N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies

Trends in Biotechnology

Volumn 34, Issue 10, 2016, Pages 835-846

  Sha, Sha ^a   Agarabi, Cyrus ^b   Brorson, Kurt ^b   Lee, Dong Yup ^c   Yoon, Seongkyu ^a  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

glycoengineering; mathematical modeling; metabolic characterization; monoclonal antibody; N glycosylation

Indexed keywords

GLYCOSYLATION; MATHEMATICAL MODELS; METABOLISM; MONOCLONAL ANTIBODIES; POLYSACCHARIDES; SURFACE PLASMON RESONANCE;

BIOPROCESS DEVELOPMENT; GENETIC MODIFICATIONS; GLYCOENGINEERING; MONOCLONAL ANTIBODIES (MABS); N-GLYCOSYLATION; OPTIMIZATION AND CONTROL; RECOMBINANT MONOCLONAL ANTIBODY; THERAPEUTIC MONOCLONAL ANTIBODIES;

ANTIBODIES;

AMMONIA; BIOSIMILAR AGENT; GLYCAN; MONOCLONAL ANTIBODY; GLYCOPROTEIN; POLYSACCHARIDE; RECOMBINANT PROTEIN;

BIOPROCESS; CELL CULTURE; COMPUTER MODEL; CULTURE MEDIUM; GENETIC ENGINEERING; GENOTYPE; GLYCOSYLATION; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; CELL LINE; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HAMSTER; HUMAN; METABOLIC ENGINEERING; METABOLISM; MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; METABOLIC ENGINEERING; MICE; POLYSACCHARIDES; RECOMBINANT PROTEINS;

EID: 84962166067     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2016.02.013     Document Type: Review

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