (United States)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Dynamics; ERK signaling pathway; Feedback regulation; Mathematical modeling; RKIP; Systems biology

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAF PROTEIN; RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; NONHUMAN; OSCILLATION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; FEEDBACK SYSTEM; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; THEORETICAL MODEL;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, BIOCHEMICAL; MAP KINASE KINASE KINASES; MODELS, THEORETICAL; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHORYLATION; RAF KINASES; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 65249103982     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.036319     Document Type: Article

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