Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells

Journal of Experimental and Clinical Cancer Research

Volumn 33, Issue 1, 2014, Pages

  Kumar, Sanjay ^a   Yedjou, Clement G ^a   Tchounwou, Paul B ^a  

^a Jackson State University   (United States)

Author keywords

Apoptosis; Arsenic trioxide; DNA damage; HL 60 cells; Oxidative stress

Indexed keywords

ARSENIC TRIOXIDE; CASPASE 3; CYTOCHROME C; GLUTATHIONE; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL MEMBRANE DEPOLARIZATION; COMET ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LEUKEMIA CELL; LIPID PEROXIDATION ASSAY; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENICALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CYTOCHROMES C; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; GLUTATHIONE; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; OXIDES; PROTEIN TRANSPORT; SINGLE-CELL ANALYSIS;

EID: 84902250809     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-33-42     Document Type: Article

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