Dynamics of immature mAb glycoform secretion during CHO cell culture: An integrated modelling framework

Biotechnology Journal

Volumn 11, Issue 5, 2016, Pages 610-623

  Jimenez del Val, Ioscani ^a   Fan, Yuzhou ^b,c   Weilguny, Dietmar ^c  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c Symphogen AS   (Denmark)

Author keywords

CHO cells; Dynamic glycosylation model; In silico glycoengineering; Pharmaceutical bioprocessing; Therapeutic protein glycosylation

Indexed keywords

ANTIBODIES; CELL CULTURE; CELL ENGINEERING; MACHINERY; MONOCLONAL ANTIBODIES;

BIOPROCESSING; CHO CELL; IN-SILICO; INTEGRATED MODELLING; INTRACELLULAR PROCESS; SPECIFIC PRODUCTIVITY; THERAPEUTIC MONOCLONAL ANTIBODIES; THERAPEUTIC PROTEIN;

GLYCOSYLATION;

MONOCLONAL ANTIBODY;

ARTICLE; BIOPROCESS; CELL CULTURE; CELL ENGINEERING; CELL METABOLISM; CHO CELL LINE; ENZYME GLYCOSYLATION; GOLGI COMPLEX; KINETIC PARAMETERS; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE TECHNIQUE; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; CRICETULUS; GLYCOSYLATION; METABOLISM; PROCEDURES; PROTEIN PROCESSING; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL TRANSPORT; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETULUS; GLYCOSYLATION; GOLGI APPARATUS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84969369434     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201400663     Document Type: Article

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