Structurally designed trans -2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

Biochemistry

Volumn 49, Issue 30, 2010, Pages 6494-6503

  Mimasu, Shinya ^a,b   Umezawa, Naoki ^c   Sato, Shin ^a   Higuchi, Tsunehiko ^c   Umehara, Takashi ^a   Yokoyama, Shigeyuki ^a,b  

^a RIKEN   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER AGENTS; CANCEROUS CELLS; CHROMATIN STRUCTURE; DEMETHYLASE; DEMETHYLATION; DNA METHYLTRANSFERASES; ENHANCED STABILITY; EUKARYOTIC GENE EXPRESSION; HISTONE H3; MONOAMINE OXIDASE; MONOAMINE OXIDASE B; RESEARCH TOOLS; SPECIFIC INHIBITORS; TUMOR SUPPRESSORS; VIRUS INFECTION;

AMINO ACIDS; GENE EXPRESSION; PROTEINS; VIRUSES;

GENE EXPRESSION REGULATION;

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; LYSINE SPECIFIC DEMETHYLASE 1; METHYLTRANSFERASE; TRANYLCYPROMINE; TRANYLCYPROMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; DEMETHYLATION; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; LATENT VIRUS INFECTION; MOLECULAR INTERACTION; PRIORITY JOURNAL; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL LINE; DRUG DESIGN; ENZYME INHIBITORS; HISTONE DEMETHYLASES; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANYLCYPROMINE;

EUKARYOTA;

EID: 77955025931     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100299r     Document Type: Article

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