Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Nature Biotechnology

Volumn 29, Issue 3, 2011, Pages 255-268

  Bantscheff, Marcus ^a   Hopf, Carsten ^a   Savitski, Mikhail M ^a   Dittmann, Antje ^a   Grandi, Paola ^a   Michon, Anne Marie ^a   Schlegl, Judith ^a   Abraham, Yann ^a   Becher, Isabelle ^a   Bergamini, Giovanna ^a   Boesche, Markus ^a   Delling, Manja ^a   Dümpelfeld, Birgit ^a   Eberhard, Dirk ^a   Huthmacher, Carola ^a   Mathieson, Toby ^a   Poeckel, Daniel ^a   Reader, Valérie ^b   Strunk, Katja ^a   Sweetman, Gavain ^a   Kruse, Ulrich ^a   Neubauer, Gitte ^a   Ramsden, Nigel G ^b   Drewes, Gerard ^a   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b Cellzome Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY DRUGS; CATALYTIC SUBUNITS; CHEMOPROTEOMICS; DEACETYLASE; DIFFERENT EFFECTS; DOWNSTREAM TARGET; HDAC INHIBITORS; HISTONE DEACETYLASES; HYDROXAMATE; LARGE PARTS; PROTEIN COMPLEXES; SMALL MOLECULES;

MASS SPECTROMETRY;

COMPLEXATION;

BENZAMIDE DERIVATIVE; BML 210; BUFEXAMAC; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; ROMIDEPSIN; TACEDINALINE; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN TARGETING; PROTEOMICS; QUANTITATIVE ANALYSIS;

HISTONE DEACETYLASES; MASS SPECTROMETRY; PEPTIDE MAPPING; PROTEIN INTERACTION MAPPING; PROTEOMICS;

EID: 79952396960     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1759     Document Type: Article

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