Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

Nature Medicine

Volumn 18, Issue 4, 2012, Pages 605-611

  Schenk, Tino ^a   Chen, Weihsu Claire ^b   Göllner, Stefanie ^c   Howell, Louise ^a   Jin, Liqing ^b   Hebestreit, Katja ^c   Klein, Hans Ulrich ^c   Popescu, Andreea C ^b   Burnett, Alan ^d   Mills, Ken ^e   Casero Jr , Robert A ^f   Marton, Laurence ^g   Woster, Patrick ^h   Minden, Mark D ⁱ   Dugas, Martin ^c   Wang, Jean C Y ^b,i   Dick, John E ^b,i   Müller Tidow, Carsten ^c   Petrie, Kevin ^a   Zelent, Arthur ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^f JOHNS HOPKINS UNIVERSITY   (United States)

^g Progen Pharmaceuticals Inc   (United States)

^h MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

ⁱ UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; ENZYME INHIBITOR; HISTONE H3; LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR; RETINOIC ACID; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; EPIGENETICS; FEMALE; GENE EXPRESSION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; TUMOR ENGRAFTMENT;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD34; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HISTONE DEMETHYLASES; HUMANS; LEUKEMIA, MYELOID, ACUTE; LYSINE; MICE; MICE, INBRED NOD; MICE, SCID; RNA, SMALL INTERFERING; STEM CELL FACTOR; TIME FACTORS; TRANSPLANTS; TRANYLCYPROMINE; TRETINOIN;

MUS;

EID: 84862777766     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2661     Document Type: Article

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