Small-molecule ligands of methyl-lysine binding proteins: Optimization of selectivity for L3MBTL3

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7358-7371

  James, Lindsey I ^a   Korboukh, Victoria K ^a,e   Krichevsky, Liubov ^b,c,d   Baughman, Brandi M ^a   Herold, J Martin ^a,f   Norris, Jacqueline L ^a   Jin, Jian ^a   Kireev, Dmitri B ^a   Janzen, William P ^a   Arrowsmith, Cheryl H ^b,c,d   Frye, Stephen V ^a  

^a University of North Carolina   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d PRINCESS MARGARET HOSPITAL   (Canada)

^e ASTRAZENECA   (United Kingdom)

^f ABBVIE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; METHYL LYSINE BINDING PROTEIN; PROTEIN INHIBITOR; PROTEIN L3MBTL3; UNC 1679; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; L3MBTL3 PROTEIN, HUMAN; LIGAND; LYSINE; MOLECULAR LIBRARY;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; HEK293 CELL LINE; HUMAN; IC50; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; PROTEIN TERTIARY STRUCTURE;

DNA-BINDING PROTEINS; DRUG DESIGN; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; LYSINE; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84884993346     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400919p     Document Type: Article

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