-
1
-
-
0026740497
-
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germline
-
Kafri, T. et al. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germline. Genes Dev. 6, 705-714 (1992).
-
(1992)
Genes Dev
, vol.6
, pp. 705-714
-
-
Kafri, T.1
-
2
-
-
0023119242
-
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
-
Monk, M., Boubelik, M. & Lehnert, S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99, 371-382 (1987).
-
(1987)
Development
, vol.99
, pp. 371-382
-
-
Monk, M.1
Boubelik, M.2
Lehnert, S.3
-
3
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
Okano, M., Bell, D. W., Haber, D. A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999).
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
4
-
-
0028104109
-
Sp1 elements protect a CpG island from de novo methylation
-
Brandeis, M. et al. Sp1 elements protect a CpG island from de novo methylation. Nature 371, 435-438 (1994).
-
(1994)
Nature
, vol.371
, pp. 435-438
-
-
Brandeis, M.1
-
5
-
-
0032992224
-
DNA methylation represses transcription in vivo
-
Siegfried, Z. et al. DNA methylation represses transcription in vivo. Nature Genet. 22, 203-206 (1999).
-
(1999)
Nature Genet
, vol.22
, pp. 203-206
-
-
Siegfried, Z.1
-
6
-
-
0027960055
-
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island
-
Macleod, D., Charlton, J., Mullins, J. & Bird, A. P. Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8, 2282-2292 (1994).
-
(1994)
Genes Dev
, vol.8
, pp. 2282-2292
-
-
Macleod, D.1
Charlton, J.2
Mullins, J.3
Bird, A.P.4
-
7
-
-
0025869047
-
Demethylation of CpG islands in embryonic cells
-
Frank, D. et al. Demethylation of CpG islands in embryonic cells. Nature 351, 239-241 (1991).
-
(1991)
Nature
, vol.351
, pp. 239-241
-
-
Frank, D.1
-
8
-
-
34547725157
-
-
Ooi, S. K. et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 448, 714-717 (2007). References 8 and 10 show that Dnmt3L interacts with unmethylated H3K4 through its n terminus and with Dnmt3a through its C terminus, thus linking the Dna methylation machinery to the modification state of histone tails.
-
Ooi, S. K. et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 448, 714-717 (2007). References 8 and 10 show that Dnmt3L interacts with unmethylated H3K4 through its n terminus and with Dnmt3a through its C terminus, thus linking the Dna methylation machinery to the modification state of histone tails.
-
-
-
-
9
-
-
34447098370
-
-
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R. & Young, R. A. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130, 77-88 (2007).
-
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R. & Young, R. A. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130, 77-88 (2007).
-
-
-
-
10
-
-
34548603504
-
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
-
Jia, D., Jurkowska, R. Z., Zhang, X., Jeltsch, A. & Cheng, X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 449, 248-251 (2007).
-
(2007)
Nature
, vol.449
, pp. 248-251
-
-
Jia, D.1
Jurkowska, R.Z.2
Zhang, X.3
Jeltsch, A.4
Cheng, X.5
-
11
-
-
0035930660
-
Dnmt3L and the establishment of maternal genomic imprints
-
Bourc'his, D., Xu, G. L., Lin, C. S., Bollman, B. & Bestor, T. H. Dnmt3L and the establishment of maternal genomic imprints. Science 294, 2536-2539 (2001).
-
(2001)
Science
, vol.294
, pp. 2536-2539
-
-
Bourc'his, D.1
Xu, G.L.2
Lin, C.S.3
Bollman, B.4
Bestor, T.H.5
-
12
-
-
34047116826
-
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
-
Weber, M. et al. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nature Genet. 39, 457-466 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 457-466
-
-
Weber, M.1
-
13
-
-
51649129596
-
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
-
Mohn, F. et al. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol. Cell 30, 755-766 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 755-766
-
-
Mohn, F.1
-
14
-
-
49649125042
-
Genome-scale DNA methylation maps of pluripotent and differentiated cells
-
Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766-770 (2008).
-
(2008)
Nature
, vol.454
, pp. 766-770
-
-
Meissner, A.1
-
15
-
-
34147197541
-
DNA methylation dictates histone H3K4 methylation
-
Okitsu, C. Y. & Hsieh, C. L. DNA methylation dictates histone H3K4 methylation. Mol. Cell. Biol. 27, 2746-2757 (2007).
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 2746-2757
-
-
Okitsu, C.Y.1
Hsieh, C.L.2
-
16
-
-
23044514626
-
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber, M. et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nature Genet. 37, 853-862 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 853-862
-
-
Weber, M.1
-
17
-
-
0037072943
-
A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element
-
Gidekel, S. & Bergman, Y. A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J. Biol. Chem. 277, 34521-34530 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 34521-34530
-
-
Gidekel, S.1
Bergman, Y.2
-
18
-
-
23444450223
-
Regulation of the Oct-4 gene by nuclear receptors
-
Sylvester, I. & Scholer, H. R. Regulation of the Oct-4 gene by nuclear receptors. Nucleic Acids Res. 22, 901-911 (1994).
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 901-911
-
-
Sylvester, I.1
Scholer, H.R.2
-
19
-
-
0028821102
-
A dynamic balance between ARP-1/ COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells
-
Ben-Shushan, E., Sharir, H., Pikarsky, E. & Bergman, Y. A dynamic balance between ARP-1/ COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol. Cell. Biol. 15, 1034-1048 (1995).
-
(1995)
Mol. Cell. Biol
, vol.15
, pp. 1034-1048
-
-
Ben-Shushan, E.1
Sharir, H.2
Pikarsky, E.3
Bergman, Y.4
-
20
-
-
0035460556
-
Mouse germline restriction of Oct4 expression by germ cell nuclear factor
-
Fuhrmann, G. et al. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev. Cell 1, 377-387 (2001).
-
(2001)
Dev. Cell
, vol.1
, pp. 377-387
-
-
Fuhrmann, G.1
-
21
-
-
33645132331
-
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
-
References 21 and 22 show that G9a inactivates early embryonic genes. Histone methylation is shown to block target gene reactivation in the absence of repressors, whereas Dna methylation prevents reprogramming
-
Feldman, N. et al. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nature Cell Biol. 8, 188-194 (2006). References 21 and 22 show that G9a inactivates early embryonic genes. Histone methylation is shown to block target gene reactivation in the absence of repressors, whereas Dna methylation prevents reprogramming.
-
(2006)
Nature Cell Biol
, vol.8
, pp. 188-194
-
-
Feldman, N.1
-
22
-
-
55549145072
-
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
-
Epsztejn-Litman, S. et al. De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nature Struct. Mol. Biol. 15, 1176-1183 (2008).
-
(2008)
Nature Struct. Mol. Biol
, vol.15
, pp. 1176-1183
-
-
Epsztejn-Litman, S.1
-
23
-
-
10744230544
-
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
-
Lehnertz, B. et al. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13, 1192-1200 (2003).
-
(2003)
Curr. Biol
, vol.13
, pp. 1192-1200
-
-
Lehnertz, B.1
-
24
-
-
0038412822
-
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
-
Fuks, F., Hurd, P. J., Deplus, R. & Kouzarides, T. The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res. 31, 2305-2312 (2003).
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 2305-2312
-
-
Fuks, F.1
Hurd, P.J.2
Deplus, R.3
Kouzarides, T.4
-
25
-
-
11844265935
-
RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production
-
Sugiyama, T. , Cam, H., Verdel, A., Moazed, D. & Grewal, S. I. RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc. Natl. Acad. Sci. USA 102, 152-157 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 152-157
-
-
Sugiyama, T.1
Cam, H.2
Verdel, A.3
Moazed, D.4
Grewal, S.I.5
-
26
-
-
13844294261
-
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
-
Kanellopoulou, C. et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 19, 489-501 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 489-501
-
-
Kanellopoulou, C.1
-
27
-
-
4143149753
-
Dicer is essential for formation of the heterochromatin structure in vertebrate cells
-
Fukagawa, T. et al. Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nature Cell Biol. 6, 784-791 (2004).
-
(2004)
Nature Cell Biol
, vol.6
, pp. 784-791
-
-
Fukagawa, T.1
-
28
-
-
27844468128
-
Possible involvement of the RNAi pathway in trinucleotide repeat expansion diseases
-
Malinina, L. Possible involvement of the RNAi pathway in trinucleotide repeat expansion diseases. J. Biomol. Struct. Dyn. 23, 233-235 (2005).
-
(2005)
J. Biomol. Struct. Dyn
, vol.23
, pp. 233-235
-
-
Malinina, L.1
-
29
-
-
54049138948
-
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation
-
Pandey, R. R. et al. Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol. Cell 32, 232-246 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 232-246
-
-
Pandey, R.R.1
-
30
-
-
55349109963
-
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
-
Zhao, J., Sun, B. K., Erwin, J. A., Song, J. J. & Lee, J. T. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322, 750-756 (2008).
-
(2008)
Science
, vol.322
, pp. 750-756
-
-
Zhao, J.1
Sun, B.K.2
Erwin, J.A.3
Song, J.J.4
Lee, J.T.5
-
31
-
-
56549111129
-
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin
-
Nagano, T. et al. The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science 322, 1717-1720 (2008).
-
(2008)
Science
, vol.322
, pp. 1717-1720
-
-
Nagano, T.1
-
32
-
-
0035891265
-
A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
-
Tamaru, H. & Selker, E. U. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414, 277-283 (2001).
-
(2001)
Nature
, vol.414
, pp. 277-283
-
-
Tamaru, H.1
Selker, E.U.2
-
33
-
-
0037041422
-
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
-
Jackson, J. P. , Lindroth, A. M., Cao, X. & Jacobsen, S. E. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416, 556-560 (2002).
-
(2002)
Nature
, vol.416
, pp. 556-560
-
-
Jackson, J.P.1
Lindroth, A.M.2
Cao, X.3
Jacobsen, S.E.4
-
34
-
-
1542377316
-
-
Osipovich, O. t al. Targeted inhibition of V(D)J recombination by a histone methyltransferase. Nature Immunol. 5, 309-316 (2004).
-
Osipovich, O. t al. Targeted inhibition of V(D)J recombination by a histone methyltransferase. Nature Immunol. 5, 309-316 (2004).
-
-
-
-
35
-
-
0027096740
-
Properties and localization of DNA methyltransferase in preimplantation mouse embryos: Implications for genomic imprinting
-
Carlson, L. L., Page, A. W. amp; Bestor, T. H. Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting. Genes Dev. 6, 2536-2541 (1992).
-
(1992)
Genes Dev
, vol.6
, pp. 2536-2541
-
-
Carlson, L.L.1
Page, A.W.2
Bestor, T.H.3
-
36
-
-
0026439115
-
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
-
Leonhardt, H., Page, A. W., Weier, H. U. amp; Bestor, T. H. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71, 865-873 (1992).
-
(1992)
Cell
, vol.71
, pp. 865-873
-
-
Leonhardt, H.1
Page, A.W.2
Weier, H.U.3
Bestor, T.H.4
-
37
-
-
34648833002
-
UHRF1 plays a role in maintaining DNA methylation in mammalian cells
-
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760-1764 (2007).
-
(2007)
Science
, vol.317
, pp. 1760-1764
-
-
Bostick, M.1
-
38
-
-
36849072573
-
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
-
Sharif, J. et al. The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature 450, 908-912 (2007).
-
(2007)
Nature
, vol.450
, pp. 908-912
-
-
Sharif, J.1
-
39
-
-
41649115827
-
The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression
-
Achour, M. et al. The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene 27, 2187-2197 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 2187-2197
-
-
Achour, M.1
-
40
-
-
43749098985
-
DNA methylation landscapes: Provocative insights from epigenomics
-
Suzuki, M. M. amp; Bird, A. DNA methylation landscapes: provocative insights from epigenomics. Nature Rev. Genet. 9, 465-476 (2008).
-
(2008)
Nature Rev. Genet
, vol.9
, pp. 465-476
-
-
Suzuki, M.M.1
Bird, A.2
-
41
-
-
34250188803
-
Genomic patterns of DNA methylation: Targets and function of an epigenetic mark
-
Weber, M. amp; Schubeler, D. Genomic patterns of DNA methylation: targets and function of an epigenetic mark. Curr. Opin. Cell Biol. 19, 273-280 (2007).
-
(2007)
Curr. Opin. Cell Biol
, vol.19
, pp. 273-280
-
-
Weber, M.1
Schubeler, D.2
-
42
-
-
67349238669
-
-
Eden, S., Hashimshony, T. , Keshet, I., Thorne, A. W. amp; Cedar, H. DNA methylation models histone acetylation. Nature 394, 842-843 (1998).
-
Eden, S., Hashimshony, T. , Keshet, I., Thorne, A. W. amp; Cedar, H. DNA methylation models histone acetylation. Nature 394, 842-843 (1998).
-
-
-
-
43
-
-
0038243168
-
-
Hashimshony, T. , Zhang, J., Keshet, I., Bustin, M. amp; Cedar, H. The role of DNA methylation in setting up chromatin structure during development. Nature Genet. 34, 187-192 (2003).
-
Hashimshony, T. , Zhang, J., Keshet, I., Bustin, M. amp; Cedar, H. The role of DNA methylation in setting up chromatin structure during development. Nature Genet. 34, 187-192 (2003).
-
-
-
-
44
-
-
0032574977
-
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
-
Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389 (1998).
-
(1998)
Nature
, vol.393
, pp. 386-389
-
-
Nan, X.1
-
45
-
-
0031837109
-
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
-
Jones, P. L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet. 19, 187-191 (1998).
-
(1998)
Nature Genet
, vol.19
, pp. 187-191
-
-
Jones, P.L.1
-
46
-
-
33751209468
-
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication
-
Esteve, P. O. et al. Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev. 20, 3089-3103 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 3089-3103
-
-
Esteve, P.O.1
-
47
-
-
34249692514
-
Role of DNA methylation in stable gene repression
-
Lande-Diner, L. et al. Role of DNA methylation in stable gene repression. J. Biol. Chem. 282, 12194-12200 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 12194-12200
-
-
Lande-Diner, L.1
-
48
-
-
55549141877
-
Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks
-
Zilberman, D., Coleman-Derr, D., Ballinger, T. amp; Henikoff, S. Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature 456, 125-129 (2008).
-
(2008)
Nature
, vol.456
, pp. 125-129
-
-
Zilberman, D.1
Coleman-Derr, D.2
Ballinger, T.3
Henikoff, S.4
-
49
-
-
54349095323
-
-
Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H. amp; Shinkai, Y. G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J. 27, 2681-2690 (2008).
-
Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H. amp; Shinkai, Y. G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J. 27, 2681-2690 (2008).
-
-
-
-
50
-
-
54349114603
-
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity
-
Dong, K. B. et al. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J. 27, 2691-2701 (2008).
-
(2008)
EMBO J
, vol.27
, pp. 2691-2701
-
-
Dong, K.B.1
-
51
-
-
32844459336
-
The Polycomb group protein EZH2 directly controls DNA methylation
-
Vire, E. et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439, 871-874 (2006).
-
(2006)
Nature
, vol.439
, pp. 871-874
-
-
Vire, E.1
-
52
-
-
33745811234
-
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells
-
Li, H. et al. The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells. J. Biol. Chem. 281, 19489-19500 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 19489-19500
-
-
Li, H.1
-
53
-
-
34249066239
-
Functional cooperation between HP1 and DNMT1 mediates gene silencing
-
Smallwood, A., Esteve, P. O., Pradhan, S. amp; Carey, M. Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev. 21, 1169-1178 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 1169-1178
-
-
Smallwood, A.1
Esteve, P.O.2
Pradhan, S.3
Carey, M.4
-
54
-
-
1242271994
-
-
Freitag, M., Hickey, P. C., Khlafallah, T. K., Read, N. D. amp; Selker, E. U. HP1 is essential for DNA methylation in Neurospora. Mol. Cell 13, 427-434 (2004).
-
Freitag, M., Hickey, P. C., Khlafallah, T. K., Read, N. D. amp; Selker, E. U. HP1 is essential for DNA methylation in Neurospora. Mol. Cell 13, 427-434 (2004).
-
-
-
-
55
-
-
22944489197
-
Silence of the genes - mechanisms of long-term repression
-
Lande-Diner, L. amp; Cedar, H. Silence of the genes - mechanisms of long-term repression. Nature Rev. Genet. 6, 648-654 (2005).
-
(2005)
Nature Rev. Genet
, vol.6
, pp. 648-654
-
-
Lande-Diner, L.1
Cedar, H.2
-
56
-
-
0028968802
-
The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
-
Schoenherr, C. J. amp; Anderson, D. J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267, 1360-1363 (1995).
-
(1995)
Science
, vol.267
, pp. 1360-1363
-
-
Schoenherr, C.J.1
Anderson, D.J.2
-
57
-
-
0026762526
-
Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster
-
Franke, A. et al. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 11 , 2941-2950 (1992).
-
(1992)
EMBO J
, vol.11
, pp. 2941-2950
-
-
Franke, A.1
-
58
-
-
33646882068
-
Polycomb complexes repress developmental regulators in murine embryonic stem cells
-
Boyer, L. A. et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-353 (2006).
-
(2006)
Nature
, vol.441
, pp. 349-353
-
-
Boyer, L.A.1
-
59
-
-
33646865180
-
Control of developmental regulators by polycomb in human embryonic stem cells
-
Lee, T. I. et al. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125, 301-313 (2006).
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
-
60
-
-
55549103314
-
A model for transmission of the H3K27me3 epigenetic mark
-
Hansen, K. H. et al. A model for transmission of the H3K27me3 epigenetic mark. Nature Cell Biol. 10, 1291-1300 (2008).
-
(2008)
Nature Cell Biol
, vol.10
, pp. 1291-1300
-
-
Hansen, K.H.1
-
61
-
-
42249094716
-
Chromatin dynamics during epigenetic reprogramming in the mouse germ line
-
Hajkova, P. et al. Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature 452, 877-881 (2008).
-
(2008)
Nature
, vol.452
, pp. 877-881
-
-
Hajkova, P.1
-
62
-
-
44649200464
-
Polycomb complexes and epigenetic states
-
Schwartz, Y. B. amp; Pirrotta, V. Polycomb complexes and epigenetic states. Curr. Opin. Cell Biol. 20, 266-273 (2008).
-
(2008)
Curr. Opin. Cell Biol
, vol.20
, pp. 266-273
-
-
Schwartz, Y.B.1
Pirrotta, V.2
-
63
-
-
41749108163
-
Stem cell regulation by polycomb repressors: Postponing commitment
-
Pietersen, A. M. amp; van Lohuizen, M. Stem cell regulation by polycomb repressors: postponing commitment. Curr. Opin. Cell Biol. 20, 201-207 (2008).
-
(2008)
Curr. Opin. Cell Biol
, vol.20
, pp. 201-207
-
-
Pietersen, A.M.1
van Lohuizen, M.2
-
64
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326 (2006).
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
-
65
-
-
34547624303
-
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
-
Mikkelsen, T. S. et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448, 553-560 (2007).
-
(2007)
Nature
, vol.448
, pp. 553-560
-
-
Mikkelsen, T.S.1
-
66
-
-
34548434716
-
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells
-
Pan, G. et al. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell 1, 299-312 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 299-312
-
-
Pan, G.1
-
67
-
-
34548424709
-
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells
-
Zhao, X. D. et al. Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 1, 286-298 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 286-298
-
-
Zhao, X.D.1
-
68
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007).
-
(2007)
Cell
, vol.129
, pp. 823-837
-
-
Barski, A.1
-
69
-
-
0037413703
-
Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development
-
Hershko, A. Y., Kafri, T., Fainsod, A. amp; Razin, A. Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development. Gene 302, 65-72 (2003).
-
(2003)
Gene
, vol.302
, pp. 65-72
-
-
Hershko, A.Y.1
Kafri, T.2
Fainsod, A.3
Razin, A.4
-
70
-
-
58549109636
-
X chromosome dosage compensation: How mammals keep the balance
-
Payer, B. amp; Lee, J. T. X chromosome dosage compensation: how mammals keep the balance. Annu. Rev. Genet. 42, 733-772 (2008).
-
(2008)
Annu. Rev. Genet
, vol.42
, pp. 733-772
-
-
Payer, B.1
Lee, J.T.2
-
71
-
-
0023657424
-
Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation
-
Lock, L. F., Takagi, N. amp; Martin, G. R. Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation. Cell 48, 39-46 (1987).
-
(1987)
Cell
, vol.48
, pp. 39-46
-
-
Lock, L.F.1
Takagi, N.2
Martin, G.R.3
-
72
-
-
0029144450
-
Developmental progression of Gpd expression from the inactive X chromosome of the virginia opossum
-
Samollow, P. B., Robinson, E. S., Ford, A. L. amp; Vandeberg, J. L. Developmental progression of Gpd expression from the inactive X chromosome of the virginia opossum. Dev. Genet. 16, 367-378 (1995).
-
(1995)
Dev. Genet
, vol.16
, pp. 367-378
-
-
Samollow, P.B.1
Robinson, E.S.2
Ford, A.L.3
Vandeberg, J.L.4
-
73
-
-
0024343450
-
-
Migeon, B. R., Jan de Beur, S. amp; Axelman, J. Frequent derepression of G6PD and HPRT on the marsupial inactive X chromosome associated with cell proliferation in vitro. Exp. Cell Res. 182, 597-609 (1989).
-
Migeon, B. R., Jan de Beur, S. amp; Axelman, J. Frequent derepression of G6PD and HPRT on the marsupial inactive X chromosome associated with cell proliferation in vitro. Exp. Cell Res. 182, 597-609 (1989).
-
-
-
-
74
-
-
0020672756
-
Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression
-
Gautsch, J. W. amp; Wilson, M. C. Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression. Nature 301, 32-37 (1983).
-
(1983)
Nature
, vol.301
, pp. 32-37
-
-
Gautsch, J.W.1
Wilson, M.C.2
-
75
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K. amp; Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
76
-
-
34249909232
-
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution
-
Maherali, N. et al. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1, 55-70 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 55-70
-
-
Maherali, N.1
-
77
-
-
34249908901
-
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
-
Wernig, M. et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324 (2007).
-
(2007)
Nature
, vol.448
, pp. 318-324
-
-
Wernig, M.1
-
78
-
-
44349164658
-
The reprogramming language of pluripotency
-
Welstead, G. G., Schorderet, P. amp; Boyer, L. A. The reprogramming language of pluripotency. Curr. Opin. Genet. Dev. 18, 123-129 (2008).
-
(2008)
Curr. Opin. Genet. Dev
, vol.18
, pp. 123-129
-
-
Welstead, G.G.1
Schorderet, P.2
Boyer, L.A.3
-
79
-
-
46449094276
-
Dissecting direct reprogramming through integrative genomic analysis
-
Mikkelsen, T. S. et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 454, 49-55 (2008).
-
(2008)
Nature
, vol.454
, pp. 49-55
-
-
Mikkelsen, T.S.1
-
80
-
-
44349103591
-
A combined chemical and genetic approach for the generation of induced pluripotent stem cells
-
Shi, Y. et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2, 525-528 (2008).
-
(2008)
Cell Stem Cell
, vol.2
, pp. 525-528
-
-
Shi, Y.1
-
81
-
-
54949115497
-
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds
-
Shi, Y. et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3, 568-574 (2008).
-
(2008)
Cell Stem Cell
, vol.3
, pp. 568-574
-
-
Shi, Y.1
-
82
-
-
54949141718
-
-
Ma, D. K., Chiang, C. H., Ponnusamy, K., Ming, G. L. amp; Song, H. G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells 26, 2131-2141 (2008).
-
Ma, D. K., Chiang, C. H., Ponnusamy, K., Ming, G. L. amp; Song, H. G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells 26, 2131-2141 (2008).
-
-
-
-
83
-
-
33847065486
-
The epigenomics of cancer
-
Jones, P. A. amp; Baylin, S. B. The epigenomics of cancer. Cell 128, 683-692 (2007).
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
84
-
-
0033566973
-
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis
-
De Marzo, A. M. et al. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res. 59, 3855-3860 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 3855-3860
-
-
De Marzo, A.M.1
-
85
-
-
0033153303
-
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
-
Robertson, K. D. et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 27, 2291-2298 (1999).
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 2291-2298
-
-
Robertson, K.D.1
-
86
-
-
31744433660
-
Evidence for an instructive mechanism of de novo methylation in cancer cells
-
Keshet, I. et al. Evidence for an instructive mechanism of de novo methylation in cancer cells. Nature Genet. 38, 149-153 (2006).
-
(2006)
Nature Genet
, vol.38
, pp. 149-153
-
-
Keshet, I.1
-
87
-
-
33846649587
-
Polycomb mediated histone H3(K27) methylation pre-marks genes for de novo methylation in cancer
-
Schlesinger, Y. et al. Polycomb mediated histone H3(K27) methylation pre-marks genes for de novo methylation in cancer. Nature Genet. 39, 232-236 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 232-236
-
-
Schlesinger, Y.1
-
88
-
-
33846569960
-
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
-
Ohm, J. E. et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nature Genet. 39, 237-242 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 237-242
-
-
Ohm, J.E.1
-
89
-
-
33846576622
-
Epigenetic stem cell signature in cancer
-
Widschwendter, M. et al. Epigenetic stem cell signature in cancer. Nature Genet. 39, 157-158 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 157-158
-
-
Widschwendter, M.1
-
90
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally, S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-629 (2002).
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
-
91
-
-
58149239686
-
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
-
Varambally, S. et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322, 1695-1699 (2008).
-
(2008)
Science
, vol.322
, pp. 1695-1699
-
-
Varambally, S.1
-
92
-
-
40949100837
-
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases
-
Benetti, R. et al. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nature Struct. Mol. Biol. 15, 268-279 (2008).
-
(2008)
Nature Struct. Mol. Biol
, vol.15
, pp. 268-279
-
-
Benetti, R.1
-
93
-
-
40949130398
-
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells
-
Sinkkonen, L. et al. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nature Struct. Mol. Biol. 15, 259-267 (2008).
-
(2008)
Nature Struct. Mol. Biol
, vol.15
, pp. 259-267
-
-
Sinkkonen, L.1
-
94
-
-
51349105905
-
Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line
-
Gal-Yam, E. N. et al. Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc. Natl. Acad. Sci. USA 105, 12979-12984 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 12979-12984
-
-
Gal-Yam, E.N.1
-
95
-
-
34347233479
-
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2
-
McGarvey, K. M., Greene, E., Fahrner, J. A., Jenuwein, T. amp; Baylin, S. B. DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res. 67, 5097-5102 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 5097-5102
-
-
McGarvey, K.M.1
Greene, E.2
Fahrner, J.A.3
Jenuwein, T.4
Baylin, S.B.5
-
96
-
-
50849107031
-
-
Lindroth, A. M. et al. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf 1 locus. PLoS Genet. 4, e1000145 (2008).
-
Lindroth, A. M. et al. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf 1 locus. PLoS Genet. 4, e1000145 (2008).
-
-
-
-
97
-
-
62049086288
-
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
-
Zhao, Q. et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nature Struct. Mol. Biol. 16, 304-311 (2009).
-
(2009)
Nature Struct. Mol. Biol
, vol.16
, pp. 304-311
-
-
Zhao, Q.1
-
98
-
-
58149156264
-
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
-
Wang, J. et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nature Genet. 41, 125-129 (2009).
-
(2009)
Nature Genet
, vol.41
, pp. 125-129
-
-
Wang, J.1
-
99
-
-
13944262010
-
Epigenetic ontogeny of the ? locus during B cell development
-
Goldmit, M. et al. Epigenetic ontogeny of the ? locus during B cell development. Nature Immunol. 6, 198-203 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 198-203
-
-
Goldmit, M.1
-
100
-
-
35348982301
-
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
-
Loh, Y. H., Zhang, W., Chen, X., George, J. amp; Ng, H. H. Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev. 21, 2545-2557 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 2545-2557
-
-
Loh, Y.H.1
Zhang, W.2
Chen, X.3
George, J.4
Ng, H.H.5
-
101
-
-
44649163849
-
Mechanisms involved in the regulation of histone lysine demethylases
-
Lan, F., Nottke, A. C. amp; Shi, Y. Mechanisms involved in the regulation of histone lysine demethylases. Curr. Opin. Cell Biol. 20, 316-325 (2008).
-
(2008)
Curr. Opin. Cell Biol
, vol.20
, pp. 316-325
-
-
Lan, F.1
Nottke, A.C.2
Shi, Y.3
-
102
-
-
44149105533
-
The emerging functions of histone demethylases
-
Agger, K., Christensen, J., Cloos, P. A. amp; Helin, K. The emerging functions of histone demethylases. Curr. Opin. Genet. Dev. 18, 159-168 (2008).
-
(2008)
Curr. Opin. Genet. Dev
, vol.18
, pp. 159-168
-
-
Agger, K.1
Christensen, J.2
Cloos, P.A.3
Helin, K.4
-
103
-
-
0025637814
-
Dynamics of demethylation and activation of the α actin gene in myoblasts
-
Paroush, Z., Keshet, I., Yisraeli, J. amp; Cedar, H. Dynamics of demethylation and activation of the α actin gene in myoblasts. Cell 63, 1229-1237 (1990).
-
(1990)
Cell
, vol.63
, pp. 1229-1237
-
-
Paroush, Z.1
Keshet, I.2
Yisraeli, J.3
Cedar, H.4
-
104
-
-
33846933274
-
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
-
Barreto, G. et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.Nature 445, 671-675 (2007).
-
(2007)
Nature
, vol.445
, pp. 671-675
-
-
Barreto, G.1
-
105
-
-
57649196594
-
DNA Demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and Gadd45
-
s
-
Rai, K. et al. DNA Demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and Gadd45.Cell 135s, 1201-1212 (2008).
-
(2008)
Cell
, vol.135
, pp. 1201-1212
-
-
Rai, K.1
-
106
-
-
0030572637
-
DNA demethylation in vitro: Involvement of RNA
-
Weiss, A., Keshet, I., Razin, A. & Cedar, H. DNA demethylation in vitro: involvement of RNA.Cell 86, 709-718 (1996).
-
(1996)
Cell
, vol.86
, pp. 709-718
-
-
Weiss, A.1
Keshet, I.2
Razin, A.3
Cedar, H.4
-
107
-
-
59849090498
-
TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation
-
Schmmitz, K. M. et al. TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol.Cell 33, 344-353 (2009).
-
(2009)
Mol.Cell
, vol.33
, pp. 344-353
-
-
Schmmitz, K.M.1
-
108
-
-
60749094831
-
Neuronal sctivity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
-
Ma, D. K. et al. Neuronal sctivity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323, 1074-1077 (2009).
-
(2009)
Science
, vol.323
, pp. 1074-1077
-
-
Ma, D.K.1
|