-
1
-
-
84957846754
-
The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography
-
Hotchkiss, R.D., The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography. J Biol Chem 175:1 (1948), 315–332.
-
(1948)
J Biol Chem
, vol.175
, Issue.1
, pp. 315-332
-
-
Hotchkiss, R.D.1
-
2
-
-
0004204454
-
Handbook of biochemistry
-
2d ed. Cleveland, OH Chemical Rubber Company
-
Sober, H.A., Handbook of biochemistry. 2d ed., 1970, Cleveland, OH, Chemical Rubber Company.
-
(1970)
-
-
Sober, H.A.1
-
3
-
-
0004049580
-
The modified nucleosides in nucleic acids
-
Columbia University Press New York
-
Hall, R., The modified nucleosides in nucleic acids. 1972, Columbia University Press, New York.
-
(1972)
-
-
Hall, R.1
-
4
-
-
0019875880
-
Methylation of CpG sequences in eukaryotic DNA
-
Gruenbaum, Y., Stein, R., Cedar, H., Razin, A., Methylation of CpG sequences in eukaryotic DNA. FEBS Lett 124:1 (1981), 67–71.
-
(1981)
FEBS Lett
, vol.124
, Issue.1
, pp. 67-71
-
-
Gruenbaum, Y.1
Stein, R.2
Cedar, H.3
Razin, A.4
-
5
-
-
84899091504
-
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
-
Wen, L., Li, X., Yan, L., Tan, Y., Li, R., Zhao, Y., et al. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biol, 15(3), 2014, R49.
-
(2014)
Genome Biol
, vol.15
, Issue.3
, pp. R49
-
-
Wen, L.1
Li, X.2
Yan, L.3
Tan, Y.4
Li, R.5
Zhao, Y.6
-
6
-
-
0020489781
-
Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells
-
Ehrlich, M., Gama-Sosa, M.A., Huang, L.H., Midgett, R.M., Kuo, K.C., McCune, R.A., et al. Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res 10:8 (1982), 2709–2721.
-
(1982)
Nucleic Acids Res
, vol.10
, Issue.8
, pp. 2709-2721
-
-
Ehrlich, M.1
Gama-Sosa, M.A.2
Huang, L.H.3
Midgett, R.M.4
Kuo, K.C.5
McCune, R.A.6
-
7
-
-
66449121652
-
Finding the fifth base: genome-wide sequencing of cytosine methylation
-
Lister, R., Ecker, J.R., Finding the fifth base: genome-wide sequencing of cytosine methylation. Genome Res 19:6 (2009), 959–966.
-
(2009)
Genome Res
, vol.19
, Issue.6
, pp. 959-966
-
-
Lister, R.1
Ecker, J.R.2
-
8
-
-
0021086610
-
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA
-
Bestor, T.H., Ingram, V.M., Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc Natl Acad Sci U S A 80:18 (1983), 5559–5563.
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, Issue.18
, pp. 5559-5563
-
-
Bestor, T.H.1
Ingram, V.M.2
-
9
-
-
9144256125
-
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites
-
Hermann, A., Goyal, R., Jeltsch, A., The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites. J Biol Chem 279:46 (2004), 48350–48359.
-
(2004)
J Biol Chem
, vol.279
, Issue.46
, pp. 48350-48359
-
-
Hermann, A.1
Goyal, R.2
Jeltsch, A.3
-
10
-
-
12844278737
-
Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase
-
Vilkaitis, G., Suetake, I., Klimasauskas, S., Tajima, S., Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase. J Biol Chem 280:1 (2005), 64–72.
-
(2005)
J Biol Chem
, vol.280
, Issue.1
, pp. 64-72
-
-
Vilkaitis, G.1
Suetake, I.2
Klimasauskas, S.3
Tajima, S.4
-
11
-
-
0031860739
-
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
-
Okano, M., Xie, S., Li, E., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 19:3 (1998), 219–220.
-
(1998)
Nat Genet
, vol.19
, Issue.3
, pp. 219-220
-
-
Okano, M.1
Xie, S.2
Li, E.3
-
12
-
-
3743083805
-
Clonal inheritance of the pattern of DNA methylation in mouse cells
-
Stein, R., Gruenbaum, Y., Pollack, Y., Razin, A., Cedar, H., Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci U S A 79:1 (1982), 61–65.
-
(1982)
Proc Natl Acad Sci U S A
, vol.79
, Issue.1
, pp. 61-65
-
-
Stein, R.1
Gruenbaum, Y.2
Pollack, Y.3
Razin, A.4
Cedar, H.5
-
13
-
-
0035933337
-
Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites
-
Gowher, H., Jeltsch, A., Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites. J Mol Biol 309:5 (2001), 1201–1208.
-
(2001)
J Mol Biol
, vol.309
, Issue.5
, pp. 1201-1208
-
-
Gowher, H.1
Jeltsch, A.2
-
14
-
-
0037023761
-
Preferential methylation of unmethylated DNA by mammalian de novo DNA methyltransferase Dnmt3a
-
Yokochi, T., Robertson, K.D., Preferential methylation of unmethylated DNA by mammalian de novo DNA methyltransferase Dnmt3a. J Biol Chem 277:14 (2002), 11735–11745.
-
(2002)
J Biol Chem
, vol.277
, Issue.14
, pp. 11735-11745
-
-
Yokochi, T.1
Robertson, K.D.2
-
15
-
-
0036415141
-
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA
-
Fatemi, M., Hermann, A., Gowher, H., Jeltsch, A., Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur J Biochem 269:20 (2002), 4981–4984.
-
(2002)
Eur J Biochem
, vol.269
, Issue.20
, pp. 4981-4984
-
-
Fatemi, M.1
Hermann, A.2
Gowher, H.3
Jeltsch, A.4
-
16
-
-
0036142089
-
Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro
-
Lin, I.G., Han, L., Taghva, A., O'Brien, L.E., Hsieh, C.L., Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro. Mol Cell Biol 22:3 (2002), 704–723.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.3
, pp. 704-723
-
-
Lin, I.G.1
Han, L.2
Taghva, A.3
O'Brien, L.E.4
Hsieh, C.L.5
-
17
-
-
0035937404
-
Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene
-
Howell, C.Y., Bestor, T.H., Ding, F., Latham, K.E., Mertineit, C., Trasler, J.M., et al. Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. Cell 104:6 (2001), 829–838.
-
(2001)
Cell
, vol.104
, Issue.6
, pp. 829-838
-
-
Howell, C.Y.1
Bestor, T.H.2
Ding, F.3
Latham, K.E.4
Mertineit, C.5
Trasler, J.M.6
-
18
-
-
0035930660
-
Dnmt3L and the establishment of maternal genomic imprints
-
Bourc'his, D., Xu, G.L., Lin, C.S., Bollman, B., Bestor, T.H., Dnmt3L and the establishment of maternal genomic imprints. Science 294:5551 (2001), 2536–2539.
-
(2001)
Science
, vol.294
, Issue.5551
, pp. 2536-2539
-
-
Bourc'his, D.1
Xu, G.L.2
Lin, C.S.3
Bollman, B.4
Bestor, T.H.5
-
19
-
-
0036333103
-
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
-
Hata, K., Okano, M., Lei, H., Li, E., Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129:8 (2002), 1983–1993.
-
(2002)
Development
, vol.129
, Issue.8
, pp. 1983-1993
-
-
Hata, K.1
Okano, M.2
Lei, H.3
Li, E.4
-
20
-
-
82855176833
-
Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells
-
Saitou, M., Kagiwada, S., Kurimoto, K., Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells. Development 139:1 (2012), 15–31.
-
(2012)
Development
, vol.139
, Issue.1
, pp. 15-31
-
-
Saitou, M.1
Kagiwada, S.2
Kurimoto, K.3
-
21
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
Okano, M., Bell, D.W., Haber, D.A., Li, E., DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:3 (1999), 247–257.
-
(1999)
Cell
, vol.99
, Issue.3
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
22
-
-
33744552284
-
CpG sites preferentially methylated by Dnmt3a in vivo
-
Oka, M., Rodic, N., Graddy, J., Chang, L.J., Terada, N., CpG sites preferentially methylated by Dnmt3a in vivo. J Biol Chem 281:15 (2006), 9901–9908.
-
(2006)
J Biol Chem
, vol.281
, Issue.15
, pp. 9901-9908
-
-
Oka, M.1
Rodic, N.2
Graddy, J.3
Chang, L.J.4
Terada, N.5
-
23
-
-
4644221440
-
Preference of DNA methyltransferases for CpG islands in mouse embryonic stem cells
-
Hattori, N., Abe, T., Hattori, N., Suzuki, M., Matsuyama, T., Yoshida, S., et al. Preference of DNA methyltransferases for CpG islands in mouse embryonic stem cells. Genome Res 14:9 (2004), 1733–1740.
-
(2004)
Genome Res
, vol.14
, Issue.9
, pp. 1733-1740
-
-
Hattori, N.1
Abe, T.2
Hattori, N.3
Suzuki, M.4
Matsuyama, T.5
Yoshida, S.6
-
24
-
-
66149123748
-
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
-
Kriaucionis, S., Heintz, N., The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324:5929 (2009), 929–930.
-
(2009)
Science
, vol.324
, Issue.5929
, pp. 929-930
-
-
Kriaucionis, S.1
Heintz, N.2
-
25
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani, M., Koh, K.P., Shen, Y., Pastor, W.A., Bandukwala, H., Brudno, Y., et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324:5929 (2009), 930–935.
-
(2009)
Science
, vol.324
, Issue.5929
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
-
26
-
-
84866419591
-
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
-
Lian, C.G., Xu, Y., Ceol, C., Wu, F., Larson, A., Dresser, K., et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150:6 (2012), 1135–1146.
-
(2012)
Cell
, vol.150
, Issue.6
, pp. 1135-1146
-
-
Lian, C.G.1
Xu, Y.2
Ceol, C.3
Wu, F.4
Larson, A.5
Dresser, K.6
-
27
-
-
77956189495
-
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
-
Ito, S., D'Alessio, A.C., Taranova, O.V., Hong, K., Sowers, L.C., Zhang, Y., Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466:7310 (2010), 1129–1133.
-
(2010)
Nature
, vol.466
, Issue.7310
, pp. 1129-1133
-
-
Ito, S.1
D'Alessio, A.C.2
Taranova, O.V.3
Hong, K.4
Sowers, L.C.5
Zhang, Y.6
-
28
-
-
79955948324
-
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells
-
Xu, Y., Wu, F., Tan, L., Kong, L., Xiong, L., Deng, J., et al. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell 42:4 (2011), 451–464.
-
(2011)
Mol Cell
, vol.42
, Issue.4
, pp. 451-464
-
-
Xu, Y.1
Wu, F.2
Tan, L.3
Kong, L.4
Xiong, L.5
Deng, J.6
-
29
-
-
79952534189
-
Regulation of chromatin by histone modifications
-
Bannister, A.J., Kouzarides, T., Regulation of chromatin by histone modifications. Cell Res 21:3 (2011), 381–395.
-
(2011)
Cell Res
, vol.21
, Issue.3
, pp. 381-395
-
-
Bannister, A.J.1
Kouzarides, T.2
-
30
-
-
78650304236
-
Charting histone modifications and the functional organization of mammalian genomes
-
Zhou, V.W., Goren, A., Bernstein, B.E., Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 12:1 (2011), 7–18.
-
(2011)
Nat Rev Genet
, vol.12
, Issue.1
, pp. 7-18
-
-
Zhou, V.W.1
Goren, A.2
Bernstein, B.E.3
-
31
-
-
0037372003
-
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
-
Jaenisch, R., Bird, A., Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33:Suppl (2003), 245–254.
-
(2003)
Nat Genet
, vol.33
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
32
-
-
33847047461
-
Epigenetics: a landscape takes shape
-
Goldberg, A.D., Allis, C.D., Bernstein, E., Epigenetics: a landscape takes shape. Cell 128:4 (2007), 635–638.
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 635-638
-
-
Goldberg, A.D.1
Allis, C.D.2
Bernstein, E.3
-
33
-
-
84863773570
-
The epigenotype. 1942
-
Waddington, C.H., The epigenotype. 1942. Int J Epidemiol 41:1 (2012), 10–13.
-
(2012)
Int J Epidemiol
, vol.41
, Issue.1
, pp. 10-13
-
-
Waddington, C.H.1
-
34
-
-
0016651630
-
-
Genetic control of wing disc development in Drosophila. Ciba Found Symp
-
Garcia-Bellido A. Genetic control of wing disc development in Drosophila. Ciba Found Symp 1975;0(29):161–82.
-
(1975)
, vol.29
, pp. 161-82
-
-
Garcia-Bellido, A.1
-
35
-
-
0003419060
-
Epigenetic mechanisms of gene regulation
-
Cold Spring Harbor Laboratory Press New York
-
Russo, V.E.A., Martienssen, R.A., Riggs, A.D., Epigenetic mechanisms of gene regulation. 1996, Cold Spring Harbor Laboratory Press, New York.
-
(1996)
-
-
Russo, V.E.A.1
Martienssen, R.A.2
Riggs, A.D.3
-
36
-
-
34249337761
-
Perceptions of epigenetics
-
Bird, A., Perceptions of epigenetics. Nature 447:7143 (2007), 396–398.
-
(2007)
Nature
, vol.447
, Issue.7143
, pp. 396-398
-
-
Bird, A.1
-
37
-
-
33845877732
-
Defining an epigenetic code
-
Turner, B.M., Defining an epigenetic code. Nat Cell Biol 9:1 (2007), 2–6.
-
(2007)
Nat Cell Biol
, vol.9
, Issue.1
, pp. 2-6
-
-
Turner, B.M.1
-
38
-
-
0019425529
-
DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells
-
Compere, S.J., Palmiter, R.D., DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell 25:1 (1981), 233–240.
-
(1981)
Cell
, vol.25
, Issue.1
, pp. 233-240
-
-
Compere, S.J.1
Palmiter, R.D.2
-
39
-
-
84875177348
-
X-inactivation, imprinting, and long noncoding RNAs in health and disease
-
Lee, Jeannie T., Bartolomei, Marisa S., X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell 152:6 (2013), 1308–1323.
-
(2013)
Cell
, vol.152
, Issue.6
, pp. 1308-1323
-
-
Lee, J.T.1
Bartolomei, M.S.2
-
40
-
-
0028940587
-
Gene number, noise reduction and biological complexity
-
Bird, A.P., Gene number, noise reduction and biological complexity. Trends Genet 11:3 (1995), 94–100.
-
(1995)
Trends Genet
, vol.11
, Issue.3
, pp. 94-100
-
-
Bird, A.P.1
-
41
-
-
0019786495
-
DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning
-
Harbers, K., Schnieke, A., Stuhlmann, H., Jahner, D., Jaenisch, R., DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. Proc Natl Acad Sci U S A 78:12 (1981), 7609–7613.
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, Issue.12
, pp. 7609-7613
-
-
Harbers, K.1
Schnieke, A.2
Stuhlmann, H.3
Jahner, D.4
Jaenisch, R.5
-
42
-
-
3042822370
-
DNA hypomethylation and ovarian cancer biology
-
Widschwendter, M., Jiang, G., Woods, C., Muller, H.M., Fiegl, H., Goebel, G., et al. DNA hypomethylation and ovarian cancer biology. Cancer Res 64:13 (2004), 4472–4480.
-
(2004)
Cancer Res
, vol.64
, Issue.13
, pp. 4472-4480
-
-
Widschwendter, M.1
Jiang, G.2
Woods, C.3
Muller, H.M.4
Fiegl, H.5
Goebel, G.6
-
43
-
-
22844457491
-
DNA methylation and human disease
-
Robertson, K.D., DNA methylation and human disease. Nat Rev Genet 6:8 (2005), 597–610.
-
(2005)
Nat Rev Genet
, vol.6
, Issue.8
, pp. 597-610
-
-
Robertson, K.D.1
-
44
-
-
0030840954
-
Cytosine methylation and the ecology of intragenomic parasites
-
Yoder, J.A., Walsh, C.P., Bestor, T.H., Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13:8 (1997), 335–340.
-
(1997)
Trends Genet
, vol.13
, Issue.8
, pp. 335-340
-
-
Yoder, J.A.1
Walsh, C.P.2
Bestor, T.H.3
-
45
-
-
84856916060
-
The pathogenesis of mixed-lineage leukemia
-
Muntean, A.G., Hess, J.L., The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol 7 (2012), 283–301.
-
(2012)
Annu Rev Pathol
, vol.7
, pp. 283-301
-
-
Muntean, A.G.1
Hess, J.L.2
-
46
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman, J.G., Baylin, S.B., Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:21 (2003), 2042–2054.
-
(2003)
N Engl J Med
, vol.349
, Issue.21
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
47
-
-
0034625064
-
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
-
Ramsahoye, B.H., Biniszkiewicz, D., Lyko, F., Clark, V., Bird, A.P., Jaenisch, R., Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A 97:10 (2000), 5237–5242.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.10
, pp. 5237-5242
-
-
Ramsahoye, B.H.1
Biniszkiewicz, D.2
Lyko, F.3
Clark, V.4
Bird, A.P.5
Jaenisch, R.6
-
48
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
Lister, R., Pelizzola, M., Dowen, R.H., Hawkins, R.D., Hon, G., Tonti-Filippini, J., et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462:7271 (2009), 315–322.
-
(2009)
Nature
, vol.462
, Issue.7271
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
Hawkins, R.D.4
Hon, G.5
Tonti-Filippini, J.6
-
49
-
-
84875467145
-
Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
-
Ichiyanagi, T., Ichiyanagi, K., Miyake, M., Sasaki, H., Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development. Nucleic Acids Res 41:2 (2013), 738–745.
-
(2013)
Nucleic Acids Res
, vol.41
, Issue.2
, pp. 738-745
-
-
Ichiyanagi, T.1
Ichiyanagi, K.2
Miyake, M.3
Sasaki, H.4
-
50
-
-
84874194072
-
DNA methylation: roles in mammalian development
-
Smith, Z.D., Meissner, A., DNA methylation: roles in mammalian development. Nat Rev Genet 14:3 (2013), 204–220.
-
(2013)
Nat Rev Genet
, vol.14
, Issue.3
, pp. 204-220
-
-
Smith, Z.D.1
Meissner, A.2
-
51
-
-
0028358421
-
The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA
-
Shen, J.C., Rideout, W.M. 3rd, Jones, P.A., The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA. Nucleic Acids Res 22:6 (1994), 972–976.
-
(1994)
Nucleic Acids Res
, vol.22
, Issue.6
, pp. 972-976
-
-
Shen, J.C.1
Rideout, W.M.2
Jones, P.A.3
-
52
-
-
0023853921
-
The CpG dinucleotide and human genetic disease
-
Cooper, D.N., Youssoufian, H., The CpG dinucleotide and human genetic disease. Hum Genet 78:2 (1988), 151–155.
-
(1988)
Hum Genet
, vol.78
, Issue.2
, pp. 151-155
-
-
Cooper, D.N.1
Youssoufian, H.2
-
53
-
-
0026656818
-
Assessing the underlying pattern of human germline mutations: lessons from the factor IX gene
-
Sommer, S.S., Assessing the underlying pattern of human germline mutations: lessons from the factor IX gene. FASEB J 6:10 (1992), 2767–2774.
-
(1992)
FASEB J
, vol.6
, Issue.10
, pp. 2767-2774
-
-
Sommer, S.S.1
-
54
-
-
0025145277
-
5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
-
Rideout, W.M. 3rd, Coetzee, G.A., Olumi, A.F., Jones, P.A., 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 249:4974 (1990), 1288–1290.
-
(1990)
Science
, vol.249
, Issue.4974
, pp. 1288-1290
-
-
Rideout, W.M.1
Coetzee, G.A.2
Olumi, A.F.3
Jones, P.A.4
-
55
-
-
31944432339
-
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
-
Saxonov, S., Berg, P., Brutlag, D.L., A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A 103:5 (2006), 1412–1417.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.5
, pp. 1412-1417
-
-
Saxonov, S.1
Berg, P.2
Brutlag, D.L.3
-
56
-
-
77957257570
-
CpG island clusters and pro-epigenetic selection for CpGs in protein-coding exons of HOX and other transcription factors
-
Branciamore, S., Chen, Z.X., Riggs, A.D., Rodin, S.N., CpG island clusters and pro-epigenetic selection for CpGs in protein-coding exons of HOX and other transcription factors. Proc Natl Acad Sci U S A 107:35 (2010), 15485–15490.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.35
, pp. 15485-15490
-
-
Branciamore, S.1
Chen, Z.X.2
Riggs, A.D.3
Rodin, S.N.4
-
57
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li, E., Bestor, T.H., Jaenisch, R., Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:6 (1992), 915–926.
-
(1992)
Cell
, vol.69
, Issue.6
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
58
-
-
0029803192
-
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
-
Lei, H., Oh, S.P., Okano, M., Juttermann, R., Goss, K.A., Jaenisch, R., et al. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122:10 (1996), 3195–3205.
-
(1996)
Development
, vol.122
, Issue.10
, pp. 3195-3205
-
-
Lei, H.1
Oh, S.P.2
Okano, M.3
Juttermann, R.4
Goss, K.A.5
Jaenisch, R.6
-
59
-
-
0032697888
-
Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila
-
Lyko, F., Ramsahoye, B.H., Kashevsky, H., Tudor, M., Mastrangelo, M.A., Orr-Weaver, T.L., et al. Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nat Genet 23:3 (1999), 363–366.
-
(1999)
Nat Genet
, vol.23
, Issue.3
, pp. 363-366
-
-
Lyko, F.1
Ramsahoye, B.H.2
Kashevsky, H.3
Tudor, M.4
Mastrangelo, M.A.5
Orr-Weaver, T.L.6
-
60
-
-
0037068372
-
DNA methylation and chromatin — unraveling the tangled web
-
Robertson, K.D., DNA methylation and chromatin — unraveling the tangled web. Oncogene 21:35 (2002), 5361–5379.
-
(2002)
Oncogene
, vol.21
, Issue.35
, pp. 5361-5379
-
-
Robertson, K.D.1
-
61
-
-
70350046301
-
Rethinking how DNA methylation patterns are maintained
-
Jones, P.A., Liang, G., Rethinking how DNA methylation patterns are maintained. Nat Rev Genet 10:11 (2009), 805–811.
-
(2009)
Nat Rev Genet
, vol.10
, Issue.11
, pp. 805-811
-
-
Jones, P.A.1
Liang, G.2
-
62
-
-
0015298215
-
The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
-
Penn, N.W., Suwalski, R., O'Riley, C., Bojanowski, K., Yura, R., The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J 126:4 (1972), 781–790.
-
(1972)
Biochem J
, vol.126
, Issue.4
, pp. 781-790
-
-
Penn, N.W.1
Suwalski, R.2
O'Riley, C.3
Bojanowski, K.4
Yura, R.5
-
63
-
-
78650826181
-
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
-
Globisch, D., Münzel, M., Müller, M., Michalakis, S., Wagner, M., Koch, S., et al. Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One, 5(12), 2010, e15367.
-
(2010)
PLoS One
, vol.5
, Issue.12
-
-
Globisch, D.1
Münzel, M.2
Müller, M.3
Michalakis, S.4
Wagner, M.5
Koch, S.6
-
64
-
-
79959987448
-
5-Hydroxymethylcytosine, the sixth base of the genome
-
Munzel, M., Globisch, D., Carell, T., 5-Hydroxymethylcytosine, the sixth base of the genome. Angew Chem Int Ed Engl 50:29 (2011), 6460–6468.
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, Issue.29
, pp. 6460-6468
-
-
Munzel, M.1
Globisch, D.2
Carell, T.3
-
65
-
-
65649133977
-
Superior sulcus tumors with vertebral body involvement: a multimodality approach
-
Bolton, W.D., Rice, D.C., Goodyear, A., Correa, A.M., Erasmus, J., Hofstetter, W., et al. Superior sulcus tumors with vertebral body involvement: a multimodality approach. J Thorac Cardiovasc Surg 137:6 (2009), 1379–1387.
-
(2009)
J Thorac Cardiovasc Surg
, vol.137
, Issue.6
, pp. 1379-1387
-
-
Bolton, W.D.1
Rice, D.C.2
Goodyear, A.3
Correa, A.M.4
Erasmus, J.5
Hofstetter, W.6
-
66
-
-
84860749868
-
Tet family proteins and 5-hydroxymethylcytosine in development and disease
-
Tan, L., Shi, Y.G., Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development 139:11 (2012), 1895–1902.
-
(2012)
Development
, vol.139
, Issue.11
, pp. 1895-1902
-
-
Tan, L.1
Shi, Y.G.2
-
67
-
-
84865801083
-
Differential effect of three base modifications on DNA thermostability revealed by high resolution melting
-
Lopez, C.M., Lloyd, A.J., Leonard, K., Wilkinson, M.J., Differential effect of three base modifications on DNA thermostability revealed by high resolution melting. Anal Chem 84:17 (2012), 7336–7342.
-
(2012)
Anal Chem
, vol.84
, Issue.17
, pp. 7336-7342
-
-
Lopez, C.M.1
Lloyd, A.J.2
Leonard, K.3
Wilkinson, M.J.4
-
68
-
-
84908679499
-
Hydroxymethylation of DNA influences nucleosomal conformation and stability in vitro
-
Mendonca, A., Chang, E.H., Liu, W., Yuan, C., Hydroxymethylation of DNA influences nucleosomal conformation and stability in vitro. Biochim Biophys Acta 1839:11 (2014), 1323–1329.
-
(2014)
Biochim Biophys Acta
, vol.1839
, Issue.11
, pp. 1323-1329
-
-
Mendonca, A.1
Chang, E.H.2
Liu, W.3
Yuan, C.4
-
69
-
-
84892540146
-
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis
-
Madzo, J., Liu, H., Rodriguez, A., Vasanthakumar, A., Sundaravel, S., Caces, D.B., et al. Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. Cell Rep 6:1 (2014), 231–244.
-
(2014)
Cell Rep
, vol.6
, Issue.1
, pp. 231-244
-
-
Madzo, J.1
Liu, H.2
Rodriguez, A.3
Vasanthakumar, A.4
Sundaravel, S.5
Caces, D.B.6
-
70
-
-
84915789576
-
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
-
Rampal, R., Alkalin, A., Madzo, J., Vasanthakumar, A., Pronier, E., Patel, J., et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep 9:5 (2014), 1841–1855.
-
(2014)
Cell Rep
, vol.9
, Issue.5
, pp. 1841-1855
-
-
Rampal, R.1
Alkalin, A.2
Madzo, J.3
Vasanthakumar, A.4
Pronier, E.5
Patel, J.6
-
71
-
-
84930330789
-
New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine
-
Moen, E.L., Mariani, C.J., Zullow, H., Jeff-Eke, M., Litwin, E., Nikitas, J.N., et al. New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine. Immunol Rev 263:1 (2015), 36–49.
-
(2015)
Immunol Rev
, vol.263
, Issue.1
, pp. 36-49
-
-
Moen, E.L.1
Mariani, C.J.2
Zullow, H.3
Jeff-Eke, M.4
Litwin, E.5
Nikitas, J.N.6
-
72
-
-
77749277177
-
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing
-
Huang, Y., Pastor, W.A., Shen, Y., Tahiliani, M., Liu, D.R., Rao, A., The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One, 5(1), 2010, e8888.
-
(2010)
PLoS One
, vol.5
, Issue.1
-
-
Huang, Y.1
Pastor, W.A.2
Shen, Y.3
Tahiliani, M.4
Liu, D.R.5
Rao, A.6
-
73
-
-
77954061853
-
Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA
-
Nestor, C., Ruzov, A., Meehan, R., Dunican, D., Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA. Biotechniques 48:4 (2010), 317–319.
-
(2010)
Biotechniques
, vol.48
, Issue.4
, pp. 317-319
-
-
Nestor, C.1
Ruzov, A.2
Meehan, R.3
Dunican, D.4
-
74
-
-
79851474623
-
Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules
-
Wanunu, M., Cohen-Karni, D., Johnson, R.R., Fields, L., Benner, J., Peterman, N., et al. Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules. J Am Chem Soc 133:3 (2011), 486–492.
-
(2011)
J Am Chem Soc
, vol.133
, Issue.3
, pp. 486-492
-
-
Wanunu, M.1
Cohen-Karni, D.2
Johnson, R.R.3
Fields, L.4
Benner, J.5
Peterman, N.6
-
75
-
-
1842411320
-
Crystal structure of the nucleosome core particle at 2.8 A resolution
-
Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F., Richmond, T.J., Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389:6648 (1997), 251–260.
-
(1997)
Nature
, vol.389
, Issue.6648
, pp. 251-260
-
-
Luger, K.1
Mader, A.W.2
Richmond, R.K.3
Sargent, D.F.4
Richmond, T.J.5
-
76
-
-
15044358494
-
Reading signals on the nucleosome with a new nomenclature for modified histones
-
Turner, B.M., Reading signals on the nucleosome with a new nomenclature for modified histones. Nat Struct Mol Biol 12:2 (2005), 110–112.
-
(2005)
Nat Struct Mol Biol
, vol.12
, Issue.2
, pp. 110-112
-
-
Turner, B.M.1
-
77
-
-
84870792079
-
Perceiving the epigenetic landscape through histone readers
-
Musselman, C.A., Lalonde, M.E., Cote, J., Kutateladze, T.G., Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol 19:12 (2012), 1218–1227.
-
(2012)
Nat Struct Mol Biol
, vol.19
, Issue.12
, pp. 1218-1227
-
-
Musselman, C.A.1
Lalonde, M.E.2
Cote, J.3
Kutateladze, T.G.4
-
78
-
-
77953747413
-
Tools and landscapes of epigenetics
-
Tarakhovsky, A., Tools and landscapes of epigenetics. Nat Immunol 11:7 (2010), 565–568.
-
(2010)
Nat Immunol
, vol.11
, Issue.7
, pp. 565-568
-
-
Tarakhovsky, A.1
-
79
-
-
33846019277
-
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark
-
Ruthenburg, A.J., Allis, C.D., Wysocka, J., Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell 25:1 (2007), 15–30.
-
(2007)
Mol Cell
, vol.25
, Issue.1
, pp. 15-30
-
-
Ruthenburg, A.J.1
Allis, C.D.2
Wysocka, J.3
-
80
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl, B.D., Allis, C.D., The language of covalent histone modifications. Nature 403:6765 (2000), 41–45.
-
(2000)
Nature
, vol.403
, Issue.6765
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
81
-
-
84883781627
-
-
Contribution of histone N-terminal tails to the structure and stability of nucleosomes. FEBS Open Bio
-
Iwasaki W, Miya Y, Horikoshi N, Osakabe A, Taguchi H, Tachiwana H, et al. Contribution of histone N-terminal tails to the structure and stability of nucleosomes. FEBS Open Bio 2013;3(0):363–9.
-
(2013)
, vol.3
, pp. 363-9
-
-
Iwasaki, W.1
Miya, Y.2
Horikoshi, N.3
Osakabe, A.4
Taguchi, H.5
Tachiwana, H.6
-
82
-
-
32444436223
-
Molecular biology. Protein tail modification opens way for gene activity
-
Marx, J., Molecular biology. Protein tail modification opens way for gene activity. Science, 311(5762), 2006, 757.
-
(2006)
Science
, vol.311
, Issue.5762
, pp. 757
-
-
Marx, J.1
-
83
-
-
32444434989
-
Histone H4-K16 acetylation controls chromatin structure and protein interactions
-
Shogren-Knaak, M., Ishii, H., Sun, J.M., Pazin, M.J., Davie, J.R., Peterson, C.L., Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 311:5762 (2006), 844–847.
-
(2006)
Science
, vol.311
, Issue.5762
, pp. 844-847
-
-
Shogren-Knaak, M.1
Ishii, H.2
Sun, J.M.3
Pazin, M.J.4
Davie, J.R.5
Peterson, C.L.6
-
84
-
-
84917690836
-
Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions
-
Dhall, A., Wei, S., Fierz, B., Woodcock, C.L., Lee, T.H., Chatterjee, C., Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions. J Biol Chem 289:49 (2014), 33827–33837.
-
(2014)
J Biol Chem
, vol.289
, Issue.49
, pp. 33827-33837
-
-
Dhall, A.1
Wei, S.2
Fierz, B.3
Woodcock, C.L.4
Lee, T.H.5
Chatterjee, C.6
-
85
-
-
67349190247
-
Linking DNA methylation and histone modification: patterns and paradigms
-
Cedar, H., Bergman, Y., Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 10:5 (2009), 295–304.
-
(2009)
Nat Rev Genet
, vol.10
, Issue.5
, pp. 295-304
-
-
Cedar, H.1
Bergman, Y.2
-
86
-
-
0035312289
-
The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
-
Feng, Q., Zhang, Y., The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev 15:7 (2001), 827–832.
-
(2001)
Genes Dev
, vol.15
, Issue.7
, pp. 827-832
-
-
Feng, Q.1
Zhang, Y.2
-
87
-
-
0036733675
-
Chromatin modification and epigenetic reprogramming in mammalian development
-
Li, E., Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 3:9 (2002), 662–673.
-
(2002)
Nat Rev Genet
, vol.3
, Issue.9
, pp. 662-673
-
-
Li, E.1
-
88
-
-
34547897023
-
Histone deacetylases and cancer
-
Glozak, M.A., Seto, E., Histone deacetylases and cancer. Oncogene 26:37 (2007), 5420–5432.
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5420-5432
-
-
Glozak, M.A.1
Seto, E.2
-
89
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
-
Haberland, M., Montgomery, R.L., Olson, E.N., The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10:1 (2009), 32–42.
-
(2009)
Nat Rev Genet
, vol.10
, Issue.1
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
90
-
-
79952389087
-
Chemoproteomics quantifies complexity
-
Holson, E.B., Schreiber, S.L., Chemoproteomics quantifies complexity. Nat Biotechnol 29:3 (2011), 235–236.
-
(2011)
Nat Biotechnol
, vol.29
, Issue.3
, pp. 235-236
-
-
Holson, E.B.1
Schreiber, S.L.2
-
91
-
-
79952396960
-
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
-
Bantscheff, M., Hopf, C., Savitski, M.M., Dittmann, A., Grandi, P., Michon, A.M., et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol 29:3 (2011), 255–265.
-
(2011)
Nat Biotechnol
, vol.29
, Issue.3
, pp. 255-265
-
-
Bantscheff, M.1
Hopf, C.2
Savitski, M.M.3
Dittmann, A.4
Grandi, P.5
Michon, A.M.6
-
92
-
-
70349311616
-
Histone acetyl transferases as emerging drug targets
-
Dekker, F.J., Haisma, H.J., Histone acetyl transferases as emerging drug targets. Drug Discov Today 14:19–20 (2009), 942–948.
-
(2009)
Drug Discov Today
, vol.14
, Issue.19-20
, pp. 942-948
-
-
Dekker, F.J.1
Haisma, H.J.2
-
93
-
-
67649379393
-
Histone acetyltransferase inhibitors and preclinical studies
-
Manzo, F., Tambaro, F.P., Mai, A., Altucci, L., Histone acetyltransferase inhibitors and preclinical studies. Expert Opin Ther Pat 19:6 (2009), 761–774.
-
(2009)
Expert Opin Ther Pat
, vol.19
, Issue.6
, pp. 761-774
-
-
Manzo, F.1
Tambaro, F.P.2
Mai, A.3
Altucci, L.4
-
94
-
-
69949148388
-
Protein methyltransferases as a target class for drug discovery
-
Copeland, R.A., Solomon, M.E., Richon, V.M., Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov 8:9 (2009), 724–732.
-
(2009)
Nat Rev Drug Discov
, vol.8
, Issue.9
, pp. 724-732
-
-
Copeland, R.A.1
Solomon, M.E.2
Richon, V.M.3
-
95
-
-
84871712509
-
Protein arginine methyltransferases and cancer
-
Yang, Y., Bedford, M.T., Protein arginine methyltransferases and cancer. Nat Rev Cancer 13:1 (2013), 37–50.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.1
, pp. 37-50
-
-
Yang, Y.1
Bedford, M.T.2
-
96
-
-
33846783261
-
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
-
Kubicek, S., O'Sullivan, R.J., August, E.M., Hickey, E.R., Zhang, Q., Teodoro, M.L., et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25:3 (2007), 473–481.
-
(2007)
Mol Cell
, vol.25
, Issue.3
, pp. 473-481
-
-
Kubicek, S.1
O'Sullivan, R.J.2
August, E.M.3
Hickey, E.R.4
Zhang, Q.5
Teodoro, M.L.6
-
97
-
-
77953691195
-
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases
-
Chang, Y., Ganesh, T., Horton, J.R., Spannhoff, A., Liu, J., Sun, A., et al. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol 400:1 (2010), 1–7.
-
(2010)
J Mol Biol
, vol.400
, Issue.1
, pp. 1-7
-
-
Chang, Y.1
Ganesh, T.2
Horton, J.R.3
Spannhoff, A.4
Liu, J.5
Sun, A.6
-
98
-
-
77955363182
-
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines
-
Liu, F., Chen, X., Allali-Hassani, A., Quinn, A.M., Wigle, T.J., Wasney, G.A., et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem 53:15 (2010), 5844–5857.
-
(2010)
J Med Chem
, vol.53
, Issue.15
, pp. 5844-5857
-
-
Liu, F.1
Chen, X.2
Allali-Hassani, A.3
Quinn, A.M.4
Wigle, T.J.5
Wasney, G.A.6
-
99
-
-
79960493567
-
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
-
Vedadi, M., Barsyte-Lovejoy, D., Liu, F., Rival-Gervier, S., Allali-Hassani, A., Labrie, V., et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol 7:8 (2011), 566–574.
-
(2011)
Nat Chem Biol
, vol.7
, Issue.8
, pp. 566-574
-
-
Vedadi, M.1
Barsyte-Lovejoy, D.2
Liu, F.3
Rival-Gervier, S.4
Allali-Hassani, A.5
Labrie, V.6
-
100
-
-
80052473151
-
Structural basis of substrate methylation and inhibition of SMYD2
-
Ferguson, A.D., Larsen, N.A., Howard, T., Pollard, H., Green, I., Grande, C., et al. Structural basis of substrate methylation and inhibition of SMYD2. Structure 19:9 (2011), 1262–1273.
-
(2011)
Structure
, vol.19
, Issue.9
, pp. 1262-1273
-
-
Ferguson, A.D.1
Larsen, N.A.2
Howard, T.3
Pollard, H.4
Green, I.5
Grande, C.6
-
101
-
-
79956042756
-
Structural basis for CARM1 inhibition by indole and pyrazole inhibitors
-
Sack, J.S., Thieffine, S., Bandiera, T., Fasolini, M., Duke, G.J., Jayaraman, L., et al. Structural basis for CARM1 inhibition by indole and pyrazole inhibitors. Biochem J 436:2 (2011), 331–339.
-
(2011)
Biochem J
, vol.436
, Issue.2
, pp. 331-339
-
-
Sack, J.S.1
Thieffine, S.2
Bandiera, T.3
Fasolini, M.4
Duke, G.J.5
Jayaraman, L.6
-
102
-
-
79960058024
-
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
-
Daigle, S.R., Olhava, E.J., Therkelsen, C.A., Majer, C.R., Sneeringer, C.J., Song, J., et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 20:1 (2011), 53–65.
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Majer, C.R.4
Sneeringer, C.J.5
Song, J.6
-
103
-
-
30644474460
-
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
-
Greiner, D., Bonaldi, T., Eskeland, R., Roemer, E., Imhof, A., Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1:3 (2005), 143–145.
-
(2005)
Nat Chem Biol
, vol.1
, Issue.3
, pp. 143-145
-
-
Greiner, D.1
Bonaldi, T.2
Eskeland, R.3
Roemer, E.4
Imhof, A.5
-
104
-
-
59349115177
-
Chemical mechanisms of histone lysine and arginine modifications
-
Smith, B.C., Denu, J.M., Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta 1789:1 (2009), 45–57.
-
(2009)
Biochim Biophys Acta
, vol.1789
, Issue.1
, pp. 45-57
-
-
Smith, B.C.1
Denu, J.M.2
-
105
-
-
84860371953
-
Epigenetic protein families: a new frontier for drug discovery
-
Arrowsmith, C.H., Bountra, C., Fish, P.V., Lee, K., Schapira, M., Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov 11:5 (2012), 384–400.
-
(2012)
Nat Rev Drug Discov
, vol.11
, Issue.5
, pp. 384-400
-
-
Arrowsmith, C.H.1
Bountra, C.2
Fish, P.V.3
Lee, K.4
Schapira, M.5
-
106
-
-
84889573275
-
Histone lysine demethylases as targets for anticancer therapy
-
Hojfeldt, J.W., Agger, K., Helin, K., Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov 12:12 (2013), 917–930.
-
(2013)
Nat Rev Drug Discov
, vol.12
, Issue.12
, pp. 917-930
-
-
Hojfeldt, J.W.1
Agger, K.2
Helin, K.3
-
107
-
-
84860215207
-
Molecular mechanisms and potential functions of histone demethylases
-
Kooistra, S.M., Helin, K., Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 13:5 (2012), 297–311.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, Issue.5
, pp. 297-311
-
-
Kooistra, S.M.1
Helin, K.2
-
108
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J.R., Cole, P.A., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119:7 (2004), 941–953.
-
(2004)
Cell
, vol.119
, Issue.7
, pp. 941-953
-
-
Shi, Y.1
Lan, F.2
Matson, C.3
Mulligan, P.4
Whetstine, J.R.5
Cole, P.A.6
-
109
-
-
25144519737
-
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
-
Lee, M.G., Wynder, C., Cooch, N., Shiekhattar, R., An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437:7057 (2005), 432–435.
-
(2005)
Nature
, vol.437
, Issue.7057
, pp. 432-435
-
-
Lee, M.G.1
Wynder, C.2
Cooch, N.3
Shiekhattar, R.4
-
110
-
-
24944535335
-
Regulation of LSD1 histone demethylase activity by its associated factors
-
Shi, Y.J., Matson, C., Lan, F., Iwase, S., Baba, T., Shi, Y., Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell 19:6 (2005), 857–864.
-
(2005)
Mol Cell
, vol.19
, Issue.6
, pp. 857-864
-
-
Shi, Y.J.1
Matson, C.2
Lan, F.3
Iwase, S.4
Baba, T.5
Shi, Y.6
-
111
-
-
33747455678
-
JmjC-domain-containing proteins and histone demethylation
-
Klose, R.J., Kallin, E.M., Zhang, Y., JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet 7:9 (2006), 715–727.
-
(2006)
Nat Rev Genet
, vol.7
, Issue.9
, pp. 715-727
-
-
Klose, R.J.1
Kallin, E.M.2
Zhang, Y.3
-
112
-
-
33845762289
-
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
-
Kahl, P., Gullotti, L., Heukamp, L.C., Wolf, S., Friedrichs, N., Vorreuther, R., et al. Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res 66:23 (2006), 11341–11347.
-
(2006)
Cancer Res
, vol.66
, Issue.23
, pp. 11341-11347
-
-
Kahl, P.1
Gullotti, L.2
Heukamp, L.C.3
Wolf, S.4
Friedrichs, N.5
Vorreuther, R.6
-
113
-
-
48549090170
-
Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors
-
Heidenblad, M., Lindgren, D., Jonson, T., Liedberg, F., Veerla, S., Chebil, G., et al. Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors. BMC Med Genomics, 1, 2008, 3.
-
(2008)
BMC Med Genomics
, vol.1
, pp. 3
-
-
Heidenblad, M.1
Lindgren, D.2
Jonson, T.3
Liedberg, F.4
Veerla, S.5
Chebil, G.6
-
114
-
-
62449197931
-
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy
-
Schulte, J.H., Lim, S., Schramm, A., Friedrichs, N., Koster, J., Versteeg, R., et al. Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res 69:5 (2009), 2065–2071.
-
(2009)
Cancer Res
, vol.69
, Issue.5
, pp. 2065-2071
-
-
Schulte, J.H.1
Lim, S.2
Schramm, A.3
Friedrichs, N.4
Koster, J.5
Versteeg, R.6
-
115
-
-
77950868547
-
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
-
Lim, S., Janzer, A., Becker, A., Zimmer, A., Schule, R., Buettner, R., et al. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis 31:3 (2010), 512–520.
-
(2010)
Carcinogenesis
, vol.31
, Issue.3
, pp. 512-520
-
-
Lim, S.1
Janzer, A.2
Becker, A.3
Zimmer, A.4
Schule, R.5
Buettner, R.6
-
116
-
-
78649815150
-
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
-
Hayami, S., Kelly, J.D., Cho, H.S., Yoshimatsu, M., Unoki, M., Tsunoda, T., et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 128:3 (2011), 574–586.
-
(2011)
Int J Cancer
, vol.128
, Issue.3
, pp. 574-586
-
-
Hayami, S.1
Kelly, J.D.2
Cho, H.S.3
Yoshimatsu, M.4
Unoki, M.5
Tsunoda, T.6
-
117
-
-
80255137124
-
Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer
-
Kauffman, E.C., Robinson, B.D., Downes, M.J., Powell, L.G., Lee, M.M., Scherr, D.S., et al. Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. Mol Carcinog 50:12 (2011), 931–944.
-
(2011)
Mol Carcinog
, vol.50
, Issue.12
, pp. 931-944
-
-
Kauffman, E.C.1
Robinson, B.D.2
Downes, M.J.3
Powell, L.G.4
Lee, M.M.5
Scherr, D.S.6
-
118
-
-
34147173308
-
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1
-
Schmidt, D.M., McCafferty, D.G., trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 46:14 (2007), 4408–4416.
-
(2007)
Biochemistry
, vol.46
, Issue.14
, pp. 4408-4416
-
-
Schmidt, D.M.1
McCafferty, D.G.2
-
119
-
-
72249117352
-
Identification of cell-active lysine specific demethylase 1-selective inhibitors
-
Ueda, R., Suzuki, T., Mino, K., Tsumoto, H., Nakagawa, H., Hasegawa, M., et al. Identification of cell-active lysine specific demethylase 1-selective inhibitors. J Am Chem Soc 131:48 (2009), 17536–17537.
-
(2009)
J Am Chem Soc
, vol.131
, Issue.48
, pp. 17536-17537
-
-
Ueda, R.1
Suzuki, T.2
Mino, K.3
Tsumoto, H.4
Nakagawa, H.5
Hasegawa, M.6
-
120
-
-
77949421463
-
Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
-
Culhane, J.C., Wang, D., Yen, P.M., Cole, P.A., Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc 132:9 (2010), 3164–3176.
-
(2010)
J Am Chem Soc
, vol.132
, Issue.9
, pp. 3164-3176
-
-
Culhane, J.C.1
Wang, D.2
Yen, P.M.3
Cole, P.A.4
-
121
-
-
77955025931
-
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1
-
Mimasu, S., Umezawa, N., Sato, S., Higuchi, T., Umehara, T., Yokoyama, S., Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1. Biochemistry 49:30 (2010), 6494–6503.
-
(2010)
Biochemistry
, vol.49
, Issue.30
, pp. 6494-6503
-
-
Mimasu, S.1
Umezawa, N.2
Sato, S.3
Higuchi, T.4
Umehara, T.5
Yokoyama, S.6
-
122
-
-
77952355653
-
Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2
-
Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., et al. Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. J Am Chem Soc 132:19 (2010), 6827–6833.
-
(2010)
J Am Chem Soc
, vol.132
, Issue.19
, pp. 6827-6833
-
-
Binda, C.1
Valente, S.2
Romanenghi, M.3
Pilotto, S.4
Cirilli, R.5
Karytinos, A.6
-
123
-
-
79958247398
-
Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor
-
Ogasawara, D., Suzuki, T., Mino, K., Ueda, R., Khan, M.N., Matsubara, T., et al. Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. Bioorg Med Chem 19:12 (2011), 3702–3708.
-
(2011)
Bioorg Med Chem
, vol.19
, Issue.12
, pp. 3702-3708
-
-
Ogasawara, D.1
Suzuki, T.2
Mino, K.3
Ueda, R.4
Khan, M.N.5
Matsubara, T.6
-
124
-
-
79958247128
-
Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors
-
Benelkebir, H., Hodgkinson, C., Duriez, P.J., Hayden, A.L., Bulleid, R.A., Crabb, S.J., et al. Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors. Bioorg Med Chem 19:12 (2011), 3709–3716.
-
(2011)
Bioorg Med Chem
, vol.19
, Issue.12
, pp. 3709-3716
-
-
Benelkebir, H.1
Hodgkinson, C.2
Duriez, P.J.3
Hayden, A.L.4
Bulleid, R.A.5
Crabb, S.J.6
-
125
-
-
84867091498
-
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor
-
Willmann, D., Lim, S., Wetzel, S., Metzger, E., Jandausch, A., Wilk, W., et al. Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer 131:11 (2012), 2704–2709.
-
(2012)
Int J Cancer
, vol.131
, Issue.11
, pp. 2704-2709
-
-
Willmann, D.1
Lim, S.2
Wetzel, S.3
Metzger, E.4
Jandausch, A.5
Wilk, W.6
-
126
-
-
84885013682
-
Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity
-
Schmitt, M.L., Hauser, A.T., Carlino, L., Pippel, M., Schulz-Fincke, J., Metzger, E., et al. Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity. J Med Chem 56:18 (2013), 7334–7342.
-
(2013)
J Med Chem
, vol.56
, Issue.18
, pp. 7334-7342
-
-
Schmitt, M.L.1
Hauser, A.T.2
Carlino, L.3
Pippel, M.4
Schulz-Fincke, J.5
Metzger, E.6
-
127
-
-
84906839626
-
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A
-
Vianello, P., Botrugno, O.A., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., et al. Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. Eur J Med Chem 86 (2014), 352–363.
-
(2014)
Eur J Med Chem
, vol.86
, pp. 352-363
-
-
Vianello, P.1
Botrugno, O.A.2
Cappa, A.3
Ciossani, G.4
Dessanti, P.5
Mai, A.6
-
128
-
-
84920853656
-
Further insights into the SAR of alpha-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A
-
Pieroni, M., Annunziato, G., Azzali, E., Dessanti, P., Mercurio, C., Meroni, G., et al. Further insights into the SAR of alpha-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A. Eur J Med Chem 92 (2015), 377–386.
-
(2015)
Eur J Med Chem
, vol.92
, pp. 377-386
-
-
Pieroni, M.1
Annunziato, G.2
Azzali, E.3
Dessanti, P.4
Mercurio, C.5
Meroni, G.6
-
129
-
-
84862777766
-
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
-
Schenk, T., Chen, W.C., Gollner, S., Howell, L., Jin, L., Hebestreit, K., et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 18:4 (2012), 605–611.
-
(2012)
Nat Med
, vol.18
, Issue.4
, pp. 605-611
-
-
Schenk, T.1
Chen, W.C.2
Gollner, S.3
Howell, L.4
Jin, L.5
Hebestreit, K.6
-
130
-
-
84922288173
-
Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells
-
Fiskus, W., Sharma, S., Shah, B., Portier, B.P., Devaraj, S.G., Liu, K., et al. Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia 28:11 (2014), 2155–2164.
-
(2014)
Leukemia
, vol.28
, Issue.11
, pp. 2155-2164
-
-
Fiskus, W.1
Sharma, S.2
Shah, B.3
Portier, B.P.4
Devaraj, S.G.5
Liu, K.6
-
131
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M.E., Borchers, C.H., Tempst, P., et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 439:7078 (2006), 811–816.
-
(2006)
Nature
, vol.439
, Issue.7078
, pp. 811-816
-
-
Tsukada, Y.1
Fang, J.2
Erdjument-Bromage, H.3
Warren, M.E.4
Borchers, C.H.5
Tempst, P.6
-
132
-
-
56749151276
-
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases
-
Rose, N.R., Ng, S.S., Mecinovic, J., Lienard, B.M., Bello, S.H., Sun, Z., et al. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem 51:22 (2008), 7053–7056.
-
(2008)
J Med Chem
, vol.51
, Issue.22
, pp. 7053-7056
-
-
Rose, N.R.1
Ng, S.S.2
Mecinovic, J.3
Lienard, B.M.4
Bello, S.H.5
Sun, Z.6
-
133
-
-
78649528262
-
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
-
King, O.N., Li, X.S., Sakurai, M., Kawamura, A., Rose, N.R., Ng, S.S., et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One, 5(11), 2010, e15535.
-
(2010)
PLoS One
, vol.5
, Issue.11
-
-
King, O.N.1
Li, X.S.2
Sakurai, M.3
Kawamura, A.4
Rose, N.R.5
Ng, S.S.6
-
134
-
-
79959204866
-
A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases
-
Luo, X., Liu, Y., Kubicek, S., Myllyharju, J., Tumber, A., Ng, S., et al. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. J Am Chem Soc 133:24 (2011), 9451–9456.
-
(2011)
J Am Chem Soc
, vol.133
, Issue.24
, pp. 9451-9456
-
-
Luo, X.1
Liu, Y.2
Kubicek, S.3
Myllyharju, J.4
Tumber, A.5
Ng, S.6
-
135
-
-
79955035374
-
Inhibition of histone demethylases by 4-carboxy-2,2′-bipyridyl compounds
-
Chang, K.H., King, O.N., Tumber, A., Woon, E.C., Heightman, T.D., McDonough, M.A., et al. Inhibition of histone demethylases by 4-carboxy-2,2′-bipyridyl compounds. ChemMedChem 6:5 (2011), 759–764.
-
(2011)
ChemMedChem
, vol.6
, Issue.5
, pp. 759-764
-
-
Chang, K.H.1
King, O.N.2
Tumber, A.3
Woon, E.C.4
Heightman, T.D.5
McDonough, M.A.6
-
136
-
-
14744276712
-
Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
-
Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., et al. Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc 127:8 (2005), 2376–2377.
-
(2005)
J Am Chem Soc
, vol.127
, Issue.8
, pp. 2376-2377
-
-
Zeng, L.1
Li, J.2
Muller, M.3
Yan, S.4
Mujtaba, S.5
Pan, C.6
-
137
-
-
34249027590
-
Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor
-
Pan, C., Mezei, M., Mujtaba, S., Muller, M., Zeng, L., Li, J., et al. Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. J Med Chem 50:10 (2007), 2285–2288.
-
(2007)
J Med Chem
, vol.50
, Issue.10
, pp. 2285-2288
-
-
Pan, C.1
Mezei, M.2
Mujtaba, S.3
Muller, M.4
Zeng, L.5
Li, J.6
-
138
-
-
79955410483
-
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes
-
Borah, J.C., Mujtaba, S., Karakikes, I., Zeng, L., Muller, M., Patel, J., et al. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol 18:4 (2011), 531–541.
-
(2011)
Chem Biol
, vol.18
, Issue.4
, pp. 531-541
-
-
Borah, J.C.1
Mujtaba, S.2
Karakikes, I.3
Zeng, L.4
Muller, M.5
Patel, J.6
-
139
-
-
79958078949
-
Discovery and characterization of small molecule inhibitors of the BET family bromodomains
-
Chung, C.W., Coste, H., White, J.H., Mirguet, O., Wilde, J., Gosmini, R.L., et al. Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem 54:11 (2011), 3827–3838.
-
(2011)
J Med Chem
, vol.54
, Issue.11
, pp. 3827-3838
-
-
Chung, C.W.1
Coste, H.2
White, J.H.3
Mirguet, O.4
Wilde, J.5
Gosmini, R.L.6
-
140
-
-
84940533695
-
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
-
Hammitzsch, A., Tallant, C., Fedorov, O., O'Mahony, A., Brennan, P.E., Hay, D.A., et al. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc Natl Acad Sci U S A 112:34 (2015), 10768–10773.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, Issue.34
, pp. 10768-10773
-
-
Hammitzsch, A.1
Tallant, C.2
Fedorov, O.3
O'Mahony, A.4
Brennan, P.E.5
Hay, D.A.6
-
141
-
-
84903739739
-
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
-
Hay, D.A., Fedorov, O., Martin, S., Singleton, D.C., Tallant, C., Wells, C., et al. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J Am Chem Soc 136:26 (2014), 9308–9319.
-
(2014)
J Am Chem Soc
, vol.136
, Issue.26
, pp. 9308-9319
-
-
Hay, D.A.1
Fedorov, O.2
Martin, S.3
Singleton, D.C.4
Tallant, C.5
Wells, C.6
-
142
-
-
78650806593
-
Suppression of inflammation by a synthetic histone mimic
-
Nicodeme, E., Jeffrey, K.L., Schaefer, U., Beinke, S., Dewell, S., Chung, C.W., et al. Suppression of inflammation by a synthetic histone mimic. Nature 468:7327 (2010), 1119–1123.
-
(2010)
Nature
, vol.468
, Issue.7327
, pp. 1119-1123
-
-
Nicodeme, E.1
Jeffrey, K.L.2
Schaefer, U.3
Beinke, S.4
Dewell, S.5
Chung, C.W.6
-
143
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W.B., Fedorov, O., et al. Selective inhibition of BET bromodomains. Nature 468:7327 (2010), 1067–1073.
-
(2010)
Nature
, vol.468
, Issue.7327
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
-
144
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore, J.E., Issa, G.C., Lemieux, M.E., Rahl, P.B., Shi, J., Jacobs, H.M., et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146:6 (2011), 904–917.
-
(2011)
Cell
, vol.146
, Issue.6
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
-
145
-
-
84888106365
-
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer
-
Shimamura, T., Chen, Z., Soucheray, M., Carretero, J., Kikuchi, E., Tchaicha, J.H., et al. Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. Clin Cancer Res 19:22 (2013), 6183–6192.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.22
, pp. 6183-6192
-
-
Shimamura, T.1
Chen, Z.2
Soucheray, M.3
Carretero, J.4
Kikuchi, E.5
Tchaicha, J.H.6
-
146
-
-
84906968200
-
BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
-
Henssen, A., Thor, T., Odersky, A., Heukamp, L., El-Hindy, N., Beckers, A., et al. BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Oncotarget 4:11 (2013), 2080–2095.
-
(2013)
Oncotarget
, vol.4
, Issue.11
, pp. 2080-2095
-
-
Henssen, A.1
Thor, T.2
Odersky, A.3
Heukamp, L.4
El-Hindy, N.5
Beckers, A.6
-
147
-
-
84896714612
-
BET bromodomain inhibition of MYC-amplified medulloblastoma
-
Bandopadhayay, P., Bergthold, G., Nguyen, B., Schubert, S., Gholamin, S., Tang, Y., et al. BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res 20:4 (2014), 912–925.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.4
, pp. 912-925
-
-
Bandopadhayay, P.1
Bergthold, G.2
Nguyen, B.3
Schubert, S.4
Gholamin, S.5
Tang, Y.6
-
148
-
-
84901236445
-
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
-
Venkataraman, S., Alimova, I., Balakrishnan, I., Harris, P., Birks, D.K., Griesinger, A., et al. Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget 5:9 (2014), 2355–2371.
-
(2014)
Oncotarget
, vol.5
, Issue.9
, pp. 2355-2371
-
-
Venkataraman, S.1
Alimova, I.2
Balakrishnan, I.3
Harris, P.4
Birks, D.K.5
Griesinger, A.6
-
149
-
-
80053651202
-
Targeting MYC dependence in cancer by inhibiting BET bromodomains
-
Mertz, J.A., Conery, A.R., Bryant, B.M., Sandy, P., Balasubramanian, S., Mele, D.A., et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A 108:40 (2011), 16669–16674.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.40
, pp. 16669-16674
-
-
Mertz, J.A.1
Conery, A.R.2
Bryant, B.M.3
Sandy, P.4
Balasubramanian, S.5
Mele, D.A.6
-
150
-
-
84874720284
-
Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML
-
Herrmann, H., Blatt, K., Shi, J., Gleixner, K.V., Cerny-Reiterer, S., Mullauer, L., et al. Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML. Oncotarget 3:12 (2012), 1588–1599.
-
(2012)
Oncotarget
, vol.3
, Issue.12
, pp. 1588-1599
-
-
Herrmann, H.1
Blatt, K.2
Shi, J.3
Gleixner, K.V.4
Cerny-Reiterer, S.5
Mullauer, L.6
-
151
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
Dawson, M.A., Prinjha, R.K., Dittmann, A., Giotopoulos, G., Bantscheff, M., Chan, W.I., et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478:7370 (2011), 529–533.
-
(2011)
Nature
, vol.478
, Issue.7370
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.I.6
-
152
-
-
84942531832
-
BET inhibitor resistance emerges from leukaemia stem cells
-
Fong, C.Y., Gilan, O., Lam, E.Y., Rubin, A.F., Ftouni, S., Tyler, D., et al. BET inhibitor resistance emerges from leukaemia stem cells. Nature 525:7570 (2015), 538–542.
-
(2015)
Nature
, vol.525
, Issue.7570
, pp. 538-542
-
-
Fong, C.Y.1
Gilan, O.2
Lam, E.Y.3
Rubin, A.F.4
Ftouni, S.5
Tyler, D.6
-
153
-
-
84942531799
-
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
-
Rathert, P., Roth, M., Neumann, T., Muerdter, F., Roe, J.S., Muhar, M., et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature 525:7570 (2015), 543–547.
-
(2015)
Nature
, vol.525
, Issue.7570
, pp. 543-547
-
-
Rathert, P.1
Roth, M.2
Neumann, T.3
Muerdter, F.4
Roe, J.S.5
Muhar, M.6
-
154
-
-
79953783228
-
Small-molecule ligands of methyl-lysine binding proteins
-
Herold, J.M., Wigle, T.J., Norris, J.L., Lam, R., Korboukh, V.K., Gao, C., et al. Small-molecule ligands of methyl-lysine binding proteins. J Med Chem 54:7 (2011), 2504–2511.
-
(2011)
J Med Chem
, vol.54
, Issue.7
, pp. 2504-2511
-
-
Herold, J.M.1
Wigle, T.J.2
Norris, J.L.3
Lam, R.4
Korboukh, V.K.5
Gao, C.6
-
155
-
-
84884993346
-
Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3
-
James, L.I., Korboukh, V.K., Krichevsky, L., Baughman, B.M., Herold, J.M., Norris, J.L., et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem 56:18 (2013), 7358–7371.
-
(2013)
J Med Chem
, vol.56
, Issue.18
, pp. 7358-7371
-
-
James, L.I.1
Korboukh, V.K.2
Krichevsky, L.3
Baughman, B.M.4
Herold, J.M.5
Norris, J.L.6
-
156
-
-
84874116695
-
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
-
James, L.I., Barsyte-Lovejoy, D., Zhong, N., Krichevsky, L., Korboukh, V.K., Herold, J.M., et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol 9:3 (2013), 184–191.
-
(2013)
Nat Chem Biol
, vol.9
, Issue.3
, pp. 184-191
-
-
James, L.I.1
Barsyte-Lovejoy, D.2
Zhong, N.3
Krichevsky, L.4
Korboukh, V.K.5
Herold, J.M.6
-
157
-
-
84875232371
-
Epigenetic drugs: new modulators of readers and erasers
-
Harrison, C., Epigenetic drugs: new modulators of readers and erasers. Nat Rev Drug Discov, 12(3), 2013, 188.
-
(2013)
Nat Rev Drug Discov
, vol.12
, Issue.3
, pp. 188
-
-
Harrison, C.1
-
158
-
-
0015043748
-
Mutation and cancer: statistical study of retinoblastoma
-
Knudson, A.G. Jr., Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68:4 (1971), 820–823.
-
(1971)
Proc Natl Acad Sci U S A
, vol.68
, Issue.4
, pp. 820-823
-
-
Knudson, A.G.1
-
159
-
-
60849089645
-
Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
-
Jiang, Y., Dunbar, A., Gondek, L.P., Mohan, S., Rataul, M., O'Keefe, C., et al. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 113:6 (2009), 1315–1325.
-
(2009)
Blood
, vol.113
, Issue.6
, pp. 1315-1325
-
-
Jiang, Y.1
Dunbar, A.2
Gondek, L.P.3
Mohan, S.4
Rataul, M.5
O'Keefe, C.6
-
160
-
-
84878372012
-
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
-
Cancer Genome Atlas Research N, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 368:22 (2013), 2059–2074.
-
(2013)
N Engl J Med
, vol.368
, Issue.22
, pp. 2059-2074
-
-
Cancer Genome Atlas Research N1
-
161
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
Challen, G.A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J.S., et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 44:1 (2012), 23–31.
-
(2012)
Nat Genet
, vol.44
, Issue.1
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
Luo, M.4
Jelinek, J.5
Berg, J.S.6
-
162
-
-
84894304555
-
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
-
Corces-Zimmerman, M.R., Hong, W.J., Weissman, I.L., Medeiros, B.C., Majeti, R., Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A 111:7 (2014), 2548–2553.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.7
, pp. 2548-2553
-
-
Corces-Zimmerman, M.R.1
Hong, W.J.2
Weissman, I.L.3
Medeiros, B.C.4
Majeti, R.5
-
163
-
-
84894245627
-
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
-
Shlush, L.I., Zandi, S., Mitchell, A., Chen, W.C., Brandwein, J.M., Gupta, V., et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 506:7488 (2014), 328–333.
-
(2014)
Nature
, vol.506
, Issue.7488
, pp. 328-333
-
-
Shlush, L.I.1
Zandi, S.2
Mitchell, A.3
Chen, W.C.4
Brandwein, J.M.5
Gupta, V.6
-
164
-
-
84891372425
-
Large conserved domains of low DNA methylation maintained by Dnmt3a
-
Jeong, M., Sun, D., Luo, M., Huang, Y., Challen, G.A., Rodriguez, B., et al. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet 46:1 (2014), 17–23.
-
(2014)
Nat Genet
, vol.46
, Issue.1
, pp. 17-23
-
-
Jeong, M.1
Sun, D.2
Luo, M.3
Huang, Y.4
Challen, G.A.5
Rodriguez, B.6
-
165
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley, T.J., Ding, L., Walter, M.J., McLellan, M.D., Lamprecht, T., Larson, D.E., et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 363:25 (2010), 2424–2433.
-
(2010)
N Engl J Med
, vol.363
, Issue.25
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
McLellan, M.D.4
Lamprecht, T.5
Larson, D.E.6
-
166
-
-
79960255863
-
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
-
Walter, M.J., Ding, L., Shen, D., Shao, J., Grillot, M., McLellan, M., et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 25:7 (2011), 1153–1158.
-
(2011)
Leukemia
, vol.25
, Issue.7
, pp. 1153-1158
-
-
Walter, M.J.1
Ding, L.2
Shen, D.3
Shao, J.4
Grillot, M.5
McLellan, M.6
-
167
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa, M.E., Abdel-Wahab, O., Lu, C., Ward, P.S., Patel, J., Shih, A., et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18:6 (2010), 553–567.
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
168
-
-
70350438115
-
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
-
Kosmider, O., Gelsi-Boyer, V., Cheok, M., Grabar, S., Della-Valle, V., Picard, F., et al. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood 114:15 (2009), 3285–3291.
-
(2009)
Blood
, vol.114
, Issue.15
, pp. 3285-3291
-
-
Kosmider, O.1
Gelsi-Boyer, V.2
Cheok, M.3
Grabar, S.4
Della-Valle, V.5
Picard, F.6
-
169
-
-
67651065502
-
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
-
Abdel-Wahab, O., Mullally, A., Hedvat, C., Garcia-Manero, G., Patel, J., Wadleigh, M., et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 114:1 (2009), 144–147.
-
(2009)
Blood
, vol.114
, Issue.1
, pp. 144-147
-
-
Abdel-Wahab, O.1
Mullally, A.2
Hedvat, C.3
Garcia-Manero, G.4
Patel, J.5
Wadleigh, M.6
-
170
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang, L., White, D.W., Gross, S., Bennett, B.D., Bittinger, M.A., Driggers, E.M., et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:7274 (2009), 739–744.
-
(2009)
Nature
, vol.462
, Issue.7274
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
-
171
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
Gross, S., Cairns, R.A., Minden, M.D., Driggers, E.M., Bittinger, M.A., Jang, H.G., et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med 207:2 (2010), 339–344.
-
(2010)
J Exp Med
, vol.207
, Issue.2
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
Driggers, E.M.4
Bittinger, M.A.5
Jang, H.G.6
-
172
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward, P.S., Patel, J., Wise, D.R., Abdel-Wahab, O., Bennett, B.D., Coller, H.A., et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17:3 (2010), 225–234.
-
(2010)
Cancer Cell
, vol.17
, Issue.3
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
-
173
-
-
84861407516
-
Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production
-
Ward, P.S., Cross, J.R., Lu, C., Weigert, O., Abel-Wahab, O., Levine, R.L., et al. Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production. Oncogene 31:19 (2012), 2491–2498.
-
(2012)
Oncogene
, vol.31
, Issue.19
, pp. 2491-2498
-
-
Ward, P.S.1
Cross, J.R.2
Lu, C.3
Weigert, O.4
Abel-Wahab, O.5
Levine, R.L.6
-
174
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
-
Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19:1 (2011), 17–30.
-
(2011)
Cancer Cell
, vol.19
, Issue.1
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.-H.6
-
175
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
-
Marcucci, G., Maharry, K., Wu, Y.Z., Radmacher, M.D., Mrozek, K., Margeson, D., et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 28:14 (2010), 2348–2355.
-
(2010)
J Clin Oncol
, vol.28
, Issue.14
, pp. 2348-2355
-
-
Marcucci, G.1
Maharry, K.2
Wu, Y.Z.3
Radmacher, M.D.4
Mrozek, K.5
Margeson, D.6
-
176
-
-
77955907891
-
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
-
Paschka, P., Schlenk, R.F., Gaidzik, V.I., Habdank, M., Kronke, J., Bullinger, L., et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 28:22 (2010), 3636–3643.
-
(2010)
J Clin Oncol
, vol.28
, Issue.22
, pp. 3636-3643
-
-
Paschka, P.1
Schlenk, R.F.2
Gaidzik, V.I.3
Habdank, M.4
Kronke, J.5
Bullinger, L.6
-
177
-
-
79251510890
-
Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features
-
Patel, K.P., Ravandi, F., Ma, D., Paladugu, A., Barkoh, B.A., Medeiros, L.J., et al. Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features. Am J Clin Pathol 135:1 (2011), 35–45.
-
(2011)
Am J Clin Pathol
, vol.135
, Issue.1
, pp. 35-45
-
-
Patel, K.P.1
Ravandi, F.2
Ma, D.3
Paladugu, A.4
Barkoh, B.A.5
Medeiros, L.J.6
-
178
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle, D., Popovici-Muller, J., Palaskas, N., Turcan, S., Grommes, C., Campos, C., et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340:6132 (2013), 626–630.
-
(2013)
Science
, vol.340
, Issue.6132
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
Turcan, S.4
Grommes, C.5
Campos, C.6
-
179
-
-
85033980833
-
-
editor Clinical safety and activity of AG-120, a first-in-class potent inhibitor of the IDH1 mutant protein, in a phase I study of patients with advanced, IDH1-mutant hematological malignancies. 20th Congress of the European Hematology Association; 2015; Vienna, Austria2015.
-
de Botton S PD, Stein EM, DiNardo C, Fathi AT, Roboz GJ, et al., editor Clinical safety and activity of AG-120, a first-in-class potent inhibitor of the IDH1 mutant protein, in a phase I study of patients with advanced, IDH1-mutant hematological malignancies. 20th Congress of the European Hematology Association; 2015; Vienna, Austria2015.
-
-
-
de Botton, S.P.D.1
Stein, E.M.2
DiNardo, C.3
Fathi, A.T.4
Roboz, G.J.5
-
180
-
-
85033981992
-
-
editor AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant enzyme, induced durable responses in a phase I study of IDH2 mutation-positive advanced hematologic malignancies. 20th Congress of the European Hematology Association; 2015; Vienna, Austria
-
DiNardo C SE, Altman JK, Collins R, DeAngelo DJ, Fathi AT, et al., editor AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant enzyme, induced durable responses in a phase I study of IDH2 mutation-positive advanced hematologic malignancies. 20th Congress of the European Hematology Association; 2015; Vienna, Austria 2015.
-
(2015)
-
-
DiNardo, C.S.1
Altman, J.K.2
Collins, R.3
DeAngelo, D.J.4
Fathi, A.T.5
-
181
-
-
77449149371
-
DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
-
Shen, L., Kantarjian, H., Guo, Y., Lin, E., Shan, J., Huang, X., et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 28:4 (2010), 605–613.
-
(2010)
J Clin Oncol
, vol.28
, Issue.4
, pp. 605-613
-
-
Shen, L.1
Kantarjian, H.2
Guo, Y.3
Lin, E.4
Shan, J.5
Huang, X.6
-
182
-
-
73649110641
-
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
-
Figueroa, M.E., Lugthart, S., Li, Y., Erpelinck-Verschueren, C., Deng, X., Christos, P.J., et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell 17:1 (2010), 13–27.
-
(2010)
Cancer Cell
, vol.17
, Issue.1
, pp. 13-27
-
-
Figueroa, M.E.1
Lugthart, S.2
Li, Y.3
Erpelinck-Verschueren, C.4
Deng, X.5
Christos, P.J.6
-
183
-
-
77449157068
-
Quantitative DNA methylation predicts survival in adult acute myeloid leukemia
-
Bullinger, L., Ehrich, M., Dohner, K., Schlenk, R.F., Dohner, H., Nelson, M.R., et al. Quantitative DNA methylation predicts survival in adult acute myeloid leukemia. Blood 115:3 (2010), 636–642.
-
(2010)
Blood
, vol.115
, Issue.3
, pp. 636-642
-
-
Bullinger, L.1
Ehrich, M.2
Dohner, K.3
Schlenk, R.F.4
Dohner, H.5
Nelson, M.R.6
-
184
-
-
84905667923
-
Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes
-
Qu, Y., Lennartsson, A., Gaidzik, V.I., Deneberg, S., Karimi, M., Bengtzen, S., et al. Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes. Epigenetics 9:8 (2014), 1108–1119.
-
(2014)
Epigenetics
, vol.9
, Issue.8
, pp. 1108-1119
-
-
Qu, Y.1
Lennartsson, A.2
Gaidzik, V.I.3
Deneberg, S.4
Karimi, M.5
Bengtzen, S.6
-
185
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau, F., Dupont, S., Della Valle, V., James, C., Trannoy, S., Masse, A., et al. Mutation in TET2 in myeloid cancers. N Engl J Med 360:22 (2009), 2289–2301.
-
(2009)
N Engl J Med
, vol.360
, Issue.22
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Della Valle, V.3
James, C.4
Trannoy, S.5
Masse, A.6
-
186
-
-
67650924270
-
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
-
Tefferi, A., Lim, K.H., Abdel-Wahab, O., Lasho, T.L., Patel, J., Patnaik, M.M., et al. Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia 23:7 (2009), 1343–1345.
-
(2009)
Leukemia
, vol.23
, Issue.7
, pp. 1343-1345
-
-
Tefferi, A.1
Lim, K.H.2
Abdel-Wahab, O.3
Lasho, T.L.4
Patel, J.5
Patnaik, M.M.6
-
187
-
-
33847065486
-
The epigenomics of cancer
-
Jones, P.A., Baylin, S.B., The epigenomics of cancer. Cell 128:4 (2007), 683–692.
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
188
-
-
84901487838
-
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia
-
Sonnet, M., Claus, R., Becker, N., Zucknick, M., Petersen, J., Lipka, D.B., et al. Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia. Genome Med, 6(4), 2014, 34.
-
(2014)
Genome Med
, vol.6
, Issue.4
, pp. 34
-
-
Sonnet, M.1
Claus, R.2
Becker, N.3
Zucknick, M.4
Petersen, J.5
Lipka, D.B.6
-
189
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
-
Fenaux, P., Mufti, G.J., Hellstrom-Lindberg, E., Santini, V., Finelli, C., Giagounidis, A., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 10:3 (2009), 223–232.
-
(2009)
Lancet Oncol
, vol.10
, Issue.3
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
Santini, V.4
Finelli, C.5
Giagounidis, A.6
-
190
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
-
Kantarjian, H., Issa, J.P., Rosenfeld, C.S., Bennett, J.M., Albitar, M., DiPersio, J., et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 106:8 (2006), 1794–1803.
-
(2006)
Cancer
, vol.106
, Issue.8
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
Bennett, J.M.4
Albitar, M.5
DiPersio, J.6
-
191
-
-
77955170877
-
Therapy with azanucleosides for myelodysplastic syndromes
-
Quintas-Cardama, A., Santos, F.P., Garcia-Manero, G., Therapy with azanucleosides for myelodysplastic syndromes. Nat Rev Clin Oncol 7:8 (2010), 433–444.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, Issue.8
, pp. 433-444
-
-
Quintas-Cardama, A.1
Santos, F.P.2
Garcia-Manero, G.3
-
192
-
-
0020308438
-
Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA
-
Taylor, S.M., Jones, P.A., Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA. J Mol Biol 162:3 (1982), 679–692.
-
(1982)
J Mol Biol
, vol.162
, Issue.3
, pp. 679-692
-
-
Taylor, S.M.1
Jones, P.A.2
-
193
-
-
0842347353
-
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation
-
Weisenberger, D.J., Velicescu, M., Cheng, J.C., Gonzales, F.A., Liang, G., Jones, P.A., Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res 2:1 (2004), 62–72.
-
(2004)
Mol Cancer Res
, vol.2
, Issue.1
, pp. 62-72
-
-
Weisenberger, D.J.1
Velicescu, M.2
Cheng, J.C.3
Gonzales, F.A.4
Liang, G.5
Jones, P.A.6
-
194
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
Jones, P.A., Taylor, S.M., Cellular differentiation, cytidine analogs and DNA methylation. Cell 20:1 (1980), 85–93.
-
(1980)
Cell
, vol.20
, Issue.1
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
195
-
-
0020032366
-
Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2′-deoxycytidine
-
Creusot, F., Acs, G., Christman, J.K., Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2′-deoxycytidine. J Biol Chem 257:4 (1982), 2041–2048.
-
(1982)
J Biol Chem
, vol.257
, Issue.4
, pp. 2041-2048
-
-
Creusot, F.1
Acs, G.2
Christman, J.K.3
-
196
-
-
0020664023
-
Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60)
-
Christman, J.K., Mendelsohn, N., Herzog, D., Schneiderman, N., Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60). Cancer Res 43:2 (1983), 763–769.
-
(1983)
Cancer Res
, vol.43
, Issue.2
, pp. 763-769
-
-
Christman, J.K.1
Mendelsohn, N.2
Herzog, D.3
Schneiderman, N.4
-
197
-
-
34247094617
-
Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC–MS/MS method
-
Liu, Z., Liu, S., Xie, Z., Blum, W., Perrotti, D., Paschka, P., et al. Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC–MS/MS method. Nucleic Acids Res, 35(5), 2007, e31.
-
(2007)
Nucleic Acids Res
, vol.35
, Issue.5
-
-
Liu, Z.1
Liu, S.2
Xie, Z.3
Blum, W.4
Perrotti, D.5
Paschka, P.6
-
198
-
-
37549022694
-
DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
-
Griffiths, E.A., Gore, S.D., DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol 45:1 (2008), 23–30.
-
(2008)
Semin Hematol
, vol.45
, Issue.1
, pp. 23-30
-
-
Griffiths, E.A.1
Gore, S.D.2
-
199
-
-
70350506791
-
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
-
Fandy, T.E., Herman, J.G., Kerns, P., Jiemjit, A., Sugar, E.A., Choi, S.H., et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 114:13 (2009), 2764–2773.
-
(2009)
Blood
, vol.114
, Issue.13
, pp. 2764-2773
-
-
Fandy, T.E.1
Herman, J.G.2
Kerns, P.3
Jiemjit, A.4
Sugar, E.A.5
Choi, S.H.6
-
200
-
-
80051718182
-
Mechanisms of resistance to decitabine in the myelodysplastic syndrome
-
Qin, T., Castoro, R., El Ahdab, S., Jelinek, J., Wang, X., Si, J., et al. Mechanisms of resistance to decitabine in the myelodysplastic syndrome. PLoS One, 6(8), 2011, e23372.
-
(2011)
PLoS One
, vol.6
, Issue.8
-
-
Qin, T.1
Castoro, R.2
El Ahdab, S.3
Jelinek, J.4
Wang, X.5
Si, J.6
-
201
-
-
84876444289
-
Genomic impact of transient low-dose decitabine treatment on primary AML cells
-
Klco, J.M., Spencer, D.H., Lamprecht, T.L., Sarkaria, S.M., Wylie, T., Magrini, V., et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood 121:9 (2013), 1633–1643.
-
(2013)
Blood
, vol.121
, Issue.9
, pp. 1633-1643
-
-
Klco, J.M.1
Spencer, D.H.2
Lamprecht, T.L.3
Sarkaria, S.M.4
Wylie, T.5
Magrini, V.6
-
202
-
-
84928982643
-
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia
-
Meldi, K., Qin, T., Buchi, F., Droin, N., Sotzen, J., Micol, J.B., et al. Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia. J Clin Invest 125:5 (2015), 1857–1872.
-
(2015)
J Clin Invest
, vol.125
, Issue.5
, pp. 1857-1872
-
-
Meldi, K.1
Qin, T.2
Buchi, F.3
Droin, N.4
Sotzen, J.5
Micol, J.B.6
-
203
-
-
84864031521
-
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
-
Akalin, A., Garrett-Bakelman, F.E., Kormaksson, M., Busuttil, J., Zhang, L., Khrebtukova, I., et al. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet, 8(6), 2012, e1002781.
-
(2012)
PLoS Genet
, vol.8
, Issue.6
-
-
Akalin, A.1
Garrett-Bakelman, F.E.2
Kormaksson, M.3
Busuttil, J.4
Zhang, L.5
Khrebtukova, I.6
-
204
-
-
33745714230
-
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
-
Gore, S.D., Baylin, S., Sugar, E., Carraway, H., Miller, C.B., Carducci, M., et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 66:12 (2006), 6361–6369.
-
(2006)
Cancer Res
, vol.66
, Issue.12
, pp. 6361-6369
-
-
Gore, S.D.1
Baylin, S.2
Sugar, E.3
Carraway, H.4
Miller, C.B.5
Carducci, M.6
-
205
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment
-
Daskalakis, M., Nguyen, T.T., Nguyen, C., Guldberg, P., Kohler, G., Wijermans, P., et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment. Blood 100:8 (2002), 2957–2964.
-
(2002)
Blood
, vol.100
, Issue.8
, pp. 2957-2964
-
-
Daskalakis, M.1
Nguyen, T.T.2
Nguyen, C.3
Guldberg, P.4
Kohler, G.5
Wijermans, P.6
-
206
-
-
29144469286
-
Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia
-
Galm, O., Wilop, S., Luders, C., Jost, E., Gehbauer, G., Herman, J.G., et al. Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia. Ann Hematol 84:Suppl. 1 (2005), 39–46.
-
(2005)
Ann Hematol
, vol.84
, pp. 39-46
-
-
Galm, O.1
Wilop, S.2
Luders, C.3
Jost, E.4
Gehbauer, G.5
Herman, J.G.6
-
207
-
-
0035870248
-
A gene hypermethylation profile of human cancer
-
Esteller, M., Corn, P.G., Baylin, S.B., Herman, J.G., A gene hypermethylation profile of human cancer. Cancer Res 61:8 (2001), 3225–3229.
-
(2001)
Cancer Res
, vol.61
, Issue.8
, pp. 3225-3229
-
-
Esteller, M.1
Corn, P.G.2
Baylin, S.B.3
Herman, J.G.4
-
208
-
-
27144535374
-
Trapped in action: direct visualization of DNA methyltransferase activity in living cells
-
Schermelleh, L., Spada, F., Easwaran, H.P., Zolghadr, K., Margot, J.B., Cardoso, M.C., et al. Trapped in action: direct visualization of DNA methyltransferase activity in living cells. Nat Methods 2:10 (2005), 751–756.
-
(2005)
Nat Methods
, vol.2
, Issue.10
, pp. 751-756
-
-
Schermelleh, L.1
Spada, F.2
Easwaran, H.P.3
Zolghadr, K.4
Margot, J.B.5
Cardoso, M.C.6
-
209
-
-
0000418476
-
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
-
Santi, D.V., Norment, A., Garrett, C.E., Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci U S A 81:22 (1984), 6993–6997.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, Issue.22
, pp. 6993-6997
-
-
Santi, D.V.1
Norment, A.2
Garrett, C.E.3
-
210
-
-
0028920604
-
The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor
-
Gabbara, S., Bhagwat, A.S., The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor. Biochem J 307 (1995), 87–92.
-
(1995)
Biochem J
, vol.307
, pp. 87-92
-
-
Gabbara, S.1
Bhagwat, A.S.2
-
211
-
-
0031434813
-
Role of estrogen receptor gene demethylation and DNA methyltransferase. DNA adduct formation in 5-aza-2′deoxycytidine-induced cytotoxicity in human breast cancer cells
-
Ferguson, A.T., Vertino, P.M., Spitzner, J.R., Baylin, S.B., Muller, M.T., Davidson, N.E., Role of estrogen receptor gene demethylation and DNA methyltransferase. DNA adduct formation in 5-aza-2′deoxycytidine-induced cytotoxicity in human breast cancer cells. J Biol Chem 272:51 (1997), 32260–32266.
-
(1997)
J Biol Chem
, vol.272
, Issue.51
, pp. 32260-32266
-
-
Ferguson, A.T.1
Vertino, P.M.2
Spitzner, J.R.3
Baylin, S.B.4
Muller, M.T.5
Davidson, N.E.6
-
212
-
-
37849026412
-
DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
-
Palii, S.S., Van Emburgh, B.O., Sankpal, U.T., Brown, K.D., Robertson, K.D., DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol 28:2 (2008), 752–771.
-
(2008)
Mol Cell Biol
, vol.28
, Issue.2
, pp. 752-771
-
-
Palii, S.S.1
Van Emburgh, B.O.2
Sankpal, U.T.3
Brown, K.D.4
Robertson, K.D.5
-
213
-
-
77749302093
-
A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
-
Hollenbach, P.W., Nguyen, A.N., Brady, H., Williams, M., Ning, Y., Richard, N., et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS One, 5(2), 2010, e9001.
-
(2010)
PLoS One
, vol.5
, Issue.2
-
-
Hollenbach, P.W.1
Nguyen, A.N.2
Brady, H.3
Williams, M.4
Ning, Y.5
Richard, N.6
-
214
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
-
Issa, J.P., Garcia-Manero, G., Giles, F.J., Mannari, R., Thomas, D., Faderl, S., et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 103:5 (2004), 1635–1640.
-
(2004)
Blood
, vol.103
, Issue.5
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
Mannari, R.4
Thomas, D.5
Faderl, S.6
-
215
-
-
84863337757
-
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
-
Tsai, H.C., Li, H., Van Neste, L., Cai, Y., Robert, C., Rassool, F.V., et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 21:3 (2012), 430–446.
-
(2012)
Cancer Cell
, vol.21
, Issue.3
, pp. 430-446
-
-
Tsai, H.C.1
Li, H.2
Van Neste, L.3
Cai, Y.4
Robert, C.5
Rassool, F.V.6
-
216
-
-
34250634403
-
A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy
-
Karpf, A.R., A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy. Epigenetics 1:3 (2006), 116–120.
-
(2006)
Epigenetics
, vol.1
, Issue.3
, pp. 116-120
-
-
Karpf, A.R.1
-
217
-
-
42549133624
-
The DNA demethylating agent 5-aza-2′-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma
-
Natsume, A., Wakabayashi, T., Tsujimura, K., Shimato, S., Ito, M., Kuzushima, K., et al. The DNA demethylating agent 5-aza-2′-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma. Int J Cancer 122:11 (2008), 2542–2553.
-
(2008)
Int J Cancer
, vol.122
, Issue.11
, pp. 2542-2553
-
-
Natsume, A.1
Wakabayashi, T.2
Tsujimura, K.3
Shimato, S.4
Ito, M.5
Kuzushima, K.6
-
218
-
-
77952952304
-
The DNA demethylating agent 5-aza-2′-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells
-
Almstedt, M., Blagitko-Dorfs, N., Duque-Afonso, J., Karbach, J., Pfeifer, D., Jager, E., et al. The DNA demethylating agent 5-aza-2′-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells. Leuk Res 34:7 (2010), 899–905.
-
(2010)
Leuk Res
, vol.34
, Issue.7
, pp. 899-905
-
-
Almstedt, M.1
Blagitko-Dorfs, N.2
Duque-Afonso, J.3
Karbach, J.4
Pfeifer, D.5
Jager, E.6
-
219
-
-
80054689372
-
MAGE-A1, MAGE-A3, and NY-ESO-1 can be upregulated on neuroblastoma cells to facilitate cytotoxic T lymphocyte-mediated tumor cell killing
-
Bao, L., Dunham, K., Lucas, K., MAGE-A1, MAGE-A3, and NY-ESO-1 can be upregulated on neuroblastoma cells to facilitate cytotoxic T lymphocyte-mediated tumor cell killing. Cancer Immunol Immunother 60:9 (2011), 1299–1307.
-
(2011)
Cancer Immunol Immunother
, vol.60
, Issue.9
, pp. 1299-1307
-
-
Bao, L.1
Dunham, K.2
Lucas, K.3
-
220
-
-
84860327244
-
Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo
-
Yang, D., Torres, C.M., Bardhan, K., Zimmerman, M., McGaha, T.L., Liu, K., Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo. J Immunol 188:9 (2012), 4441–4449.
-
(2012)
J Immunol
, vol.188
, Issue.9
, pp. 4441-4449
-
-
Yang, D.1
Torres, C.M.2
Bardhan, K.3
Zimmerman, M.4
McGaha, T.L.5
Liu, K.6
-
221
-
-
80355131506
-
Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway
-
Konkankit, V.V., Kim, W., Koya, R.C., Eskin, A., Dam, M.A., Nelson, S., et al. Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway. J Transl Med, 9, 2011, 192.
-
(2011)
J Transl Med
, vol.9
, pp. 192
-
-
Konkankit, V.V.1
Kim, W.2
Koya, R.C.3
Eskin, A.4
Dam, M.A.5
Nelson, S.6
-
222
-
-
0036593490
-
Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses
-
Yee, C., Greenberg, P., Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses. Nat Rev Cancer 2:6 (2002), 409–419.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.6
, pp. 409-419
-
-
Yee, C.1
Greenberg, P.2
-
223
-
-
0029957792
-
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation
-
De Smet, C., De Backer, O., Faraoni, I., Lurquin, C., Brasseur, F., Boon, T., The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc Natl Acad Sci U S A 93:14 (1996), 7149–7153.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.14
, pp. 7149-7153
-
-
De Smet, C.1
De Backer, O.2
Faraoni, I.3
Lurquin, C.4
Brasseur, F.5
Boon, T.6
-
224
-
-
0032694084
-
DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter
-
De Smet, C., Lurquin, C., Lethe, B., Martelange, V., Boon, T., DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol 19:11 (1999), 7327–7335.
-
(1999)
Mol Cell Biol
, vol.19
, Issue.11
, pp. 7327-7335
-
-
De Smet, C.1
Lurquin, C.2
Lethe, B.3
Martelange, V.4
Boon, T.5
-
225
-
-
50349087907
-
Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer
-
Woloszynska-Read, A., Mhawech-Fauceglia, P., Yu, J., Odunsi, K., Karpf, A.R., Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer. Clin Cancer Res 14:11 (2008), 3283–3290.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.11
, pp. 3283-3290
-
-
Woloszynska-Read, A.1
Mhawech-Fauceglia, P.2
Yu, J.3
Odunsi, K.4
Karpf, A.R.5
-
226
-
-
84910087763
-
Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts
-
Srivastava, P., Paluch, B.E., Matsuzaki, J., James, S.R., Collamat-Lai, G., Karbach, J., et al. Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts. Leuk Res 38:11 (2014), 1332–1341.
-
(2014)
Leuk Res
, vol.38
, Issue.11
, pp. 1332-1341
-
-
Srivastava, P.1
Paluch, B.E.2
Matsuzaki, J.3
James, S.R.4
Collamat-Lai, G.5
Karbach, J.6
-
227
-
-
84877151648
-
Immunomodulatory activity of SGI-110, a 5-aza-2′-deoxycytidine-containing demethylating dinucleotide
-
Coral, S., Parisi, G., Nicolay, H.J., Colizzi, F., Danielli, R., Fratta, E., et al. Immunomodulatory activity of SGI-110, a 5-aza-2′-deoxycytidine-containing demethylating dinucleotide. Cancer Immunol Immunother 62:3 (2013), 605–614.
-
(2013)
Cancer Immunol Immunother
, vol.62
, Issue.3
, pp. 605-614
-
-
Coral, S.1
Parisi, G.2
Nicolay, H.J.3
Colizzi, F.4
Danielli, R.5
Fratta, E.6
-
228
-
-
33644879237
-
Phenotypic and functional changes of human melanoma xenografts induced by DNA hypomethylation: immunotherapeutic implications
-
Coral, S., Sigalotti, L., Colizzi, F., Spessotto, A., Nardi, G., Cortini, E., et al. Phenotypic and functional changes of human melanoma xenografts induced by DNA hypomethylation: immunotherapeutic implications. J Cell Physiol 207:1 (2006), 58–66.
-
(2006)
J Cell Physiol
, vol.207
, Issue.1
, pp. 58-66
-
-
Coral, S.1
Sigalotti, L.2
Colizzi, F.3
Spessotto, A.4
Nardi, G.5
Cortini, E.6
-
229
-
-
84892915092
-
Clinical development of demethylating agents in hematology
-
Navada, S.C., Steinmann, J., Lubbert, M., Silverman, L.R., Clinical development of demethylating agents in hematology. J Clin Invest 124:1 (2014), 40–46.
-
(2014)
J Clin Invest
, vol.124
, Issue.1
, pp. 40-46
-
-
Navada, S.C.1
Steinmann, J.2
Lubbert, M.3
Silverman, L.R.4
-
230
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic, M., Talpur, R., Ni, X., Zhang, C., Hazarika, P., Kelly, C., et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 109:1 (2007), 31–39.
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
Zhang, C.4
Hazarika, P.5
Kelly, C.6
-
231
-
-
84908133944
-
Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial
-
San-Miguel, J.F., Hungria, V.T., Yoon, S.S., Beksac, M., Dimopoulos, M.A., Elghandour, A., et al. Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. Lancet Oncol 15:11 (2014), 1195–1206.
-
(2014)
Lancet Oncol
, vol.15
, Issue.11
, pp. 1195-1206
-
-
San-Miguel, J.F.1
Hungria, V.T.2
Yoon, S.S.3
Beksac, M.4
Dimopoulos, M.A.5
Elghandour, A.6
-
232
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G., Baylin, S.B., Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21:1 (1999), 103–107.
-
(1999)
Nat Genet
, vol.21
, Issue.1
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
Baylin, S.B.5
-
233
-
-
31344446955
-
Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies
-
Gore, S.D., Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies. Nat Clin Pract Oncol 2:Suppl. 1 (2005), S30–S35.
-
(2005)
Nat Clin Pract Oncol
, vol.2
, pp. S30-S35
-
-
Gore, S.D.1
-
234
-
-
84904066247
-
Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905
-
Prebet, T., Sun, Z., Figueroa, M.E., Ketterling, R., Melnick, A., Greenberg, P.L., et al. Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905. J Clin Oncol 32:12 (2014), 1242–1248.
-
(2014)
J Clin Oncol
, vol.32
, Issue.12
, pp. 1242-1248
-
-
Prebet, T.1
Sun, Z.2
Figueroa, M.E.3
Ketterling, R.4
Melnick, A.5
Greenberg, P.L.6
-
235
-
-
84919769943
-
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer
-
Fang, F., Munck, J., Tang, J., Taverna, P., Wang, Y., Miller, D.F., et al. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clin Cancer Res 20:24 (2014), 6504–6516.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.24
, pp. 6504-6516
-
-
Fang, F.1
Munck, J.2
Tang, J.3
Taverna, P.4
Wang, Y.5
Miller, D.F.6
-
236
-
-
84945485095
-
Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin
-
Kuang, Y., El-Khoueiry, A., Taverna, P., Ljungman, M., Neamati, N., Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin. Mol Oncol 9:9 (2015), 1799–1814.
-
(2015)
Mol Oncol
, vol.9
, Issue.9
, pp. 1799-1814
-
-
Kuang, Y.1
El-Khoueiry, A.2
Taverna, P.3
Ljungman, M.4
Neamati, N.5
-
237
-
-
84944452952
-
Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma
-
Leshchenko, V.V., Kuo, P.Y., Jiang, Z., Weniger, M.A., Overbey, J., Dunleavy, K., et al. Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma. Oncotarget 6:29 (2015), 27332–27342.
-
(2015)
Oncotarget
, vol.6
, Issue.29
, pp. 27332-27342
-
-
Leshchenko, V.V.1
Kuo, P.Y.2
Jiang, Z.3
Weniger, M.A.4
Overbey, J.5
Dunleavy, K.6
-
238
-
-
84939894917
-
Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide)
-
Xia, C., Leon-Ferre, R., Laux, D., Deutsch, J., Smith, B.J., Frees, M., et al. Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide). Cancer Chemother Pharmacol 74:4 (2014), 691–697.
-
(2014)
Cancer Chemother Pharmacol
, vol.74
, Issue.4
, pp. 691-697
-
-
Xia, C.1
Leon-Ferre, R.2
Laux, D.3
Deutsch, J.4
Smith, B.J.5
Frees, M.6
-
239
-
-
84921329779
-
Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer
-
Vendetti, F.P., Topper, M., Huang, P., Dobromilskaya, I., Easwaran, H., Wrangle, J., et al. Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Oncotarget 6:1 (2015), 56–70.
-
(2015)
Oncotarget
, vol.6
, Issue.1
, pp. 56-70
-
-
Vendetti, F.P.1
Topper, M.2
Huang, P.3
Dobromilskaya, I.4
Easwaran, H.5
Wrangle, J.6
-
240
-
-
84949293174
-
Carboplatin with decitabine therapy, in recurrent platinum resistant ovarian cancer, alters circulating miRNAs concentrations: a pilot study
-
Benson, E.A., Skaar, T.C., Liu, Y., Nephew, K.P., Matei, D., Carboplatin with decitabine therapy, in recurrent platinum resistant ovarian cancer, alters circulating miRNAs concentrations: a pilot study. PLoS One, 10(10), 2015, e0141279.
-
(2015)
PLoS One
, vol.10
, Issue.10
-
-
Benson, E.A.1
Skaar, T.C.2
Liu, Y.3
Nephew, K.P.4
Matei, D.5
-
241
-
-
80051604949
-
Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML
-
Scandura, J.M., Roboz, G.J., Moh, M., Morawa, E., Brenet, F., Bose, J.R., et al. Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. Blood 118:6 (2011), 1472–1480.
-
(2011)
Blood
, vol.118
, Issue.6
, pp. 1472-1480
-
-
Scandura, J.M.1
Roboz, G.J.2
Moh, M.3
Morawa, E.4
Brenet, F.5
Bose, J.R.6
-
242
-
-
84948718840
-
Etiology, clinical course and outcome of healthcare-associated bloodstream infections in patients with hematological malignancies: a retrospective study of 350 patients in a Finnish tertiary care hospital
-
Attman, E., Aittoniemi, J., Sinisalo, M., Vuento, R., Lyytikainen, O., Karki, T., et al. Etiology, clinical course and outcome of healthcare-associated bloodstream infections in patients with hematological malignancies: a retrospective study of 350 patients in a Finnish tertiary care hospital. Leuk Lymphoma, 1–8, 2015.
-
(2015)
Leuk Lymphoma
, vol.1-8
-
-
Attman, E.1
Aittoniemi, J.2
Sinisalo, M.3
Vuento, R.4
Lyytikainen, O.5
Karki, T.6
-
243
-
-
84928490666
-
Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia
-
Ranganathan, P., Yu, X., Santhanam, R., Hofstetter, J., Walker, A., Walsh, K., et al. Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia. Blood 125:17 (2015), 2689–2692.
-
(2015)
Blood
, vol.125
, Issue.17
, pp. 2689-2692
-
-
Ranganathan, P.1
Yu, X.2
Santhanam, R.3
Hofstetter, J.4
Walker, A.5
Walsh, K.6
-
244
-
-
84884587225
-
Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma
-
Clozel, T., Yang, S., Elstrom, R.L., Tam, W., Martin, P., Kormaksson, M., et al. Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. Cancer Discov 3:9 (2013), 1002–1019.
-
(2013)
Cancer Discov
, vol.3
, Issue.9
, pp. 1002-1019
-
-
Clozel, T.1
Yang, S.2
Elstrom, R.L.3
Tam, W.4
Martin, P.5
Kormaksson, M.6
-
245
-
-
34547915603
-
Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer
-
Odunsi, K., Qian, F., Matsuzaki, J., Mhawech-Fauceglia, P., Andrews, C., Hoffman, E.W., et al. Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer. Proc Natl Acad Sci U S A 104:31 (2007), 12837–12842.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.31
, pp. 12837-12842
-
-
Odunsi, K.1
Qian, F.2
Matsuzaki, J.3
Mhawech-Fauceglia, P.4
Andrews, C.5
Hoffman, E.W.6
-
246
-
-
84894106057
-
Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer
-
Odunsi, K., Matsuzaki, J., James, S.R., Mhawech-Fauceglia, P., Tsuji, T., Miller, A., et al. Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer. Cancer Immunol Res 2:1 (2014), 37–49.
-
(2014)
Cancer Immunol Res
, vol.2
, Issue.1
, pp. 37-49
-
-
Odunsi, K.1
Matsuzaki, J.2
James, S.R.3
Mhawech-Fauceglia, P.4
Tsuji, T.5
Miller, A.6
-
247
-
-
84962018342
-
Decitabine enhances lymphocyte migration and function and synergizes with CTLA-4 blockade in a murine ovarian cancer model
-
Wang, L., Amoozgar, Z., Huang, J., Saleh, M.H., Xing, D., Orsulic, S., et al. Decitabine enhances lymphocyte migration and function and synergizes with CTLA-4 blockade in a murine ovarian cancer model. Cancer Immunol Res 3:9 (2015), 1030–1041.
-
(2015)
Cancer Immunol Res
, vol.3
, Issue.9
, pp. 1030-1041
-
-
Wang, L.1
Amoozgar, Z.2
Huang, J.3
Saleh, M.H.4
Xing, D.5
Orsulic, S.6
-
248
-
-
84890130945
-
Alterations of immune response of non-small cell lung cancer with azacytidine
-
Wrangle, J., Wang, W., Koch, A., Easwaran, H., Mohammad, H.P., Vendetti, F., et al. Alterations of immune response of non-small cell lung cancer with azacytidine. Oncotarget 4:11 (2013), 2067–2079.
-
(2013)
Oncotarget
, vol.4
, Issue.11
, pp. 2067-2079
-
-
Wrangle, J.1
Wang, W.2
Koch, A.3
Easwaran, H.4
Mohammad, H.P.5
Vendetti, F.6
|