Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism; Evidence for the role of the ROS-ERK-CHOP-death receptor pathway

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32343-32356

  Gupta, Subash C ^a,c   Francis, Sajin K ^b   Nair, Mangalam S ^b   Mo, Yin Yuan ^c   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b REGIONAL RESEARCH LABORATORY CSIR   (India)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOWN-REGULATION; ERK ACTIVATION; HOMOLOGOUS PROTEINS; HUMAN CANCER CELLS; HUMAN TUMOR CELLS; REACTIVE OXYGEN SPECIES; SIGNALING MOLECULES; TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGANDS;

CELL DEATH; GLYCOPROTEINS; LIGANDS; MACROPHAGES; PROTEINS; TRANSCRIPTION; TUMORS;

CELL SIGNALING;

AZADIRONE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FLICE INHIBITORY PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN MCL 1; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SURVIVIN; TRITERPENE DERIVATIVE; TUMOR NECROSIS FACTOR DECOY RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AZADIRACHTA INDICA; BINDING SITE; CANCER CELL CULTURE; CELL SPECIFICITY; CELL SURVIVAL; CHEMOSENSITIZATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; PLANT SEED; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTICANCER DRUG; APOPTOSIS; CANCER THERAPY; CHOP; DEATH RECEPTOR; LIMONOID; MAP KINASES (MAPKS); REACTIVE OXYGEN SPECIES (ROS); TRAIL;

ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIMONINS; MAP KINASE SIGNALING SYSTEM; NEOPLASMS; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RESPONSE ELEMENTS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84887496136     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.455188     Document Type: Article

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