Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases

Journal of Molecular Biology

Volumn 400, Issue 1, 2010, Pages 1-7

  Chang, Yanqi ^a   Ganesh, Thota ^b   Horton, John R ^a   Spannhoff, Astrid ^c   Liu, Jin ^b   Sun, Aiming ^b   Zhang, Xing ^a   Bedford, Mark T ^c   Shinkai, Yoichi ^d   Snyder, James P ^b   Cheng, Xiaodong ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Enzymatic inhibition; Epigenetics; Histone lysine methylation; Lysine mimics

Indexed keywords

BIX 01294; HISTONE; HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; METHYLTRANSFERASE INHIBITOR; MONOCLONAL ANTIBODY E72; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME SUBSTRATE; EPIGENETICS; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN METHYLATION; STRUCTURE ACTIVITY RELATION;

EID: 77953691195     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.04.048     Document Type: Article

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