Par-3 controls tight junction assembly through the Rac exchange factor Tiam1

Nature Cell Biology

Volumn 7, Issue 3, 2005, Pages 262-269

  Chen, Xinyu ^a   Macara, Ian G ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE C; PROTEINASE ACTIVATED RECEPTOR 3; RAC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL POLARITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; GENE ACTIVATION; GENE DISRUPTION; GENETIC CONSERVATION; MAMMAL CELL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; TIGHT JUNCTION;

ACTINS; ANIMALS; BLOTTING, WESTERN; CDC42 GTP-BINDING PROTEIN; CELL ADHESION MOLECULES; CELL LINE; DOGS; ELECTROPORATION; EPITHELIAL CELLS; EPITHELIUM; GENES, DOMINANT; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RNA, MESSENGER; TIME FACTORS; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 14744289370     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1226     Document Type: Article

References (30)

1. Kemphues, K. J., Priess, J. R., Morton, D. G. & Cheng, N. S. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52, 311-320 (1988).
2. Doe, C. Q. & Bowerman, B. Asymmetric cell division: fly neuroblast meets worm zygote. Curr. Opin. Cell Biol. 13, 68-75 (2001).
3. Izumi, Y. et al. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J. Cell Biol. 143, 95-106 (1998).
4. Joberty, G., Petersen, C., Gao, L. & Macara, I. G. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nature Cell Biol. 2, 531-539 (2000).
5. Lin, D. et al. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nature Cell Biol. 2, 540-547 (2000).
6. Tepass, U., Tanentzapf, G., Ward, R. & Fehon, R. Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35, 747-784 (2001).
7. Mertens, A. E., Roovers, R. C. & Collard, J. G. Regulation of Tiam1-Rac signalling. FEBS Lett. 546, 11-16 (2003).
8. Macara, I. G. Parsing the polarity code. Nature Rev. Mol. Cell Biol. 5, 220-231 (2004).
9. Nelson, W. J. Adaptation of core mechanisms to generate cell polarity, Nature 422, 766-774 (2003).
10. Perez-Moreno, M., Jamora, C. & Fuchs, E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 112, 535-548 (2003).
11. Gibson, M. C. & Perrimon, N. Apicobasal polarization: epithelial form and function. Curr. Opin. Cell Biol. 15, 747-752 (2003).
12. Hirose, T. et al. Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J. Cell Sci. 115, 2485-2495 (2002).
13. Matter, K. & Balda, M. S. Functional analysis of tight junctions. Methods 30, 228-234 (2003).
14. Furuse, M., Furuse, K., Sasaki, H. & Tsukita, S. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J. Cell Biol. 153, 263-272 (2001).
15. Gao, L., Joberty, G. & Macara, I. G. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr. Biol. 12, 221-225 (2002).
16. Benton, R. & Johnston, D. S. A conserved oligomerization domain in Drosophila Bazooka/PAR-3 is important for apical localization and elpithelial polarity. Curr. Biol. 13, 1330-1334 (2003).
17. Mizuno, K. et al. Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions. J. Biol. Chem. 278, 31240-31250 (2003).
18. Wodarz, A., Ramrath, A., Grimm, A. & Knust, E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J. Cell Biol. 150, 1361-1374 (2000).
19. Ebnet, K. et al. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J. 20, 3738-3748 (2001).
20. Takekuni, K. et al. Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J. Biol. Chem. 278, 5497-5500 (2003).
21. Kovacs, M., Toth, J., Hetenyi, C., Malnasi-Csizmadia, A. & Sellers, J. R. Mechanism of blebbistatin inhibition of myosin II. J. Biol. Chem. 279, 35557-35563 (2004).
22. Kosako, H. et al. Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene 19, 6059-6064 (2000).
23. Totsukawa, G. et al. Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibres and focal adhesions in 3T3 fibroblasts. J. Cell Biol. 150, 797-806 (2000).
24. Noren, N. K., Niessen, C. M., Gumbiner, B. M. & Burridge, K. Cadherin engagement regulates Rho family GTPases. J. Biol. Chem. 276, 33305-33308 (2001).
25. Malliri, A., van Es, S., Huveneers, S. & Collard, J. G. The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions. J. Biol. Chem. 279, 30092-30098 (2004).
26. Stam, J. C. et al. Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain. J. Biol. Chem. 272, 28447-28454 (1997).
27. Knoblich, J. A. Asymmetric cell division during animal development. Nature Rev. Mol. Cell Biol. 2, 11-20 (2001).
28. Jan, Y. N. & Jan, L. Y. Asymmetric cell division in the Drosophila nervous system. Nature Rev. Neurosci. 2, 772-779 (2001).
29. Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
30. Ren, X. D. & Schwartz, M. A. Determination of GTP loading on Rho. Methods Enzymol. 325, 264-272 (2000).