A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus

Biotechnology Progress

Volumn 27, Issue 6, 2011, Pages 1730-1743

  Jimenez del Val, Ioscani ^a   Nagy, Judit M ^a   Kontoravdi, Cleo ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Dynamic mathematical modeling; Golgi cisternal maturation; Monoclonal antibodies; N linked glycosylation; Nucleotide sugars

Indexed keywords

BIOPHARMACEUTICAL INDUSTRY; CELL ENGINEERING; CELLULAR METABOLISM; CONCENTRATION PROFILES; CYTOSOLIC; CYTOSOLS; DYNAMIC MATHEMATICAL MODEL; GENE SILENCING; GLYCOSYLATION REACTIONS; GOLGI APPARATUS; GOLGI CISTERNAL MATURATION; KINETIC MECHANISM; MANUFACTURING PROCESS; MATHEMATICAL MODELING; MONOCLONAL ANTIBODIES (MABS); N-LINKED GLYCOSYLATION; NUCLEOTIDE SUGAR; NUCLEOTIDE SUGARS; PLUG FLOW REACTOR; PROCESS CONDITION; RATE EXPRESSION; THERAPEUTIC EFFICACY; TRANSPORT PROTEINS;

CELLULAR MANUFACTURING; ENZYMES; ESTERIFICATION; GENES; GENETIC ENGINEERING; GLYCOSYLATION; INDUSTRIAL ENGINEERING; METABOLISM; MONOCLONAL ANTIBODIES; NUCLEOTIDES; OPTIMIZATION; PHYSIOLOGY; PRODUCTION ENGINEERING; REACTION RATES; SUGAR INDUSTRY; SUGARS; SURFACE PLASMON RESONANCE; TURBOFAN ENGINES;

MATHEMATICAL MODELS;

ENZYME; MONOCLONAL ANTIBODY; NUCLEOSIDE DIPHOSPHATE SUGAR;

ANIMAL; ARTICLE; CELL LINE; CHEMISTRY; ENZYMOLOGY; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; KINETICS; METABOLISM; PROTEIN MOTIF; PROTEIN PROCESSING; THEORETICAL MODEL; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID MOTIFS; ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL TRANSPORT; CELL LINE; ENZYMES; GLYCOSYLATION; GOLGI APPARATUS; HUMANS; KINETICS; MODELS, THEORETICAL; NUCLEOSIDE DIPHOSPHATE SUGARS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 82955237386     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.688     Document Type: Article

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