A Markov chain model for N-linked protein glycosylation - towards a low-parameter tool for model-driven glycoengineering

Metabolic Engineering

Volumn 33, Issue , 2016, Pages 52-66

  Spahn, Philipp N ^a,c   Hansen, Anders H ^d   Hansen, Henning G ^d   Arnsdorf, Johnny ^d   Kildegaard, Helene F ^d   Lewis, Nathan E ^b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Chalmers University of Technology   (Denmark)

Author keywords

Flux balance analysis; Glycoengineering; Glycosylation; Markov chains

Indexed keywords

CELL CULTURE; CELL ENGINEERING; CHAINS; COMPLEX NETWORKS; GLYCOSYLATION; MAMMALS;

BIOLOGICAL COMPLEXITY; CHINESE HAMSTER OVARY CELLS; COMPUTATIONAL ENGINEERING; FLUX BALANCE ANALYSIS; GLYCOENGINEERING; GLYCOSYL TRANSFERASE; PROTEIN GLYCOSYLATION; USER-FRIENDLY PLATFORMS;

MARKOV PROCESSES;

ERYTHROPOIETIN; GLYCOSYLTRANSFERASE; IMMUNOGLOBULIN G; GLYCOPROTEIN; POLYSACCHARIDE;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CHO CELL LINE; CONTROLLED STUDY; DRUG DEVELOPMENT; ENZYME ACTIVITY; ENZYME MECHANISM; GENE INACTIVATION; GENE SILENCING; GLYCOENGINEERING; GOLGI COMPLEX; MAMMAL CELL; METABOLIC ENGINEERING; MONTE CARLO METHOD; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; QUANTITATIVE ANALYSIS; SCALE UP; STATISTICAL PARAMETERS; STOICHIOMETRY; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; CRICETULUS; GENETICS; GLYCOSYLATION; MARKOV CHAIN; METABOLIC FLUX ANALYSIS; METABOLISM; PROCEDURES; STATISTICAL MODEL;

ANIMALS; CHO CELLS; COMPUTER SIMULATION; CRICETULUS; GLYCOPROTEINS; GLYCOSYLATION; MARKOV CHAINS; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; POLYSACCHARIDES;

EID: 84947982943     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2015.10.007     Document Type: Article

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