메뉴 건너뛰기




Volumn 2, Issue 6, 2002, Pages 409-419

Modulating T-cell immunity to tumours: New strategies for monitoring T-cell responses

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; TUMOR ANTIGEN; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; VACCINE;

EID: 0036593490     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc820     Document Type: Review
Times cited : (65)

References (107)
  • 2
    • 0031648808 scopus 로고    scopus 로고
    • Perspective on allogeneic melanoma lysates in active specific immunotherapy
    • Mitchell, M. S. Perspective on allogeneic melanoma lysates in active specific immunotherapy. Semin. Oncol. 25, 623-635 (1998).
    • (1998) Semin. Oncol. , vol.25 , pp. 623-635
    • Mitchell, M.S.1
  • 3
    • 0033562786 scopus 로고    scopus 로고
    • Active specific immunotherapy with polyvalent melanoma cell vaccine for patients with intransit melanoma metastases
    • Hsueh, E. C. et al. Active specific immunotherapy with polyvalent melanoma cell vaccine for patients with intransit melanoma metastases. Cancer 85, 2160-2169 (1999).
    • (1999) Cancer , vol.85 , pp. 2160-2169
    • Hsueh, E.C.1
  • 4
    • 0035489696 scopus 로고    scopus 로고
    • Keyhole limpet hemocyanin conjugate vaccines against cancer: The Memorial Sloan-Kettering experience
    • Musselli, C., Livingston, P. O. #38; Ragupathi, G. Keyhole limpet hemocyanin conjugate vaccines against cancer: The Memorial Sloan-Kettering experience. J. Cancer Res. Clin. Oncol. 127 (Suppl. 2), R20-R26 (2001).
    • (2001) J. Cancer Res. Clin. Oncol. , vol.127 , pp. R20-R26
    • Musselli, C.1    Livingston, P.O.2    Ragupathi, G.3
  • 5
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff, G. et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl Acad. Sci. USA 90, 3539-3543 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1
  • 6
    • 0029841918 scopus 로고    scopus 로고
    • +cell-mediated immunity against tumors located in the 'immunologically privileged' central nervous system
    • +cell-mediated immunity against tumors located in the 'immunologically privileged' central nervous system. Proc. Natl Acad. Sci. USA 93, 10399-10404 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 10399-10404
    • Sampson, J.H.1
  • 7
    • 0030944023 scopus 로고    scopus 로고
    • Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer
    • Simons, J. W. et al. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res. 57, 1537-1546 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 1537-1546
    • Simons, J.W.1
  • 8
    • 2642679384 scopus 로고    scopus 로고
    • 1-biasing cytokines IL-12 and IFN-α
    • 1-biasing cytokines IL-12 and IFN-α. J. Immunol. 160, 1139-1147 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 1139-1147
    • Tuting, T.1
  • 9
    • 0026793994 scopus 로고
    • Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors
    • Kwak, L. W. et al. Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N. Engl. J. Med. 327, 1209-1215 (1992).
    • (1992) N. Engl. J. Med. , vol.327 , pp. 1209-1215
    • Kwak, L.W.1
  • 10
    • 0029839058 scopus 로고    scopus 로고
    • Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo
    • Boczkowski, D., Nair, S. K., Snyder, D. #38; Gilboa, E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. 184, 465-472 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 465-472
    • Boczkowski, D.1    Nair, S.K.2    Snyder, D.3    Gilboa, E.4
  • 11
    • 0035013594 scopus 로고    scopus 로고
    • Direct transfection and activation of human cutaneous dendritic cells
    • Larregina, A. T. et al. Direct transfection and activation of human cutaneous dendritic cells. Gene Ther. 8, 608-617 (2001).
    • (2001) Gene Ther. , vol.8 , pp. 608-617
    • Larregina, A.T.1
  • 12
    • 0033120389 scopus 로고    scopus 로고
    • Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma: A feasibility study
    • Reichardt, V. L. et al. Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma: a feasibility study. Blood 93, 2411-2419 (1999).
    • (1999) Blood , vol.93 , pp. 2411-2419
    • Reichardt, V.L.1
  • 13
    • 0034813794 scopus 로고    scopus 로고
    • T cell antigen receptor vaccines for active therapy of T cell malignancies
    • Reddy, S. A., Okada, C., Wong, C., Bahler, D. #38; Levy, R. T cell antigen receptor vaccines for active therapy of T cell malignancies. Ann. NY Acad. Sci. 941, 97-105 (2001).
    • (2001) Ann. NY Acad. Sci. , vol.941 , pp. 97-105
    • Reddy, S.A.1    Okada, C.2    Wong, C.3    Bahler, D.4    Levy, R.5
  • 14
    • 0031941423 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
    • Nestle, F. O. et al. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nature Med. 4, 328-332 (1998).
    • (1998) Nature Med. , vol.4 , pp. 328-332
    • Nestle, F.O.1
  • 15
    • 0035902607 scopus 로고    scopus 로고
    • Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy
    • Fong, L. et al. Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc. Natl Acad. Sci. USA 98, 8809-8814 (2001). In a clinical trial using dendritic cells pulsed with an altered peptide ligand of CEA to vaccinate patients with colon cancer, the authors show, using tetramer analysis, that expansion of CEA-specific T cells in vivo correlated with clinical responses.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 8809-8814
    • Fong, L.1
  • 16
    • 0033405438 scopus 로고    scopus 로고
    • Vaccination with Mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
    • Thurner, B. et al. Vaccination with Mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J. Exp. Med. 190, 1669-1678 (1999). Regression of individual lesions were observed in 6 out of 11 patients with advanced melanoma receiving a MAGE3-pulsed dendritic-cell vaccine. Antigen-loss variants were identified in residual tumour of some patients.
    • (1999) J. Exp. Med. , vol.190 , pp. 1669-1678
    • Thurner, B.1
  • 17
    • 0022473607 scopus 로고
    • A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes
    • Rosenberg, S. A., Spiess, P. #38; Lafreniere, R. A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science 233, 1318-1321 (1986).
    • (1986) Science , vol.233 , pp. 1318-1321
    • Rosenberg, S.A.1    Spiess, P.2    Lafreniere, R.3
  • 18
    • 0026871222 scopus 로고
    • +HIV-specific T cells for HIV seropositive patients undergoing allogeneic bone marrow transplant
    • The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Department of Medicine, Division of Oncology
    • +HIV-specific T cells for HIV seropositive patients undergoing allogeneic bone marrow transplant. The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Department of Medicine, Division of Oncology. Hum. Gene Ther. 3, 319-338 (1992).
    • (1992) Hum. Gene Ther. , vol.3 , pp. 319-338
    • Riddell, S.R.1
  • 19
    • 0034606276 scopus 로고    scopus 로고
    • Melanocyte destruction after antigen-specific immunotherapy of melanoma: Direct evidence of T cell-mediated vitiligo
    • Yee, C. et al. Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of T cell-mediated vitiligo. J. Exp. Med. 192, 1637-1644 (2000). In a patient receiving adoptive therapy with T-cell clones targeting MART1, transferred T cells were tracked with peptide-MHC tetramers and shown to migrate to antigen-positive sites of skin and tumour and to mediate an antigen-specific immune response.
    • (2000) J. Exp. Med. , vol.192 , pp. 1637-1644
    • Yee, C.1
  • 21
    • 0033558363 scopus 로고    scopus 로고
    • Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
    • Yee, C., Savage, P. A., Lee, P. P., Davis, M. M. #38; Greenberg, P. D. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 162, 2227-2234 (1999). Peptide-MHC tetramers were used to define the TCR affinity of antigen-specific T cells (see also reference 87).
    • (1999) J. Immunol. , vol.162 , pp. 2227-2234
    • Yee, C.1    Savage, P.A.2    Lee, P.P.3    Davis, M.M.4    Greenberg, P.D.5
  • 22
    • 0035868647 scopus 로고    scopus 로고
    • Clinical trial designs for the early clinical development of therapeutic cancer vaccines
    • Simon, R. M. et al. Clinical trial designs for the early clinical development of therapeutic cancer vaccines. J. Clin. Oncol. 19, 1848-1854 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1848-1854
    • Simon, R.M.1
  • 23
    • 0034006703 scopus 로고    scopus 로고
    • Delayed-type hypersensitivity response is a predictor of peripheral blood T-cell immunity after HER-2/neu peptide immunization
    • Disis, M. L. et al. Delayed-type hypersensitivity response is a predictor of peripheral blood T-cell immunity after HER-2/neu peptide immunization. Clin. Cancer Res. 6, 1347-1350 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1347-1350
    • Disis, M.L.1
  • 24
    • 0035013150 scopus 로고    scopus 로고
    • CancerVax, an allogeneic tumor cell vaccine, induces specific humoral and cellular immune responses in advanced colon cancer
    • Habal, N. et al. CancerVax, an allogeneic tumor cell vaccine, induces specific humoral and cellular immune responses in advanced colon cancer. Ann. Surg. Oncol. 8, 389-401 (2001).
    • (2001) Ann. Surg. Oncol. , vol.8 , pp. 389-401
    • Habal, N.1
  • 25
    • 0031713904 scopus 로고    scopus 로고
    • Correlation of specific immune responses with survival in melanoma patients with distant metastases receiving polyvalent melanoma cell vaccine
    • Hsueh, E. C., Gupta, R. K., Qi, K. #38; Morton, D. L. Correlation of specific immune responses with survival in melanoma patients with distant metastases receiving polyvalent melanoma cell vaccine. J. Clin. Oncol. 16, 2913-2920 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2913-2920
    • Hsueh, E.C.1    Gupta, R.K.2    Qi, K.3    Morton, D.L.4
  • 26
    • 0035884621 scopus 로고    scopus 로고
    • Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma
    • Lee, P. et al. Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma. J. Clin. Oncol. 19, 3836-3847 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3836-3847
    • Lee, P.1
  • 27
    • 0030026776 scopus 로고    scopus 로고
    • Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
    • Hsu, F. J. et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med. 2, 52-58 (1996).
    • (1996) Nature Med. , vol.2 , pp. 52-58
    • Hsu, F.J.1
  • 28
    • 0032828653 scopus 로고    scopus 로고
    • Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma
    • Bendandi, M. et al. Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nature Med. 5, 1171-1177 (1999).
    • (1999) Nature Med. , vol.5 , pp. 1171-1177
    • Bendandi, M.1
  • 29
    • 0029642252 scopus 로고
    • Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE3
    • Marchand, M. et al. Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE3. Int. J. Cancer 63, 883-885 (1995).
    • (1995) Int. J. Cancer , vol.63 , pp. 883-885
    • Marchand, M.1
  • 30
    • 0033579934 scopus 로고    scopus 로고
    • Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1
    • Marchand, M. et al. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1. Int. J. Cancer 80, 219-230 (1999).
    • (1999) Int. J. Cancer , vol.80 , pp. 219-230
    • Marchand, M.1
  • 31
    • 0028979830 scopus 로고
    • Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells
    • Mukherji, B. et al. Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells. Proc. Natl Acad. Sci. USA 92, 8078-8082 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 8078-8082
    • Mukherji, B.1
  • 32
    • 0030996710 scopus 로고    scopus 로고
    • Enhancement of cellular immunity in melanoma patients immunized with a peptide from Mart1/Melan A
    • Cormier, J. N. et al. Enhancement of cellular immunity in melanoma patients immunized with a peptide from Mart1/Melan A. Cancer J. Sci. Am. 3, 37-44 (1997).
    • (1997) Cancer J. Sci. Am. , vol.3 , pp. 37-44
    • Cormier, J.N.1
  • 33
    • 0031890206 scopus 로고    scopus 로고
    • Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
    • Rosenberg, S. A. et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nature Med. 4, 321-327 (1998).
    • (1998) Nature Med. , vol.4 , pp. 321-327
    • Rosenberg, S.A.1
  • 34
    • 0038691976 scopus 로고    scopus 로고
    • Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses
    • Jager, E. et al. Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. Proc. Natl Acad. Sci. USA 97, 4760-4765 (2000). References 26-34 describe some of the clinical trials that involve augmentation of an antigen-specific T-cell response.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4760-4765
    • Jager, E.1
  • 35
    • 0029743737 scopus 로고    scopus 로고
    • Phenotypic analysis of antigen-specific T lymphocytes
    • Altman, J. D. et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94-96 (1996).
    • (1996) Science , vol.274 , pp. 94-96
    • Altman, J.D.1
  • 36
    • 0030640564 scopus 로고    scopus 로고
    • T cell receptor biochemistry, repertoire selection and general features of TCR and Ig structure
    • discussion 100-104
    • Davis, M. M. et al. T cell receptor biochemistry, repertoire selection and general features of TCR and Ig structure. Ciba Found. Symp. 204, 94-100; discussion 100-104 (1997).
    • (1997) Ciba Found. Symp. , vol.204 , pp. 94-100
    • Davis, M.M.1
  • 37
    • 0034069840 scopus 로고    scopus 로고
    • Monitoring antigen-specific T cells using MHC-Ig dimers
    • Schneck, J. P. Monitoring antigen-specific T cells using MHC-Ig dimers. Immunol. Invest. 29, 163-169 (2000).
    • (2000) Immunol. Invest. , vol.29 , pp. 163-169
    • Schneck, J.P.1
  • 39
    • 0033056073 scopus 로고    scopus 로고
    • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
    • Lee, P. P. et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nature Med. 5, 677-685 (1999). Multiparametric analysis of endogenous populations of circulating tumour-specific T cells revealed an activational defect in T cells that recognize melanoma-associated differentiation antigens.
    • (1999) Nature Med. , vol.5 , pp. 677-685
    • Lee, P.P.1
  • 40
    • 0032482177 scopus 로고    scopus 로고
    • +T cells during the primary immune response to Epstein-Barr virus in vivo
    • +T cells during the primary immune response to Epstein-Barr virus in vivo. J. Exp. Med. 187, 1395-1402 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 1395-1402
    • Callan, M.F.1
  • 41
    • 0033830856 scopus 로고    scopus 로고
    • In situ detection of virus- and tumor-specific T-cell immunity
    • Haanen, J. et al. In situ detection of virus- and tumor-specific T-cell immunity. Nature Med. 6, 1056-1060 (2000).
    • (2000) Nature Med. , vol.6 , pp. 1056-1060
    • Haanen, J.1
  • 42
    • 0032531977 scopus 로고    scopus 로고
    • Functional dissociation between local and systemic immune response during anti-melanoma peptide vaccination
    • Lee, K. H. et al. Functional dissociation between local and systemic immune response during anti-melanoma peptide vaccination. J. Immunol. 161, 4183-4194 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 4183-4194
    • Lee, K.H.1
  • 43
    • 0031760453 scopus 로고    scopus 로고
    • Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes
    • Pongers-Willemse, M. J. et al. Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes. Leukemia 12, 2006-2014 (1998).
    • (1998) Leukemia , vol.12 , pp. 2006-2014
    • Pongers-Willemse, M.J.1
  • 44
    • 0035964396 scopus 로고    scopus 로고
    • A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3
    • Coulie, P. G. et al. A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3. Proc. Natl Acad. Sci. USA 98, 10290-10295 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10290-10295
    • Coulie, P.G.1
  • 45
    • 13344261952 scopus 로고    scopus 로고
    • T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
    • Riddell, S. R. et al. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med. 2, 216-223 (1996).
    • (1996) Nature Med. , vol.2 , pp. 216-223
    • Riddell, S.R.1
  • 46
    • 0035282726 scopus 로고    scopus 로고
    • A FAS-based suicide switch in human T cells for the treatment of graft-versus-host disease
    • Thomis, D. C. et al. A FAS-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood 97, 1249-1257 (2001).
    • (2001) Blood , vol.97 , pp. 1249-1257
    • Thomis, D.C.1
  • 47
    • 0032973455 scopus 로고    scopus 로고
    • In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
    • Brodie, S. J. et al. In vivo migration and function of transferred HIV-1-specific cytotoxic T cells. Nature Med. 5, 34-41 (1999). In situ localization of gene-marked T-cell clones in situ following adoptive T-cell therapy.
    • (1999) Nature Med. , vol.5 , pp. 34-41
    • Brodie, S.J.1
  • 48
    • 0035227912 scopus 로고    scopus 로고
    • Systematic analysis of clinically applicable conditions leading to a high efficiency of transduction and transgene expression in human T cells
    • Lamana, M. L., Segovia, J. C., Guenechea, G. #38; Bueren, J. A. Systematic analysis of clinically applicable conditions leading to a high efficiency of transduction and transgene expression in human T cells. J. Gene Med. 3, 32-41 (2001).
    • (2001) J. Gene Med. , vol.3 , pp. 32-41
    • Lamana, M.L.1    Segovia, J.C.2    Guenechea, G.3    Bueren, J.A.4
  • 49
    • 0032715902 scopus 로고    scopus 로고
    • Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens
    • Kammula, U. S. et al. Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. J. Immunol. 163, 6867-6875 (1999). Application of real-time PCR analysis of cytokine expression to evaluate antigen-specific T-cell response to vaccination.
    • (1999) J. Immunol. , vol.163 , pp. 6867-6875
    • Kammula, U.S.1
  • 50
    • 0035879817 scopus 로고    scopus 로고
    • Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness
    • Mocellin, S., Ohnmacht, G. A., Wang, E. #38; Marincola, F. M. Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness. Int. J. Cancer 93, 236-242 (2001).
    • (2001) Int. J. Cancer , vol.93 , pp. 236-242
    • Mocellin, S.1    Ohnmacht, G.A.2    Wang, E.3    Marincola, F.M.4
  • 51
    • 0034699514 scopus 로고    scopus 로고
    • Flow cytometric measurement of intracellular cytokines
    • Pala, P., Hussell, T. #38; Openshaw, P. J. M. Flow cytometric measurement of intracellular cytokines. J. Immunol. Methods 243, 107-124 (2000).
    • (2000) J. Immunol. Methods , vol.243 , pp. 107-124
    • Pala, P.1    Hussell, T.2    Openshaw, P.J.M.3
  • 52
    • 0032005477 scopus 로고    scopus 로고
    • Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
    • Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177-187 (1998).
    • (1998) Immunity , vol.8 , pp. 177-187
    • Murali-Krishna, K.1
  • 53
    • 0034781060 scopus 로고    scopus 로고
    • Adoptive tumor therapy with T lymphocytes enriched through an IFN-γ capture assay
    • Becker, C. et al. Adoptive tumor therapy with T lymphocytes enriched through an IFN-γ capture assay. Nature Med. 7, 1159-1162 (2001).
    • (2001) Nature Med. , vol.7 , pp. 1159-1162
    • Becker, C.1
  • 55
    • 12944265542 scopus 로고    scopus 로고
    • Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele
    • Grijatic, S. et al. Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele. Proc. Natl Acad. Sci. USA 97, 10917-10922 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10917-10922
    • Grijatic, S.1
  • 56
    • 0030934741 scopus 로고    scopus 로고
    • +T lymphocytes producing tumor necrosis factor-α spots in response to peptide antigens
    • +T lymphocytes producing tumor necrosis factor-α spots in response to peptide antigens. J. Immunol. Methods 203, 141-152 (1997).
    • (1997) J. Immunol. Methods , vol.203 , pp. 141-152
    • Herr, W.1
  • 57
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • Zajac, A. J. et al. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med 188, 2205-2213 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 2205-2213
    • Zajac, A.J.1
  • 58
    • 0021280520 scopus 로고
    • Limiting dilution assays for the determination of immunocompetent cell frequencies. III. Validity tests for the single-hit Poisson model
    • Taswell, C. Limiting dilution assays for the determination of immunocompetent cell frequencies. III. Validity tests for the single-hit Poisson model. J. Immunol. Methods 72, 29-40 (1984).
    • (1984) J. Immunol. Methods , vol.72 , pp. 29-40
    • Taswell, C.1
  • 59
    • 3242680077 scopus 로고    scopus 로고
    • +cancers
    • +cancers. Proc. Natl Acad. Sci. USA 97, 12198-12203 (2000). Stabilization and regression of individual metastases in some patients with melanoma, receiving a peptide vaccine that targets NY-ESO-1, provide evidence of clinical correlation with ELISPOT analyses.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 12198-12203
    • Jager, E.1
  • 60
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
    • Molldrem, J. J. et al. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nature Med. 6, 1018-1023 (2000).
    • (2000) Nature Med. , vol.6 , pp. 1018-1023
    • Molldrem, J.J.1
  • 61
    • 0033485764 scopus 로고    scopus 로고
    • Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression
    • Lee, K. H. et al. Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression. J. Immunol. 163, 6292-6300 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 6292-6300
    • Lee, K.H.1
  • 62
    • 0035892759 scopus 로고    scopus 로고
    • Dendritic cell-based xenoantigen vaccination for prostate cancer immunotherapy
    • Fong, L. et al. Dendritic cell-based xenoantigen vaccination for prostate cancer immunotherapy. J. Immunol. 167, 7150-7156 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 7150-7156
    • Fong, L.1
  • 63
    • 0022546602 scopus 로고
    • Antigen-driven long term-cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory T cells
    • Cheever, M. A., Thompson, D. B., Klarnet, J. P. #38; Greenberg, P. D. Antigen-driven long term-cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory T cells. J. Exp. Med. 163, 1100-1112 (1986).
    • (1986) J. Exp. Med. , vol.163 , pp. 1100-1112
    • Cheever, M.A.1    Thompson, D.B.2    Klarnet, J.P.3    Greenberg, P.D.4
  • 65
    • 0033514923 scopus 로고    scopus 로고
    • Immune surveillance against a solid tumor fails because of immunological ignorance
    • Ochsenbein, A. F. et al. Immune surveillance against a solid tumor fails because of immunological ignorance. Proc. Natl Acad. Sci. USA 96, 2233-2238 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2233-2238
    • Ochsenbein, A.F.1
  • 66
    • 0030052833 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes in lymph node melanoma metastases: A histopathologic prognostic indicator and an expression of local immune response
    • Mihm, M. C. Jr, Clemente, C. G. #38; Cascinelli, N. Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response. Lab. Invest. 74, 43-47 (1996).
    • (1996) Lab. Invest. , vol.74 , pp. 43-47
    • Mihm, M.C.1    Clemente, C.G.2    Cascinelli, N.3
  • 67
    • 0016333115 scopus 로고
    • Lymphoreticular infiltration in human tumours: Prognostic and biological implications: A review
    • Underwood, J. C. Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review. Br. J. Cancer 30, 538-548 (1974).
    • (1974) Br. J. Cancer , vol.30 , pp. 538-548
    • Underwood, J.C.1
  • 68
    • 0017875251 scopus 로고    scopus 로고
    • Colonic carcinoma: A quantitative assessment of lymphocyte infiltration at the periphery of colonic tumors related to prognosis
    • Watt, A. G. #38; House, A. K. Colonic carcinoma: a quantitative assessment of lymphocyte infiltration at the periphery of colonic tumors related to prognosis. Cancer 41, 279-282.
    • Cancer , vol.41 , pp. 279-282
    • Watt, A.G.1    House, A.K.2
  • 69
    • 0017844528 scopus 로고
    • The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer
    • van Nagell, J. R. Jr, Donaldson, E. S. Wood, E. G. #38; Parker, J. C. Jr. The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer. Cancer 41, 228-234 (1978).
    • (1978) Cancer , vol.41 , pp. 228-234
    • Van Nagell, J.R.1    Donaldson, E.S.2    Wood, E.G.3    Parker, J.C.4
  • 70
    • 0033680870 scopus 로고    scopus 로고
    • +T cell adoptive immunotherapy
    • +T cell adoptive immunotherapy. Immunity 13, 265-276 (2000).
    • (2000) Immunity , vol.13 , pp. 265-276
    • Hanson, H.L.1
  • 71
    • 0031980506 scopus 로고    scopus 로고
    • Activation of cytotoxic T cells by solid tumours?
    • Speiser, D. E. #38; Ohashi, P. S. Activation of cytotoxic T cells by solid tumours? Cell. Mol. Life Sci. 54, 263-271 (1998).
    • (1998) Cell. Mol. Life Sci. , vol.54 , pp. 263-271
    • Speiser, D.E.1    Ohashi, P.S.2
  • 72
    • 0035963379 scopus 로고    scopus 로고
    • Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction
    • Ochsenbein, A. F. et al. Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature 411, 1058-1064 (2001).
    • (2001) Nature , vol.411 , pp. 1058-1064
    • Ochsenbein, A.F.1
  • 73
    • 0035655953 scopus 로고    scopus 로고
    • Bioluminescence imaging of lymphocyte trafficking in vivo
    • Hardy, J. et al. Bioluminescence imaging of lymphocyte trafficking in vivo. Exp. Hematol. 29, 1353-1360 (2001).
    • (2001) Exp. Hematol. , vol.29 , pp. 1353-1360
    • Hardy, J.1
  • 74
    • 0027056895 scopus 로고
    • Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
    • Mizoguchi, H. et al. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 258, 1795-1798 (1992).
    • (1992) Science , vol.258 , pp. 1795-1798
    • Mizoguchi, H.1
  • 75
    • 0031157453 scopus 로고    scopus 로고
    • Sequential development of structural and functional alterations in T cells from tumor-bearing mice
    • Correa, M. R. et al. Sequential development of structural and functional alterations in T cells from tumor-bearing mice. J. Immunol. 158, 5292-5296 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 5292-5296
    • Correa, M.R.1
  • 77
    • 0033168651 scopus 로고    scopus 로고
    • +T cells become nonresponsive (anergic) following activation in the presence of costimulation
    • +T cells become nonresponsive (anergic) following activation in the presence of costimulation. J. Immunol. 163, 102-110 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 102-110
    • Deeths, M.J.1    Kedl, R.M.2    Mescher, M.F.3
  • 78
    • 0032477815 scopus 로고    scopus 로고
    • Induction of antigen-specific T cell anergy: An early event in the course of tumor progression
    • Staveley-O'Carroll, K. et al. Induction of antigen-specific T cell anergy: an early event in the course of tumor progression. Proc. Natl Acad. Sci. USA 95, 1178-1183 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 1178-1183
    • Staveley-O'Carroll, K.1
  • 79
    • 0025055406 scopus 로고
    • A highly immunogenic tumor transfected with a murine transforming growth factor type-B1 cDNA escapes immune surveillance
    • Torre-Amione, G. et al. A highly immunogenic tumor transfected with a murine transforming growth factor type-B1 cDNA escapes immune surveillance. Proc. Natl Acad. Sci. USA 87, 1486-1490 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 1486-1490
    • Torre-Amione, G.1
  • 81
    • 0029798058 scopus 로고    scopus 로고
    • Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction
    • Toes, R. E., Offringa, R., Blom, R. J., Melief, C. J. #38; Kast, W. M. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. Proc. Natl Acad. Sci. USA 93, 7855-7860 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 7855-7860
    • Toes, R.E.1    Offringa, R.2    Blom, R.J.3    Melief, C.J.4    Kast, W.M.5
  • 82
    • 0029965055 scopus 로고    scopus 로고
    • Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
    • Alexander-Miller, M. A., Leggatt, G. R. #38; Berzofsky, J. A. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl Acad. Sci. USA 93, 4102-4107 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4102-4107
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Berzofsky, J.A.3
  • 83
    • 0029895748 scopus 로고    scopus 로고
    • Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions
    • Gervois, N., Guilloux, Y., Diez, E. #38; Jotereau, F. Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions. J. Exp. Med. 183, 2403-2407 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 2403-2407
    • Gervois, N.1    Guilloux, Y.2    Diez, E.3    Jotereau, F.4
  • 84
    • 0032101405 scopus 로고    scopus 로고
    • Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
    • Crawford, F., Kozono, H., White, J., Marrack, P. #38; Kappler, J. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 8, 675-682 (1998).
    • (1998) Immunity , vol.8 , pp. 675-682
    • Crawford, F.1    Kozono, H.2    White, J.3    Marrack, P.4    Kappler, J.5
  • 85
    • 0033118739 scopus 로고    scopus 로고
    • A kinetic basis for T cell receptor repertoire selection during an immune response
    • Savage, P. A., Boniface, J. J. #38; Davis, M. M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10, 485-492 (1999).
    • (1999) Immunity , vol.10 , pp. 485-492
    • Savage, P.A.1    Boniface, J.J.2    Davis, M.M.3
  • 86
    • 0029810990 scopus 로고    scopus 로고
    • Isolation of multiple mRNAs from a few eukaryotic cells: A fast method to obtain templates for RT-PCR
    • Noppen, C., Spagnoli, G. C. #38; Schaefer, C, Isolation of multiple mRNAs from a few eukaryotic cells: a fast method to obtain templates for RT-PCR. Biotechniques 21, 394-396 (1996).
    • (1996) Biotechniques , vol.21 , pp. 394-396
    • Noppen, C.1    Spagnoli, G.C.2    Schaefer, C.3
  • 87
    • 0036467414 scopus 로고    scopus 로고
    • Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR
    • Dutoit, V. et al. Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR. J. Immunol. 168, 1167-1171 (2002). Peptide-MHC tetramers were used to define the TCR affinity of antigen-specific T cells (see also reference 21).
    • (2002) J. Immunol. , vol.168 , pp. 1167-1171
    • Dutoit, V.1
  • 89
    • 0019977370 scopus 로고
    • Immunoselection of tumor cell variants by mice suppressed with ultraviolet radiation
    • Urban, J. L., Holland, J. M., Kripke, M. L. Schreider H. Immunoselection of tumor cell variants by mice suppressed with ultraviolet radiation. J. Exp. Med. 156, 1025-1041 (1982).
    • (1982) J. Exp. Med. , vol.156 , pp. 1025-1041
    • Urban, J.L.1    Holland, J.M.2    Kripke, M.L.3    Schreider, H.4
  • 90
    • 0035889605 scopus 로고    scopus 로고
    • Primary melanoma tumour regression associated with an immune response to the tumour-associated antigen Melan-A/MART-1
    • Saleh, F. H., Crotty, K. A., Hersey, P. #38; Menzies, S. W. Primary melanoma tumour regression associated with an immune response to the tumour-associated antigen Melan-A/MART-1. Int. J. Cancer 94, 551-557 (2001).
    • (2001) Int. J. Cancer , vol.94 , pp. 551-557
    • Saleh, F.H.1    Crotty, K.A.2    Hersey, P.3    Menzies, S.W.4
  • 91
    • 0035953308 scopus 로고    scopus 로고
    • IFN-γ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran, V. et al. IFN-γ and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410, 1107-1111 (2001). Endogenous immunoselection of tumour cells can lead to the appearance of antigen-loss tumour variants that escape immune detection in the immunocompetent host.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1
  • 92
    • 0033985781 scopus 로고    scopus 로고
    • Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases
    • Panelli, M. C. et al. Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases. J. Immunol. 164, 495-504 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 495-504
    • Panelli, M.C.1
  • 93
    • 0032520053 scopus 로고    scopus 로고
    • HLA class I antigen and transporter associated with antigen processing (TAP1 and TAP2) down-regulation in high-grade primary breast carcinoma lesions
    • Vitale, M. et al. HLA class I antigen and transporter associated with antigen processing (TAP1 and TAP2) down-regulation in high-grade primary breast carcinoma lesions. Cancer Res. 58, 737-742 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 737-742
    • Vitale, M.1
  • 94
    • 0029057043 scopus 로고
    • Loss of HLA class I antigens by melanoma cells: Molecular mechanisms, functional significance and clinical relevance
    • Ferrone, S. #38; Marincola, F. M. Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance. Immunol. Today 16, 487-494 (1995).
    • (1995) Immunol. Today , vol.16 , pp. 487-494
    • Ferrone, S.1    Marincola, F.M.2
  • 95
    • 0029794179 scopus 로고    scopus 로고
    • Development and characterization of rabbit antisera to human MHC-linked transporters associated with antigen processing
    • Hicklin, D. J., Kageshita, T. #38; Ferrone, S. Development and characterization of rabbit antisera to human MHC-linked transporters associated with antigen processing. Tissue Antigens 48, 38-46 (1996).
    • (1996) Tissue Antigens , vol.48 , pp. 38-46
    • Hicklin, D.J.1    Kageshita, T.2    Ferrone, S.3
  • 96
    • 0030011689 scopus 로고    scopus 로고
    • Molecular and functional phenotypes of melanoma cells with abnormalities in HLA class I antigen expression
    • Wang, Z., Margulies, L., Hicklin, D. J. #38; Ferrone, S. Molecular and functional phenotypes of melanoma cells with abnormalities in HLA class I antigen expression. Tissue Antigens 47, 382-390 (1996).
    • (1996) Tissue Antigens , vol.47 , pp. 382-390
    • Wang, Z.1    Margulies, L.2    Hicklin, D.J.3    Ferrone, S.4
  • 97
    • 0029094021 scopus 로고
    • In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD 28 costimulation
    • Yang, G., Hellstrom, K. E., Mizuno, M. T. #38; Chen, L. In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD28 costimulation. J. Immunol. 155, 3897-3903 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 3897-3903
    • Yang, G.1    Hellstrom, K.E.2    Mizuno, M.T.3    Chen, L.4
  • 98
    • 0035865146 scopus 로고    scopus 로고
    • Role of TGF-β in immune-evasion of cancer
    • Beck, C., Schreiber, H. #38; Rowley, D. Role of TGF-β in immune-evasion of cancer. Microsc. Res. Tech. 52, 387-395 (2001).
    • (2001) Microsc. Res. Tech. , vol.52 , pp. 387-395
    • Beck, C.1    Schreiber, H.2    Rowley, D.3
  • 99
    • 9544237126 scopus 로고    scopus 로고
    • The cytokine microenvironment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-α and interleukin-4 predicts improved survival
    • Barth, R. J. Jr, Camp, B. J., Martuscello, T. A., Dain, B. J. #38; Memoli, V.A. The cytokine microenvironment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-α and interleukin-4 predicts improved survival. Cancer 78, 1168-1178 (1996).
    • (1996) Cancer , vol.78 , pp. 1168-1178
    • Barth, R.J.1    Camp, B.J.2    Martuscello, T.A.3    Dain, B.J.4    Memoli, V.A.5
  • 100
    • 0028829736 scopus 로고
    • Alterations in T cell receptor and signal transduction molecules in melanoma patients
    • Zea, A. H. et al. Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin. Cancer Res. 1, 1327-1335 (1995).
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1327-1335
    • Zea, A.H.1
  • 101
    • 0032715757 scopus 로고    scopus 로고
    • Differential loss of T cell signaling molecules in metastatic melanoma patients' T lymphocyte subsets expressing distinct TCR variable regions
    • Maccalli, C. et al. Differential loss of T cell signaling molecules in metastatic melanoma patients' T lymphocyte subsets expressing distinct TCR variable regions J. Immunol. 163, 6912-6923 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 6912-6923
    • Maccalli, C.1
  • 102
    • 0036095702 scopus 로고    scopus 로고
    • Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: A novel protective mechanism for tumor cells to circumvent the immune system?
    • Bladergroen, B. A. et al. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? Blood 99, 232-237 (2002).
    • (2002) Blood , vol.99 , pp. 232-237
    • Bladergroen, B.A.1
  • 103
    • 0033523670 scopus 로고    scopus 로고
    • Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    • Medema, J. P., de Jong, J., van Hall, T, Melief, C. J. #38; Offringa, R. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J. Exp. Med. 190, 1033-1038 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1033-1038
    • Medema, J.P.1    De Jong, J.2    Van Hall, T.3    Melief, C.J.4    Offringa, R.5
  • 104
    • 0030746636 scopus 로고    scopus 로고
    • A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma
    • Ambrosini, G., Adida, C. #38; Altieri, D.C. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma. Nature Med. 3, 917-921 (1997).
    • (1997) Nature Med. , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 105
    • 0032779988 scopus 로고    scopus 로고
    • Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1
    • Nakashima, M., Sonoda, K. #38; Watanabe, T. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1. Nature Med. 5, 938-942 (1999).
    • (1999) Nature Med. , vol.5 , pp. 938-942
    • Nakashima, M.1    Sonoda, K.2    Watanabe, T.3
  • 106
    • 0035339270 scopus 로고    scopus 로고
    • A potential immune escape mechanism by melanoma cells through the activation of chemokine-induced T cell death
    • Mellado, M., de Ana, A. M., Moreno, M. C., Martinez, C. #38; Rodriguez-Frade, J. M. A potential immune escape mechanism by melanoma cells through the activation of chemokine-induced T cell death. Curr. Biol. 11, 691-696 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 691-696
    • Mellado, M.1    De Ana, A.M.2    Moreno, M.C.3    Martinez, C.4    Rodriguez-Frade, J.M.5
  • 107
    • 0032883551 scopus 로고    scopus 로고
    • Development and characterization of melanoma cell lines established by fine-needle aspiration biopsy: Advances in the monitoring of patients with metastatic melanoma
    • Riker, A. I. et al. Development and characterization of melanoma cell lines established by fine-needle aspiration biopsy: advances in the monitoring of patients with metastatic melanoma. Cancer Detect. Prev. 23, 387-396 (1999). References 93-107 describe mechanisms of tumour immune escape through defects in antigen expression or antigen presentation (references 93-96), the presence of an immune-suppressive tumour microenvironment (references 97-101) and tumour upregulation of immunoprotective mechanisms (references 101-107).
    • (1999) Cancer Detect. Prev. , vol.23 , pp. 387-396
    • Riker, A.I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.