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Volumn 15, Issue 1, 2003, Pages 67-72

Cell polarity: Par6, aPKC and cytoskeletal crosstalk

Author keywords

[No Author keywords available]

Indexed keywords

PARTITIONING DEFECTIVE PROTEIN 3; PARTITIONING DEFECTIVE PROTEIN 6; PROTEIN; PROTEIN CDC42; PROTEIN KINASE C; PROTEIN P56; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

EID: 0037222950     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(02)00005-4     Document Type: Review
Times cited : (263)

References (37)
  • 1
    • 0035479930 scopus 로고    scopus 로고
    • Intercellular junctions and cellular polarity: The Par-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity
    • Ohno S. Intercellular junctions and cellular polarity: the Par-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr Opin Cell Biol. 13:2001;641-648.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 641-648
    • Ohno, S.1
  • 2
    • 0029850113 scopus 로고    scopus 로고
    • par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of Par-3
    • Watts J.L., Etemad-Moghadam B., Guo S., Boyd L., Draper B.W., Mello C.C., Priess J.R., Kemphues K.J. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of Par-3. Development. 122:1996;3133-3140.
    • (1996) Development , vol.122 , pp. 3133-3140
    • Watts, J.L.1    Etemad-Moghadam, B.2    Guo, S.3    Boyd, L.4    Draper, B.W.5    Mello, C.C.6    Priess, J.R.7    Kemphues, K.J.8
  • 3
    • 0035427318 scopus 로고    scopus 로고
    • Axis determination in C. elegans: Initiating and transducing polarity
    • Gotta M., Ahringer J. Axis determination in C. elegans: initiating and transducing polarity. Curr Opin Gen Dev. 11:2001;367-373.
    • (2001) Curr Opin Gen Dev , vol.11 , pp. 367-373
    • Gotta, M.1    Ahringer, J.2
  • 4
    • 0035141027 scopus 로고    scopus 로고
    • DmPar-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    • Petronczki M., Knoblich J.A. DmPar-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nat Cell Biol. 3:2001;43-49.
    • (2001) Nat Cell Biol , vol.3 , pp. 43-49
    • Petronczki, M.1    Knoblich, J.A.2
  • 5
    • 0035811044 scopus 로고    scopus 로고
    • Bazooka and Par-6 are required with Par-1 for the maintenance of oocyte fate in Drosophila
    • Bazooka and Par6 are involved in the differentiation of the Drosophila oocyte. They control the polarised organisation of the microtubule cytoskeleton directing the microtubule-organising centre at the posterior of the oocyte.
    • Huynh J.-R., Petronczki M., Knoblich J.A., St Johnston D. Bazooka and Par-6 are required with Par-1 for the maintenance of oocyte fate in Drosophila. Curr Biol. 11:2001;901-906 Bazooka and Par6 are involved in the differentiation of the Drosophila oocyte. They control the polarised organisation of the microtubule cytoskeleton directing the microtubule-organising centre at the posterior of the oocyte.
    • (2001) Curr Biol , vol.11 , pp. 901-906
    • Huynh, J.-R.1    Petronczki, M.2    Knoblich, J.A.3    St Johnston, D.4
  • 7
    • 0035943401 scopus 로고    scopus 로고
    • Integrin-mediated Cdc42 activation controls cell polarity in migrating astrocytes through PKCζ
    • •].
    • •].
    • (2001) Cell , vol.106 , pp. 489-498
    • Etienne-Manneville, S.1    Hall, A.2
  • 8
    • 0032949091 scopus 로고    scopus 로고
    • PAR-6 is a conserved PDZ domain containing protein that colocalizes with Par-3 in C. elegans embryo
    • Hung T.-J., Kemphues K.J. PAR-6 is a conserved PDZ domain containing protein that colocalizes with Par-3 in C. elegans embryo. Development. 126:1999;127-135.
    • (1999) Development , vol.126 , pp. 127-135
    • Hung, T.-J.1    Kemphues, K.J.2
  • 9
    • 0034253536 scopus 로고    scopus 로고
    • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    • Joberty G., Petersen C., Gao L., Macara I.G. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2:2000;531-539.
    • (2000) Nat Cell Biol , vol.2 , pp. 531-539
    • Joberty, G.1    Petersen, C.2    Gao, L.3    Macara, I.G.4
  • 10
    • 0034659420 scopus 로고    scopus 로고
    • A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation
    • Qiu R.-G., Abo A., Martin G.S. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation. Curr Biol. 10:2000;697-707.
    • (2000) Curr Biol , vol.10 , pp. 697-707
    • Qiu, R.-G.1    Abo, A.2    Martin, G.S.3
  • 11
    • 0037022122 scopus 로고    scopus 로고
    • Assembly of epithelial tight junctions is negatively regulated by Par-6
    • •], this paper demonstrates the role of Par6 in tight-junction assembly. It also characterises more precisely the interaction between Par6 and atypical protein kinase Cs (PKCs). Finally, it proposes a model for the regulation of Par6 by aPKCs.
    • •], this paper demonstrates the role of Par6 in tight-junction assembly. It also characterises more precisely the interaction between Par6 and atypical protein kinase Cs (PKCs). Finally, it proposes a model for the regulation of Par6 by aPKCs.
    • (2002) Curr Biol , vol.12 , pp. 221-225
    • Gao, L.1    Joberty, G.2    Macara, I.G.3
  • 12
    • 0031674842 scopus 로고    scopus 로고
    • Atypical protein kinase C is essential for generating early embryonic asymmetry in Caenorhabditis elegans
    • Tabuse Y., Izumi Y., Fabio P., Kemphues K., Miwa J., Ohno S. Atypical protein kinase C is essential for generating early embryonic asymmetry in Caenorhabditis elegans. Development. 125:1998;3607-3614.
    • (1998) Development , vol.125 , pp. 3607-3614
    • Tabuse, Y.1    Izumi, Y.2    Fabio, P.3    Kemphues, K.4    Miwa, J.5    Ohno, S.6
  • 13
    • 0035807836 scopus 로고    scopus 로고
    • Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary
    • This paper shows the involvement of Bazooka and atypical protein kinase Cs (aPKCs) in the polarisation of the Drosophila oocyte. Bazooka and DaPKC co-localise with junctional molecules in belt structures, through which the microtubules project. The two molecules are required for the accumulation of dynein in the oocyte.
    • Cox D.N., Abdelilah Seyfried S., Jan Y.L., Jan Y.N. Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary. Proc Natl Acad Sci USA. 98:2001;14475-14480 This paper shows the involvement of Bazooka and atypical protein kinase Cs (aPKCs) in the polarisation of the Drosophila oocyte. Bazooka and DaPKC co-localise with junctional molecules in belt structures, through which the microtubules project. The two molecules are required for the accumulation of dynein in the oocyte.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14475-14480
    • Cox, D.N.1    Abdelilah Seyfried, S.2    Jan, Y.L.3    Jan, Y.N.4
  • 14
    • 0034528218 scopus 로고    scopus 로고
    • Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes
    • Nakaya M., Fukui A., Izumi Y., Akimoto K., Asashima M., Ohno S. Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes. Development. 127:2000;5021-5031.
    • (2000) Development , vol.127 , pp. 5021-5031
    • Nakaya, M.1    Fukui, A.2    Izumi, Y.3    Akimoto, K.4    Asashima, M.5    Ohno, S.6
  • 15
    • 0034003326 scopus 로고    scopus 로고
    • Identification and developmental expression of par-6 gene in Xenopus laevis
    • Choi S.C., Kim J., Han J.K. Identification and developmental expression of par-6 gene in Xenopus laevis. Mech Dev. 91:2000;347-350.
    • (2000) Mech Dev , vol.91 , pp. 347-350
    • Choi, S.C.1    Kim, J.2    Han, J.K.3
  • 16
    • 0033007293 scopus 로고    scopus 로고
    • Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
    • Johnson D.J. Cdc42: an essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev. 63:1999;54-105.
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 54-105
    • Johnson, D.J.1
  • 17
    • 0029008280 scopus 로고
    • Regulation of the polarization of T cells towards antigen-presenting cells by Ras-related GTPase Cdc42
    • Stowers L., Yelon D., Berg L.J., Chant J. Regulation of the polarization of T cells towards antigen-presenting cells by Ras-related GTPase Cdc42. Proc Natl Acad Sci USA. 92:1995;5027-5031.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5027-5031
    • Stowers, L.1    Yelon, D.2    Berg, L.J.3    Chant, J.4
  • 19
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion and adhesion during cell movement
    • Nobes C.D., Hall A. Rho GTPases control polarity, protrusion and adhesion during cell movement. J Cell Biol. 144:1999;1235-1244.
    • (1999) J Cell Biol , vol.144 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 20
    • 0035799292 scopus 로고    scopus 로고
    • Cdc-42 controls early cell polarity and spindle orientation in C. elegans
    • Cdc42 is required for polarisation of the C. elegans zygote, and in the absence of Cdc42, Par proteins are mislocalised. This paper also shows that C. elegans Cdc42 interacts with Par6 in a yeast two-hybrid system.
    • Gotta M., Abraham M.C., Ahringer J. Cdc-42 controls early cell polarity and spindle orientation in C. elegans. Curr Biol. 11:2001;482-488 Cdc42 is required for polarisation of the C. elegans zygote, and in the absence of Cdc42, Par proteins are mislocalised. This paper also shows that C. elegans Cdc42 interacts with Par6 in a yeast two-hybrid system.
    • (2001) Curr Biol , vol.11 , pp. 482-488
    • Gotta, M.1    Abraham, M.C.2    Ahringer, J.3
  • 21
    • 0000202186 scopus 로고    scopus 로고
    • A mammalian Par-3-Par-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
    • Lin D., Edwards A.S., Fawcett J.P., Mbamalu G., Scott J.D., Pawson T. A mammalian Par-3-Par-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2:2000;540-547.
    • (2000) Nat Cell Biol , vol.2 , pp. 540-547
    • Lin, D.1    Edwards, A.S.2    Fawcett, J.P.3    Mbamalu, G.4    Scott, J.D.5    Pawson, T.6
  • 22
    • 0035159369 scopus 로고    scopus 로고
    • Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells
    • Rojas R., Ruiz W.G., Leung S.M., Jou T.S., Apodaca G. Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 12:2001;2257-2274.
    • (2001) Mol Biol Cell , vol.12 , pp. 2257-2274
    • Rojas, R.1    Ruiz, W.G.2    Leung, S.M.3    Jou, T.S.4    Apodaca, G.5
  • 24
    • 0035817623 scopus 로고    scopus 로고
    • JAM binds to Par-3: A possible mechanism behind the recruitment of Par-3 to tight junctions
    • Itoh M., Sasaki H., Furuse M., Ozak H., Kita T., Tsukita S. JAM binds to Par-3: a possible mechanism behind the recruitment of Par-3 to tight junctions. J Cell Biol. 154:2001;491-498.
    • (2001) J Cell Biol , vol.154 , pp. 491-498
    • Itoh, M.1    Sasaki, H.2    Furuse, M.3    Ozak, H.4    Kita, T.5    Tsukita, S.6
  • 26
    • 0035998268 scopus 로고    scopus 로고
    • Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells
    • Par-3 overexpression increases the motile activity of MDCK cells, even if the cells are establishing cell-cell contacts. Rac1 and microtubules appear to be involved in this effect.
    • Mishima A., Suzuki A., Enaka M., Hirose T., Mizuno K., Ohnishi T., Mohri H., Ishigatsubo Y., Ohno S. Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells. Genes Cells. 7:2002;581-596 Par-3 overexpression increases the motile activity of MDCK cells, even if the cells are establishing cell-cell contacts. Rac1 and microtubules appear to be involved in this effect.
    • (2002) Genes Cells , vol.7 , pp. 581-596
    • Mishima, A.1    Suzuki, A.2    Enaka, M.3    Hirose, T.4    Mizuno, K.5    Ohnishi, T.6    Mohri, H.7    Ishigatsubo, Y.8    Ohno, S.9
  • 27
    • 0034212508 scopus 로고    scopus 로고
    • The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in Caenorhabditis elegans zygote
    • O'Connell K.F., Maxwell K.N., White J.G. The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in Caenorhabditis elegans zygote. Dev Biol. 000:2000;55-70.
    • (2000) Dev Biol , vol.0 , pp. 55-70
    • O'Connell, K.F.1    Maxwell, K.N.2    White, J.G.3
  • 28
    • 0034597760 scopus 로고    scopus 로고
    • Polarization of the anterior-posterior axis of C. elegans is a microtubule directed process
    • Wallenfang M.R., Seydoux G. Polarization of the anterior-posterior axis of C. elegans is a microtubule directed process. Nature. 408:2000;89-92.
    • (2000) Nature , vol.408 , pp. 89-92
    • Wallenfang, M.R.1    Seydoux, G.2
  • 29
    • 0035252546 scopus 로고    scopus 로고
    • Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo
    • The authors describe analysis of the forces that control the spindle position during C. elegans first cell division. Par genes are responsible for the forces applied to each spindle pole and therefore for the generation of an asymmetric cell division.
    • Grill S.W., Gonczy P., Stelzer E.H., Hyman A.A. Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo. Nature. 409:2001;630-633 The authors describe analysis of the forces that control the spindle position during C. elegans first cell division. Par genes are responsible for the forces applied to each spindle pole and therefore for the generation of an asymmetric cell division.
    • (2001) Nature , vol.409 , pp. 630-633
    • Grill, S.W.1    Gonczy, P.2    Stelzer, E.H.3    Hyman, A.A.4
  • 30
    • 0027264593 scopus 로고
    • A central role for microtubules in the differentiation of Drosophila oocytes
    • Theurkauf W.E., Alberts B.M., Jan Y.N., Jongens T.A. A central role for microtubules in the differentiation of Drosophila oocytes. Development. 118:1993;1169-1180.
    • (1993) Development , vol.118 , pp. 1169-1180
    • Theurkauf, W.E.1    Alberts, B.M.2    Jan, Y.N.3    Jongens, T.A.4
  • 32
    • 0033538842 scopus 로고    scopus 로고
    • Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila
    • Robinson J.T., Wojcik E.J., Sanders M.A., McGrail M., Hays T.S. Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila. J Cell Biol. 146:1999;597-608.
    • (1999) J Cell Biol , vol.146 , pp. 597-608
    • Robinson, J.T.1    Wojcik, E.J.2    Sanders, M.A.3    McGrail, M.4    Hays, T.S.5
  • 33
    • 0012346003 scopus 로고    scopus 로고
    • The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila
    • McGrail M., Hays T.S. The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila. Development. 127:1997;2785-2794.
    • (1997) Development , vol.127 , pp. 2785-2794
    • McGrail, M.1    Hays, T.S.2
  • 34
    • 0036479109 scopus 로고    scopus 로고
    • Glyceraldehyde 3-phosphate dehydrogenase is phosphorylated by protein kinase Cι/λ and plays a key role in microtubule dynamics in the early secretory pathway
    • Tisdale E.J. Glyceraldehyde 3-phosphate dehydrogenase is phosphorylated by protein kinase Cι/λ and plays a key role in microtubule dynamics in the early secretory pathway. J Biol Chem. 277:2002;3334-3341.
    • (2002) J Biol Chem , vol.277 , pp. 3334-3341
    • Tisdale, E.J.1
  • 35
    • 0033621957 scopus 로고    scopus 로고
    • Atypical protein kinases Cλ and -ζ associate with the GTP-binding protein Cdc42 and mediate stress fiber loss
    • Coghlan M.P., Chou M.M., Carpenter C.L. Atypical protein kinases Cλ and -ζ associate with the GTP-binding protein Cdc42 and mediate stress fiber loss. Mol Cell Biol. 20:2000;2880-2889.
    • (2000) Mol Cell Biol , vol.20 , pp. 2880-2889
    • Coghlan, M.P.1    Chou, M.M.2    Carpenter, C.L.3
  • 36
    • 0035070099 scopus 로고    scopus 로고
    • Human homologues of the Caenorhabditis elegans cell polarity protein Par-6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C
    • Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H. Human homologues of the Caenorhabditis elegans cell polarity protein Par-6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells. 6:2001;107-119.
    • (2001) Genes Cells , vol.6 , pp. 107-119
    • Noda, Y.1    Takeya, R.2    Ohno, S.3    Naito, S.4    Ito, T.5    Sumimoto, H.6
  • 37
    • 0035911955 scopus 로고    scopus 로고
    • Atypical protein kinase C is involved in the evolutionarily conserved Par protein complex and plays a critical role in establishing epithelia-specific junctional structures
    • Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., Ohno S. Atypical protein kinase C is involved in the evolutionarily conserved Par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol. 152:2001;1183-1196.
    • (2001) J Cell Biol , vol.152 , pp. 1183-1196
    • Suzuki, A.1    Yamanaka, T.2    Hirose, T.3    Manabe, N.4    Mizuno, K.5    Shimizu, M.6    Akimoto, K.7    Izumi, Y.8    Ohnishi, T.9    Ohno, S.10


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