Discovery and characterization of small molecule inhibitors of the BET family bromodomains

Journal of Medicinal Chemistry

Volumn 54, Issue 11, 2011, Pages 3827-3838

  Chung, Chun Wa ^a   Coste, Hervé ^b   White, Julia H ^a   Mirguet, Olivier ^b   Wilde, Jonathan ^a   Gosmini, Romain L ^b   Delves, Chris ^a   Magny, Sylvie M ^b   Woodward, Robert ^a   Hughes, Stephen A ^a   Boursier, Eric V ^b   Flynn, Helen ^a   Bouillot, Anne M ^b   Bamborough, Paul ^a   Brusq, Jean Marie G ^b   Gellibert, Franc Oise J ^b   Jones, Emma J ^a   Riou, Alizon M ^b   Homes, Paul ^a   Martin, Sandrine L ^b   Uings, Iain J ^a   Toum, Jérôme ^b   Clément, Catherine A ^b   Boullay, Anne Bénédicte ^b   Grimley, Rachel L ^a   Blandel, Florence M ^b   Prinjha, Rab K ^a   Lee, Kevin ^a   Kirilovsky, Jorge ^b   Nicodeme, Edwige ^b   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b Glaxo Smith Kline   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BROMODOMAIN; HISTONE; LYSINE; PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BIOPHYSICS; CRYSTAL STRUCTURE; HUMAN; MOLECULAR DYNAMICS; MOLECULE; PHENOTYPE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SCREENING; STEREOCHEMISTRY; X RAY;

ACETYLATION; AMINO ACID SEQUENCE; APOLIPOPROTEIN A-I; BENZODIAZEPINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; EPIGENOMICS; HEP G2 CELLS; HISTONES; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; STEREOISOMERISM; UP-REGULATION;

EID: 79958078949     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200108t     Document Type: Article

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