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Volumn 6, Issue , 2013, Pages 767-777

Drugs for solid cancer: The productivity crisis prompts a rethink

Author keywords

Cancer; Drug resistance; Metastasis; Paradigms; Src inhibitors; Translation

Indexed keywords

BOSUTINIB; DASATINIB; DOXORUBICIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SARACATINIB; TRASTUZUMAB;

EID: 84879924314     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S45177     Document Type: Article
Times cited : (12)

References (115)
  • 1
    • 84861910638 scopus 로고    scopus 로고
    • Two hundred years of cancer research
    • DeVita VT Jr, Rosenberg SA. Two hundred years of cancer research. N Engl J Med. 2012;366(23):2207-2214.
    • (2012) N Engl J Med , vol.366 , Issue.23 , pp. 2207-2214
    • Devita Jr, V.T.1    Rosenberg, S.A.2
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 54249127873 scopus 로고    scopus 로고
    • The history of tumor virology
    • Javier RT, Butel JS. The history of tumor virology. Cancer Res. 2008;68(19):7693-7706.
    • (2008) Cancer Res , vol.68 , Issue.19 , pp. 7693-7706
    • Javier, R.T.1    Butel, J.S.2
  • 6
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov. 2004;3(8):711-715.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.8 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 7
    • 84879985346 scopus 로고    scopus 로고
    • Judging a cancer drug: Avastin's story [letter]
    • section A
    • Fernandes M. Judging a cancer drug: Avastin's story [letter]. New York Times. 2011;160(55423):section A.
    • (2011) New York Times , vol.160
    • Fernandes, M.1
  • 8
    • 84855321136 scopus 로고    scopus 로고
    • Affordable cancer care
    • Brábek J, Fernandes M. Affordable cancer care. Lancet Oncol. 2012;13(1):2-3.
    • (2012) Lancet Oncol , vol.13 , Issue.1 , pp. 2-3
    • Brábek, J.1    Fernandes, M.2
  • 10
    • 80053238941 scopus 로고    scopus 로고
    • Delivering affordable cancer care in high-income countries
    • Sullivan R, Peppercorn J, Sikora K, et al. Delivering affordable cancer care in high-income countries. Lancet Oncol. 2011;12(10):933-980.
    • (2011) Lancet Oncol , vol.12 , Issue.10 , pp. 933-980
    • Sullivan, R.1    Peppercorn, J.2    Sikora, K.3
  • 11
    • 84866257885 scopus 로고    scopus 로고
    • Provocative questions initiative to fund innovative cancer research
    • Benowitz S. Provocative questions initiative to fund innovative cancer research. J Natl Cancer Inst. 2012:104(13):966-967.
    • (2012) J Natl Cancer Inst , vol.104 , Issue.13 , pp. 966-967
    • Benowitz, S.1
  • 12
    • 84870365240 scopus 로고    scopus 로고
    • Why does cancer therapy lack effective anti-metastasis drugs?
    • Weber GF. Why does cancer therapy lack effective anti-metastasis drugs? Cancer Lett. 2013;328(2):207-211.
    • (2013) Cancer Lett , vol.328 , Issue.2 , pp. 207-211
    • Weber, G.F.1
  • 13
    • 84861199307 scopus 로고    scopus 로고
    • Concepts of metastasis in flux: The stromal progression model
    • Sleeman JP, Christofori G, Fodde R, et al. Concepts of metastasis in flux: the stromal progression model. Semin Cancer Biol. 2012;22(3): 174-186.
    • (2012) Semin Cancer Biol , vol.22 , Issue.3 , pp. 174-186
    • Sleeman, J.P.1    Christofori, G.2    Fodde, R.3
  • 14
    • 84861880572 scopus 로고    scopus 로고
    • Strategies for the discovery and development of therapies for metastatic breast cancer
    • Eckhardt BL, Francis PA, Parker BS, Anderson R. Strategies for the discovery and development of therapies for metastatic breast cancer. Nat Rev Drug Discov. 2012;11(6):479-497.
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.6 , pp. 479-497
    • Eckhardt, B.L.1    Francis, P.A.2    Parker, B.S.3    Anderson, R.4
  • 15
    • 77950593889 scopus 로고    scopus 로고
    • Cancer metastasis as a therapeutic target
    • Sleeman J, Steeg PS. Cancer metastasis as a therapeutic target. Eur J Cancer. 2010;46(7):177-180.
    • (2010) Eur J Cancer , vol.46 , Issue.7 , pp. 177-180
    • Sleeman, J.1    Steeg, P.S.2
  • 16
    • 84979948588 scopus 로고
    • A sarcoma of the fowl transmissible by an agent separable from the tumor cells
    • Rous P. A sarcoma of the fowl transmissible by an agent separable from the tumor cells. J Exp Med. 1911;13(4):397-411.
    • (1911) J Exp Med , vol.13 , Issue.4 , pp. 397-411
    • Rous, P.1
  • 17
    • 84855497782 scopus 로고    scopus 로고
    • 100 years of Rous sarcoma virus
    • Weiss RA, Vogt PK. 100 years of Rous sarcoma virus. J Exp Med. 2011;208(12):2351-2355.
    • (2011) J Exp Med , vol.208 , Issue.12 , pp. 2351-2355
    • Weiss, R.A.1    Vogt, P.K.2
  • 18
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • Stehelin D, Varmus HE, Bishop JM, Vogt PK. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 1976;260(5547):170-173.
    • (1976) Nature , vol.260 , Issue.5547 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 20
    • 76349103508 scopus 로고    scopus 로고
    • Scientific discovery and scientific reputation: The reception of Peyton Rous' discovery of the chicken sarcoma virus
    • Becsei-Kilborn E. Scientific discovery and scientific reputation: the reception of Peyton Rous' discovery of the chicken sarcoma virus. J Hist Biol. 2010;43(1):111-157.
    • (2010) J Hist Biol , vol.43 , Issue.1 , pp. 111-157
    • Becsei-Kilborn, E.1
  • 21
    • 84876089304 scopus 로고    scopus 로고
    • E-cadherin-integrin crosstalk in cancer invasion and metastasis
    • Canel M, Serrels A, Frame MC, Brunton VG. E-cadherin-integrin crosstalk in cancer invasion and metastasis. J Cell Sci. 2013;126(Pt 2): 393-401.
    • (2013) J Cell Sci , vol.126 , Issue.PART. 2 , pp. 393-401
    • Canel, M.1    Serrels, A.2    Frame, M.C.3    Brunton, V.G.4
  • 22
    • 84857916018 scopus 로고    scopus 로고
    • Targeting Src family kinases in anti-cancer therapies: Turning promise into triumph
    • Zhang S, Yu D. Targeting Src family kinases in anti-cancer therapies: turning promise into triumph. Trends Pharmacol Sci. 2012;33(3): 122-128.
    • (2012) Trends Pharmacol Sci , vol.33 , Issue.3 , pp. 122-128
    • Zhang, S.1    Yu, D.2
  • 23
    • 84870704092 scopus 로고    scopus 로고
    • Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer
    • Sirvent A, Benistant C, Roche S. Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer. Am J Cancer Res. 2012;2(4):357-371.
    • (2012) Am J Cancer Res , vol.2 , Issue.4 , pp. 357-371
    • Sirvent, A.1    Benistant, C.2    Roche, S.3
  • 24
    • 84875493705 scopus 로고    scopus 로고
    • Roles for Crk in cancer metastasis and invasion
    • Tsuda M, Tanaka S. Roles for Crk in cancer metastasis and invasion. Genes Cancer. 2012;3(5-6):334-340.
    • (2012) Genes Cancer , vol.3 , Issue.5-6 , pp. 334-340
    • Tsuda, M.1    Tanaka, S.2
  • 26
    • 77956042544 scopus 로고    scopus 로고
    • SRC: A century of science brought to the clinic
    • Aleshin A, Finn RS. SRC: a century of science brought to the clinic. Neoplasia. 2010;12(8):599-607.
    • (2010) Neoplasia , vol.12 , Issue.8 , pp. 599-607
    • Aleshin, A.1    Finn, R.S.2
  • 27
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: A dynamic niche in cancer progression
    • Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012;196(4):395-406.
    • (2012) J Cell Biol , vol.196 , Issue.4 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 28
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2010;17(3):320-329.
    • (2010) Nat Med , vol.17 , Issue.3 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 29
    • 77956619068 scopus 로고    scopus 로고
    • Tumor-microenvironmental interactions: Paths to progression and targets for treatment
    • Box C, Rogers SJ, Mendiola M, Eccles SA. Tumor-microenvironmental interactions: paths to progression and targets for treatment. Semin Cancer Biol. 2010;20(3):128-138.
    • (2010) Semin Cancer Biol , vol.20 , Issue.3 , pp. 128-138
    • Box, C.1    Rogers, S.J.2    Mendiola, M.3    Eccles, S.A.4
  • 30
    • 77956472212 scopus 로고    scopus 로고
    • The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
    • Brábek J, Mierke CT, Rösel D, Veselý P, Fabry B. The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal. 2010;8:22.
    • (2010) Cell Commun Signal , vol.8 , pp. 22
    • Brábek, J.1    Mierke, C.T.2    Rösel, D.3    Veselý, P.4    Fabry, B.5
  • 32
    • 78649369742 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition (EMT) phenomenon
    • Savagner P. The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol. 2010;21 Suppl 7:S87-S92.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 7
    • Savagner, P.1
  • 34
  • 35
    • 79959636906 scopus 로고    scopus 로고
    • The physics of cancer: The role of physical interactions and mechanical forces in metastasis
    • Wirtz D, Konstantopoulos K, Searson PC. The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer. 2011;11(7):512-522.
    • (2011) Nat Rev Cancer , vol.11 , Issue.7 , pp. 512-522
    • Wirtz, D.1    Konstantopoulos, K.2    Searson, P.C.3
  • 36
    • 77956611459 scopus 로고    scopus 로고
    • Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors
    • Cukierman E, Bassi DE. Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. Semin Cancer Biol. 2010;20(3):139-145.
    • (2010) Semin Cancer Biol , vol.20 , Issue.3 , pp. 139-145
    • Cukierman, E.1    Bassi, D.E.2
  • 37
    • 78149268479 scopus 로고    scopus 로고
    • Critical review: Cellular mechanobiology and amoeboid migration
    • Guck J, Lautenschläger F, Paschke S, Beil M. Critical review: cellular mechanobiology and amoeboid migration. Integr Biol. 2010;2(11-12): 575-583.
    • (2010) Integr Biol , vol.2 , Issue.11-12 , pp. 575-583
    • Guck, J.1    Lautenschläger, F.2    Paschke, S.3    Beil, M.4
  • 38
    • 73749086570 scopus 로고    scopus 로고
    • The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
    • Panková K, Rösel D, Novotný M, Brábek J. The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci. 2010;67(1):63-71.
    • (2010) Cell Mol Life Sci , vol.67 , Issue.1 , pp. 63-71
    • Panková, K.1    Rösel, D.2    Novotný, M.3    Brábek, J.4
  • 39
    • 68549112897 scopus 로고    scopus 로고
    • Mechanics, malignancy, and metastasis: The force journey of a tumor cell
    • Kumar S, Weaver VM. Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev. 2009;28(1-2): 113-127.
    • (2009) Cancer Metastasis Rev , vol.28 , Issue.1-2 , pp. 113-127
    • Kumar, S.1    Weaver, V.M.2
  • 41
    • 84867399470 scopus 로고    scopus 로고
    • Pathological roles of invadopodia in cancer invasion and metastasis
    • Yamaguchi H. Pathological roles of invadopodia in cancer invasion and metastasis. Eur J Cell Biol. 2012;91(11-12):902-907.
    • (2012) Eur J Cell Biol , vol.91 , Issue.11-12 , pp. 902-907
    • Yamaguchi, H.1
  • 42
    • 79251594353 scopus 로고    scopus 로고
    • Invadosomes: Intriguing structures with promise
    • Saltel F, Daubon T, Juin A, et al. Invadosomes: intriguing structures with promise. Eur J Cell Biol. 2011;90(2-3):100-107.
    • (2011) Eur J Cell Biol , vol.90 , Issue.2-3 , pp. 100-107
    • Saltel, F.1    Daubon, T.2    Juin, A.3
  • 43
    • 77954958925 scopus 로고    scopus 로고
    • The structure of invadopodia in a complex 3D environment
    • Tolde O, Rosel D, Vesely P, Folk P, Brábek J. The structure of invadopodia in a complex 3D environment. Eur J Cell Biol. 2010;89(9): 674-680.
    • (2010) Eur J Cell Biol , vol.89 , Issue.9 , pp. 674-680
    • Tolde, O.1    Rosel, D.2    Vesely, P.3    Folk, P.4    Brábek, J.5
  • 45
    • 84859375474 scopus 로고    scopus 로고
    • Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex
    • Wang Y, McNiven MA. Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex. J Cell Biol. 2012;196(3):375-385.
    • (2012) J Cell Biol , vol.196 , Issue.3 , pp. 375-385
    • Wang, Y.1    McNiven, M.A.2
  • 46
    • 84875547010 scopus 로고    scopus 로고
    • Src, p130Cas, and mechanotransduction in cancer cells
    • Matsui H, Harada I, Sawada Y. Src, p130Cas, and mechanotransduction in cancer cells. Genes Cancer. 2012;3(5-6):394-401.
    • (2012) Genes Cancer , vol.3 , Issue.5-6 , pp. 394-401
    • Matsui, H.1    Harada, I.2    Sawada, Y.3
  • 47
    • 44249097734 scopus 로고    scopus 로고
    • Invadopodia: At the cutting edge of tumour invasion
    • Stylli SS, Kaye AH, Lock P. Invadopodia: at the cutting edge of tumour invasion. J Clin Neurosci. 2008;15(7):725-737.
    • (2008) J Clin Neurosci , vol.15 , Issue.7 , pp. 725-737
    • Stylli, S.S.1    Kaye, A.H.2    Lock, P.3
  • 48
    • 79952499030 scopus 로고    scopus 로고
    • Twist1-induced invadopodia formation promotes tumor metastasis
    • Eckert MA, Lwin TM, Chang AT, et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell. 2011;19(3):372-386.
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 372-386
    • Eckert, M.A.1    Lwin, T.M.2    Chang, A.T.3
  • 49
    • 0842304432 scopus 로고    scopus 로고
    • Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src
    • Plé PA, Green TP, Hennequin LF, et al. Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. J Med Chem. 2004;47(4):871-887.
    • (2004) J Med Chem , vol.47 , Issue.4 , pp. 871-887
    • Plé, P.A.1    Green, T.P.2    Hennequin, L.F.3
  • 50
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2- methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2- methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004;47(27):6658-6661.
    • (2004) J Med Chem , vol.47 , Issue.27 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3
  • 51
    • 33750491945 scopus 로고    scopus 로고
    • N-(5-chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy.-5 -(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor
    • Hennequin LF, Allen J, Breed J, et al. N-(5-chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy.-5 -(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J Med Chem. 2006;49(22):6465-6488.
    • (2006) J Med Chem , vol.49 , Issue.22 , pp. 6465-6488
    • Hennequin, L.F.1    Allen, J.2    Breed, J.3
  • 52
    • 20144361879 scopus 로고    scopus 로고
    • Synthesis and Src kinase inhibitory activity of 2-phenyl-and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles
    • Boschelli DH, Wu B, Barrios Sosa AC, et al. Synthesis and Src kinase inhibitory activity of 2-phenyl-and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles. J Med Chem. 2005;48(11):3891-3902.
    • (2005) J Med Chem , vol.48 , Issue.11 , pp. 3891-3902
    • Boschelli, D.H.1    Wu, B.2    Barrios, S.A.C.3
  • 53
    • 33847728182 scopus 로고    scopus 로고
    • A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivo
    • Jallal H, Valentino ML, Chen G, Boschelli F, Ali S, Rabbani SA. A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivo. Cancer Res. 2007;67(4):1580-1588.
    • (2007) Cancer Res , vol.67 , Issue.4 , pp. 1580-1588
    • Jallal, H.1    Valentino, M.L.2    Chen, G.3    Boschelli, F.4    Ali, S.5    Rabbani, S.A.6
  • 54
    • 49849096075 scopus 로고    scopus 로고
    • SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells
    • Vultur A, Buettner R, Kowolik C, et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther. 2008;7(5):1185-1194.
    • (2008) Mol Cancer Ther , vol.7 , Issue.5 , pp. 1185-1194
    • Vultur, A.1    Buettner, R.2    Kowolik, C.3
  • 55
    • 67349263598 scopus 로고    scopus 로고
    • Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530
    • Green TP, Fennell M, Whittaker R, et al. Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Mol Oncol. 2009;3(3): 248-261.
    • (2009) Mol Oncol , vol.3 , Issue.3 , pp. 248-261
    • Green, T.P.1    Fennell, M.2    Whittaker, R.3
  • 56
    • 67649846431 scopus 로고    scopus 로고
    • Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells
    • Pichot CS, Hartig SM, Xia L, et al. Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells. Br J Cancer. 2009;101(1):38-47.
    • (2009) Br J Cancer , vol.101 , Issue.1 , pp. 38-47
    • Pichot, C.S.1    Hartig, S.M.2    Xia, L.3
  • 57
    • 78650255275 scopus 로고    scopus 로고
    • Impact of the Src inhibitor Saracatinib on the metastatic phenotype of a fibrosarcoma KHT tumor model
    • Dong M, Rice L, Lepler S, Pampo C, Siemann DW. Impact of the Src inhibitor Saracatinib on the metastatic phenotype of a fibrosarcoma KHT tumor model. Anticancer Res. 2010;30(11):4405-4413.
    • (2010) Anticancer Res , vol.30 , Issue.11 , pp. 4405-4413
    • Dong, M.1    Rice, L.2    Lepler, S.3    Pampo, C.4    Siemann, D.W.5
  • 58
    • 66749155964 scopus 로고    scopus 로고
    • Inhibition of Src with AZD0530 reveals the Src-focal adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer
    • Schweppe RE, Kerege AA, French JD, Sharma V, Grzywa RL, Haugen BR. Inhibition of Src with AZD0530 reveals the Src-focal adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer. J Clin Endocrinol Metab. 2009;94(6):2199-2203.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.6 , pp. 2199-2203
    • Schweppe, R.E.1    Kerege, A.A.2    French, J.D.3    Sharma, V.4    Grzywa, R.L.5    Haugen, B.R.6
  • 59
    • 84863335331 scopus 로고    scopus 로고
    • Targeted inhibition of SRC kinase with dasatinib blocks thyroid cancer growth and metastasis
    • Chan CM, Jing X, Pike LA, et al. Targeted inhibition of SRC kinase with dasatinib blocks thyroid cancer growth and metastasis. Clin Cancer Res. 2012;18(13):3580-3591.
    • (2012) Clin Cancer Res , vol.18 , Issue.13 , pp. 3580-3591
    • Chan, C.M.1    Jing, X.2    Pike, L.A.3
  • 60
    • 77952203697 scopus 로고    scopus 로고
    • SKI-606 (bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis
    • Rabbani SA, Valentino ML, Arakelian AS, Boschelli F. SKI-606 (bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis. Mol Cancer Ther. 2010;9(5):1147-1157.
    • (2010) Mol Cancer Ther , vol.9 , Issue.5 , pp. 1147-1157
    • Rabbani, S.A.1    Valentino, M.L.2    Arakelian, A.S.3    Boschelli, F.4
  • 61
    • 77953898050 scopus 로고    scopus 로고
    • Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma
    • Morton JP, Karim SA, Graham K, et al. Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology. 2010;139(1):292-303.
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 292-303
    • Morton, J.P.1    Karim, S.A.2    Graham, K.3
  • 62
    • 78649710071 scopus 로고    scopus 로고
    • Saracatinib impairs head and neck squamous cell carcinoma invasion by disrupting invadopodia function
    • Ammer AG, Kelley LC, Hayes KE, et al. Saracatinib impairs head and neck squamous cell carcinoma invasion by disrupting invadopodia function. J Cancer Sci Ther. 2009;1(2):52-61.
    • (2009) J Cancer Sci Ther , vol.1 , Issue.2 , pp. 52-61
    • Ammer, A.G.1    Kelley, L.C.2    Hayes, K.E.3
  • 63
    • 84869884521 scopus 로고    scopus 로고
    • Src inhibitors in the treatment of metastatic bone disease: Rationale and clinical data
    • Boyce B, Xing L. Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data. Clin Investig (Lond). 2011;1(12): 1695-1706.
    • (2011) Clin Investig (Lond) , vol.1 , Issue.12 , pp. 1695-1706
    • Boyce, B.1    Xing, L.2
  • 64
    • 84861491693 scopus 로고    scopus 로고
    • Src kinase inhibitors: Promising cancer therapeutics?
    • Creedon H, Brunton VG. Src kinase inhibitors: promising cancer therapeutics? Crit Rev Oncog. 2012;17(2):145-159.
    • (2012) Crit Rev Oncog , vol.17 , Issue.2 , pp. 145-159
    • Creedon, H.1    Brunton, V.G.2
  • 65
    • 79956283619 scopus 로고    scopus 로고
    • Current status of Src inhibitors in solid tumor malignancies
    • Puls LN, Eadens M, Messersmith W. Current status of Src inhibitors in solid tumor malignancies. Oncologist. 2012;16(5):566-578.
    • (2012) Oncologist , vol.16 , Issue.5 , pp. 566-578
    • Puls, L.N.1    Eadens, M.2    Messersmith, W.3
  • 66
    • 33646460814 scopus 로고    scopus 로고
    • What do, can, and should we learn from models to evaluate potential anticancer agents?
    • Burchill SA. What do, can, and should we learn from models to evaluate potential anticancer agents? Future Oncol. 2006;2(2):201-211.
    • (2006) Future Oncol , vol.2 , Issue.2 , pp. 201-211
    • Burchill, S.A.1
  • 67
    • 80052472086 scopus 로고    scopus 로고
    • Primary human tumor xenografted models ('tumorgrafts') for good management of patients with cancer
    • Decaudin D. Primary human tumor xenografted models ('tumorgrafts') for good management of patients with cancer. Anticancer Drugs. 2011;22(9):827-841.
    • (2011) Anticancer Drugs , vol.22 , Issue.9 , pp. 827-841
    • Decaudin, D.1
  • 68
    • 79953244384 scopus 로고    scopus 로고
    • Preclinical development of molecular-targeted agents for cancer
    • Ocana A, Pandiella A, Siu LL, Tannock IF. Preclinical development of molecular-targeted agents for cancer. Nat Rev Clin Oncol. 2011;8(4): 200-209.
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.4 , pp. 200-209
    • Ocana, A.1    Pandiella, A.2    Siu, L.L.3    Tannock, I.F.4
  • 69
    • 79952160304 scopus 로고    scopus 로고
    • Advances in the preclinical testing of cancer therapeutic hypotheses
    • Caponigro G, Sellers WR. Advances in the preclinical testing of cancer therapeutic hypotheses. Nat Rev Drug Discov. 2011;10(3): 179-187.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.3 , pp. 179-187
    • Caponigro, G.1    Sellers, W.R.2
  • 70
    • 62749107149 scopus 로고    scopus 로고
    • In vivo/ex vivo and in situ assays used in cancer research: A brief review
    • Teicher BA. In vivo/ex vivo and in situ assays used in cancer research: a brief review. Toxicol Pathol. 2009;37(1):114-122.
    • (2009) Toxicol Pathol , vol.37 , Issue.1 , pp. 114-122
    • Teicher, B.A.1
  • 72
    • 77953262592 scopus 로고    scopus 로고
    • Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
    • Singh M, Lima A, Molina R, et al. Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nat Biotechnol. 2010;28(6):585-593.
    • (2010) Nat Biotechnol , vol.28 , Issue.6 , pp. 585-593
    • Singh, M.1    Lima, A.2    Molina, R.3
  • 73
    • 77953256460 scopus 로고    scopus 로고
    • Raising the bar for cancer therapy models
    • Francia G, Kerbel RS. Raising the bar for cancer therapy models. Nat Biotechnol. 2010;28(6):561-562.
    • (2010) Nat Biotechnol , vol.28 , Issue.6 , pp. 561-562
    • Francia, G.1    Kerbel, R.S.2
  • 74
    • 38349123867 scopus 로고    scopus 로고
    • Harnessing genetically engineered mouse models for preclinical testing
    • Robles AI, Varticovski L. Harnessing genetically engineered mouse models for preclinical testing. Chem Biol Interact. 2008;171(12): 159-164.
    • (2008) Chem Biol Interact , vol.171 , Issue.12 , pp. 159-164
    • Robles, A.I.1    Varticovski, L.2
  • 75
    • 33749363890 scopus 로고    scopus 로고
    • Mouse modeling in oncologic preclinical and translational research
    • Carver BS, Pandolfi PP. Mouse modeling in oncologic preclinical and translational research. Clin Cancer Res. 2006;12(18):5305-5311.
    • (2006) Clin Cancer Res , vol.12 , Issue.18 , pp. 5305-5311
    • Carver, B.S.1    Pandolfi, P.P.2
  • 76
    • 79251468712 scopus 로고    scopus 로고
    • Mouse models of advanced spontaneous metastasis for experimental therapeutics
    • Francia G, Cruz-Munoz W, Man S, Xu P, Kerbel RS. Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer. 2011;11(2):135-141.
    • (2011) Nat Rev Cancer , vol.11 , Issue.2 , pp. 135-141
    • Francia, G.1    Cruz-Munoz, W.2    Man, S.3    Xu, P.4    Kerbel, R.S.5
  • 77
    • 84867887350 scopus 로고    scopus 로고
    • Deconstructing the third dimension - how 3D culture microenvironments alter cellular cues
    • Baker BM, Chen CS. Deconstructing the third dimension - how 3D culture microenvironments alter cellular cues. J Cell Sci. 2012;125(Pt 13): 3015-3024.
    • (2012) J Cell Sci , vol.125 , Issue.PART. 13 , pp. 3015-3024
    • Baker, B.M.1    Chen, C.S.2
  • 78
    • 84857651643 scopus 로고    scopus 로고
    • Optimizing a 3D culture system to study the interaction between epithelial breast cancer and its surrounding fibroblasts
    • Li L, Lu Y. Optimizing a 3D culture system to study the interaction between epithelial breast cancer and its surrounding fibroblasts. J Cancer. 2011;2:458-466.
    • (2011) J Cancer , vol.2 , pp. 458-466
    • Li, L.1    Lu, Y.2
  • 79
    • 80053925801 scopus 로고    scopus 로고
    • Cell-matrix adhesions in 3D
    • Harunaga JS, Yamada KM. Cell-matrix adhesions in 3D. Matrix Biol. 2011;30(7/8):363-368.
    • (2011) Matrix Biol , vol.30 , Issue.7-8 , pp. 363-368
    • Harunaga, J.S.1    Yamada, K.M.2
  • 80
    • 77953066865 scopus 로고    scopus 로고
    • The microenvironment determines the breast cancer cells' phenotype: Organization of MCF7 cells in 3D cultures
    • Krause S, Maffini MV, Soto AM, Sonnenschein C. The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures. BMC Cancer. 2010;10:263.
    • (2010) BMC Cancer , vol.10 , pp. 263
    • Krause, S.1    Maffini, M.V.2    Soto, A.M.3    Sonnenschein, C.4
  • 81
    • 34547931078 scopus 로고    scopus 로고
    • Modeling tissue morphogenesis and cancer in 3D
    • Yamada KM, Cukierman S. Modeling tissue morphogenesis and cancer in 3D. Cell. 2007;130(4):601-610.
    • (2007) Cell , vol.130 , Issue.4 , pp. 601-610
    • Yamada, K.M.1    Cukierman, S.2
  • 82
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol. 2006;7(3):211-224.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.3 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 83
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumors: Revised RECIST guideline version 1.1
    • Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumors: revised RECIST guideline version 1.1. Eur J Cancer. 2009;45(2):228-247.
    • (2009) Eur J Cancer , vol.45 , Issue.2 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 84
    • 33749029255 scopus 로고    scopus 로고
    • Sometimes size doesn't matter: Reevaluating RECIST and tumor response rate endpoints
    • Tuma RS. Sometimes size doesn't matter: reevaluating RECIST and tumor response rate endpoints. J Natl Cancer Inst. 2006;98(18):1272-1274.
    • (2006) J Natl Cancer Inst , vol.98 , Issue.18 , pp. 1272-1274
    • Tuma, R.S.1
  • 86
    • 70350141199 scopus 로고    scopus 로고
    • Tumor shrinkage and objective response rates: Gold standard for oncology efficacy screening trials, or an outdated end point?
    • Bradbury P, Seymour L. Tumor shrinkage and objective response rates: gold standard for oncology efficacy screening trials, or an outdated end point? Cancer J. 2009;15(5):354-360.
    • (2009) Cancer J , vol.15 , Issue.5 , pp. 354-360
    • Bradbury, P.1    Seymour, L.2
  • 87
    • 84860679509 scopus 로고    scopus 로고
    • The use of tumour volumetrics to assess response to therapy in anticancer clinical trials
    • Goldmacher GV, Conklin J. The use of tumour volumetrics to assess response to therapy in anticancer clinical trials. Br J Clin Pharmacol. 2012;73(6):846-854.
    • (2012) Br J Clin Pharmacol , vol.73 , Issue.6 , pp. 846-854
    • Goldmacher, G.V.1    Conklin, J.2
  • 88
    • 79960481685 scopus 로고    scopus 로고
    • Response to treatment series: Part 1 and introduction, measuring tumor response - challenges in the era of molecular medicine
    • Sullivan DC, Gatsonis C. Response to treatment series: part 1 and introduction, measuring tumor response - challenges in the era of molecular medicine. AJR Am J Roentgenol. 2011;197(1):15-17.
    • (2011) AJR Am J Roentgenol , vol.197 , Issue.1 , pp. 15-17
    • Sullivan, D.C.1    Gatsonis, C.2
  • 89
    • 66149156964 scopus 로고    scopus 로고
    • Assessing tumor response to therapy
    • Weber WA. Assessing tumor response to therapy. J Nucl Med. 2009; 50 Suppl 1:S1-S10.
    • (2009) J Nucl Med , vol.50 , Issue.SUPPL.
    • Weber, W.A.1
  • 90
    • 84862915437 scopus 로고    scopus 로고
    • Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer
    • Mozley PM, Bendtsen C, Zhao B, et al. Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer. Transl Oncol. 2012;5(1):19-25.
    • (2012) Transl Oncol , vol.5 , Issue.1 , pp. 19-25
    • Mozley, P.M.1    Bendtsen, C.2    Zhao, B.3
  • 91
    • 60049100489 scopus 로고    scopus 로고
    • Early changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival
    • Birchard KR, Hoang JK, Herndon JE Jr, Patz EF Jr. Early changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival. Cancer. 2009;115(3): 581-586.
    • (2009) Cancer , vol.115 , Issue.3 , pp. 581-586
    • Birchard, K.R.1    Hoang, J.K.2    Herndon Jr., J.E.3    Patz Jr., E.F.4
  • 92
    • 0031796399 scopus 로고    scopus 로고
    • Response rate as an endpoint for evaluating new cytotoxic agents in phase II trials of non-small-cell lung cancer
    • Sekine I, Kubota K, Nishiwaki Y, Sasaki Y, Saijo N. Response rate as an endpoint for evaluating new cytotoxic agents in phase II trials of non-small-cell lung cancer. Ann Oncol. 1998;9(10):1079-1084.
    • (1998) Ann Oncol , vol.9 , Issue.10 , pp. 1079-1084
    • Sekine, I.1    Kubota, K.2    Nishiwaki, Y.3    Sasaki, Y.4    Saijo, N.5
  • 93
    • 38449107451 scopus 로고    scopus 로고
    • Technology insight: Novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs
    • Weber WA, Czernin J, Phelps ME, Herschman HR. Technology insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs. Nat Clin Pract Oncol. 2008;5(1): 44-54.
    • (2008) Nat Clin Pract Oncol , vol.5 , Issue.1 , pp. 44-54
    • Weber, W.A.1    Czernin, J.2    Phelps, M.E.3    Herschman, H.R.4
  • 95
    • 80052028859 scopus 로고    scopus 로고
    • Translational imaging endpoints to predict treatment response to novel targeted anticancer agents
    • Serkova NJ. Translational imaging endpoints to predict treatment response to novel targeted anticancer agents. Drug Resist Updat. 2011;14(4-5):224-235.
    • (2011) Drug Resist Updat , vol.14 , Issue.4-5 , pp. 224-235
    • Serkova, N.J.1
  • 96
    • 81255184673 scopus 로고    scopus 로고
    • Novel oncologic drugs: What they do and how they affect images
    • Garcia Figuerias R, Padhani AR, Goh VJ, et al. Novel oncologic drugs: what they do and how they affect images. Radiographics. 2011;31(17): 2059-2091.
    • (2011) Radiographics , vol.31 , Issue.17 , pp. 2059-2091
    • Garcia, F.R.1    Padhani, A.R.2    Goh, V.J.3
  • 97
    • 84863336576 scopus 로고    scopus 로고
    • Imaging-based tumor treatment response evaluation: Review of conventional, new and emerging concepts
    • Kang H, Lee HY, Lee KS, Kim JH. Imaging-based tumor treatment response evaluation: review of conventional, new and emerging concepts. Korean J Radiol. 2012;13(4):371-390.
    • (2012) Korean J Radiol , vol.13 , Issue.4 , pp. 371-390
    • Kang, H.1    Lee, H.Y.2    Lee, K.S.3    Kim, J.H.4
  • 98
    • 21644479899 scopus 로고    scopus 로고
    • Tumor invasion and metastasis: Challenges facing drug discovery
    • Elvin P, Garner AP. Tumor invasion and metastasis: challenges facing drug discovery. Curr Opin Pharmacol. 2005;5(4):374-381.
    • (2005) Curr Opin Pharmacol , vol.5 , Issue.4 , pp. 374-381
    • Elvin, P.1    Garner, A.P.2
  • 99
    • 38649107709 scopus 로고    scopus 로고
    • Pericytes: Gatekeepers in tumour cell metastasis?
    • Gerhardt H, Semb H. Pericytes: gatekeepers in tumour cell metastasis? J Mol Med (Berl). 2008;86(2):135-144.
    • (2008) J Mol Med (Berl) , vol.86 , Issue.2 , pp. 135-144
    • Gerhardt, H.1    Semb, H.2
  • 100
    • 84855912001 scopus 로고    scopus 로고
    • Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by MET signaling pathway
    • Cooke VG, LeBleu VS, Keskin D, et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by MET signaling pathway. Cancer Cell. 2012;21(1): 66-81.
    • (2012) Cancer Cell , vol.21 , Issue.1 , pp. 66-81
    • Cooke, V.G.1    Lebleu, V.S.2    Keskin, D.3
  • 101
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Pàez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009;15(3):220-231.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Pàez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 102
    • 79953244361 scopus 로고    scopus 로고
    • Antiangiogenic therapy:Impact on invasion, disease progression, and metastasis
    • Ebos JML, Kerbel RS. Antiangiogenic therapy:impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol. 2011;8(4):210-221.
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.4 , pp. 210-221
    • Ebos, J.M.L.1    Kerbel, R.S.2
  • 103
    • 84859575611 scopus 로고    scopus 로고
    • Anti-angiogenesis therapy in cancer: Current challenges and future perspectives
    • Shojaei F. Anti-angiogenesis therapy in cancer: current challenges and future perspectives. Cancer Lett. 2012;320(2):130-137.
    • (2012) Cancer Lett , vol.320 , Issue.2 , pp. 130-137
    • Shojaei, F.1
  • 104
    • 79953745096 scopus 로고    scopus 로고
    • Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
    • Zhang S, Huang WC, Li P, et al. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med. 2011;17(4):461-469.
    • (2011) Nat Med , vol.17 , Issue.4 , pp. 461-469
    • Zhang, S.1    Huang, W.C.2    Li, P.3
  • 105
    • 79953738465 scopus 로고    scopus 로고
    • Trastuzumab resistance: All roads lead to SRC
    • Muthuswamy SK. Trastuzumab resistance: all roads lead to SRC. Nat Med. 2011;17(4):416-418.
    • (2011) Nat Med , vol.17 , Issue.4 , pp. 416-418
    • Muthuswamy, S.K.1
  • 106
    • 79952779822 scopus 로고    scopus 로고
    • Development of novel combination therapies
    • Woodcock J, Griffin JP, Behrman RE. Development of novel combination therapies. N Engl J Med. 2011;364(11):985-987.
    • (2011) N Engl J Med , vol.364 , Issue.11 , pp. 985-987
    • Woodcock, J.1    Griffin, J.P.2    Behrman, R.E.3
  • 107
    • 84255183718 scopus 로고    scopus 로고
    • Accelerating identification and regulatory approval of investigational cancer drugs
    • Esserman LJ, Woodcock J. Accelerating identification and regulatory approval of investigational cancer drugs. JAMA. 2011;306(23): 2608-2609.
    • (2011) JAMA , vol.306 , Issue.23 , pp. 2608-2609
    • Esserman, L.J.1    Woodcock, J.2
  • 108
    • 84865607729 scopus 로고    scopus 로고
    • In retrospect: The structure of scientific revolutions
    • Kaiser D. In retrospect: the structure of scientific revolutions. Nature. 2012;484(7393):164-166.
    • (2012) Nature , vol.484 , Issue.7393 , pp. 164-166
    • Kaiser, D.1
  • 109
    • 44449085539 scopus 로고    scopus 로고
    • Paul Ehrlich's magic bullet concept: 100 years of progress
    • Strebhardt K, Ullrich A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat Rev Cancer. 2008;8(6):473-480.
    • (2008) Nat Rev Cancer , vol.8 , Issue.6 , pp. 473-480
    • Strebhardt, K.1    Ullrich, A.2
  • 110
    • 77950650137 scopus 로고    scopus 로고
    • Biology-driven cancer drug development: Back to the future
    • Lord CJ, Ashworth A. Biology-driven cancer drug development: back to the future. BMC Biol. 2010;8:38.
    • (2010) BMC Biol , vol.8 , pp. 38
    • Lord, C.J.1    Ashworth, A.2
  • 111
    • 33746628593 scopus 로고    scopus 로고
    • Case histories, magic bullets and the state of drug discovery
    • Drews J. Case histories, magic bullets and the state of drug discovery. Nat Rev Drug Discov. 2006;5(8):635-640.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.8 , pp. 635-640
    • Drews, J.1
  • 112
    • 0012196927 scopus 로고    scopus 로고
    • Cell proliferation, differentiation, and apoptosis
    • In: Bast RC Jr, Kufe DW, Pollock RE, et al, editors, 5th ed. Hamilton (ON): BC Decker
    • Andreeff M, Goodrich DW, Pardee AB. Cell proliferation, differentiation, and apoptosis. In: Bast RC Jr, Kufe DW, Pollock RE, et al, editors. Holland-Frei Cancer Medicine. 5th ed. Hamilton (ON): BC Decker; 2000:17-32.
    • (2000) Holland-Frei Cancer Medicine , pp. 17-32
    • Andreeff, M.1    Goodrich, D.W.2    Pardee, A.B.3
  • 113
    • 0037150728 scopus 로고    scopus 로고
    • Src in cancer: Deregulation and consequences for cell behaviour
    • Frame MC. Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta. 2002;1602(2):114-130.
    • (2002) Biochim Biophys Acta , vol.1602 , Issue.2 , pp. 114-130
    • Frame, M.C.1
  • 114
    • 84871077272 scopus 로고    scopus 로고
    • Is science mostly driven by ideas or by tools?
    • Dyson FJ. Is science mostly driven by ideas or by tools? Science. 2012;338(6113):1426-1427.
    • (2012) Science , vol.338 , Issue.6113 , pp. 1426-1427
    • Dyson, F.J.1
  • 115
    • 4544327145 scopus 로고    scopus 로고
    • Paul Ehrlich: Magister mundi
    • Drews J. Paul Ehrlich: magister mundi. Nat Rev Drug Discov. 2004;3(9):797-801.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.9 , pp. 797-801
    • Drews, J.1


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