The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Cancer Cell

Volumn 17, Issue 3, 2010, Pages 225-234

  Ward, Patrick S ^a   Patel, Jay ^c   Wise, David R ^a   Abdel Wahab, Omar ^c   Bennett, Bryson D ^d   Coller, Hilary A ^d   Cross, Justin R ^a   Fantin, Valeria R ^e   Hedvat, Cyrus V ^c   Perl, Alexander E ^a   Rabinowitz, Joshua D ^d   Carroll, Martin ^a   Su, Shinsan M ^e   Sharp, Kim A ^b   Levine, Ross L ^c   Thompson, Craig B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d PRINCETON UNIVERSITY   (United States)

^e AGIOS PHARMACEUTICALS   (United States)

Author keywords

CELLCYCLE; DNA; HUMDISEASE

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; ISOCITRATE DEHYDROGENASE (NADP); TUMOR MARKER;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; DISEASE MARKER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FEMALE; GENE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IDH1 GENE; IDH2 GENE; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCREENING TEST;

EID: 77649305610     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2010.01.020     Document Type: Article

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