trans-2-phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1

Biochemistry

Volumn 46, Issue 14, 2007, Pages 4408-4416

  Schmidt, Dawn M Z ^a   McCafferty, Dewey G ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASES; ENZYME CATALYSIS; INACTIVATION; TRANS-2-PHENYLCYCLOPROPYLAMINE;

AMINES; AMINO ACIDS; BIOCHEMISTRY; CATALYST ACTIVITY; ENZYME INHIBITION;

ENZYME ACTIVITY;

AMINE OXIDASE (FLAVIN CONTAINING); HISTONE DEACETYLASE; LYSINE SPECIFIC DEMETHYLASE 1; POLYAMINE OXIDASE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; ENZYME INHIBITORS; ESCHERICHIA COLI; FLAVINS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LYSINE; MASS SPECTROMETRY; METHYLATION; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MONOAMINE OXIDASE INHIBITORS; OXIDOREDUCTASES, N-DEMETHYLATING; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEMPERATURE; TRANYLCYPROMINE;

GYMNOMYZA;

EID: 34147173308     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0618621     Document Type: Article

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