Stress management by autophagy: Implications for chemoresistance

International Journal of Cancer

Volumn 139, Issue 1, 2016, Pages 23-32

  Huang, Zhao ^a,b   Zhou, Li ^a   Chen, Zhibin ^b   Nice, Edouard C ^c   Huang, Canhua ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

^c MONASH UNIVERSITY   (Australia)

Author keywords

autophagy; chemoresistance; ER stress; genotoxic stress; oxidative stress

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ATM PROTEIN; ATR PROTEIN; INOSITOL REQUIRING PROTEIN 1ALPHA; PROTEIN IRE1; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

AUTOPHAGY; CANCER CELL; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CARCINOGENESIS; CELL DEATH; CELL STIMULATION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; DNA DAMAGE; DNA REPAIR; DRUG RESISTANCE; ENDOPLASMIC RETICULUM STRESS; GENOTOXICITY; HUMAN; INTRACELLULAR SIGNALING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REDOX STRESS; REVIEW; STRESS MANAGEMENT; UNFOLDED PROTEIN RESPONSE; APOPTOSIS; DRUG EFFECTS; GENETICS; NEOPLASMS; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 84958825037     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29990     Document Type: Review

References (149)

1. Holohan C, Van Schaeybroeck S, Longley DB, et al., Cancer drug resistance: an evolving paradigm. Nat Rev Cancer 2013; 13: 714-26.
2. Hughes D, Andersson DI., Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms. Nat Rev Genet 2015; 16: 459-71.
3. Weisberg E, Liu Q, Nelson E, et al., Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors. Leukemia 2012; 26: 2233-44.
4. Sun Y, Campisi J, Higano C, et al., Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 2012; 18: 1359-68.
5. Fletcher JI, Haber M, Henderson MJ, et al., ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer 2010; 10: 147-56.
6. Gross E, L'Faqihi-Olive FE, Ysebaert L, et al., B-chronic lymphocytic leukemia chemoresistance involves innate and acquired leukemic side population cells. Leukemia 2010; 24: 1885-92.
7. Green DR, Levine B., To be or not to be? How selective autophagy and cell death govern cell fate. Cell 2014; 157: 65-75.
8. Galluzzi L, Pietrocola F, Levine B, et al., Metabolic control of autophagy. Cell 2014; 159: 1263-76.
9. Tian L, Ma L, Guo E, et al., 20-Hydroxyecdysone upregulates Atg genes to induce autophagy in the Bombyx fat body. Autophagy 2013; 9: 1172-87.
10. Schmeisser H, Fey SB, Horowitz J, et al., Type I interferons induce autophagy in certain human cancer cell lines. Autophagy 2013; 9: 683-96.
11. Tan Q, Joshua AM, Saggar JK, et al., Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy. Br J Cancer 2015; 112: 832-40.
12. Kondo Y, Kanzawa T, Sawaya R, et al., The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5: 726-34.
13. Wang M, Kaufman RJ., The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nat Rev Cancer 2014; 14: 581-97.
14. Puthalakath H, O'Reilly LA, Gunn P, et al., ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 2007; 129: 1337-49.
15. Verfaillie T, Rubio N, Garg AD, et al., PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ 2012; 19: 1880-91.
16. Han J, Back SH, Hur J, et al., ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 2013; 15: 481-90.
17. Zheng QY, Li PP, Jin FS, et al., Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell Signal 2013; 25: 206-13.
18. Hetz C., The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012; 13: 89-102.
19. Qin L, Wang Z, Tao L, et al., ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 2010; 6: 239-47.
20. Hoyer-Hansen M, Jaattela M., Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 2007; 14: 1576-82.
21. Verfaillie T, Salazar M, Velasco G, et al., Linking ER stress to autophagy: potential implications for cancer therapy. Int J Cell Biol 2010; 2010: 930509.
22. Ma T, Trinh MA, Wexler AJ, et al., Suppression of eIF2alpha kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci 2013; 16: 1299-305.
23. Boyce M, Yuan J., Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 2006; 13: 363-73.
24. Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, et al., Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene 2013; 32: 4932-40.
25. Kouroku Y, Fujita E, Tanida I, et al., ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 2007; 14: 230-9.
26. Lv S, Sun EC, Xu QY, et al., Endoplasmic reticulum stress-mediated autophagy contributes to bluetongue virus infection via the PERK-eIF2alpha pathway. Biochem Biophys Res Commun 2015; 466: 406-12.
27. Walter F, Schmid J, Dussmann H, et al., Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival. Cell Death Differ 2015; 22: 1502-16.
28. Rzymski T, Milani M, Pike L, et al., Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 2010; 29: 4424-35.
29. Ishida Y, Yamamoto A, Kitamura A, et al., Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection. Mol Biol Cell 2009; 20: 2744-54.
30. Rzymski T, Milani M, Singleton DC, et al., Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. Cell Cycle 2009; 8: 3838-47.
31. Jagannathan S, Abdel-Malek MA, Malek E, et al., Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib. Leukemia 2015; 29: 2184-91.
32. Tabas I, Ron D., Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 2011; 13: 184-90.
33. Teske BF, Fusakio ME, Zhou D, et al., CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell 2013; 24: 2477-90.
34. Gupta SC, Francis SK, Nair MS, et al., Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. J Biol Chem 2013; 288: 32343-56.
35. Rao J, Zhang C, Wang P, et al., C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1alpha signalling in acute liver failure. Biochem J 2015; 466: 369-78.
36. Sanchez-Lopez E, Zimmerman T, Gomez del Pulgar T, et al., Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells. Cell Death Dis 2013; 4: e933.
37. B'Chir W, Chaveroux C, Carraro V, et al., Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation. Cell Signal 2014; 26: 1385-91.
38. Liu K, Shi Y, Guo X, et al., CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2. Cell Death Dis 2014; 5: e1323.
39. Urano F, Wang X, Bertolotti A, et al., Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664-6.
40. Surani MA., Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: compaction and trophoblast adhesion. Cell 1979; 18: 217-27.
41. Schleicher SM, Moretti L, Varki V, et al., Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: implications for future therapeutic approaches. Drug Resist Updates 2010; 13: 79-86.
42. Bernales S, McDonald KL, Walter P., Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 2006; 4: e423.
43. Cheng X, Liu H, Jiang CC, et al., Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells. Int J Mol Med 2014; 34: 772-81.
44. Li C, Johnson DE., Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation. Cancer Lett 2012; 314: 102-7.
45. Margariti A, Li H, Chen T, et al., XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J Biol Chem 2013; 288: 859-72.
46. Zhao Y, Li X, Cai MY, et al., XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells. Cell Res 2013; 23: 491-507.
47. Wilhelm SM, Adnane L, Newell P, et al., Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Therap 2008; 7: 3129-40.
48. Rahmani M, Davis EM, Crabtree TR, et al., The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol 2007; 27: 5499-513.
49. Shi YH, Ding ZB, Zhou J, et al., Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 2011; 7: 1159-72.
50. Zhai B, Hu F, Jiang X, et al., Inhibition of Akt reverses the acquired resistance to sorafenib by switching protective autophagy to autophagic cell death in hepatocellular carcinoma. Mol Cancer Therap 2014; 13: 1589-98.
51. Yamamoto K, Sato T, Matsui T, et al., Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell 2007; 13: 365-76.
52. Wang J, Kang R, Huang H, et al., Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression. Autophagy 2014; 10: 766-84.
53. Gade P, Ramachandran G, Maachani UB, et al., An IFN-gamma-stimulated ATF6-C/EBP-beta-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy. Proc Natl Acad Sci USA 2012; 109: 10316-21.
54. Schubeler D., Function and information content of DNA methylation. Nature 2015; 517: 321-6.
55. Hoeijmakers JH., DNA damage, aging, and cancer. N Engl J Med 2009; 361: 1475-85.
56. Pearl LH, Schierz AC, Ward SE, et al., Therapeutic opportunities within the DNA damage response. Nat Rev Cancer 2015; 15: 166-80.
57. Gordon RR, Nelson PS., Cellular senescence and cancer chemotherapy resistance. Drug Resist Updates 2012; 15: 123-31.
58. Shen DW, Pouliot LM, Hall MD, et al., Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev 2012; 64: 706-21.
59. Robert T, Vanoli F, Chiolo I, et al., HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature 2011; 471: 74-9.
60. Eapen VV, Haber JE., DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression. Autophagy 2013; 9: 440-1.
61. Orlotti NI, Cimino-Reale G, Borghini E, et al., Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage. Autophagy 2012; 8: 1185-96.
62. Park C, Suh Y, Cuervo AM., Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. Nat Commun 2015; 6: 6823.
63. SenGupta T, Torgersen ML, Kassahun H, et al., Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy. Nat Commun 2013; 4: 2674.
64. Alexander A, Cai SL, Kim J, et al., ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci USA 2010; 107: 4153-8.
65. Tripathi DN, Chowdhury R, Trudel LJ, et al., Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci USA 2013; 110: E2950-E2957.
66. Chen LH, Loong CC, Su TL, et al., Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway. Biochem Pharmacol 2011; 81: 594-605.
67. de la Cruz-Morcillo MA, Valero ML, Callejas-Valera JL, et al., P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance. Oncogene 2012; 31: 1073-85.
68. Yoon JH, Ahn SG, Lee BH, et al., Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. Biochem Pharmacol 2012; 83: 747-57.
69. Tasdemir E, Chiara Maiuri M, Morselli E, et al., A dual role of p53 in the control of autophagy. Autophagy 2008; 4: 810-4.
70. Zhang D, Tang B, Xie X, et al., The interplay between DNA repair and autophagy in cancer therapy. Cancer Biol Ther 2015; 16: 1005-13.
71. Feng Z, Hu W, de Stanchina E, et al., The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 2007; 67: 3043-53.
72. Crighton D, Wilkinson S, O'Prey J, et al., DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126: 121-34.
73. Crighton D, Wilkinson S, Ryan KM., DRAM links autophagy to p53 and programmed cell death. Autophagy 2007; 3: 72-4.
74. Zalckvar E, Berissi H, Eisenstein M, et al., Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy 2009; 5: 720-2.
75. Zalckvar E, Berissi H, Mizrachy L, et al., DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 2009; 10: 285-92.
76. Eisenberg-Lerner A, Kimchi A., PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk. Cell Death Differ 2012; 19: 788-97.
77. Bialik S, Kimchi A., Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy. Curr Opin Cell Biol 2010; 22: 199-205.
78. Budanov AV, Karin M., p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008; 134: 451-60.
79. Rhee SG, Bae SH., The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1. Free Radic Biol Med 2015; 88: 205-11.
80. Lorin S, Pierron G, Ryan KM, et al., Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. Autophagy 2010; 6: 153-4.
81. Gomes LR, Vessoni AT, Menck CF., Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy. Oncogene 2015; 34: 5329-40.
82. Tasdemir E, Maiuri MC, Orhon I, et al., p53 represses autophagy in a cell cycle-dependent fashion. Cell Cycle 2008; 7: 3006-11.
83. Livesey KM, Kang R, Vernon P, et al., p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer Res 2012; 72: 1996-2005.
84. Roth JA, Nguyen D, Lawrence DD, et al., Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 1996; 2: 985-91.
85. Shimada H, Matsubara H, Ochiai T., p53 gene therapy for esophageal cancer. J Gastroenterol 2002; 37 (Suppl 14): 87-91.
86. Nakase M, Inui M, Okumura K, et al., p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome. Mol Cancer Ther 2005; 4: 625-31.
87. Nielsen LL, Lipari P, Dell J, et al., Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer. Clin Cancer Res 1998; 4: 835-46.
88. Lang FF, Yung WK, Raju U, et al., Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene. J Neurosurg 1998; 89: 125-32.
89. Kim EL, Wustenberg R, Rubsam A, et al., Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells. Neuro-Oncology 2010; 12: 389-400.
90. Hasei J, Sasaki T, Tazawa H, et al., Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells. Mol Cancer Ther 2013; 12: 314-25.
91. Sperka T, Wang J, Rudolph KL., DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol 2012; 13: 579-90.
92. Capparelli C, Chiavarina B, Whitaker-Menezes D, et al., CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 2012; 11: 3599-610.
93. Portillo JA, Okenka G, Reed E, et al., The CD40-autophagy pathway is needed for host protection despite IFN-Gamma-dependent immunity and CD40 induces autophagy via control of P21 levels. PLoS One 2010; 5: e14472.
94. Li X, Li X, Wang J, et al., Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci 2012; 8: 901-12.
95. Farmer H, McCabe N, Lord CJ, et al., Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917-21.
96. Kirchhoff T, Kauff ND, Mitra N, et al., BRCA mutations and risk of prostate cancer in Ashkenazi Jews. Clin Cancer Res 2004; 10: 2918-21.
97. Yang D, Khan S, Sun Y, et al., Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA 2011; 306: 1557-65.
98. Lord CJ, Ashworth A., Mechanisms of resistance to therapies targeting BRCA-mutant cancers. Nat Med 2013; 19: 1381-8.
99. Gorodnova TV, Sokolenko AP, Ivantsov AO, et al., High response rates to neoadjuvant platinum-based therapy in ovarian cancer patients carrying germ-line BRCA mutation. Cancer Lett 2015; 369: 363-7.
100. Tang MK, Kwong A, Tam KF, et al., BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis. Cancer Lett 2014; 346: 139-47.
101. Salem AF, Howell A, Sartini M, et al., Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1alpha, autophagy and ketone body production. Cell Cycle 2012; 11: 4167-73.
102. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, et al., The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
103. Holmstrom KM, Finkel T., Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 2014; 15: 411-21.
104. Trachootham D, Lu W, Ogasawara MA, et al., Redox regulation of cell survival. Antioxidants Redox Signal 2008; 10: 1343-74.
105. White E., Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12: 401-10.
106. Schieber M, Chandel NS., ROS function in redox signaling and oxidative stress. Curr Biol 2014; 24: R453-62.
107. Paulsen CE, Carroll KS., Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery. Chem Rev 2013; 113: 4633-79.
108. Filomeni G, Rotilio G, Ciriolo MR., Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways. Cell Death Differ 2005; 12: 1555-63.
109. Filomeni G, Rotilio G, Ciriolo MR., Cell signalling and the glutathione redox system. Biochem Pharmacol 2002; 64: 1057-64.
110. Filomeni G, De Zio D, Cecconi F., Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ 2015; 22: 377-88.
111. Bhattacharyya A, Chattopadhyay R, Mitra S, et al., Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev 2014; 94: 329-54.
112. Gorrini C, Harris IS, Mak TW., Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discover 2013; 12: 931-47.
113. Perez-Perez ME, Zaffagnini M, Marchand CH, et al., The yeast autophagy protease Atg4 is regulated by thioredoxin. Autophagy 2014; 10: 1953-64.
114. Satoo K, Noda NN, Kumeta H, et al., The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J 2009; 28: 1341-50.
115. Cardaci S, Filomeni G, Ciriolo MR., Redox implications of AMPK-mediated signal transduction beyond energetic clues. J Cell Sci 2012; 125: 2115-25.
116. Komatsu M, Kurokawa H, Waguri S, et al., The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 2010; 12: 213-23.
117. Ichimura Y, Waguri S, Sou YS, et al., Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 2013; 51: 618-31.
118. Taguchi K, Fujikawa N, Komatsu M, et al., Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci USA 2012; 109: 13561-6.
119. Ma Q., Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 2013; 53: 401-26.
120. Kumar S, Yedjou CG, Tchounwou PB., Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. J Exp Clin Cancer Res 2014; 33: 42.
121. Jeanne M, Lallemand-Breitenbach V, Ferhi O, et al., PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3. Cancer Cell 2010; 18: 88-98.
122. Huang M, Thomas D, Li MX, et al., Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. Leukemia 2013; 27: 1970-80.
123. Zhou P, Kalakonda N, Comenzo RL., Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol 2005; 128: 636-44.
124. Wang L, Kou MC, Weng CY, et al., Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-kappaB, and MAPK pathways. Arch Toxicol 2012; 86: 879-96.
125. Smith DM, Patel S, Raffoul F, et al., Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ 2010; 17: 1867-81.
126. Yang L, Yang M, Zhang H, et al., S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy. Int J Mol Med 2012; 29: 65-72.
127. Alexandre J, Hu Y, Lu W, et al., Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species. Cancer Res 2007; 67: 3512-17.
128. Alexandre J, Batteux F, Nicco C, et al., Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int J Cancer 2006; 119: 41-8.
129. Ramanathan B, Jan KY, Chen CH, et al., Resistance to paclitaxel is proportional to cellular total antioxidant capacity. Cancer Res 2005; 65: 8455-60.
130. Fukui M, Yamabe N, Zhu BT., Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. Eur J Cancer 2010; 46: 1882-91.
131. Wang K, Liu R, Li J, et al., Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy 2011; 7: 966-78.
132. Duvic M, Talpur R, Ni X, et al., Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007; 109: 31-9.
133. Zhang QL, Wang L, Zhang YW, et al., The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis. Leukemia 2009; 23: 1507-14.
134. Li J, Liu R, Lei Y, et al., Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy 2010; 6: 711-24.
135. Deeley RG, Westlake C, Cole SP., Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006; 86: 849-99.
136. Cole SP., Targeting multidrug resistance protein 1 (MRP1, ABCC1): past, present, and future. Annu Rev Pharmacol Toxicol 2014; 54: 95-117.
137. Desideri E, Filomeni G, Ciriolo MR., Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells. Autophagy 2012; 8: 1769-81.
138. Kuo MT., Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities. Antioxidants Redox Signal 2009; 11: 99-133.
139. Hu YL, Jahangiri A, Delay M, et al., Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. Cancer Res 2012; 72: 4294-9.
140. Hu YL, Jahangiri A, De Lay M, et al., Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy. Autophagy 2012; 8: 979-81.
141. Buchser WJ, Laskow TC, Pavlik PJ, et al., Cell-mediated autophagy promotes cancer cell survival. Cancer Res 2012; 72: 2970-9.
142. Campos T, Ziehe J, Palma M, et al., Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy. Mol Carcinogen 2015; 55: 220-9.
143. Baehrecke EH., Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6: 505-10.
144. Mathew R, Karantza-Wadsworth V, White E., Role of autophagy in cancer. Nat Rev Cancer 2007; 7: 961-7.
145. Kroemer G, Galluzzi L, Vandenabeele P, et al., Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16: 3-11.
146. Xiong HY, Guo XL, Bu XX, et al., Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell. Cancer Lett 2010; 288: 68-74.
147. Chen YJ, Chi CW, Su WC, et al., Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma. Oncotarget 2014; 5: 4845-54.
148. Kim TH, Kim HS, Kang YJ, et al., Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta 2015; 1850: 401-10.
149. Sui X, Chen R, Wang Z, et al., Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis 2013; 4: e838.