Etiology, clinical course and outcome of healthcare-associated bloodstream infections in patients with hematological malignancies: A retrospective study of 350 patients in a Finnish tertiary care hospital

Leukemia and Lymphoma

Volumn 56, Issue 12, 2015, Pages 3370-3377

  Åttman, Emilia ^a,b   Aittoniemi, Janne ^c   Sinisalo, Marjatta ^a   Vuento, Risto ^c   Lyytikainen, Outi ^d   Karki, Tommi ^d   Syrjanen, Jaana ^a   Huttunen, Reetta ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c FIMLAB LABORATORIES   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Bacteraemia; healthcare associated; hematological; incidence density

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CEFOTAXIME; CEFTAZIDIME; CEFUROXIME; CIPROFLOXACIN; CLINDAMYCIN; ERYTHROMYCIN; FUSIDATE SODIUM; LEVOFLOXACIN; MEROPENEM; METHICILLIN PLUS OXACILLIN; NETILMICIN PLUS TOBRAMYCIN; PIPERACILLIN PLUS TAZOBACTAM; RIFAMPICIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC RESISTANCE; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BLOOD SAMPLING; BLOODSTREAM INFECTION; BONE MARROW TRANSPLANTATION; CENTRAL VENOUS CATHETER; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; COAGULASE NEGATIVE STAPHYLOCOCCUS; DISEASE COURSE; ENTEROCOCCUS; ESCHERICHIA COLI; FATALITY; FEMALE; FINLAND; FUNGUS; HEALTHCARE ASSOCIATED INFECTION; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMODIALYSIS; HODGKIN DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MYELODYSPLASTIC SYNDROME; MYELOMA; NONHODGKIN LYMPHOMA; PRACTICE GUIDELINE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; TERTIARY CARE CENTER; COMPLICATION; CROSS INFECTION; DISEASE MANAGEMENT; HEALTH SURVEY; HEMATOLOGIC DISEASE; INCIDENCE; MIDDLE AGED; MORTALITY; SEPSIS; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CROSS INFECTION; DISEASE MANAGEMENT; FEMALE; FINLAND; HEMATOLOGIC NEOPLASMS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MORTALITY; PUBLIC HEALTH SURVEILLANCE; RETROSPECTIVE STUDIES; SEPSIS; TERTIARY CARE CENTERS; YOUNG ADULT;

EID: 84948718840     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2015.1032967     Document Type: Article

References (29)

1. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1994; 271: 1598-1601.
2. Wisplinghoff H, Seifert H, Wenzel RP, et al. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis 2003; 36: 1103-1110.
3. Zinner SH. Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria. Clin Infect Dis 1999; 29: 490-494.
4. Elting LS, Rubenstein EB, Rolston KV, et al. Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials. Clin Infect Dis 1997; 25: 247-259.
5. Ortega M, Rovira M, Almela M, et al. Bacterial and fungal bloodstream isolates from 796 hematopoietic stem cell transplant recipients between 1991 and 2000. Ann Hematol 2005; 84: 40-46.
6. Mikulska M, Del Bono V, Raiola AM, et al. Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of gram-negative rods and increasing antibiotic resistance. Biol Blood Marrow Transplant 2009; 15: 47-53.
7. Cattaneo C, Quaresmini G, Casari S, et al. Recent changes in bacterial epidemiology and the emergence of fluoroquinolone-resistant Escherichia coli among patients with haematological malignancies: results of a prospective study on 823 patients at a single institution. J Antimicrob Chemother 2008; 61: 721-728.
8. Mendes ET, Dulley F, Basso M, et al. Healthcare-associated infection in hematopoietic stem cell transplantation patients: risk factors and impact on outcome. Int J Infect Dis 2012; 16: e424-428.
9. Official Statistics of Finland (OSF). Population Structure. Helsinki: Statistics Finland 2011.[Internet]-[cited 2011 October]; Available from: http://www.stat.fi/til/vrm-en.html
10. Lyytikainen O, Lumio J, Sarkkinen H, Kolho E, Kostiala A, Ruutu P, Hospital, Infection Surveillance T. Nosocomial bloodstream infections in Finnish hospitals during 1999-2000. Clin Infect Dis 2002; 35: e14-9.
11. Garner JS, Jarvis WR, Emori TG, et al. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16: 128-140.
12. Velasco E, Byington R, Martins CA, et al. Prospective evaluation of the epidemiology, microbiology, and outcome of bloodstream infections in hematologic patients in a single cancer center. Eur J Clin Microbiol Infect Dis 2003; 22: 137-143.
13. Syrjala H, Ohtonen P, Kinnunen U, et al., Finnish Leukemia Group. Blood stream infections during chemotherapy-induced neutropenia in adult patients with acute myeloid leukemia: treatment cycle matters. Eur J Clin Microbiol Infect Dis 2010; 29: 1211-1218.
14. Tumbarello M, Spanu T, Caira M, et al. Factors associated with mortality in bacteremic patients with hematologic malignancies. Diagnost Microbiol Infect Dis 2009; 64: 320-326.
15. Norgaard M, Larsson H, Pedersen G, et al. Risk of bacteraemia and mortality in patients with haematological malignancies. Clin Microbiol Infect 2006; 12: 217-223.
16. Cattaneo C, Antoniazzi F, Casari S, et al. Paeruginosa bloodstream infections among hematological patients: an old or new question Ann Hematol 2012; 91: 1299-304.
17. Huoi C, Vanhems P, Nicolle MC, et al. Incidence of hospital-acquired pneumonia, bacteraemia and urinary tract infections in patients with haematological malignancies, 2004-2010: A surveillance-based study. PLoS ONE [Electronic Resource] 2013; 8: e58121.
18. Madani TA. Clinical infections and bloodstream isolates associated with fever in patients undergoing chemotherapy for acute myeloid leukemia. Infection 2000; 28: 367-373.
19. Viscoli C, Cometta A, Kern WV, et al., International Antimicrobial Therapy Group of the European Organization for Research and Treatment of Cancer. Piperacillin-tazobactam monotherapy in high-risk febrile and neutropenic cancer patients. Clin Microbiol Infect 2006; 12: 212-216.
20. Steinberg JP, Coffin SE. Improving the central line-associated bloodstream infection surveillance definition: a work in progress. Infect Control Hospital Epidemiol 2013; 34: 777-779.
21. Steinberg JP, Robichaux C, Tejedor SC, et al. Distribution of pathogens in central line-associated bloodstream infections among patients with and without neutropenia following chemotherapy: evidence for a proposed modification to the current surveillance definition. Infect Control Hospital Epidemiol 2013; 34: 171-175.
22. Dutcher K, Lederman ER, Brodine S, et al. Impact of the 2013 revised centers for disease control and prevention central line-associated bloodstream infection (CLABSI) surveillance definition on inpatient hospital CLABSI rates: is it enough Infect Control Hospital Epidemiol 2013; 34: 999-1001.
23. Kjellander C, Bjorkholm M, Cherif H, et al. Hematological: low all-cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single-center study. Eur J Haematol 2012; 88: 422-430.
24. Rahikka P, Syrjanen J, Vuento R, et al. Methicillin-resistant staphylococcus aureus (MRSA) bacteraemia in Tampere University Hospital: case-control study, Finland October 2002 to January 2010. Euro Surveillance: Eur Communicable Dis Bull 2011; 16.
25. [Anonymous]. Antimicrobial resistance in Finland-Finres 2013 data, Finnish Study Group for antimicrobial resistance, National Institute for Health and Welfare 2013;35/2014.
26. Castanheira M, Deshpande LM, Costello A, et al. Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible P. aeruginosa collected during 2009-11 in 14 European and Mediterranean countries. J Antimicrob Chemother 2014; 69: 1804-1814.
27. Carmeli Y, Troillet N, Eliopoulos GM, et al. Emergence of antibiotic-resistant P. aeruginosa: comparison of risks associated with different antipseudomonal agents. Antimicrobial Agents Chemother 1999; 43: 1379-1382.
28. Flowers CR, Seidenfeld J, Bow EJ, et al. Antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 2013; 31: 794-810.
29. Mikulska M, Del Bono V, Bruzzi P, et al. Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients. Infection 2012; 40: 271-278.