Identification of cell-active lysine specific demethylase 1-selective inhibitors

Journal of the American Chemical Society

Volumn 131, Issue 48, 2009, Pages 17536-17537

  Ueda, Rie ^a   Suzuki, Takayoshi ^a   Mino, Koshiki ^b   Tsumoto, Hiroki ^a   Nakagawa, Hidehiko ^a   Hasegawa, Makoto ^b   Sasaki, Ryuzo ^c   Mizukami, Tamio ^b   Miyata, Naoki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^c Frontier Pharma Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER DRUG; ANTIPROLIFERATIVE ACTIVITIES; CHEMICAL EQUATIONS; DEMETHYLASE; HISTONE H3; IN-VIVO; LEAD STRUCTURE; METHYL GROUP; SELECTIVE INHIBITORS; SMALL MOLECULES;

CHEMICAL REACTIONS; FLUORINE CONTAINING POLYMERS; GENE EXPRESSION; HYDROCARBONS;

AMINO ACIDS;

ANTINEOPLASTIC AGENT; HISTONE H3; LYSINE SPECIFIC DEMETHYLASE 1; LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR; METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ACTIVITY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; METHYLATION; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HISTONE DEMETHYLASES; HISTONES; HUMANS; MODELS, MOLECULAR; SUBSTRATE SPECIFICITY;

EID: 72249117352     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja907055q     Document Type: Article

References (12)

1. Shi, Y. Nat. Rev. Genet. 2007, 8, 829.
2. Shi, Y.; Lan, F.; Matson, C.; Mulligan, P.; Whetstine, J. R.; Cole, P. A.; Casero, R. A.; Shi, Y. Cell 2004, 119, 941.
3. Suzuki, T.; Miyata, N. Curr. Med. Chem. 2006, 13, 935.
4. (a) Yang, M.; Culhane, J. C.; Szewczuk, L. M.; Jalili, P.; Ball, H. L.; Machius, M.; Cole, P. A.; Yu, H. Biochemistry 2007, 46, 8058.
5. (b) Metzger, E.; Wissmann, M.; Yin, N.; Müller, J. M.; Schneider, R.; Peters, A. H.; Günther, T.; Buettner, R.; Schüle, R. Nature 2005, 437, 436.
6. (a) Culhane, J. C.; Szewczuk, L. M.; Liu, X.; Da, G.; Marmorstein, R.; Cole, P. A. J. Am. Chem. Soc. 2006, 128, 4536.
7. (b) Yang, M.; Culhane, J. C.; Szewczuk, L. M.; Gocke, C. B.; Brautigam, C. A.; Tomchick, D. R.; Machius, M.; Cole, P. A.; Yu, H. Nat. Struct. Mol. Biol. 2007, 14, 535.
8. Huang, Y.; Greene, E.; Murray Stewart, T.; Goodwin, A. C.; Baylin, S. B.; Woster, P. M.; Casero, R. A., Jr. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 8023.
9. Son, S. Y.; Ma, J.; Kondou, Y.; Yoshimura, M.; Yamashita, E.; Tsukihara, T. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 5739.
10. Binda, C.; Li, M.; Hubalek, F.; Restelli, N.; Edmondson, D. E.; Mattevi, A. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 9750.
11. (a) Scoumanne, A.; Chen, X. J. Biol. Chem. 2007, 282, 15471.
12. (b) Yokoyama, A.; Takezawa, S.; Schüle, R.; Kitagawa, H.; Kato, S. Mol. Cell. Biol. 2008, 28, 3995.