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Volumn 44, Issue 1, 2012, Pages 23-31

Dnmt3a is essential for hematopoietic stem cell differentiation

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A;

EID: 84555207349     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.1009     Document Type: Article
Times cited : (896)

References (49)
  • 1
    • 0036178007 scopus 로고    scopus 로고
    • DNA methylation and the regulation of gene transcription
    • DOI 10.1007/s00018-002-8420-z
    • Attwood, J.T., Yung, R.L. & Richardson, B.C. DNA methylation and the regulation of gene transcription. Cell. Mol. Life Sci. 59, 241-257 (2002). (Pubitemid 34169512)
    • (2002) Cellular and Molecular Life Sciences , vol.59 , Issue.2 , pp. 241-257
    • Attwood, J.T.1    Yung, R.L.2    Richardson, B.C.3
  • 2
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [1]
    • DOI 10.1038/890
    • Okano, M., Xie, S. & Li, E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 19, 219-220 (1998). (Pubitemid 28309328)
    • (1998) Nature Genetics , vol.19 , Issue.3 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 3
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • DOI 10.1016/S0092-8674(00)81656-6
    • Okano, M., Bell, D.W., Haber, D.A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999). (Pubitemid 29519904)
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 4
    • 0029803192 scopus 로고    scopus 로고
    • De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
    • Lei, H. et al. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122, 3195-3205 (1996).
    • (1996) Development , vol.122 , pp. 3195-3205
    • Lei, H.1
  • 5
    • 0042132027 scopus 로고    scopus 로고
    • Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
    • DOI 10.1128/MCB.23.16.5594-5605.2003
    • Chen, T., Ueda, Y., Dodge, J.E., Wang, Z. & Li, E. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol. Cell. Biol. 23, 5594-5605 (2003). (Pubitemid 36951325)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.16 , pp. 5594-5605
    • Chen, T.1    Ueda, Y.2    Dodge, J.E.3    Wang, Z.4    Li, E.5
  • 6
    • 77954842322 scopus 로고    scopus 로고
    • Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes
    • Wu, H. et al. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 329, 444-448 (2010).
    • (2010) Science , vol.329 , pp. 444-448
    • Wu, H.1
  • 7
    • 70349469788 scopus 로고    scopus 로고
    • DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
    • Trowbridge, J.J., Snow, J.W., Kim, J. & Orkin, S.H. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell 5, 442-449 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 442-449
    • Trowbridge, J.J.1    Snow, J.W.2    Kim, J.3    Orkin, S.H.4
  • 8
    • 70350654370 scopus 로고    scopus 로고
    • DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
    • Bröske, A.M. et al. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat. Genet. 41, 1207-1215 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1207-1215
    • Bröske, A.M.1
  • 9
    • 34247337999 scopus 로고    scopus 로고
    • De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
    • DOI 10.1084/jem.20060750
    • Tadokoro, Y., Ema, H., Okano, M., Li, E. & Nakauchi, H. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J. Exp. Med. 204, 715-722 (2007). (Pubitemid 46631602)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.4 , pp. 715-722
    • Tadokoro, Y.1    Ema, H.2    Okano, M.3    Li, E.4    Nakauchi, H.5
  • 10
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley, T.J. et al. DNMT3A mutations in acute myeloid leukemia. N. Engl. J. Med. 363, 2424-2433 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2424-2433
    • Ley, T.J.1
  • 11
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan, X.J. et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat. Genet. 43, 309-315 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 309-315
    • Yan, X.J.1
  • 12
    • 77954089584 scopus 로고    scopus 로고
    • Array-based genomic resequencing of human leukemia
    • Yamashita, Y. et al. Array-based genomic resequencing of human leukemia. Oncogene 29, 3723-3731 (2010).
    • (2010) Oncogene , vol.29 , pp. 3723-3731
    • Yamashita, Y.1
  • 13
    • 79960255863 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
    • Walter, M.J. et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 25, 1153-1158 (2011).
    • (2011) Leukemia , vol.25 , pp. 1153-1158
    • Walter, M.J.1
  • 14
    • 3042584653 scopus 로고    scopus 로고
    • Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
    • DOI 10.1038/nature02633
    • Kaneda, M. et al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429, 900-903 (2004). (Pubitemid 38843304)
    • (2004) Nature , vol.429 , Issue.6994 , pp. 900-903
    • Kaneda, M.1    Okano, M.2    Hata, K.3    Sado, T.4    Tsujimoto, H.5    Li, E.6    Sasaki, H.7
  • 15
    • 77953462161 scopus 로고    scopus 로고
    • Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection
    • Baldridge, M.T., King, K.Y., Boles, N.C., Weksberg, D.C. & Goodell, M.A. Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection. Nature 465, 793-797 (2010).
    • (2010) Nature , vol.465 , pp. 793-797
    • Baldridge, M.T.1    King, K.Y.2    Boles, N.C.3    Weksberg, D.C.4    Goodell, M.A.5
  • 16
    • 77449153454 scopus 로고    scopus 로고
    • Genome-scale DNA methylation mapping of clinical samples at singlenucleotide resolution
    • Gu, H. et al. Genome-scale DNA methylation mapping of clinical samples at singlenucleotide resolution. Nat. Methods 7, 133-136 (2010).
    • (2010) Nat. Methods , vol.7 , pp. 133-136
    • Gu, H.1
  • 17
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766-770 (2008).
    • (2008) Nature , vol.454 , pp. 766-770
    • Meissner, A.1
  • 19
    • 0034908701 scopus 로고    scopus 로고
    • Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis
    • DOI 10.1016/S0301-472X(01)00670-1, PII S0301472X01006701
    • Chen, D. & Zhang, G. Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis. Exp. Hematol. 29, 971-980 (2001). (Pubitemid 32725795)
    • (2001) Experimental Hematology , vol.29 , Issue.8 , pp. 971-980
    • Chen, D.1    Zhang, G.2
  • 20
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • DOI 10.1016/S0092-8674(00)80986-1
    • Okuda, T., van Deursen, J., Hiebert, S.W., Grosveld, G. & Downing, J.R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330 (1996). (Pubitemid 26042836)
    • (1996) Cell , vol.84 , Issue.2 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 21
    • 42649142267 scopus 로고    scopus 로고
    • Pbx1 Regulates Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence
    • DOI 10.1016/j.stem.2008.03.004, PII S1934590908001161
    • Ficara, F., Murphy, M.J., Lin, M. & Cleary, M.L. Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell 2, 484-496 (2008). (Pubitemid 351598079)
    • (2008) Cell Stem Cell , vol.2 , Issue.5 , pp. 484-496
    • Ficara, F.1    Murphy, M.J.2    Lin, M.3    Cleary, M.L.4
  • 22
    • 0034629129 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    • Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804-1808 (2000).
    • (2000) Science , vol.287 , pp. 1804-1808
    • Cheng, T.1
  • 23
    • 0029097145 scopus 로고
    • Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
    • Mackarehtschian, K. et al. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3, 147-161 (1995).
    • (1995) Immunity , vol.3 , pp. 147-161
    • MacKarehtschian, K.1
  • 24
  • 25
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    • Scott, E.W., Simon, M.C., Anastasi, J. & Singh, H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265, 1573-1577 (1994).
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1    Simon, M.C.2    Anastasi, J.3    Singh, H.4
  • 26
    • 60749111430 scopus 로고    scopus 로고
    • Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c
    • Stehling-Sun, S., Dade, J., Nutt, S.L., DeKoter, R.P. & Camargo, F.D. Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat. Immunol. 10, 289-296 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 289-296
    • Stehling-Sun, S.1    Dade, J.2    Nutt, S.L.3    Dekoter, R.P.4    Camargo, F.D.5
  • 27
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister, R. et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315-322 (2009).
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1
  • 28
    • 77951459994 scopus 로고    scopus 로고
    • Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells
    • Challen, G.A. & Goodell, M.A. Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Exp. Hematol. 38, 403-416 (2010).
    • (2010) Exp. Hematol. , vol.38 , pp. 403-416
    • Challen, G.A.1    Goodell, M.A.2
  • 29
    • 78649880379 scopus 로고    scopus 로고
    • The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
    • Sirin, O., Lukov, G.L., Mao, R., Conneely, O.M. & Goodell, M.A. The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat. Cell Biol. 12, 1213-1219 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 1213-1219
    • Sirin, O.1    Lukov, G.L.2    Mao, R.3    Conneely, O.M.4    Goodell, M.A.5
  • 30
    • 84655164603 scopus 로고    scopus 로고
    • Digital restriction enzyme analysis of methylation (DREAM) by next generation sequencing yields high resolution maps of DNA methylation
    • Jelinek, J. et al. Digital restriction enzyme analysis of methylation (DREAM) by next generation sequencing yields high resolution maps of DNA methylation. Blood 114, 567 (2009).
    • (2009) Blood , vol.114 , pp. 567
    • Jelinek, J.1
  • 31
    • 8844250116 scopus 로고    scopus 로고
    • Molecular signatures of proliferation and quiescence in hematopoietic stem cells
    • Venezia, T.A. et al. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2, e301 (2004).
    • (2004) PLoS Biol. , vol.2
    • Venezia, T.A.1
  • 32
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modification: Patterns and paradigms
    • Cedar, H. & Bergman, Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat. Rev. Genet. 10, 295-304 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 33
    • 0037115392 scopus 로고    scopus 로고
    • Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
    • Fahrner, J.A., Eguchi, S., Herman, J.G. & Baylin, S.B. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res. 62, 7213-7218 (2002). (Pubitemid 36025241)
    • (2002) Cancer Research , vol.62 , Issue.24 , pp. 7213-7218
    • Fahrner, J.A.1    Eguchi, S.2    Herman, J.G.3    Baylin, S.B.4
  • 34
    • 77957348625 scopus 로고    scopus 로고
    • Combinatorial transcriptional control in blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators
    • Wilson, N.K. et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 7, 532-544 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 532-544
    • Wilson, N.K.1
  • 35
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1
  • 36
    • 33645702660 scopus 로고    scopus 로고
    • DNA methyltransferases control telomere length and telomere recombination in mammalian cells
    • Gonzalo, S. et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat. Cell Biol. 8, 416-424 (2006).
    • (2006) Nat. Cell Biol. , vol.8 , pp. 416-424
    • Gonzalo, S.1
  • 37
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • DOI 10.1182/blood-2002-07-2334
    • Allsopp, R.C., Morin, G.B., DePinho, R., Harley, C.B. & Weissman, I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102, 517-520 (2003). (Pubitemid 36841969)
    • (2003) Blood , vol.102 , Issue.2 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 39
    • 12744271900 scopus 로고    scopus 로고
    • Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer
    • Frigola, J. et al. Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum. Mol. Genet. 14, 319-326 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 319-326
    • Frigola, J.1
  • 40
    • 77955787215 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients
    • Cho, Y.H. et al. Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients. Anticancer Res. 30, 2489-2496 (2010).
    • (2010) Anticancer Res. , vol.30 , pp. 2489-2496
    • Cho, Y.H.1
  • 41
    • 0029958876 scopus 로고    scopus 로고
    • Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    • DOI 10.1084/jem.183.4.1797
    • Goodell, M.A., Brose, K., Paradis, G., Conner, A.S. & Mulligan, R.C. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 183, 1797-1806 (1996). (Pubitemid 26134320)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.4 , pp. 1797-1806
    • Goodell, M.A.1    Brose, K.2    Paradis, G.3    Conner, A.S.4    Mulligan, R.C.5
  • 42
    • 59049104555 scopus 로고    scopus 로고
    • Mouse hematopoietic stem cell identification and analysis
    • Challen, G.A., Boles, N., Lin, K.K. & Goodell, M.A. Mouse hematopoietic stem cell identification and analysis. Cytometry A 75, 14-24 (2009).
    • (2009) Cytometry A , vol.75 , pp. 14-24
    • Challen, G.A.1    Boles, N.2    Lin, K.K.3    Goodell, M.A.4
  • 43
    • 37549048915 scopus 로고    scopus 로고
    • The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation
    • Feng, C.G., Weksberg, D.C., Taylor, G.A., Sher, A. & Goodell, M.A. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2, 83-89 (2008).
    • (2008) Cell Stem Cell , vol.2 , pp. 83-89
    • Feng, C.G.1    Weksberg, D.C.2    Taylor, G.A.3    Sher, A.4    Goodell, M.A.5
  • 44
    • 77449145533 scopus 로고    scopus 로고
    • Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-β1
    • Challen, G.A., Boles, N.C., Chambers, S.M. & Goodell, M.A. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-β1. Cell Stem Cell 6, 265-278 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 265-278
    • Challen, G.A.1    Boles, N.C.2    Chambers, S.M.3    Goodell, M.A.4
  • 45
    • 12244279345 scopus 로고    scopus 로고
    • Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry
    • DOI 10.1021/ac0489420
    • Song, L., James, S.R., Kazim, L. & Karpf, A.R. Specific method for the determination of genomic DNA methylation by liquid chromatography- electrospray ionization tandem mass spectrometry. Anal. Chem. 77, 504-510 (2005). (Pubitemid 40116829)
    • (2005) Analytical Chemistry , vol.77 , Issue.2 , pp. 504-510
    • Song, L.1    James, S.R.2    Kazim, L.3    Karpf, A.R.4
  • 46
    • 44949138461 scopus 로고    scopus 로고
    • A rapid micro chromatin immunoprecipitation assay (ChIP)
    • DOI 10.1038/nprot.2008.68, PII NPROT.2008.68
    • Dahl, J.A. & Collas, P. A rapid micro chromatin immunoprecipitation assay (microChIP). Nat. Protoc. 3, 1032-1045 (2008). (Pubitemid 351818692)
    • (2008) Nature Protocols , vol.3 , Issue.6 , pp. 1032-1045
    • Dahl, J.A.1    Collas, P.2
  • 47
    • 67649854923 scopus 로고    scopus 로고
    • High-throughput bisulfite sequencing in mammalian genomes
    • Smith, Z.D., Gu, H., Bock, C., Gnirke, A. & Meissner, A. High-throughput bisulfite sequencing in mammalian genomes. Methods 48, 226-232 (2009).
    • (2009) Methods , vol.48 , pp. 226-232
    • Smith, Z.D.1    Gu, H.2    Bock, C.3    Gnirke, A.4    Meissner, A.5
  • 48
    • 68949141599 scopus 로고    scopus 로고
    • BSMAP: Whole genome bisulfite sequence MAPping program
    • Xi, Y. & Li, W. BSMAP: whole genome bisulfite sequence MAPping program. BMC Bioinformatics 10, 232 (2009).
    • (2009) BMC Bioinformatics , vol.10 , pp. 232
    • Xi, Y.1    Li, W.2
  • 49
    • 51649122312 scopus 로고    scopus 로고
    • Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
    • Kroeger, H. et al. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood 112, 1366-1373 (2008).
    • (2008) Blood , vol.112 , pp. 1366-1373
    • Kroeger, H.1


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