The nuclear DNA base 5-hydroxymethylcytosine is present in purkinje neurons and the brain

Science

Volumn 324, Issue 5929, 2009, Pages 929-930

  Kriaucionis, Skirmantas ^a   Heintz, Nathaniel ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; CELL NUCLEUS DNA; DEOXYCYTIDINE; NUCLEOTIDE; 5 HYDROXYMETHYLDEOXYCYTIDINE; 5-HYDROXYMETHYL-2'-DEOXYCYTIDINE; 5-HYDROXYMETHYLCYTOSINE; CYTOSINE; DNA; DRUG DERIVATIVE;

BRAIN; CANCER; CELL ORGANELLE; CYTOLOGY; DNA; LIQUID CHROMATOGRAPHY; NERVOUS SYSTEM;

ARTICLE; BRAIN; CANCER CELL CULTURE; CELL FUNCTION; EPIGENETICS; GENETIC REGULATION; GRANULE CELL; PRIORITY JOURNAL; PURKINJE CELL; ANIMAL; BRAIN LEVEL; CELL LINE; CEREBELLUM; CHEMISTRY; CYTOLOGY; DNA DAMAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; MOUSE; THIN LAYER CHROMATOGRAPHY;

ANIMALS; BRAIN CHEMISTRY; CELL LINE; CEREBELLUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; CYTOSINE; DEOXYCYTIDINE; DNA; DNA DAMAGE; HUMANS; MASS SPECTROMETRY; MICE; PURKINJE CELLS;

EID: 66149123748     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1169786     Document Type: Article

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15. We thank B. Gauthier for technical assistance; S. Mazel, C. Bare, and X. Fan for flow cytometry advice and nuclei sorts; and H. Deng and J. Fernandez for acquirement of MS data and help with HPLC. We are grateful to members of the Heintz laboratory for discussions and support. This work was supported by the Howard Hughes Medical Institute and the Simons Foundation Autism Research Initiative.